harmine and Carcinoma--Ovarian-Epithelial

Epithelial ovarian cancer (EOC) generates multicellular aggregates called spheroids that detach from the primary tumor and disseminate through ascites. Spheroids possess a number of characteristics of tumor dormancy including withdrawal from the cell cycle and resistance to chemotherapeutics. This report systematically analyzes the effects of RNAi depletion of 21 genes that are known to contribute to negative regulation of the cell cycle in 10 ovarian cancer cell lines. Interestingly, spheroid cell viability was compromised by loss of some cyclin-dependent kinase inhibitors such as p57

Topics: Carboplatin; Carcinoma, Ovarian Epithelial; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dyrk Kinases; Harmine; Humans; Kv Channel-Interacting Proteins; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Repressor Proteins; Spheroids, Cellular; Trans-Activators; Tumor Cells, Cultured