heliotrine and Chemical-and-Drug-Induced-Liver-Injury--Chronic

The purpose of the given research work was to study the features of morphologic changes arising during the treatment of chronic hepatitis with NEOSELEN. Chronic active hepatitis was set up in laboratory rats, post-forming in chronic persisting hepatitis and its transformation in a certain part of animals into cirrhosis by administration of HELIOTRINE over the period of 40 days. Morphologically hepatic cirrhosis was small nodular. NEOSELEN was found to have a good therapeutic effect in treatment of chronic hepatitis as we have seen noticeable remittance of destructive necrotic changes in hepatic parenchymatouse elements and reduction in a volume of proliferative inflammatory infiltration along with acceleration of fibrosis process only in periportal zones of hepatic lobules. The therapeutic efficacy of NEOSELEN prevents transmission of chronic hepatitis into cirrhosis in a greater part of animals thus giving morphologic signs of importance of NEOSELEN in a restorative process of destructive and inflammatory changes in the affected liver.

Topics: Animals; Chemical and Drug Induced Liver Injury, Chronic; Fibrosis; Pyrrolizidine Alkaloids; Rats; Selenium Compounds

The structural and morphometrical characteristics of thymus were studied in the dynamics of experimental heliotrine hepatitis. The decrease of areas and cell hypoplasia of cortical zone of the thymus were noted. The destructive processes of the thymocytes were intensified and, in response to it, thymic macrophages activity was enhanced. The facts obtained indicated that the use of the thymic peptides is necessary for correction of immune disorders in chronic hepatitis.

Topics: Animals; Chemical and Drug Induced Liver Injury, Chronic; Male; Microscopy, Electron; Pyrrolizidine Alkaloids; Rats; Rats, Wistar; Thymus Gland; Time Factors