harmine has been researched along with Diabetes-Mellitus--Type-1* in 2 studies
2 other study(ies) available for harmine and Diabetes-Mellitus--Type-1
| Article | Year |
|---|---|
Targeted delivery of harmine to xenografted human pancreatic islets promotes robust cell proliferation.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Diabetes Mellitus, Type 1; Harmine; Heterografts; Humans; Insulin; Islets of Langerhans; Mice | 2022 |
Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia and diabetes. Thus, promoting β-cell proliferation could be one approach toward diabetes intervention. In this report we describe the discovery of a potent and selective DYRK1A inhibitor GNF2133, which was identified through optimization of a 6-azaindole screening hit. Topics: Animals; Aza Compounds; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, Type 1; Dyrk Kinases; Humans; Hypoglycemic Agents; Indoles; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Molecular Docking Simulation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2020 |