hc-067047 and Inflammation

hc-067047 has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for hc-067047 and Inflammation

Article	Year
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice. Cell death & disease, 2019, 05-16, Volume: 10, Issue:6 Activation of transient receptor potential vanilloid 4 (TRPV4) induces neuronal injury. TRPV4 activation enhances inflammatory response and promotes the proinflammatory cytokine release in various types of tissue and cells. Hyperneuroinflammation contributes to neuronal damage in epilepsy. Herein, we examined the contribution of neuroinflammation to TRPV4-induced neurotoxicity and its involvement in the inflammation and neuronal damage in pilocarpine model of temporal lobe epilepsy in mice. Icv. injection of TRPV4 agonist GSK1016790A (GSK1016790A-injected mice) increased ionized calcium binding adapter molecule-1 (Iba-1) and glial fibrillary acidic protein (GFAP) protein levels and Iba-1-positive (Iba-1 Topics: Animals; Astrocytes; Epilepsy, Temporal Lobe; Inflammasomes; Inflammation; Leucine; Male; Mice; Mice, Inbred ICR; Microglia; Morpholines; Neurons; Pilocarpine; Pyrroles; Status Epilepticus; Sulfonamides; TRPV Cation Channels	2019

Article

Year

TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.

Cell death & disease, 2019, 05-16, Volume: 10, Issue:6

Activation of transient receptor potential vanilloid 4 (TRPV4) induces neuronal injury. TRPV4 activation enhances inflammatory response and promotes the proinflammatory cytokine release in various types of tissue and cells. Hyperneuroinflammation contributes to neuronal damage in epilepsy. Herein, we examined the contribution of neuroinflammation to TRPV4-induced neurotoxicity and its involvement in the inflammation and neuronal damage in pilocarpine model of temporal lobe epilepsy in mice. Icv. injection of TRPV4 agonist GSK1016790A (GSK1016790A-injected mice) increased ionized calcium binding adapter molecule-1 (Iba-1) and glial fibrillary acidic protein (GFAP) protein levels and Iba-1-positive (Iba-1

Topics: Animals; Astrocytes; Epilepsy, Temporal Lobe; Inflammasomes; Inflammation; Leucine; Male; Mice; Mice, Inbred ICR; Microglia; Morpholines; Neurons; Pilocarpine; Pyrroles; Status Epilepticus; Sulfonamides; TRPV Cation Channels

2019