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harmaline and Seizures

harmaline has been researched along with Seizures in 13 studies

Harmaline: A beta-carboline alkaloid isolated from seeds of PEGANUM.
harmaline : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
" A tremorogenic dose of harmaline (30 mg/kg intravenously) increased binding by 31%."7.66Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. ( Airaksinen, MM; Saano, V, 1982)
" Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline."7.66Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982)
"In Group VII, seizure duration showed a significant increase (P < 0."5.51The effect of harmaline on seizures induced by amygdala kindling in rats. ( Alenajaf, A; Fereidoni, M; Moghimi, A; Mohammad-Zadeh, M; Mohebi, E, 2019)
"D-CPPene antagonized seizures induced by intracerebroventricular injection of NMDA in mice."5.29Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions. ( Eblen, F; Klockgether, T; Löschmann, PA; Turski, L; Wüllner, U, 1996)
"During KA-induced seizures, an extravasation of both HRP and presumed IgG occurred in similar forebrain loci; a lamina-specific extravasation occurred within the dorsal hippocampus."5.27Foreign and endogenous serum protein extravasation during harmaline tremors or kainic acid seizures in the rat: a comparison. ( Feinerman, GS; Ruth, RE, 1988)
"2-Amino-6-trifluoromethoxy benzothiazole (PK 26124) prevented convulsions induced in rodents by maximal electroshock, inhibitors of the synthesis of gamma-aminobutyric acid (GABA) and ouabain, but was inactive against seizures provoked by GABA antagonists, unlike diazepam, chlordiazepoxide, phenobarbital and valproic acid."3.672-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties. ( Croucher, M; Gueremy, C; Le Fur, G; Legrand, JJ; Mazadier, M; Meldrum, B; Mizoule, J; Ollat, C; Uzan, A, 1985)
" A tremorogenic dose of harmaline (30 mg/kg intravenously) increased binding by 31%."3.66Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. ( Airaksinen, MM; Saano, V, 1982)
" Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline."3.66Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982)
"In Group VII, seizure duration showed a significant increase (P < 0."1.51The effect of harmaline on seizures induced by amygdala kindling in rats. ( Alenajaf, A; Fereidoni, M; Moghimi, A; Mohammad-Zadeh, M; Mohebi, E, 2019)
"Alaproclate and GEA-857 antagonized seizures induced by NMDA, 200 mg/kg subcutaneously at doses similar to those antagonizing the harmaline- and NMDA-induced elevation of cerebellar cGMP."1.30NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857. ( Hu, PS; Ross, SB, 1997)
"D-CPPene antagonized seizures induced by intracerebroventricular injection of NMDA in mice."1.29Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions. ( Eblen, F; Klockgether, T; Löschmann, PA; Turski, L; Wüllner, U, 1996)
"During KA-induced seizures, an extravasation of both HRP and presumed IgG occurred in similar forebrain loci; a lamina-specific extravasation occurred within the dorsal hippocampus."1.27Foreign and endogenous serum protein extravasation during harmaline tremors or kainic acid seizures in the rat: a comparison. ( Feinerman, GS; Ruth, RE, 1988)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-199010 (76.92)18.7374
1990's2 (15.38)18.2507
2000's0 (0.00)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alenajaf, A1
Mohebi, E1
Moghimi, A1
Fereidoni, M1
Mohammad-Zadeh, M1
Wiklund, L1
Sjölund, B1
Björklund, A1
Saano, V1
Airaksinen, MM1
Schweri, M1
Cain, M1
Cook, J1
Paul, S1
Skolnick, P1
Eblen, F1
Löschmann, PA1
Wüllner, U1
Turski, L1
Klockgether, T1
Hu, PS1
Ross, SB1
Brailowsky, S1
Walter, S1
Vuillon-Cacciuttolo, G1
Serbanescu, T1
Folco, GC1
Longiave, D1
Berti, F1
Fumagalli, R1
Paoletti, R1
Rubin, EH1
Ferrendelli, JA1
Costa, E1
Guidotti, A1
Mao, CC1
Lehmann, J1
Chapman, AG1
Meldrum, BS1
Hutchison, A1
Tsai, C1
Wood, PL1
Mizoule, J1
Meldrum, B1
Mazadier, M1
Croucher, M1
Ollat, C1
Uzan, A1
Legrand, JJ1
Gueremy, C1
Le Fur, G1
Ruth, RE1
Feinerman, GS1

Reviews

1 review available for harmaline and Seizures

ArticleYear
Evidence for involvement of GABA in the action of benzodiazepines: studies on rat cerebellum.
    Advances in biochemical psychopharmacology, 1975, Issue:14

    Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebellum; Cyclic GMP; gamma-Aminobu

1975

Other Studies

12 other studies available for harmaline and Seizures

ArticleYear
The effect of harmaline on seizures induced by amygdala kindling in rats.
    Neurological research, 2019, Volume: 41, Issue:6

    Topics: Action Potentials; Amygdala; Animals; Electric Stimulation; Epilepsy; Harmaline; Kindling, Neurologi

2019
Morphological and functional studies on the serotoninergic innervation of the inferior olive.
    Journal de physiologie, 1981, Volume: 77, Issue:2-3

    Topics: 5,6-Dihydroxytryptamine; 5,7-Dihydroxytryptamine; Action Potentials; Afferent Pathways; Animals; Aut

1981
Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor.
    Acta pharmacologica et toxicologica, 1982, Volume: 51, Issue:4

    Topics: Animals; Brain; Caffeine; Carbolines; Flunitrazepam; Harmaline; Harmine; Indoles; Male; Rats; Rats,

1982
Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:3

    Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flu

1982
Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions.
    European journal of pharmacology, 1996, Mar-28, Volume: 299, Issue:1-3

    Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclic GMP; Dose-Response Relationship, Drug; Dru

1996
NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857.
    Pharmacology & toxicology, 1997, Volume: 80, Issue:2

    Topics: 4-Aminopyridine; Alanine; Animals; Behavior, Animal; Cerebellum; Convulsants; Cyclic GMP; Drug Inter

1997
[Indole alkaloids induction of tremors: effect on photosensible epilepsy in Papiopapio].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1975, Volume: 169, Issue:5

    Topics: Alkaloids; Animals; Cerebral Cortex; Dihydroergotoxine; Haplorhini; Harmaline; Ibogaine; Papio; Phot

1975
Prostaglandin E2 and central cyclic nucleotides.
    Advances in prostaglandin and thromboxane research, 1976, Volume: 1

    Topics: Cerebellum; Cerebral Cortex; Chlordiazepoxide; Convulsants; Cyclic AMP; Cyclic GMP; Dose-Response Re

1976
Distribution and regulation of cyclic nucleotide levels in cerebellum, in vivo.
    Journal of neurochemistry, 1977, Volume: 29, Issue:1

    Topics: Amphetamine; Animals; Atropine; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Female; Harmaline; In

1977
CGS 19755 is a potent and competitive antagonist at NMDA-type receptors.
    European journal of pharmacology, 1988, Sep-01, Volume: 154, Issue:1

    Topics: Acetylcholine; Animals; Aspartic Acid; Binding, Competitive; Blood-Brain Barrier; Cerebellum; Cyclic

1988
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties.
    Neuropharmacology, 1985, Volume: 24, Issue:8

    Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Electroshock; Female; Glutamate Decarboxylase; H

1985
Foreign and endogenous serum protein extravasation during harmaline tremors or kainic acid seizures in the rat: a comparison.
    Acta neuropathologica, 1988, Volume: 76, Issue:4

    Topics: Alkaloids; Animals; Blood-Brain Barrier; Female; Harmaline; Horseradish Peroxidase; Immunoglobulin g

1988