Page last updated: 2024-10-28

harmaline and Tremor

harmaline has been researched along with Tremor in 111 studies

Harmaline: A beta-carboline alkaloid isolated from seeds of PEGANUM.
harmaline : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.

Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.

Research Excerpts

ExcerptRelevanceReference
"Cerebellar EDCS suppressed harmaline tremor in rats in a polarity-dependent manner."8.31Epicranial Direct Current Stimulation Suppresses Harmaline Tremor in Rats. ( Asamoah, B; Boogers, A; Khatoun, A; Mc Laughlin, M, 2023)
"The results indicated that ABA (10 μg/rat) can improve harmaline-induced tremor in rats."8.12Phytohormone abscisic acid elicits positive effects on harmaline-induced cognitive and motor disturbances in a rat model of essential tremor. ( Naderi, R; Shabani, M, 2022)
"While harmaline has been used as a pharmacological model of essential tremor (ET) in rodents and pigs, less is known about the effects of this pharmacological treatment in awake-behaving non-human primates."8.02Considerations Using Harmaline for a Primate Model of Tremor. ( Bello, EM; Blumenfeld, M; Dao, J; Johnson, MD; Krieg, JDS; Wilmerding, LK, 2021)
"In a pig model, tremor was induced with harmaline and measured with wireless accelerometers attached to the limbs."7.88Development of Harmaline-induced Tremor in a Swine Model. ( Chang, SY; Cheng, L; Jang, DP; Kang, SI; Kim, I; Knight, E; Lee, J, 2018)
"Harmaline was injected at a dose of 15 mg/kg ip and tremor was measured automatically in force-plate actimeters by an increased averaged power in the frequency band of 9-15 Hz (AP2) and by tremor index (a difference in power between AP2 and averaged power in the frequency band of 0-8 Hz)."7.85Tremorolytic effect of 5'-chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A1 receptor agonist, evaluated in the harmaline-induced model in rats. ( Głowacka, U; Kosmowska, B; Ossowska, K; Wardas, J, 2017)
"To study the effect of pretreatment with low doses of vanillin, a flavoring agent used as a food additive, on harmaline-induced tremor in rats."7.85Low-dose acute vanillin is beneficial against harmaline-induced tremors in rats. ( Abdulrahman, AA; Arshaduddin, M; Faisal, K; Meshref, AA, 2017)
" Finally, we demonstrate that loss of NCB5OR in the cerebellum and midbrain exacerbated harmaline-induced tremor activity."7.83Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice. ( McCarson, KE; Stroh, MA; Swerdlow, RH; Winter, MK; Zhu, H, 2016)
"Harmaline-induced tremor is a well-known model of essential tremor in humans."7.81Apomorphine enhances harmaline-induced tremor in rats. ( Głowacka, U; Kosmowska, B; Ossowska, K; Wardas, J, 2015)
"Harmaline induces tremor in animals resembling essential tremor which has been suggested to result from activation of the glutamatergic olivo-cerebellar projection."7.80Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats. ( Berghauzen-Maciejewska, K; Doller, D; Głowacka, U; Kuter, K; Ossowska, K; Pilc, A; Wardas, J; Zorn, SH, 2014)
"The aim of the present study was to examine the influence of a unilateral 6-hydroxydopamine (6-OHDA)-induced partial lesion of both the substantia nigra pars compacta (SNc, A9) and retrorubral field (RRF, A8) on the tremor evoked by harmaline."7.786-OHDA injections into A8-A9 dopaminergic neurons modelling early stages of Parkinson's disease increase the harmaline-induced tremor in rats. ( Berghauzen, K; Kolasiewicz, W; Kuter, K; Nowak, P; Ossowska, K; Schulze, G, 2012)
" Thus, we aimed to investigate the therapeutic effects of riluzole on harmaline-induced tremor and ataxia in rat, and determining whether riluzole exerts its effect through modulation of glutamate levels in cerebellum."7.78Effects of riluzole on harmaline induced tremor and ataxia in rats: biochemical, histological and behavioral studies. ( Abrari, K; Elahdadi Salmani, M; Goudarzi, A; Goudarzi, I; Lashkarbolouki, T; Rahimi Shourmasti, F, 2012)
"Abnormal synchronous activation of the glutamatergic olivo-cerebellar pathway has been suggested to be crucial for the harmaline-induced tremor."7.77Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats. ( Kolasiewicz, W; Kuter, K; Nowak, P; Ossowska, K; Pastuszka, A, 2011)
" The current study aims to investigate the anti-tremogenic and neuroprotective effects of memantine (NMDA receptor antagonist) on the harmaline model of transient action tremor."7.77The effect of memantine in harmaline-induced tremor and neurodegeneration. ( Akman, O; Ates, N; Erturk, S; Gullu, KM; Iseri, PK; Karson, A; Kokturk, S; Yardýmoglu, M, 2011)
" This hypothesis was tested by searching for the expression of the Cx57 transcripts in the mouse cerebellum of the harmaline-tremor model."7.76Expression of connexin57 in mouse development and in harmaline-tremor model. ( Cicirata, F; Cicirata, V; La Delia, F; Parenti, R; Zappalà, A, 2010)
"Harmaline-induced tremor in rodents is a model of essential tremor."7.75Pharmacological characterization of harmaline-induced tremor activity in mice. ( Foreman, MM; Hanania, T; Malekiani, SA; Olivier, B; Paterson, NE, 2009)
"32 mg/kg sc strongly enhances tremor of forelimbs, head and trunk, hypolocomotion, and ataxia induced by harmaline (7."7.75Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats. ( Kolasiewicz, W; Kuter, K; Ossowska, K; Wardas, J, 2009)
"Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied."7.74Effects of zonisamide on experimental tremors in rats. ( Hama, K; Kajimoto, Y; Kondo, T; Miwa, H, 2008)
"Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor."7.72Vagus nerve stimulation inhibits harmaline-induced tremor. ( Handforth, A; Krahl, SE; Martin, FC, 2004)
"We studied whether vagus nerve stimulation could suppress tremor in the harmaline tremor model in the rat."7.71Suppression of harmaline-induced tremor in rats by vagus nerve stimulation. ( Handforth, A; Krahl, SE, 2001)
"Recent experimental and clinical studies clearly suggest the role of gamma-aminobutyric acid (GABA) in the pathogenesis of tremors."7.71Baclofen attenuates harmaline induced tremors in rats. ( Al Deeb, S; Al Moutaery, K; Arshaduddin, M; Biary, N; Tariq, M, 2001)
"Both harmaline and physostigmine are known to produce whole-body tremors in rodents, yet there is little quantitative information on the differential frequency characteristics of these tremors or on other possible motor effects of these drugs."7.71Concurrent quantification of tremor and depression of locomotor activity induced in rats by harmaline and physostigmine. ( Fowler, SC; Wang, G, 2001)
"Recent studies suggest an association between caffeine consumption and tremor."7.71Effect of acute caffeine on severity of harmaline induced tremor in rats. ( Al-Deeb, S; Al-Moutaery, K; Arshaduddin, M; Biary, N; Tariq, M, 2002)
"A behavioral preparation especially sensitive to low-dose drug effects on fine motor behavior in rats was used to assess the tremorogenic effects of harmaline, an indole alkaloid and beta-carboline derivative."7.70At low doses, harmaline increases forelimb tremor in the rat. ( Fowler, SC; Stanford, JA, 1998)
"The present study was undertaken to investigate the effect of lidocaine on harmaline-induced tremors in the rat."7.70Effect of lidocaine on harmaline-induced tremors in the rat. ( Al Deeb, S; Al Moutaery, K; Arshaduddin, M; Biary, N; Tariq, M, 2000)
"This study reports that corticotropin-releasing factor (CRF) expression within the inferior olivary complex (IOC) of the cat is increased 8 h after administration of the tremor-inducing beta-carboline harmaline."7.69Corticotropin-releasing factor mRNA increases in the inferior olivary complex during harmaline-induced tremor. ( Cummings, S; Hinds, D; Young, WS, 1994)
"Harmaline is known to produce tremors and retard acquisition of the rabbit's nictitating membrane response."7.69Harmaline-induced tremor and impairment of learning are both blocked by dizocilpine in the rabbit. ( Du, W; Harvey, JA, 1997)
"The genetically dystonic rat is insensitive to the tremorogenic effects of harmaline."7.68Effect of harmaline on cells of the inferior olive in the absence of tremor: differential response of genetically dystonic and harmaline-tolerant rats. ( Lorden, JF; Stratton, SE, 1991)
" Harmaline produced tremor has been shown to induce rhythmic activity and increase glucose consumption in the IO."7.67Inferior olivary neurons: 3-acetylpyridine effects on glucose consumption, axonal transport, electrical activity and harmaline-induced tremor. ( Bernard, JF; Buisseret-Delmas, C; Laplante, S, 1984)
" Diazepam has been reported to inhibit both the tremor and mechanism of cerebellar cyclic GMP caused by harmaline by a neurotransmission in the cerebellum."7.67Ethanol effects on harmaline-induced tremor and increase of cerebellar cyclic GMP. ( Dole, VP; Gentry, RT; Rappaport, MS; Schneider, DR, 1984)
"Administration of the beta-carboline alkaloid, harmaline, causes the neurons of the inferior olive to fire synchronously and to act as a pacemaker for the generation of tremor."7.67Tolerance to the tremorogenic effects of harmaline: evidence for altered olivo-cerebellar function. ( Beales, M; Lorden, JF; Lutes, J; Oltmans, GA, 1988)
"Specific beta 1- and beta 2-adrenoceptor antagonists, acebutolol and butoxamine respectively were used to investigate the involvement of blockade of these receptors in the inhibition of harmaline-induced tremors."7.67Involvement of beta 2-adrenoceptor blockade and 5-hydroxytryptamine mechanism in inhibition of harmaline-induced tremors in rats. ( Paul, V, 1986)
"The effects of excitatory amino acids, kainic acid and quisqualic acid, on the tremorine- and harmaline-induced tremor were quantitatively examined in mice using the power spectral analyzing method."7.67Modification of drug-induced tremor by systemic administration of kainic acid and quisqualic acid in mice. ( Hirate, K; Ishida, M; Shinozaki, H, 1987)
"Harmaline produces a tremor which is prevented by diazepam."7.66Harmaline-induced tremor: the benzodiazepine receptor as a site of action. ( Robertson, HA, 1980)
" A tremorogenic dose of harmaline (30 mg/kg intravenously) increased binding by 31%."7.66Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. ( Airaksinen, MM; Saano, V, 1982)
"In the Rat under tremorogenic doses of harmaline, Purkinje cells of the vermis of the cerebellar cortex display a regular complex spike activity at 6 to 11 Hz ("harmaline-rhythm")."7.66[Harmaline tremor: topography of activity in the cerebellar cortex in rats]. ( Bernard, JF, 1983)
" Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline."7.66Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982)
"The brain structures specifically involved in harmaline-induced tremor have been identified in the Rat by using the 14C-2-deoxyglucose marking Method."7.66[Harmaline-induced tremor and cerebral activities: labeling with 14C-2-deoxyglucose in the rat]. ( Batini, C; Buisseret-Delmas, C; Conrath-Verrier, M, 1978)
"Since there is degeneration of substantia nigra concomitant with that of locus coeruleus (LC) in patients with Parkinson's disease, the study was performed to determine the role of central norepinephrine (NE) on harmaline induced tremor."7.66Significance of central noradrenergic system on harmaline induced tremor. ( Takaori, S; Tanaka, C; Yamazaki, M, 1979)
"Harmaline, an alcaloid of Paganum Armala, induces tremors of central origin and increases cerebellar cGMP without affecting cortical and cerebellar prostaglandin levels."7.66Inhibition of harmaline induced tremors by 16 (S)-16-methyl PGE2 in different mammalian species: a correlation with central cyclic nucleotides and prostaglandins. ( Berti, F; Fano, M; Folco, GC; Longiave, D; Omini, C, 1978)
"The possible involvement of serotoninergic mechanisms in the induction of harmaline generated tremor in the inferior olive has been investigated electrophysiologically in the cat and rat."7.65The indolaminergic innervation of the inferior olive. 2. Relation to harmaline induced tremor. ( Björklund, A; Sjölund, B; Wiklund, L, 1977)
"Effect of 3, 4-dihydroxyphenylserine (DOPS), a norepinephrine precurosr, on harmaline tremor was investigated in mice to elucidate the role of norepinephrine in the genesis of tremor."7.65[Inhibition of harmaline induced tremor by L-threo-3, 4-dihydroxyphenylserine, an L-norepinephrine precursor]. ( Ikeda, Y; Inagaki, C; Ishikawa, M; Tanaka, C; Yamazaki, M, 1976)
"Pramipexole was administered at a low dose of 0."5.56Pramipexole Reduces zif-268 mRNA Expression in Brain Structures involved in the Generation of Harmaline-Induced Tremor. ( Kosmowska, B; Ossowska, K; Wardas, J, 2020)
"Imipramine treatment further decreased harmaline-induced 5HT turnover in the brain stem."5.33Exacerbation of harmaline-induced tremor by imipramine. ( Al Deeb, S; Al Moutaery, K; Arshaduddin, M; Kadasah, S; Tariq, M, 2005)
"Tremor is the second most common neurological adverse effect in patients receiving treatment with SSRIs."5.32Citalopram, a selective serotonin reuptake inhibitor augments harmaline-induced tremor in rats. ( Al Deeb, S; Al Kadasah, S; Al Moutaery, K; Arshaduddin, M; Biary, N; Tariq, M, 2004)
"Harmaline was used in this study because its tremorgenic action is mediated at the level of IO; octanol was found to be a potent antagonist of harmaline-induced tremor."5.28The effectiveness of different isomers of octanol as blockers of harmaline-induced tremor. ( Krosser, BI; Llinás, RR; Sinton, CM; Walton, KD, 1989)
"Cerebellar EDCS suppressed harmaline tremor in rats in a polarity-dependent manner."4.31Epicranial Direct Current Stimulation Suppresses Harmaline Tremor in Rats. ( Asamoah, B; Boogers, A; Khatoun, A; Mc Laughlin, M, 2023)
" Only non-impairing doses were used to evaluate for anti-tremor efficacy in the harmaline model, which was assessed in wildtype and α6 subunit knockout littermates."4.31Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABA ( Ernst, M; Handforth, A; Singh, RP; Treven, M, 2023)
"The results indicated that ABA (10 μg/rat) can improve harmaline-induced tremor in rats."4.12Phytohormone abscisic acid elicits positive effects on harmaline-induced cognitive and motor disturbances in a rat model of essential tremor. ( Naderi, R; Shabani, M, 2022)
"While harmaline has been used as a pharmacological model of essential tremor (ET) in rodents and pigs, less is known about the effects of this pharmacological treatment in awake-behaving non-human primates."4.02Considerations Using Harmaline for a Primate Model of Tremor. ( Bello, EM; Blumenfeld, M; Dao, J; Johnson, MD; Krieg, JDS; Wilmerding, LK, 2021)
"Using this system, we were able to characterize both the microtremors in netrin-G2 KO mice and low-dose harmaline-induced tremors which, to date, had been difficult to detect."4.02Objective detection of microtremors in netrin-G2 knockout mice. ( Ajima, A; Itohara, S; Yaguchi, K; Yoshida, T, 2021)
"In a pig model, tremor was induced with harmaline and measured with wireless accelerometers attached to the limbs."3.88Development of Harmaline-induced Tremor in a Swine Model. ( Chang, SY; Cheng, L; Jang, DP; Kang, SI; Kim, I; Knight, E; Lee, J, 2018)
"Harmaline was injected at a dose of 15 mg/kg ip and tremor was measured automatically in force-plate actimeters by an increased averaged power in the frequency band of 9-15 Hz (AP2) and by tremor index (a difference in power between AP2 and averaged power in the frequency band of 0-8 Hz)."3.85Tremorolytic effect of 5'-chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A1 receptor agonist, evaluated in the harmaline-induced model in rats. ( Głowacka, U; Kosmowska, B; Ossowska, K; Wardas, J, 2017)
"To study the effect of pretreatment with low doses of vanillin, a flavoring agent used as a food additive, on harmaline-induced tremor in rats."3.85Low-dose acute vanillin is beneficial against harmaline-induced tremors in rats. ( Abdulrahman, AA; Arshaduddin, M; Faisal, K; Meshref, AA, 2017)
" Finally, we demonstrate that loss of NCB5OR in the cerebellum and midbrain exacerbated harmaline-induced tremor activity."3.83Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice. ( McCarson, KE; Stroh, MA; Swerdlow, RH; Winter, MK; Zhu, H, 2016)
"Hybrid tremor analysis of harmaline-induced and genetic tremor in mice revealed that two authentic tremor frequencies for each type of tremor were conserved and showed an opposite dependence on CaV3."3.81Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice. ( Chang, KY; Choi, JH; Kim, D; Kim, S; Kim, Y; Lee, C; Paek, SH; Park, YG, 2015)
"Harmaline-induced tremor is a well-known model of essential tremor in humans."3.81Apomorphine enhances harmaline-induced tremor in rats. ( Głowacka, U; Kosmowska, B; Ossowska, K; Wardas, J, 2015)
"Harmaline induces tremor in animals resembling essential tremor which has been suggested to result from activation of the glutamatergic olivo-cerebellar projection."3.80Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats. ( Berghauzen-Maciejewska, K; Doller, D; Głowacka, U; Kuter, K; Ossowska, K; Pilc, A; Wardas, J; Zorn, SH, 2014)
"The aim of the present study was to examine the influence of a partial lesion of both the substantia nigra pars compacta (SNC) and retrorubral field (RRF) on the glutamatergic transmission in the cerebellum and tremor induced by harmaline in rats."3.79A partial lesion of the substantia nigra pars compacta and retrorubral field decreases the harmaline-induced glutamate release in the rat cerebellum. ( Berghauzen-Maciejewska, K; Górska, A; Gołembiowska, K; Kamińska, K; Ossowska, K, 2013)
"The aim of the present study was to examine the influence of a unilateral 6-hydroxydopamine (6-OHDA)-induced partial lesion of both the substantia nigra pars compacta (SNc, A9) and retrorubral field (RRF, A8) on the tremor evoked by harmaline."3.786-OHDA injections into A8-A9 dopaminergic neurons modelling early stages of Parkinson's disease increase the harmaline-induced tremor in rats. ( Berghauzen, K; Kolasiewicz, W; Kuter, K; Nowak, P; Ossowska, K; Schulze, G, 2012)
" Thus, we aimed to investigate the therapeutic effects of riluzole on harmaline-induced tremor and ataxia in rat, and determining whether riluzole exerts its effect through modulation of glutamate levels in cerebellum."3.78Effects of riluzole on harmaline induced tremor and ataxia in rats: biochemical, histological and behavioral studies. ( Abrari, K; Elahdadi Salmani, M; Goudarzi, A; Goudarzi, I; Lashkarbolouki, T; Rahimi Shourmasti, F, 2012)
"Abnormal synchronous activation of the glutamatergic olivo-cerebellar pathway has been suggested to be crucial for the harmaline-induced tremor."3.77Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats. ( Kolasiewicz, W; Kuter, K; Nowak, P; Ossowska, K; Pastuszka, A, 2011)
" The current study aims to investigate the anti-tremogenic and neuroprotective effects of memantine (NMDA receptor antagonist) on the harmaline model of transient action tremor."3.77The effect of memantine in harmaline-induced tremor and neurodegeneration. ( Akman, O; Ates, N; Erturk, S; Gullu, KM; Iseri, PK; Karson, A; Kokturk, S; Yardýmoglu, M, 2011)
" This hypothesis was tested by searching for the expression of the Cx57 transcripts in the mouse cerebellum of the harmaline-tremor model."3.76Expression of connexin57 in mouse development and in harmaline-tremor model. ( Cicirata, F; Cicirata, V; La Delia, F; Parenti, R; Zappalà, A, 2010)
"Harmaline-induced tremor in rodents is a model of essential tremor."3.75Pharmacological characterization of harmaline-induced tremor activity in mice. ( Foreman, MM; Hanania, T; Malekiani, SA; Olivier, B; Paterson, NE, 2009)
"32 mg/kg sc strongly enhances tremor of forelimbs, head and trunk, hypolocomotion, and ataxia induced by harmaline (7."3.75Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats. ( Kolasiewicz, W; Kuter, K; Ossowska, K; Wardas, J, 2009)
"Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied."3.74Effects of zonisamide on experimental tremors in rats. ( Hama, K; Kajimoto, Y; Kondo, T; Miwa, H, 2008)
" As a positive control for postural instability, wild type mice were injected with harmaline, a tremorigenic agent, and the average areas of the 95% confidence ellipse, which measures 95% of the CoP trajectory values recorded in a single trial, were measured."3.74Quantitative measurement of postural sway in mouse models of human neurodegenerative disease. ( Colton, CA; Dawson, HN; Dodd, M; Ho, V; Hutchinson, D; Schmitt, D; Zumwalt, AC, 2007)
"The rodent model of harmaline-induced tremor has been widely used for experimental analysis of tremor."3.73A species-specific difference in the effects of harmaline on the rodent olivocerebellar system. ( Kihira, T; Kondo, T; Kubo, T; Miwa, H; Suzuki, A, 2006)
"Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor."3.72Vagus nerve stimulation inhibits harmaline-induced tremor. ( Handforth, A; Krahl, SE; Martin, FC, 2004)
" Harmaline, a beta-carboline derivative thought to induce tremor by facilitating rhythmogenesis in the IO, was injected systemically into WT and KO mice."3.71Rhythmicity without synchrony in the electrically uncoupled inferior olive. ( Connors, BW; Deans, MR; Long, MA; Paul, DL, 2002)
"We studied whether vagus nerve stimulation could suppress tremor in the harmaline tremor model in the rat."3.71Suppression of harmaline-induced tremor in rats by vagus nerve stimulation. ( Handforth, A; Krahl, SE, 2001)
"Recent experimental and clinical studies clearly suggest the role of gamma-aminobutyric acid (GABA) in the pathogenesis of tremors."3.71Baclofen attenuates harmaline induced tremors in rats. ( Al Deeb, S; Al Moutaery, K; Arshaduddin, M; Biary, N; Tariq, M, 2001)
"Both harmaline and physostigmine are known to produce whole-body tremors in rodents, yet there is little quantitative information on the differential frequency characteristics of these tremors or on other possible motor effects of these drugs."3.71Concurrent quantification of tremor and depression of locomotor activity induced in rats by harmaline and physostigmine. ( Fowler, SC; Wang, G, 2001)
"Recent studies suggest an association between caffeine consumption and tremor."3.71Effect of acute caffeine on severity of harmaline induced tremor in rats. ( Al-Deeb, S; Al-Moutaery, K; Arshaduddin, M; Biary, N; Tariq, M, 2002)
"A behavioral preparation especially sensitive to low-dose drug effects on fine motor behavior in rats was used to assess the tremorogenic effects of harmaline, an indole alkaloid and beta-carboline derivative."3.70At low doses, harmaline increases forelimb tremor in the rat. ( Fowler, SC; Stanford, JA, 1998)
"The present study was undertaken to investigate the effect of lidocaine on harmaline-induced tremors in the rat."3.70Effect of lidocaine on harmaline-induced tremors in the rat. ( Al Deeb, S; Al Moutaery, K; Arshaduddin, M; Biary, N; Tariq, M, 2000)
" Moreover, the tremor elicited by harmaline was also correlated with the extent of the IOC lesion."3.69Effect of administration of 3-acetylpyridine followed by niacinamide injection on survival, extent of the inferior olivary complex lesion, and response to harmaline in the young rat. ( Caston, J; Jones, N; Le Marec, N; Stelz, T, 1994)
"This study reports that corticotropin-releasing factor (CRF) expression within the inferior olivary complex (IOC) of the cat is increased 8 h after administration of the tremor-inducing beta-carboline harmaline."3.69Corticotropin-releasing factor mRNA increases in the inferior olivary complex during harmaline-induced tremor. ( Cummings, S; Hinds, D; Young, WS, 1994)
" The synchronous activation of inferior olive neurons by the drug harmaline is known to produce tremorogenic activity in rats via increased stimulation of the olivocerebellar system."3.69An experimental model for the non-invasive trans-synaptic induction of nitric oxide synthase in Purkinje cells of the rat cerebellum. ( Beitz, AJ; Saxon, DW, 1996)
"Harmaline is known to produce tremors and retard acquisition of the rabbit's nictitating membrane response."3.69Harmaline-induced tremor and impairment of learning are both blocked by dizocilpine in the rabbit. ( Du, W; Harvey, JA, 1997)
"We studied the effect of various kinds of beta-adrenergic blockers on oxotremorine-, harmaline- and thyrotropin-releasing hormone (TRH)-induced tremors in mice."3.68Effects of beta-adrenergic blockers on drug-induced tremors. ( Fukuda, T; Iwata, S; Nomoto, M, 1993)
"The genetically dystonic rat is insensitive to the tremorogenic effects of harmaline."3.68Effect of harmaline on cells of the inferior olive in the absence of tremor: differential response of genetically dystonic and harmaline-tolerant rats. ( Lorden, JF; Stratton, SE, 1991)
" Harmaline produced tremor has been shown to induce rhythmic activity and increase glucose consumption in the IO."3.67Inferior olivary neurons: 3-acetylpyridine effects on glucose consumption, axonal transport, electrical activity and harmaline-induced tremor. ( Bernard, JF; Buisseret-Delmas, C; Laplante, S, 1984)
" Diazepam has been reported to inhibit both the tremor and mechanism of cerebellar cyclic GMP caused by harmaline by a neurotransmission in the cerebellum."3.67Ethanol effects on harmaline-induced tremor and increase of cerebellar cyclic GMP. ( Dole, VP; Gentry, RT; Rappaport, MS; Schneider, DR, 1984)
"Administration of the beta-carboline alkaloid, harmaline, causes the neurons of the inferior olive to fire synchronously and to act as a pacemaker for the generation of tremor."3.67Tolerance to the tremorogenic effects of harmaline: evidence for altered olivo-cerebellar function. ( Beales, M; Lorden, JF; Lutes, J; Oltmans, GA, 1988)
"Specific beta 1- and beta 2-adrenoceptor antagonists, acebutolol and butoxamine respectively were used to investigate the involvement of blockade of these receptors in the inhibition of harmaline-induced tremors."3.67Involvement of beta 2-adrenoceptor blockade and 5-hydroxytryptamine mechanism in inhibition of harmaline-induced tremors in rats. ( Paul, V, 1986)
" Phenotypically normal rats showed tremor in response to harmaline, a drug that acts on the inferior olive to produce bursting in the climbing fiber pathway."3.67Decreased cerebellar 3',5'-cyclic guanosine monophosphate levels and insensitivity to harmaline in the genetically dystonic rat (dt). ( Beales, M; Lorden, JF; Lutes, J; McKeon, TW; Oltmans, GA, 1985)
" As regards behavioural effects, tremor induced by quipazine was present from the first postnatal day and was antagonized by methysergide, but not by p-chlorophenylalanine (PCPA) or pretreatment with 5,7-dihydroxytryptamine (5,7-DHT)."3.67Drug-induced activation of the inferior olivary nucleus in young rabbits. Differential effects of harmaline and quipazine. ( Barragan, LA; Delhaye-Bouchaud, N; Laget, P, 1985)
"The effects of excitatory amino acids, kainic acid and quisqualic acid, on the tremorine- and harmaline-induced tremor were quantitatively examined in mice using the power spectral analyzing method."3.67Modification of drug-induced tremor by systemic administration of kainic acid and quisqualic acid in mice. ( Hirate, K; Ishida, M; Shinozaki, H, 1987)
"The effects of diazepam, dantrolene and atropine on drug-induced tremors were investigated in mice from the point of view of the tremor frequency."3.67Further studies on quantification of drug-induced tremor in mice: effects of antitremorgenic agents on tremor frequency. ( Hirate, K; Ishida, M; Shinozaki, H, 1985)
"Harmaline produces a tremor which is prevented by diazepam."3.66Harmaline-induced tremor: the benzodiazepine receptor as a site of action. ( Robertson, HA, 1980)
" A tremorogenic dose of harmaline (30 mg/kg intravenously) increased binding by 31%."3.66Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. ( Airaksinen, MM; Saano, V, 1982)
"In the Rat under tremorogenic doses of harmaline, Purkinje cells of the vermis of the cerebellar cortex display a regular complex spike activity at 6 to 11 Hz ("harmaline-rhythm")."3.66[Harmaline tremor: topography of activity in the cerebellar cortex in rats]. ( Bernard, JF, 1983)
" Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline."3.66Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982)
"The brain structures specifically involved in harmaline-induced tremor have been identified in the Rat by using the 14C-2-deoxyglucose marking Method."3.66[Harmaline-induced tremor and cerebral activities: labeling with 14C-2-deoxyglucose in the rat]. ( Batini, C; Buisseret-Delmas, C; Conrath-Verrier, M, 1978)
"Since there is degeneration of substantia nigra concomitant with that of locus coeruleus (LC) in patients with Parkinson's disease, the study was performed to determine the role of central norepinephrine (NE) on harmaline induced tremor."3.66Significance of central noradrenergic system on harmaline induced tremor. ( Takaori, S; Tanaka, C; Yamazaki, M, 1979)
"Harmaline, an alcaloid of Paganum Armala, induces tremors of central origin and increases cerebellar cGMP without affecting cortical and cerebellar prostaglandin levels."3.66Inhibition of harmaline induced tremors by 16 (S)-16-methyl PGE2 in different mammalian species: a correlation with central cyclic nucleotides and prostaglandins. ( Berti, F; Fano, M; Folco, GC; Longiave, D; Omini, C, 1978)
"Cyclic GMP levels were dose-dependently increased by excitatory drugs such as picrotoxin, pentetrazol, oxotremorine and harmaline in mouse cerebellum and medial forebrain (parts of the cortex, hippocampus, hypothalamus, thalamus, striatum and midbrain) in vivo."3.65Effects of stimulatory and depressant drugs on cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate levels in mouse brain. ( Dinnedahl, V; Gumulka, SW; Opmeer, FA; Schönhöfer, PS, 1976)
" Over a 24 hour period, the following symptoms could be observed: akathisia, circling, akinesia, choreoathetoid and dystonic movements, oro-facial dyskinesias and postural tremor with or without harmaline."3.65Haloperidol-induced dyskinesias in the monkey. ( Bédard, P; Delean, J; Lafleur, J; Larochelle, L, 1977)
"The possible involvement of serotoninergic mechanisms in the induction of harmaline generated tremor in the inferior olive has been investigated electrophysiologically in the cat and rat."3.65The indolaminergic innervation of the inferior olive. 2. Relation to harmaline induced tremor. ( Björklund, A; Sjölund, B; Wiklund, L, 1977)
"Effect of 3, 4-dihydroxyphenylserine (DOPS), a norepinephrine precurosr, on harmaline tremor was investigated in mice to elucidate the role of norepinephrine in the genesis of tremor."3.65[Inhibition of harmaline induced tremor by L-threo-3, 4-dihydroxyphenylserine, an L-norepinephrine precursor]. ( Ikeda, Y; Inagaki, C; Ishikawa, M; Tanaka, C; Yamazaki, M, 1976)
"Hindlimb tremor was produced in chronic cats by intracaudate microinjection of the monoamine oxidase (MAO) inhibitors tranylcypromine and harmaline throughout a range of doses (150-385 mug)."3.65Contrasting local effects of MAO inhibitors on caudate tremor activities. ( Baker, WW; Malseed, RT; Zivanovic, D, 1975)
"Animal models of tremor have been widely used in experimental neurology, because they are an indispensable requirement for understanding the pathophysiology of human tremor disorders and the development of new therapeutic agents."2.40Animal models of tremor. ( Deuschl, G; Sievers, J; Wilms, H, 1999)
"We postulate that palatal myoclonus after infarction of the brainstem or cerebellum, or both, is the manifestation of denervation supersensitivity secondary to lesions involving the dentatorubroolivary system."2.36Palatal myoclonus and denervation supersensitivity in the central nervous system. ( Ajax, ET; Matsuo, F, 1979)
"Harmaline-induced tremor is an easily provoked model for the development of new therapies for essential tremor (ET)."1.91Mapping Pharmacologically Evoked Neurovascular Activation and Its Suppression in a Rat Model of Tremor Using Functional Ultrasound: A Feasibility Study. ( Alizad, A; Chang, SY; Fatemi, M; Lee, J; Nayak, R; Sotoudehnia, S, 2023)
"Pramipexole was administered at a low dose of 0."1.56Pramipexole Reduces zif-268 mRNA Expression in Brain Structures involved in the Generation of Harmaline-Induced Tremor. ( Kosmowska, B; Ossowska, K; Wardas, J, 2020)
"Tremor is currently ranked as the most common movement disorder."1.56Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation. ( Brown, AM; Lin, T; Sillitoe, RV; van der Heijden, ME; White, JJ; Zhou, J, 2020)
"Imipramine treatment further decreased harmaline-induced 5HT turnover in the brain stem."1.33Exacerbation of harmaline-induced tremor by imipramine. ( Al Deeb, S; Al Moutaery, K; Arshaduddin, M; Kadasah, S; Tariq, M, 2005)
"Harmaline treatment had no later effects on the climbing fiber EPSC kinetics and I/V relation in Purkinje cells (P15-36)."1.32A change in the pattern of activity affects the developmental regression of the Purkinje cell polyinnervation by climbing fibers in the rat cerebellum. ( Andjus, PR; Carulli, D; Cesa, R; Strata, P; Zhu, L, 2003)
"Tremor is the second most common neurological adverse effect in patients receiving treatment with SSRIs."1.32Citalopram, a selective serotonin reuptake inhibitor augments harmaline-induced tremor in rats. ( Al Deeb, S; Al Kadasah, S; Al Moutaery, K; Arshaduddin, M; Biary, N; Tariq, M, 2004)
" Mitochondrial swelling occurs in cerebellar stellate and basket cells within 30 minutes of dosing and persists for more than 12 hours without leading to cell death."1.30The effects of the tremorgenic mycotoxin penitrem A on the rat cerebellum. ( Cavanagh, JB; Holton, JL; Mantle, PG; Naik, JT; Nolan, CC; Ray, DE, 1998)
"Harmaline was used in this study because its tremorgenic action is mediated at the level of IO; octanol was found to be a potent antagonist of harmaline-induced tremor."1.28The effectiveness of different isomers of octanol as blockers of harmaline-induced tremor. ( Krosser, BI; Llinás, RR; Sinton, CM; Walton, KD, 1989)

Research

Studies (111)

TimeframeStudies, this research(%)All Research%
pre-199051 (45.95)18.7374
1990's14 (12.61)18.2507
2000's20 (18.02)29.6817
2010's14 (12.61)24.3611
2020's12 (10.81)2.80

Authors

AuthorsStudies
Bello, EM1
Blumenfeld, M1
Dao, J1
Krieg, JDS1
Wilmerding, LK1
Johnson, MD1
Shabani, M1
Naderi, R1
Lee, J4
Kim, J1
Cortez, J1
Chang, SY3
Khatoun, A1
Asamoah, B1
Boogers, A1
Mc Laughlin, M1
Kuo, SH1
Kosmowska, B4
Paleczna, M1
Biała, D1
Kadłuczka, J1
Wardas, J6
Witkin, JM1
Cook, JM1
Sharmin, D1
Marcinkowska, M1
Kuter, KZ1
Handforth, A4
Kosoyan, HP1
Kadam, PA1
Singh, RP2
Nayak, R1
Sotoudehnia, S1
Fatemi, M1
Alizad, A1
Treven, M1
Ernst, M1
Ossowska, K8
Brown, AM1
White, JJ1
van der Heijden, ME1
Zhou, J1
Lin, T1
Sillitoe, RV1
Ajima, A1
Yoshida, T1
Yaguchi, K1
Itohara, S1
Głowacka, U3
Kim, I1
Knight, E1
Cheng, L1
Kang, SI1
Jang, DP1
Gołembiowska, K1
Berghauzen-Maciejewska, K2
Górska, A1
Kamińska, K1
Kuter, K4
Pilc, A1
Zorn, SH1
Doller, D1
Park, YG2
Choi, JH1
Lee, C1
Kim, S1
Kim, Y1
Chang, KY1
Paek, SH1
Kim, D2
Stroh, MA1
Winter, MK1
Swerdlow, RH1
McCarson, KE1
Zhu, H1
Abdulrahman, AA1
Faisal, K1
Meshref, AA1
Arshaduddin, M7
Lamarre, Y3
Dumont, M2
Joffroy, AJ2
Paterson, NE1
Malekiani, SA1
Foreman, MM1
Olivier, B1
Hanania, T1
Kolasiewicz, W3
Park, HY1
Lee, CJ1
Choi, S1
Jo, S1
Choi, H1
Kim, YH1
Shin, HS1
Llinas, RR2
Zappalà, A1
Parenti, R1
La Delia, F1
Cicirata, V1
Cicirata, F1
Nowak, P2
Pastuszka, A1
Iseri, PK1
Karson, A1
Gullu, KM1
Akman, O1
Kokturk, S1
Yardýmoglu, M1
Erturk, S1
Ates, N1
Berghauzen, K1
Schulze, G1
Rahimi Shourmasti, F1
Goudarzi, I1
Lashkarbolouki, T1
Abrari, K1
Elahdadi Salmani, M1
Goudarzi, A1
Tariq, M6
Biary, N5
Al Moutaery, K5
Al Deeb, S5
Long, MA1
Deans, MR1
Paul, DL1
Connors, BW1
AHMED, A1
TAYLOR, NR1
Mehta, H1
Saravanan, KS1
Mohanakumar, KP1
Andjus, PR1
Zhu, L1
Cesa, R1
Carulli, D1
Strata, P1
Krahl, SE2
Martin, FC1
McMahon, A1
Fowler, SC3
Perney, TM1
Akemann, W1
Knöpfel, T1
Joho, RH1
Al Kadasah, S1
Kadasah, S1
Miwa, H4
Kubo, T1
Suzuki, A1
Kihira, T1
Kondo, T2
Hama, K1
Kajimoto, Y1
Hutchinson, D1
Ho, V1
Dodd, M1
Dawson, HN1
Zumwalt, AC1
Schmitt, D1
Colton, CA1
Fagni, L1
Weiss, M4
Pellet, J2
Hugon, M1
Bernard, JF6
Buisseret-Delmas, C7
Laplante, S2
Robertson, HA1
Knowles, WD1
Phillips, MI1
Saano, V1
Airaksinen, MM1
Rappaport, MS1
Gentry, RT1
Schneider, DR1
Dole, VP1
Shinozaki, H5
Hirate, K4
Ishida, M3
Compoint, C1
Horcholle-Bossavit, G3
Gemba, H1
Sasaki, K1
Yoneda, Y1
Hashimoto, S1
Mizuno, N1
Batini, C6
Schweri, M1
Cain, M1
Cook, J1
Paul, S1
Skolnick, P1
Conrath-Verrier, M4
Milner, TE1
Cadoret, G1
Lessard, L1
Smith, AM1
Jones, N2
Le Marec, N1
Stelz, T2
Caston, J2
Glick, SD1
Kuehne, ME1
Raucci, J1
Wilson, TE1
Larson, D1
Keller, RW1
Carlson, JN1
Cummings, S1
Hinds, D1
Young, WS1
Cross, AJ1
Misra, A1
Sandilands, A1
Taylor, MJ1
Green, AR1
Iwata, S1
Nomoto, M1
Fukuda, T1
Saxon, DW1
Beitz, AJ1
Du, W1
Harvey, JA1
Stanford, JA1
Cavanagh, JB1
Holton, JL1
Nolan, CC1
Ray, DE1
Naik, JT1
Mantle, PG1
Welsh, JP1
Wilms, H1
Sievers, J1
Deuschl, G1
Nishi, K1
Fuwa, T1
Mizuno, Y1
Wang, G1
Al-Deeb, S1
Al-Moutaery, K1
Poirier, LJ1
Sourkes, TL1
Matsuo, F1
Ajax, ET1
Brailowsky, S1
Walter, S1
Vuillon-Cacciuttolo, G1
Serbanescu, T1
Simantov, R1
Snyder, SH1
Oster-Granite, ML1
Guidotti, A2
Biggio, G1
Costa, E2
Opmeer, FA1
Gumulka, SW1
Dinnedahl, V1
Schönhöfer, PS1
Mao, CC1
Bédard, P1
Delean, J1
Lafleur, J1
Larochelle, L1
Yamazaki, M2
Tanaka, C2
Takaori, S1
Headley, PM1
Lodge, D1
Woodhams, P1
Rodd, R1
Balázs, R1
Berti, F1
Fano, M1
Folco, GC1
Longiave, D1
Omini, C1
De Montigny, C1
Grou, F1
Lund, JP1
Goldstein, M1
Anagnoste, B1
Battista, AF1
Ogawa, M1
Sjölund, B1
Björklund, A1
Wiklund, L1
Ikeda, Y1
Ishikawa, M1
Inagaki, C1
Baker, WW1
Zivanovic, D1
Malseed, RT1
Stratton, SE1
Lorden, JF3
Sinton, CM1
Krosser, BI1
Walton, KD1
Lutes, J2
Beales, M2
Oltmans, GA2
Paul, V1
Longo, VG1
Massotti, M1
McKeon, TW1
Barragan, LA1
Delhaye-Bouchaud, N1
Laget, P1
Zetler, G1
Back, G1
Iven, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessment of Routine Use of Critical View of Safety in Laparoscopic Cholecystectomy, Prospective Cohort Study[NCT03696823]50 participants (Anticipated)Interventional2018-10-01Not yet recruiting
Effect of Alcohol on Physiologic and Pathologic Tremors[NCT00001925]Phase 223 participants Interventional1999-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for harmaline and Tremor

ArticleYear
[Parkinsonian tremor and the action of harmaline: experimental facts and hypothetical mechanisms].
    Archives italiennes de biologie, 1973, Volume: 111, Issue:3-4

    Topics: Animals; Central Nervous System Stimulants; Cerebellum; Diencephalon; Efferent Pathways; Haplorhini;

1973
Rodent models of tremor.
    Cerebellum (London, England), 2007, Volume: 6, Issue:1

    Topics: Animals; Brain; Central Nervous System Stimulants; Disease Models, Animal; Harmaline; Humans; Mice;

2007
Animal models of tremor.
    Movement disorders : official journal of the Movement Disorder Society, 1999, Volume: 14, Issue:4

    Topics: Animals; Central Nervous System Diseases; Disease Models, Animal; Harmaline; Humans; Mammals; Specie

1999
Monkeys with nigrostriatal lesions: tremor induced by harmaline and other drugs.
    Pharmacology & therapeutics. Part B: General & systematic pharmacology, 1976, Volume: 2, Issue:1

    Topics: Alkaloids; Animals; Corpus Striatum; Haplorhini; Harmaline; Methyltyrosines; Phenothiazines; Substan

1976
Palatal myoclonus and denervation supersensitivity in the central nervous system.
    Annals of neurology, 1979, Volume: 5, Issue:1

    Topics: Adult; Aged; Brain Stem; Cerebellum; Cerebral Infarction; Female; Harmaline; Humans; Hypertrophy; Ma

1979
Evidence for involvement of GABA in the action of benzodiazepines: studies on rat cerebellum.
    Advances in biochemical psychopharmacology, 1975, Issue:14

    Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebellum; Cyclic GMP; gamma-Aminobu

1975
Monkeys with nigrostriatal lesions effects of monoaminergic drugs.
    Pharmacology & therapeutics. Part B: General & systematic pharmacology, 1976, Volume: 2, Issue:1

    Topics: Amino Acids; Animals; Antiparkinson Agents; Apomorphine; Biogenic Amines; Carboxy-Lyases; Catechol O

1976
Tremorgenic mechanisms in primates.
    Advances in neurology, 1975, Volume: 10

    Topics: Animals; Cerebellum; Cerebral Cortex; Harmaline; Motor Cortex; Primates; Tegmentum Mesencephali; Tha

1975
Effect of tremorigenic agents on the cerebellum: a review of biochemical and electrophysiological data.
    International review of neurobiology, 1985, Volume: 26

    Topics: Alkaloids; Animals; Cats; Cerebellar Nuclei; Cerebellum; Cyclic GMP; Diazepam; Dopamine; Electroence

1985

Other Studies

102 other studies available for harmaline and Tremor

ArticleYear
Considerations Using Harmaline for a Primate Model of Tremor.
    Tremor and other hyperkinetic movements (New York, N.Y.), 2021, Volume: 11

    Topics: Animals; Essential Tremor; Harmaline; Humans; Macaca mulatta; Swine; Tremor

2021
Phytohormone abscisic acid elicits positive effects on harmaline-induced cognitive and motor disturbances in a rat model of essential tremor.
    Brain and behavior, 2022, Volume: 12, Issue:5

    Topics: Abscisic Acid; Animals; Cognition; Essential Tremor; Harmaline; Male; Mammals; Neuroprotective Agent

2022
Thalamo-cortical network is associated with harmaline-induced tremor in rodent model.
    Experimental neurology, 2022, Volume: 358

    Topics: Animals; Deep Brain Stimulation; Essential Tremor; Harmaline; Motor Cortex; Propranolol; Rats; Roden

2022
Epicranial Direct Current Stimulation Suppresses Harmaline Tremor in Rats.
    Neuromodulation : journal of the International Neuromodulation Society, 2023, Volume: 26, Issue:4

    Topics: Animals; Cerebellum; Essential Tremor; Harmaline; Rats; Rats, Sprague-Dawley; Tremor

2023
GABA
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2023, Volume: 20, Issue:2

    Topics: Cerebellum; Essential Tremor; Harmaline; Humans; Receptors, GABA-A; Tremor

2023
GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats.
    Biomolecules, 2023, 01-18, Volume: 13, Issue:2

    Topics: Animals; Essential Tremor; gamma-Aminobutyric Acid; Harmaline; Ligands; Pimozide; Rats; Rats, Spragu

2023
Alcohol and Ganaxolone Suppress Tremor via Extra-Synaptic GABA
    Tremor and other hyperkinetic movements (New York, N.Y.), 2023, Volume: 13

    Topics: Animals; Essential Tremor; Ethanol; gamma-Aminobutyric Acid; Harmaline; Humans; Mice; Receptors, GAB

2023
Mapping Pharmacologically Evoked Neurovascular Activation and Its Suppression in a Rat Model of Tremor Using Functional Ultrasound: A Feasibility Study.
    Sensors (Basel, Switzerland), 2023, Aug-03, Volume: 23, Issue:15

    Topics: Animals; Essential Tremor; Feasibility Studies; Harmaline; Propranolol; Rats; Tremor

2023
Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABA
    Tremor and other hyperkinetic movements (New York, N.Y.), 2023, Volume: 13

    Topics: Animals; Essential Tremor; Flumazenil; gamma-Aminobutyric Acid; Harmaline; Humans; Ketamine; Mice; M

2023
Pramipexole Reduces zif-268 mRNA Expression in Brain Structures involved in the Generation of Harmaline-Induced Tremor.
    Neurochemical research, 2020, Volume: 45, Issue:7

    Topics: Animals; Antiparkinson Agents; Brain; Central Nervous System Stimulants; Early Growth Response Prote

2020
Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation.
    eLife, 2020, 03-17, Volume: 9

    Topics: Animals; Cerebellum; Deep Brain Stimulation; Female; gamma-Aminobutyric Acid; Harmaline; Male; Mice;

2020
Objective detection of microtremors in netrin-G2 knockout mice.
    Journal of neuroscience methods, 2021, 03-01, Volume: 351

    Topics: Animals; Essential Tremor; Harmaline; Humans; Mice; Mice, Knockout; Netrins; Tremor

2021
Tremorolytic effect of 5'-chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A1 receptor agonist, evaluated in the harmaline-induced model in rats.
    CNS neuroscience & therapeutics, 2017, Volume: 23, Issue:5

    Topics: Adenosine A1 Receptor Agonists; Animals; Brain; Deoxyadenosines; Disease Models, Animal; Dose-Respon

2017
Development of Harmaline-induced Tremor in a Swine Model.
    Tremor and other hyperkinetic movements (New York, N.Y.), 2018, Volume: 8

    Topics: Accelerometry; Animals; Disease Models, Animal; Harmaline; Sus scrofa; Tremor; Wireless Technology

2018
A partial lesion of the substantia nigra pars compacta and retrorubral field decreases the harmaline-induced glutamate release in the rat cerebellum.
    Brain research, 2013, Nov-06, Volume: 1537

    Topics: Animals; Cerebellum; Dopamine; Dopaminergic Neurons; Glutamic Acid; Harmaline; Male; Rats; Rats, Wis

2013
Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats.
    Neuropharmacology, 2014, Volume: 83

    Topics: Anilides; Animals; Central Nervous System Stimulants; Cerebellum; Cyclohexanecarboxylic Acids; Harma

2014
Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice.
    Molecular brain, 2015, Jan-15, Volume: 8

    Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Harmaline; Mice; Tremor

2015
Apomorphine enhances harmaline-induced tremor in rats.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:3

    Topics: Animals; Apomorphine; Central Nervous System Stimulants; Dopamine Agonists; Drug Synergism; Harmalin

2015
Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.
    Metabolic brain disease, 2016, Volume: 31, Issue:4

    Topics: Animals; Behavior, Animal; Cerebellum; Cytochrome-B(5) Reductase; Harmaline; Homeostasis; Iron; Mese

2016
Low-dose acute vanillin is beneficial against harmaline-induced tremors in rats.
    Neurological research, 2017, Volume: 39, Issue:3

    Topics: Animals; Antioxidants; Benzaldehydes; Central Nervous System Stimulants; Disease Models, Animal; Har

2017
Pharmacological characterization of harmaline-induced tremor activity in mice.
    European journal of pharmacology, 2009, Aug-15, Volume: 616, Issue:1-3

    Topics: Affect; Animals; Anticonvulsants; Baclofen; Behavior, Animal; Benzazepines; Carbolines; Chlordiazepo

2009
Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2009, Volume: 116, Issue:9

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Be

2009
Ca(V)3.1 is a tremor rhythm pacemaker in the inferior olive.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Jun-08, Volume: 107, Issue:23

    Topics: Animals; Calcium Channels, T-Type; Cell Line; Disease Models, Animal; Harmaline; Humans; Male; Mice;

2010
Expression of connexin57 in mouse development and in harmaline-tremor model.
    Neuroscience, 2010, Nov-24, Volume: 171, Issue:1

    Topics: Age Factors; Animals; Animals, Newborn; Central Nervous System; Central Nervous System Stimulants; C

2010
Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats.
    Cerebellum (London, England), 2011, Volume: 10, Issue:2

    Topics: Adrenergic Agents; Animals; Brain Chemistry; Central Nervous System Stimulants; Cerebellum; Chromato

2011
The effect of memantine in harmaline-induced tremor and neurodegeneration.
    Neuropharmacology, 2011, Volume: 61, Issue:4

    Topics: Animals; Cerebellum; Ethanol; Harmaline; Male; Memantine; Nerve Degeneration; Neuroprotective Agents

2011
6-OHDA injections into A8-A9 dopaminergic neurons modelling early stages of Parkinson's disease increase the harmaline-induced tremor in rats.
    Brain research, 2012, Oct-05, Volume: 1477

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Central Nervous System Stimulants; Cereb

2012
Effects of riluzole on harmaline induced tremor and ataxia in rats: biochemical, histological and behavioral studies.
    European journal of pharmacology, 2012, Nov-15, Volume: 695, Issue:1-3

    Topics: Animals; Ataxia; Behavior, Animal; Cerebellum; Glutamates; Harmaline; Ion Channels; Male; Neuroprote

2012
2-deoxy-D-glucose attenuates harmaline induced tremors in rats.
    Brain research, 2002, Aug-02, Volume: 945, Issue:2

    Topics: Animals; Antimetabolites; Deoxyglucose; Dose-Response Relationship, Drug; Electromyography; Female;

2002
Rhythmicity without synchrony in the electrically uncoupled inferior olive.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Dec-15, Volume: 22, Issue:24

    Topics: Action Potentials; Animals; Connexins; Culture Techniques; Gap Junction delta-2 Protein; Gap Junctio

2002
The analysis of drug-induced tremor in mice.
    British journal of pharmacology and chemotherapy, 1959, Volume: 14

    Topics: Animals; Harmaline; Lysergic Acid Diethylamide; Mice; Tremor; Tremorine

1959
Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice.
    Behavioural brain research, 2003, Oct-17, Volume: 145, Issue:1-2

    Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebellum; Chromatography, High Pressure Liquid; Dopami

2003
A change in the pattern of activity affects the developmental regression of the Purkinje cell polyinnervation by climbing fibers in the rat cerebellum.
    Neuroscience, 2003, Volume: 121, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Calbindins; Carrier Proteins; Cell Death; Centra

2003
Vagus nerve stimulation inhibits harmaline-induced tremor.
    Brain research, 2004, Jun-11, Volume: 1011, Issue:1

    Topics: Animals; Electric Stimulation Therapy; Harmaline; Male; Rats; Rats, Long-Evans; Tremor; Vagus Nerve

2004
Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3.
    The European journal of neuroscience, 2004, Volume: 19, Issue:12

    Topics: Action Potentials; Alleles; Animals; Blotting, Western; Central Nervous System Stimulants; Cerebellu

2004
Citalopram, a selective serotonin reuptake inhibitor augments harmaline-induced tremor in rats.
    Behavioural brain research, 2004, Aug-12, Volume: 153, Issue:1

    Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants;

2004
Exacerbation of harmaline-induced tremor by imipramine.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:1

    Topics: Animals; Drug Synergism; Harmaline; Imipramine; Male; Rats; Rats, Sprague-Dawley; Tremor

2005
A species-specific difference in the effects of harmaline on the rodent olivocerebellar system.
    Brain research, 2006, Jan-12, Volume: 1068, Issue:1

    Topics: Animals; Cerebellum; Data Interpretation, Statistical; Harmaline; Immunohistochemistry; Male; Mice;

2006
Effects of zonisamide on experimental tremors in rats.
    Parkinsonism & related disorders, 2008, Volume: 14, Issue:1

    Topics: Animals; Anticonvulsants; Central Nervous System Stimulants; Cholinesterase Inhibitors; Harmaline; I

2008
Quantitative measurement of postural sway in mouse models of human neurodegenerative disease.
    Neuroscience, 2007, Sep-21, Volume: 148, Issue:4

    Topics: Age Factors; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Behavior, Animal; Biomechani

2007
The possible mechanisms of the high pressure-induced motor disturbances in the cat.
    Electroencephalography and clinical neurophysiology, 1982, Volume: 53, Issue:6

    Topics: Animals; Cats; Cerebellum; Electromyography; Female; Harmaline; Male; Peripheral Nerves; Posture; Pr

1982
Inferior olivary neurons: 3-acetylpyridine effects on glucose consumption, axonal transport, electrical activity and harmaline-induced tremor.
    Brain research, 1984, Nov-26, Volume: 322, Issue:2

    Topics: Alkaloids; Animals; Autoradiography; Axonal Transport; Deoxyglucose; Glucose; Harmaline; Olivary Nuc

1984
Harmaline-induced tremor: the benzodiazepine receptor as a site of action.
    European journal of pharmacology, 1980, Oct-03, Volume: 67, Issue:1

    Topics: Alkaloids; Animals; Binding, Competitive; Brain; Flunitrazepam; Harmaline; Male; Mice; Mice, Inbred

1980
Neurophysiological and behavioral maturation of cerebellar function studied with tremorogenic drugs.
    Neuropharmacology, 1980, Volume: 19, Issue:8

    Topics: Action Potentials; Aging; Alkaloids; Animals; Animals, Newborn; Cerebellum; Harmaline; Nerve Fibers;

1980
Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor.
    Acta pharmacologica et toxicologica, 1982, Volume: 51, Issue:4

    Topics: Animals; Brain; Caffeine; Carbolines; Flunitrazepam; Harmaline; Harmine; Indoles; Male; Rats; Rats,

1982
Ethanol effects on harmaline-induced tremor and increase of cerebellar cyclic GMP.
    Life sciences, 1984, Jan-02, Volume: 34, Issue:1

    Topics: Alkaloids; Animals; Cerebellum; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Ethanol; Har

1984
[Harmaline tremor: topography of activity in the cerebellar cortex in rats].
    Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 1983, Volume: 297, Issue:4

    Topics: Animals; Cerebellar Cortex; Harmaline; Rats; Tremor

1983
[A quantitative analyzing method for drug-induced tremor].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1984, Volume: 83, Issue:6

    Topics: Animals; Ethology; Harmaline; Magnetics; Mice; Monitoring, Physiologic; Motor Activity; Oxotremorine

1984
Harmaline induced tremor. III. A combined simple units, horseradish peroxidase, and 2-deoxyglucose study of the olivocerebellar system in the rat.
    Experimental brain research, 1984, Volume: 57, Issue:1

    Topics: Alkaloids; Animals; Brain Mapping; Glucose; Harmaline; Neural Pathways; Olivary Nucleus; Purkinje Ce

1984
Quantitative analysis of drug-induced tremor in mice.
    Neuroscience research, 1984, Volume: 2, Issue:1-2

    Topics: Alkaloids; Animals; Harmaline; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Oxotremorine; Spe

1984
Harmaline-induced rhythm in the lateral reticular nucleus.
    Archives italiennes de biologie, 1983, Volume: 121, Issue:3

    Topics: Action Potentials; Alkaloids; Animals; Autoradiography; Cats; Harmaline; Lidocaine; Medulla Oblongat

1983
Tremor in the monkey with a cerebellar lesion.
    Experimental neurology, 1980, Volume: 69, Issue:1

    Topics: Animals; Bemegride; Cerebellum; Haplorhini; Harmaline; Ketamine; Macaca; Movement; Tremor

1980
[Harmaline tremor: activity of the interposito-rubral system and of the bulbo-ponto-reticular formation].
    Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles, 1980, Nov-24, Volume: 291, Issue:11

    Topics: Alkaloids; Animals; Carbon Radioisotopes; Cats; Deoxyglucose; Efferent Pathways; Harmaline; Medulla

1980
Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:3

    Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flu

1982
Rhythmic activity of spinal interneurons in harmaline-treated cats. A model for olivo-cerebellar influence at the spinal level.
    Journal of the neurological sciences, 1982, Volume: 54, Issue:3

    Topics: Action Potentials; Alkaloids; Animals; Cats; Cerebellum; Harmaline; Interneurons; Olivary Nucleus; S

1982
Harmaline-induced tremor. I. Regional metabolic activity as revealed by [14C]2-deoxyglucose in cat.
    Experimental brain research, 1981, Volume: 42, Issue:3-4

    Topics: Alkaloids; Animals; Brain; Carbon Radioisotopes; Cats; Caudate Nucleus; Cerebellar Cortex; Cerebellu

1981
Harmaline-induced tremor. II. Unit activity correlation in the interposito-rubral and oculomotor systems of cat.
    Experimental brain research, 1981, Volume: 42, Issue:3-4

    Topics: Alkaloids; Brain Stem; Electric Stimulation; Eye Movements; Harmaline; Neurons; Oculomotor Muscles;

1981
EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive.
    Journal of neurophysiology, 1995, Volume: 73, Issue:6

    Topics: Animals; Cerebellum; Electromyography; Harmaline; Injections, Intraperitoneal; Mice; Mice, Mutant St

1995
Effect of administration of 3-acetylpyridine followed by niacinamide injection on survival, extent of the inferior olivary complex lesion, and response to harmaline in the young rat.
    Brain research, 1994, Sep-12, Volume: 656, Issue:2

    Topics: Animals; Brain; Harmaline; Injections, Intraperitoneal; Niacinamide; Olivary Nucleus; Pyridines; Rat

1994
Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.
    Brain research, 1994, Sep-19, Volume: 657, Issue:1-2

    Topics: Alkaloids; Animals; Cocaine; Corpus Striatum; Dopamine; Female; Harmaline; Ibogaine; Microdialysis;

1994
Corticotropin-releasing factor mRNA increases in the inferior olivary complex during harmaline-induced tremor.
    Brain research, 1994, Oct-17, Volume: 660, Issue:2

    Topics: Animals; Autoradiography; Cats; Corticotropin-Releasing Hormone; Gene Expression; Harmaline; In Situ

1994
Effect of chlormethiazole, dizocilpine and pentobarbital on harmaline-induced increase of cerebellar cyclic GMP and tremor.
    Psychopharmacology, 1993, Volume: 111, Issue:1

    Topics: Animals; Cerebellum; Chlormethiazole; Cyclic GMP; Dizocilpine Maleate; Harmaline; Male; Mice; Mice,

1993
Effects of beta-adrenergic blockers on drug-induced tremors.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Fourier Analysis; Harmaline; Male; Mice; Mice, Inbred Strains;

1993
Effects of lesion of the inferior olivary complex in learning of the equilibrium behavior in the young rat during ontogenesis. I. Total lesion of the inferior olive by 3-acetylpyridine.
    Brain research, 1995, Oct-30, Volume: 697, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Harmaline; Learning; Motor Activity; Nerve Degeneration; Olivary N

1995
An experimental model for the non-invasive trans-synaptic induction of nitric oxide synthase in Purkinje cells of the rat cerebellum.
    Neuroscience, 1996, Volume: 72, Issue:1

    Topics: Amino Acid Sequence; Animals; Calbindins; Cerebellum; Enzyme Induction; Harmaline; Immunohistochemis

1996
Harmaline-induced tremor and impairment of learning are both blocked by dizocilpine in the rabbit.
    Brain research, 1997, Jan-16, Volume: 745, Issue:1-2

    Topics: Animals; Conditioning, Classical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory

1997
At low doses, harmaline increases forelimb tremor in the rat.
    Neuroscience letters, 1998, Jan-23, Volume: 241, Issue:1

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drinking; Drug Administration Schedule;

1998
The effects of the tremorgenic mycotoxin penitrem A on the rat cerebellum.
    Veterinary pathology, 1998, Volume: 35, Issue:1

    Topics: Animals; Brain; Capillary Permeability; Cerebellum; Cerebrovascular Circulation; Dendrites; Electrom

1998
Systemic harmaline blocks associative and motor learning by the actions of the inferior olive.
    The European journal of neuroscience, 1998, Volume: 10, Issue:11

    Topics: Animals; Association Learning; Conditioning, Classical; Female; Harmaline; Learning; Male; Memory; M

1998
Effect of lidocaine on harmaline-induced tremors in the rat.
    Pharmacology, biochemistry, and behavior, 2000, Jan-01, Volume: 65, Issue:1

    Topics: Animals; Calcium; Dose-Response Relationship, Drug; Electromyography; Harmaline; Lidocaine; Rats; Ra

2000
Differential expression of c-fos following administration of two tremorgenic agents: harmaline and oxotremorine.
    Neuroreport, 2000, Aug-03, Volume: 11, Issue:11

    Topics: Animals; Brain; Cell Count; Dose-Response Relationship, Drug; Harmaline; Male; Neural Pathways; Neur

2000
Suppression of harmaline-induced tremor in rats by vagus nerve stimulation.
    Movement disorders : official journal of the Movement Disorder Society, 2001, Volume: 16, Issue:1

    Topics: Animals; Central Nervous System Stimulants; Disease Models, Animal; Electric Stimulation; Harmaline;

2001
Baclofen attenuates harmaline induced tremors in rats.
    Neuroscience letters, 2001, Oct-19, Volume: 312, Issue:2

    Topics: Animals; Baclofen; Brain; Dose-Response Relationship, Drug; Drug Interactions; Electromyography; Ess

2001
Concurrent quantification of tremor and depression of locomotor activity induced in rats by harmaline and physostigmine.
    Psychopharmacology, 2001, Volume: 158, Issue:3

    Topics: Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Tolerance; Harmaline; Mal

2001
Effect of acute caffeine on severity of harmaline induced tremor in rats.
    Neuroscience letters, 2002, Jun-14, Volume: 325, Issue:3

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Electromyography; Harm

2002
[Harmaline-induced tremor and cerebral activities: labeling with 14C-2-deoxyglucose in the rat].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1978, Sep-18, Volume: 287, Issue:5

    Topics: Alkaloids; Animals; Brain; Carbon Radioisotopes; Cerebral Cortex; Deoxyglucose; Frontal Lobe; Harmal

1978
[Indole alkaloids induction of tremors: effect on photosensible epilepsy in Papiopapio].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1975, Volume: 169, Issue:5

    Topics: Alkaloids; Animals; Cerebral Cortex; Dihydroergotoxine; Haplorhini; Harmaline; Ibogaine; Papio; Phot

1975
Harmaline-induced tremor in the rat: abolition by 3-acetylpyridine destruction of cerebellar climbing fibers.
    Brain research, 1976, Sep-10, Volume: 114, Issue:1

    Topics: Alkaloids; Animals; Cerebellar Cortex; Harmaline; Male; Niacinamide; Nicotinic Acids; Oxotremorine;

1976
3-Acetylpyridine: a tool to inhibit the tremor and the increase of cGMP content in cerebellar cortex elicited by harmaline.
    Brain research, 1975, Oct-10, Volume: 96, Issue:1

    Topics: Alkaloids; Animals; Brain Chemistry; Cerebellar Cortex; Cyclic GMP; Glutamates; Harmaline; Male; Oxo

1975
Effects of stimulatory and depressant drugs on cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate levels in mouse brain.
    Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 292, Issue:3

    Topics: Animals; Atropine; Brain; Brain Chemistry; Convulsants; Cyclic AMP; Cyclic GMP; Diazepam; Drug Inter

1976
Haloperidol-induced dyskinesias in the monkey.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1977, Volume: 4, Issue:3

    Topics: Animals; Brain; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Harmaline; Macaca; Tremor

1977
[Effects of juxtafastigial stimulation on the rhythmic activity of Purkinje cells in harmaline-treated rats].
    Journal of the neurological sciences, 1979, Volume: 41, Issue:3

    Topics: Alkaloids; Animals; Evoked Potentials; Harmaline; Olivary Nucleus; Purkinje Cells; Rats; Reaction Ti

1979
Significance of central noradrenergic system on harmaline induced tremor.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 10, Issue:3

    Topics: Alkaloids; Animals; Corpus Striatum; Droxidopa; Electric Stimulation; Harmaline; Hydroxydopamines; I

1979
Could harmaline generate tremor by affecting 5HT release? [proceedings].
    British journal of pharmacology, 1979, Volume: 66, Issue:1

    Topics: Alkaloids; Animals; Brain; Harmaline; Rats; Serotonin; Tremor

1979
Olivo-cerebellar activity during harmaline-induced tremor.A 2-[14C]deoxyglucose study.
    Neuroscience letters, 1979, Volume: 12, Issue:2-3

    Topics: Alkaloids; Animals; Cats; Cerebellum; Deoxy Sugars; Deoxyglucose; Electric Stimulation; Harmaline; T

1979
[Influence of the olivo-cerebello-bulbar system on the motor neurons of the lumbar spinal cord in the cat after administration of harmaline].
    Archives italiennes de biologie, 1978, Volume: 116, Issue:1

    Topics: Alkaloids; Animals; Cats; Cerebellum; Harmaline; Medulla Oblongata; Motor Neurons; Olivary Nucleus;

1978
Age-dependent susceptibility of inferior olive neurones to 3-acetylpyridine in the rat.
    Brain research, 1978, Sep-15, Volume: 153, Issue:1

    Topics: Afferent Pathways; Age Factors; Animals; Cerebellum; Harmaline; Lethal Dose 50; Neurons; Olivary Nuc

1978
Inhibition of harmaline induced tremors by 16 (S)-16-methyl PGE2 in different mammalian species: a correlation with central cyclic nucleotides and prostaglandins.
    Prostaglandins, 1978, Volume: 15, Issue:5

    Topics: Alkaloids; Animals; Brain; Cats; Cerebellum; Cerebral Cortex; Harmaline; Male; Nucleotides, Cyclic;

1978
Central mechanisms of tremor in some feline and primate models.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1975, Volume: 2, Issue:3

    Topics: Animals; Brain; Cats; Cerebellum; Disease Models, Animal; Electromyography; Haplorhini; Harmaline; M

1975
The indolaminergic innervation of the inferior olive. 2. Relation to harmaline induced tremor.
    Brain research, 1977, Aug-05, Volume: 131, Issue:1

    Topics: 5,6-Dihydroxytryptamine; Afferent Pathways; Alkaloids; Animals; Cats; Cerebellum; Female; Harmaline;

1977
[Inhibition of harmaline induced tremor by L-threo-3, 4-dihydroxyphenylserine, an L-norepinephrine precursor].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1976, Volume: 72, Issue:3

    Topics: Alkaloids; Animals; Brain Chemistry; Droxidopa; Drug Synergism; Harmaline; Isomerism; Locomotion; Ma

1976
Contrasting local effects of MAO inhibitors on caudate tremor activities.
    European journal of pharmacology, 1975, Volume: 31, Issue:1

    Topics: Alkaloids; Animals; Cats; Caudate Nucleus; Harmaline; Hemicholinium 3; Male; Physostigmine; Tranylcy

1975
Effect of harmaline on cells of the inferior olive in the absence of tremor: differential response of genetically dystonic and harmaline-tolerant rats.
    Neuroscience, 1991, Volume: 41, Issue:2-3

    Topics: Animals; Dystonia; Electric Stimulation; Harmaline; Monoamine Oxidase; Olivary Nucleus; Rats; Rats,

1991
The effectiveness of different isomers of octanol as blockers of harmaline-induced tremor.
    Pflugers Archiv : European journal of physiology, 1989, Volume: 414, Issue:1

    Topics: Alkaloids; Animals; Calcium Channels; Harmaline; Isomerism; Male; Octanols; Olivary Nucleus; Rats; R

1989
Tolerance to the tremorogenic effects of harmaline: evidence for altered olivo-cerebellar function.
    Neuropharmacology, 1988, Volume: 27, Issue:8

    Topics: Alkaloids; Animals; Cerebellum; Cyclic GMP; Diazepam; Drug Tolerance; Harmaline; Morphine; Olivary N

1988
Involvement of beta 2-adrenoceptor blockade and 5-hydroxytryptamine mechanism in inhibition of harmaline-induced tremors in rats.
    European journal of pharmacology, 1986, Mar-11, Volume: 122, Issue:1

    Topics: 5-Hydroxytryptophan; Acebutolol; Adrenergic beta-Antagonists; Alkaloids; Animals; Butoxamine; Female

1986
Decreased cerebellar 3',5'-cyclic guanosine monophosphate levels and insensitivity to harmaline in the genetically dystonic rat (dt).
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1985, Volume: 5, Issue:10

    Topics: Alkaloids; Animals; Behavior, Animal; Cerebellum; Cyclic GMP; Drug Resistance; Dystonia; Harmaline;

1985
Drug-induced activation of the inferior olivary nucleus in young rabbits. Differential effects of harmaline and quipazine.
    Neuropharmacology, 1985, Volume: 24, Issue:7

    Topics: 5,7-Dihydroxytryptamine; Alkaloids; Animals; Dose-Response Relationship, Drug; Electrophysiology; Ex

1985
Modification of drug-induced tremor by systemic administration of kainic acid and quisqualic acid in mice.
    Neuropharmacology, 1987, Volume: 26, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Harmaline; Kainic Acid; Mice; Oxadiazoles; Quisqualic Aci

1987
Depression of drug-induced tremor by a new isoxazol derivative in mice.
    Japanese journal of pharmacology, 1986, Volume: 41, Issue:1

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Harmaline; Isoxazoles; Male; Mice; Mice, Inbred

1986
Further studies on quantification of drug-induced tremor in mice: effects of antitremorgenic agents on tremor frequency.
    Experimental neurology, 1985, Volume: 88, Issue:2

    Topics: Animals; Benzodiazepines; Dantrolene; Dose-Response Relationship, Drug; Harmaline; Male; Mice; Time

1985
PHARMACOKINETICS In the rat of the hallucinogenic alkaloids harmine and harmaline.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 285, Issue:3

    Topics: Alkaloids; Animals; Blood Proteins; Chromatography, Thin Layer; Erythrocytes; Half-Life; Harmaline;

1974