harmine and Osteoporosis

harmine has been researched along with Osteoporosis* in 2 studies

Reviews

1 review(s) available for harmine and Osteoporosis

Article	Year
[Novel strategies for the development of anabolic agents for treatment of osteoporosis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2014, Volume: 144, Issue:6 Topics: Anabolic Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzazepines; Biphenyl Compounds; Bone Density Conservation Agents; Bone Remodeling; Cell Differentiation; Denosumab; Drug Discovery; Drug Evaluation, Preclinical; Harmine; Humans; Indoles; Lithium Compounds; Molecular Targeted Therapy; NFATC Transcription Factors; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Parathyroid Hormone; Teriparatide; Wnt Signaling Pathway	2014

Article

Year

[Novel strategies for the development of anabolic agents for treatment of osteoporosis].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2014, Volume: 144, Issue:6

Topics: Anabolic Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzazepines; Biphenyl Compounds; Bone Density Conservation Agents; Bone Remodeling; Cell Differentiation; Denosumab; Drug Discovery; Drug Evaluation, Preclinical; Harmine; Humans; Indoles; Lithium Compounds; Molecular Targeted Therapy; NFATC Transcription Factors; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Parathyroid Hormone; Teriparatide; Wnt Signaling Pathway

2014

Other Studies

1 other study(ies) available for harmine and Osteoporosis

Article	Year
Harmine enhances type H vessel formation and prevents bone loss in ovariectomized mice. Theranostics, 2018, Volume: 8, Issue:9 Recently, researchers identified a distinct vessel subtype called type H vessels that couple angiogenesis and osteogenesis. We previously found that type H vessels are reduced in ovariectomy (OVX)-induced osteoporotic mice, and preosteoclasts are able to secrete platelet-derived growth factor-BB (PDGF-BB) to stimulate type H vessel formation and thereby to promote osteogenesis. This study aimed to explore whether harmine, a β-carboline alkaloid, is capable of preventing bone loss in OVX mice by promoting preosteoclast PDGF-BB-induced type H vessel formation.. The impact of harmine on osteoclastogenesis of RANKL-stimulated RAW264.7 cells was verified by gene expression analysis and tartrate-resistant acid phosphatase (TRAP) staining. Enzyme-linked immunosorbent assay (ELISA) was conducted to test PDGF-BB production by preosteoclasts. A series of angiogenesis-related assays. Exposure of RANKL-stimulated RAW264.7 cells to harmine enhanced the formation of preosteoclasts and the production of PDGF-BB. Harmine augmented the ability of RANKL-stimulated RAW264.7 cells to promote angiogenesis of endothelial cells, whereas the effect was blocked by PDGF-BB inhibition.. Harmine may exert bone-sparing effects by suppression of osteoclast formation and promotion of preosteoclast PDGF-BB-induced angiogenesis. Topics: Animals; Becaplermin; Bone and Bones; Bone Diseases, Metabolic; Bone Resorption; Cell Differentiation; Cell Line; Culture Media, Conditioned; Harmine; Mice; Neovascularization, Physiologic; Osteoclasts; Osteogenesis; Osteoporosis; Ovariectomy; RAW 264.7 Cells	2018

Article

Year

Harmine enhances type H vessel formation and prevents bone loss in ovariectomized mice.

Theranostics, 2018, Volume: 8, Issue:9

Recently, researchers identified a distinct vessel subtype called type H vessels that couple angiogenesis and osteogenesis. We previously found that type H vessels are reduced in ovariectomy (OVX)-induced osteoporotic mice, and preosteoclasts are able to secrete platelet-derived growth factor-BB (PDGF-BB) to stimulate type H vessel formation and thereby to promote osteogenesis. This study aimed to explore whether harmine, a β-carboline alkaloid, is capable of preventing bone loss in OVX mice by promoting preosteoclast PDGF-BB-induced type H vessel formation.. The impact of harmine on osteoclastogenesis of RANKL-stimulated RAW264.7 cells was verified by gene expression analysis and tartrate-resistant acid phosphatase (TRAP) staining. Enzyme-linked immunosorbent assay (ELISA) was conducted to test PDGF-BB production by preosteoclasts. A series of angiogenesis-related assays. Exposure of RANKL-stimulated RAW264.7 cells to harmine enhanced the formation of preosteoclasts and the production of PDGF-BB. Harmine augmented the ability of RANKL-stimulated RAW264.7 cells to promote angiogenesis of endothelial cells, whereas the effect was blocked by PDGF-BB inhibition.. Harmine may exert bone-sparing effects by suppression of osteoclast formation and promotion of preosteoclast PDGF-BB-induced angiogenesis.

Topics: Animals; Becaplermin; Bone and Bones; Bone Diseases, Metabolic; Bone Resorption; Cell Differentiation; Cell Line; Culture Media, Conditioned; Harmine; Mice; Neovascularization, Physiologic; Osteoclasts; Osteogenesis; Osteoporosis; Ovariectomy; RAW 264.7 Cells

2018