harpagoside and Anaphylaxis

harpagoside has been researched along with Anaphylaxis* in 1 studies

Other Studies

1 other study(ies) available for harpagoside and Anaphylaxis

Article	Year
Harpagoside-induced anaphylactic reaction in an IgE-independent manner both in vitro and in vivo. Immunopharmacology and immunotoxicology, 2018, Volume: 40, Issue:2 Harpagoside (HAR) is an active component of Scrophularia ningpoensis (SN), which has anti-inflammatory and anti-immune effects. SN is used widely in China to treat various diseases. Recently, SN has been used as a traditional Chinese medicine injection and used clinically. However, allergic responses to these injections are frequently reported.. We examined whether the main component of SN, HAR, is associated with the allergic reaction to SN.. This study assessed the effects of HAR in mice and mast cell activation to characterize its anaphylactic effects and underlying mechanisms. Mice hindpaw swelling, serum allergy factor detection, enzyme-linked immunosorbent assays, and degranulation assays were performed to measure allergic mediators both in vivo and in vitro.. HAR is a potential sensitization compound in SN, and these results provide information for the safe clinical use of SN. Topics: Anaphylaxis; Animals; Disease Models, Animal; Glycosides; Immunoglobulin E; Mice; Pyrans	2018

Article

Year

Harpagoside-induced anaphylactic reaction in an IgE-independent manner both in vitro and in vivo.

Immunopharmacology and immunotoxicology, 2018, Volume: 40, Issue:2

Harpagoside (HAR) is an active component of Scrophularia ningpoensis (SN), which has anti-inflammatory and anti-immune effects. SN is used widely in China to treat various diseases. Recently, SN has been used as a traditional Chinese medicine injection and used clinically. However, allergic responses to these injections are frequently reported.. We examined whether the main component of SN, HAR, is associated with the allergic reaction to SN.. This study assessed the effects of HAR in mice and mast cell activation to characterize its anaphylactic effects and underlying mechanisms. Mice hindpaw swelling, serum allergy factor detection, enzyme-linked immunosorbent assays, and degranulation assays were performed to measure allergic mediators both in vivo and in vitro.. HAR is a potential sensitization compound in SN, and these results provide information for the safe clinical use of SN.

Topics: Anaphylaxis; Animals; Disease Models, Animal; Glycosides; Immunoglobulin E; Mice; Pyrans

2018