harmaline has been researched along with Nerve Degeneration in 7 studies
Harmaline: A beta-carboline alkaloid isolated from seeds of PEGANUM.
harmaline : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The current study aims to investigate the anti-tremogenic and neuroprotective effects of memantine (NMDA receptor antagonist) on the harmaline model of transient action tremor." | 7.77 | The effect of memantine in harmaline-induced tremor and neurodegeneration. ( Akman, O; Ates, N; Erturk, S; Gullu, KM; Iseri, PK; Karson, A; Kokturk, S; Yardýmoglu, M, 2011) |
| " The current study aims to investigate the anti-tremogenic and neuroprotective effects of memantine (NMDA receptor antagonist) on the harmaline model of transient action tremor." | 3.77 | The effect of memantine in harmaline-induced tremor and neurodegeneration. ( Akman, O; Ates, N; Erturk, S; Gullu, KM; Iseri, PK; Karson, A; Kokturk, S; Yardýmoglu, M, 2011) |
| " The synchronous activation of inferior olive neurons by the drug harmaline is known to produce tremorogenic activity in rats via increased stimulation of the olivocerebellar system." | 3.69 | An experimental model for the non-invasive trans-synaptic induction of nitric oxide synthase in Purkinje cells of the rat cerebellum. ( Beitz, AJ; Saxon, DW, 1996) |
| " That a lesion of the inferior olive almost completely prevents the neurotoxicity demonstrates that ibogaine is not directly toxic to Purkinje cells, but that the toxicity is indirect and dependent on integrity of the olivocerebellar projection." | 1.30 | The olivocerebellar projection mediates ibogaine-induced degeneration of Purkinje cells: a model of indirect, trans-synaptic excitotoxicity. ( Molliver, ME; O'Hearn, E, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iseri, PK | 1 |
| Karson, A | 1 |
| Gullu, KM | 1 |
| Akman, O | 1 |
| Kokturk, S | 1 |
| Yardýmoglu, M | 1 |
| Erturk, S | 1 |
| Ates, N | 1 |
| Milner, TE | 1 |
| Cadoret, G | 1 |
| Lessard, L | 1 |
| Smith, AM | 1 |
| O'Hearn, E | 2 |
| Molliver, ME | 2 |
| Jones, N | 1 |
| Stelz, T | 1 |
| Batini, C | 1 |
| Caston, J | 1 |
| Saxon, DW | 1 |
| Beitz, AJ | 1 |
| Tolbert, DL | 1 |
| Clark, BR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open-Label Dose-Ranging Study of Oral SM-001 in Healthy Adults[NCT05894902] | Phase 1 | 12 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for harmaline and Nerve Degeneration
| Article | Year |
|---|---|
The effect of memantine in harmaline-induced tremor and neurodegeneration.
Topics: Animals; Cerebellum; Ethanol; Harmaline; Male; Memantine; Nerve Degeneration; Neuroprotective Agents | 2011 |
EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive.
Topics: Animals; Cerebellum; Electromyography; Harmaline; Injections, Intraperitoneal; Mice; Mice, Mutant St | 1995 |
Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline.
Topics: Animals; Calbindins; Cerebellum; Harmaline; Ibogaine; Male; Microtubule-Associated Proteins; Nerve D | 1993 |
Effects of lesion of the inferior olivary complex in learning of the equilibrium behavior in the young rat during ontogenesis. I. Total lesion of the inferior olive by 3-acetylpyridine.
Topics: Aging; Animals; Animals, Newborn; Harmaline; Learning; Motor Activity; Nerve Degeneration; Olivary N | 1995 |
An experimental model for the non-invasive trans-synaptic induction of nitric oxide synthase in Purkinje cells of the rat cerebellum.
Topics: Amino Acid Sequence; Animals; Calbindins; Cerebellum; Enzyme Induction; Harmaline; Immunohistochemis | 1996 |
The olivocerebellar projection mediates ibogaine-induced degeneration of Purkinje cells: a model of indirect, trans-synaptic excitotoxicity.
Topics: Aminopyridines; Animals; Behavior, Animal; Cell Death; Cerebellar Cortex; Hallucinogens; Harmaline; | 1997 |
Olivocerebellar projections modify hereditary Purkinje cell degeneration.
Topics: Animals; Behavior, Animal; Calbindins; Cell Survival; Cerebellar Cortex; Denervation; Disease Models | 2000 |