harmaline has been researched along with Seizures in 13 studies
Harmaline: A beta-carboline alkaloid isolated from seeds of PEGANUM.
harmaline : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A tremorogenic dose of harmaline (30 mg/kg intravenously) increased binding by 31%." | 7.66 | Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. ( Airaksinen, MM; Saano, V, 1982) |
| " Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline." | 7.66 | Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982) |
| "In Group VII, seizure duration showed a significant increase (P < 0." | 5.51 | The effect of harmaline on seizures induced by amygdala kindling in rats. ( Alenajaf, A; Fereidoni, M; Moghimi, A; Mohammad-Zadeh, M; Mohebi, E, 2019) |
| "D-CPPene antagonized seizures induced by intracerebroventricular injection of NMDA in mice." | 5.29 | Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions. ( Eblen, F; Klockgether, T; Löschmann, PA; Turski, L; Wüllner, U, 1996) |
| "During KA-induced seizures, an extravasation of both HRP and presumed IgG occurred in similar forebrain loci; a lamina-specific extravasation occurred within the dorsal hippocampus." | 5.27 | Foreign and endogenous serum protein extravasation during harmaline tremors or kainic acid seizures in the rat: a comparison. ( Feinerman, GS; Ruth, RE, 1988) |
| "2-Amino-6-trifluoromethoxy benzothiazole (PK 26124) prevented convulsions induced in rodents by maximal electroshock, inhibitors of the synthesis of gamma-aminobutyric acid (GABA) and ouabain, but was inactive against seizures provoked by GABA antagonists, unlike diazepam, chlordiazepoxide, phenobarbital and valproic acid." | 3.67 | 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties. ( Croucher, M; Gueremy, C; Le Fur, G; Legrand, JJ; Mazadier, M; Meldrum, B; Mizoule, J; Ollat, C; Uzan, A, 1985) |
| " A tremorogenic dose of harmaline (30 mg/kg intravenously) increased binding by 31%." | 3.66 | Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. ( Airaksinen, MM; Saano, V, 1982) |
| " Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline." | 3.66 | Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982) |
| "In Group VII, seizure duration showed a significant increase (P < 0." | 1.51 | The effect of harmaline on seizures induced by amygdala kindling in rats. ( Alenajaf, A; Fereidoni, M; Moghimi, A; Mohammad-Zadeh, M; Mohebi, E, 2019) |
| "Alaproclate and GEA-857 antagonized seizures induced by NMDA, 200 mg/kg subcutaneously at doses similar to those antagonizing the harmaline- and NMDA-induced elevation of cerebellar cGMP." | 1.30 | NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857. ( Hu, PS; Ross, SB, 1997) |
| "D-CPPene antagonized seizures induced by intracerebroventricular injection of NMDA in mice." | 1.29 | Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions. ( Eblen, F; Klockgether, T; Löschmann, PA; Turski, L; Wüllner, U, 1996) |
| "During KA-induced seizures, an extravasation of both HRP and presumed IgG occurred in similar forebrain loci; a lamina-specific extravasation occurred within the dorsal hippocampus." | 1.27 | Foreign and endogenous serum protein extravasation during harmaline tremors or kainic acid seizures in the rat: a comparison. ( Feinerman, GS; Ruth, RE, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alenajaf, A | 1 |
| Mohebi, E | 1 |
| Moghimi, A | 1 |
| Fereidoni, M | 1 |
| Mohammad-Zadeh, M | 1 |
| Wiklund, L | 1 |
| Sjölund, B | 1 |
| Björklund, A | 1 |
| Saano, V | 1 |
| Airaksinen, MM | 1 |
| Schweri, M | 1 |
| Cain, M | 1 |
| Cook, J | 1 |
| Paul, S | 1 |
| Skolnick, P | 1 |
| Eblen, F | 1 |
| Löschmann, PA | 1 |
| Wüllner, U | 1 |
| Turski, L | 1 |
| Klockgether, T | 1 |
| Hu, PS | 1 |
| Ross, SB | 1 |
| Brailowsky, S | 1 |
| Walter, S | 1 |
| Vuillon-Cacciuttolo, G | 1 |
| Serbanescu, T | 1 |
| Folco, GC | 1 |
| Longiave, D | 1 |
| Berti, F | 1 |
| Fumagalli, R | 1 |
| Paoletti, R | 1 |
| Rubin, EH | 1 |
| Ferrendelli, JA | 1 |
| Costa, E | 1 |
| Guidotti, A | 1 |
| Mao, CC | 1 |
| Lehmann, J | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 1 |
| Hutchison, A | 1 |
| Tsai, C | 1 |
| Wood, PL | 1 |
| Mizoule, J | 1 |
| Meldrum, B | 1 |
| Mazadier, M | 1 |
| Croucher, M | 1 |
| Ollat, C | 1 |
| Uzan, A | 1 |
| Legrand, JJ | 1 |
| Gueremy, C | 1 |
| Le Fur, G | 1 |
| Ruth, RE | 1 |
| Feinerman, GS | 1 |
1 review available for harmaline and Seizures
| Article | Year |
|---|---|
Evidence for involvement of GABA in the action of benzodiazepines: studies on rat cerebellum.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebellum; Cyclic GMP; gamma-Aminobu | 1975 |
12 other studies available for harmaline and Seizures
| Article | Year |
|---|---|
The effect of harmaline on seizures induced by amygdala kindling in rats.
Topics: Action Potentials; Amygdala; Animals; Electric Stimulation; Epilepsy; Harmaline; Kindling, Neurologi | 2019 |
Morphological and functional studies on the serotoninergic innervation of the inferior olive.
Topics: 5,6-Dihydroxytryptamine; 5,7-Dihydroxytryptamine; Action Potentials; Afferent Pathways; Animals; Aut | 1981 |
Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor.
Topics: Animals; Brain; Caffeine; Carbolines; Flunitrazepam; Harmaline; Harmine; Indoles; Male; Rats; Rats, | 1982 |
Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flu | 1982 |
Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclic GMP; Dose-Response Relationship, Drug; Dru | 1996 |
NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857.
Topics: 4-Aminopyridine; Alanine; Animals; Behavior, Animal; Cerebellum; Convulsants; Cyclic GMP; Drug Inter | 1997 |
[Indole alkaloids induction of tremors: effect on photosensible epilepsy in Papiopapio].
Topics: Alkaloids; Animals; Cerebral Cortex; Dihydroergotoxine; Haplorhini; Harmaline; Ibogaine; Papio; Phot | 1975 |
Prostaglandin E2 and central cyclic nucleotides.
Topics: Cerebellum; Cerebral Cortex; Chlordiazepoxide; Convulsants; Cyclic AMP; Cyclic GMP; Dose-Response Re | 1976 |
Distribution and regulation of cyclic nucleotide levels in cerebellum, in vivo.
Topics: Amphetamine; Animals; Atropine; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Female; Harmaline; In | 1977 |
CGS 19755 is a potent and competitive antagonist at NMDA-type receptors.
Topics: Acetylcholine; Animals; Aspartic Acid; Binding, Competitive; Blood-Brain Barrier; Cerebellum; Cyclic | 1988 |
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties.
Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Electroshock; Female; Glutamate Decarboxylase; H | 1985 |
Foreign and endogenous serum protein extravasation during harmaline tremors or kainic acid seizures in the rat: a comparison.
Topics: Alkaloids; Animals; Blood-Brain Barrier; Female; Harmaline; Horseradish Peroxidase; Immunoglobulin g | 1988 |