harmaline has been researched along with Parkinson Disease, Secondary in 3 studies
Harmaline: A beta-carboline alkaloid isolated from seeds of PEGANUM.
harmaline : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.
Parkinson Disease, Secondary: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tremor is currently ranked as the most common movement disorder." | 1.56 | Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation. ( Brown, AM; Lin, T; Sillitoe, RV; van der Heijden, ME; White, JJ; Zhou, J, 2020) |
| " All betaCs and MPP(+) showed general cytotoxicity in parental HEK-293 cells after 72 h with half-maximal toxic concentrations (TC(50) values) in the upper micromolar range." | 1.32 | Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake. ( Beach, JW; Collins, MA; Gearhart, DA; Hwang, YI; Neafsey, EJ; Schwarz, J; Storch, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, AM | 1 |
| White, JJ | 1 |
| van der Heijden, ME | 1 |
| Zhou, J | 1 |
| Lin, T | 1 |
| Sillitoe, RV | 1 |
| Storch, A | 1 |
| Hwang, YI | 1 |
| Gearhart, DA | 1 |
| Beach, JW | 1 |
| Neafsey, EJ | 1 |
| Collins, MA | 1 |
| Schwarz, J | 1 |
| Lamarre, Y | 1 |
| Joffroy, AJ | 1 |
| Dumont, M | 1 |
| De Montigny, C | 1 |
| Grou, F | 1 |
| Lund, JP | 1 |
3 other studies available for harmaline and Parkinson Disease, Secondary
| Article | Year |
|---|---|
Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation.
Topics: Animals; Cerebellum; Deep Brain Stimulation; Female; gamma-Aminobutyric Acid; Harmaline; Male; Mice; | 2020 |
Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Carbolines; Cell Line; Ce | 2004 |
Central mechanisms of tremor in some feline and primate models.
Topics: Animals; Brain; Cats; Cerebellum; Disease Models, Animal; Electromyography; Haplorhini; Harmaline; M | 1975 |