hc-067047 has been researched along with Urinary-Bladder--Overactive* in 1 studies
1 other study(ies) available for hc-067047 and Urinary-Bladder--Overactive
| Article | Year |
|---|---|
TRPV4 blockade reduces voiding frequency, ATP release, and pelvic sensitivity in mice with chronic urothelial overexpression of NGF.
Transient receptor potential vanilloid family member 4 (TRPV4) transcript and protein expression increased in the urinary bladder and lumbosacral dorsal root ganglia of transgenic mice with chronic urothelial overexpression of nerve growth factor (NGF-OE). We evaluated the functional role of TRPV4 in bladder function with open-outlet cystometry, void spot assays, and natural voiding (Urovoid) assays with the TRPV4 antagonist HC-067047 (1 μM) or vehicle in NGF-OE and littermate wild-type (WT) mice. Blockade of TRPV4 at the level of the urinary bladder significantly ( Topics: Adenosine Triphosphate; Animals; Brefeldin A; Female; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Nerve Growth Factor; Pelvis; Physical Stimulation; Protein Synthesis Inhibitors; Pyrroles; TRPV Cation Channels; Urinary Bladder; Urinary Bladder, Overactive; Urination; Urothelium | 2019 |