hc-067047 and Pruritus

Dry skin is a symptom of skin barrier dysfunction that evokes pruritus; however, the cutaneous neuroimmune interactions underlying dry skin-induced pruritus remain unclear. Therefore, we aimed to elucidate the mechanisms underlying dry skin-induced pruritus. To this end, an acetone/ethanol/water (AEW)-induced mouse model of dry skin was used in this study. We observed that the production of thymic stromal lymphopoietin (TSLP) significantly increased in the keratinocytes of AEW mice. Importantly, treatment with an antagonist of transient receptor potential cation channel subfamily V member 4 (TRPV4), HC067047, ameliorated dry skin conditions in AEW mice. The symptoms of dry skin were significantly reduced in

Topics: Animals; Cells, Cultured; Cytokines; Ganglia, Spinal; Humans; Keratinocytes; Male; Mast Cells; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Morpholines; Neuroimmunomodulation; Neurons; Pruritus; Pyrroles; Skin; Thymic Stromal Lymphopoietin; TRPV Cation Channels