harmine and Peripheral-Nervous-System-Diseases

harmine has been researched along with Peripheral-Nervous-System-Diseases* in 1 studies

Other Studies

1 other study(ies) available for harmine and Peripheral-Nervous-System-Diseases

Article	Year
Novel harmine derivatives for tumor targeted therapy. Oncotarget, 2015, Apr-20, Volume: 6, Issue:11 Harmine is a beta-carboline alkaloid found in medicinal plant PeganumHarmala, which has served as a folk anticancer medicine. However, clinical applications of harmine were limited by its low pharmacological effects and noticeable neurotoxicity. In this study, we modified harmine to increase the therapeutic efficacy and to decrease the systemic toxicity. Specifically, two tumor targeting harmine derivatives 2DG-Har-01 and MET-Har-02 were synthesized by modifying substituent in position-2, -7 and -9 of harmine ring with two different targeting group2-amino-2-deoxy-D-glucose (2DG) and Methionine (Met), respectively. Their therapeutic efficacy and toxicity were investigated both in vitro and in vivo. Results suggested that the two new harmine derivatives displayed much higher therapeutic effects than non-modified harmine. In particular, MET-Har-02 was more potent than 2DG-Har-01 with promising potential for targeted cancer therapy. Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Cell Shape; Chemical and Drug Induced Liver Injury; Drug Screening Assays, Antitumor; Harmine; Heart; Humans; Kidney; Lung; Mice; Molecular Structure; Molecular Targeted Therapy; PC12 Cells; Peripheral Nervous System Diseases; Rats; Tumor Stem Cell Assay	2015

Article

Year

Novel harmine derivatives for tumor targeted therapy.

Oncotarget, 2015, Apr-20, Volume: 6, Issue:11

Harmine is a beta-carboline alkaloid found in medicinal plant PeganumHarmala, which has served as a folk anticancer medicine. However, clinical applications of harmine were limited by its low pharmacological effects and noticeable neurotoxicity. In this study, we modified harmine to increase the therapeutic efficacy and to decrease the systemic toxicity. Specifically, two tumor targeting harmine derivatives 2DG-Har-01 and MET-Har-02 were synthesized by modifying substituent in position-2, -7 and -9 of harmine ring with two different targeting group2-amino-2-deoxy-D-glucose (2DG) and Methionine (Met), respectively. Their therapeutic efficacy and toxicity were investigated both in vitro and in vivo. Results suggested that the two new harmine derivatives displayed much higher therapeutic effects than non-modified harmine. In particular, MET-Har-02 was more potent than 2DG-Har-01 with promising potential for targeted cancer therapy.

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Cell Shape; Chemical and Drug Induced Liver Injury; Drug Screening Assays, Antitumor; Harmine; Heart; Humans; Kidney; Lung; Mice; Molecular Structure; Molecular Targeted Therapy; PC12 Cells; Peripheral Nervous System Diseases; Rats; Tumor Stem Cell Assay

2015