harman and Epilepsy

harman has been researched along with Epilepsy* in 1 studies

Other Studies

1 other study(ies) available for harman and Epilepsy

Article	Year
Effect of harmane on the convulsive threshold in epilepsy models in mice. Annals of the New York Academy of Sciences, 2003, Volume: 1009 The study investigated the activity of harmane on maximal electroshock seizures (MES) and seizures induced by pentilentetrazole (PTZ) in mice. Initial studies established convulsive current 50 (CC(50)) values or MES and effective dose 50 (ED(50)) for PTZ to produce seizures. Harmane (2.5, 5.0, or 10 mg/kg intraperitoneally) increased the threshold of seizures in MES dose-dependently. The convulsions produced by PTZ were decreased by the low dose of harmane (2.5 mg/kg), but the high dose of harmane (10 mg/kg) resulted in worse grade V convulsions followed by more lethality compared with PTZ alone. Therefore, harmane seems to be protective against grand mal seizures in the MES model but not against a petit mal seizure model (PTZ) in mice. Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Female; Harmine; Male; Mice; Pentylenetetrazole; Seizures	2003

Article

Year

Effect of harmane on the convulsive threshold in epilepsy models in mice.

Annals of the New York Academy of Sciences, 2003, Volume: 1009

The study investigated the activity of harmane on maximal electroshock seizures (MES) and seizures induced by pentilentetrazole (PTZ) in mice. Initial studies established convulsive current 50 (CC(50)) values or MES and effective dose 50 (ED(50)) for PTZ to produce seizures. Harmane (2.5, 5.0, or 10 mg/kg intraperitoneally) increased the threshold of seizures in MES dose-dependently. The convulsions produced by PTZ were decreased by the low dose of harmane (2.5 mg/kg), but the high dose of harmane (10 mg/kg) resulted in worse grade V convulsions followed by more lethality compared with PTZ alone. Therefore, harmane seems to be protective against grand mal seizures in the MES model but not against a petit mal seizure model (PTZ) in mice.

Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Female; Harmine; Male; Mice; Pentylenetetrazole; Seizures

2003