hc-030031 and Sunburn

Ultraviolet B (UVB) radiation exposure promotes sunburn and thereby acute and chronic inflammatory processes, contributing to pain development and maintenance. New therapeutic alternatives are necessary because typical treatments can cause adverse effects. An attractive alternative would be to target the transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable, non-selective cation channel, which is involved in a variety of inflammatory pain models.. Evaluate the peripheral participation of TRPA1 using a topical treatment (HC030031 gel formulation; a selective TRPA1 antagonist) in nociception and inflammation caused by a UVB radiation-induced burn model in male mice (25-30 g).. The mice were anaesthetised, and just the right hind paw was exposed to UVB radiation (0.75 J/cm. HC030031 gel presented suitable pH and spreadability factor, ensuring its quality and the therapeutic effect. HC030031 0.05 % reversed UVB-induced mechanical and cold allodynia, with maximum inhibition (I. These findings confirm the activation of the TRPA1 channel by UVB radiation, suggesting that topical TRPA1 antagonists can be a new strategy for the adjuvant treatment of sunburn-associated pain and inflammation.

Topics: Acetanilides; Administration, Cutaneous; Animals; Calcium; Disease Models, Animal; Humans; Hydrogen Peroxide; Inflammation; Male; Mice; Nociception; Pain; Purines; Skin; Spinal Cord; Sunburn; Synaptosomes; TRPA1 Cation Channel; Ultraviolet Rays