haouamine-a has been researched along with Colonic-Neoplasms* in 1 studies
1 other study(ies) available for haouamine-a and Colonic-Neoplasms
Article | Year |
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Haouamines A and B: a new class of alkaloids from the ascidian Aplidium haouarianum.
The chemical study of the ascidian Aplidium haouarianum has led to the isolation of the new metabolites haouamines A (1) and B (2) which belong to a novel class of alkaloids. The structure of 1 was established by interpretation of its spectroscopic data and those of the N-methyl derivative 3, and confirmed by X-ray crystallographic analysis. The structure of 2 was deduced by spectroscopic study of its peracetyl derivative 2a. In solution each haouamine exists as an unseparable mixture of two interconverting isomers derived by the presence of a highly strained 3-aza-[7]-paracyclophane moiety in their structures. Compound 1 exhibits a selective cytotoxic activity against the HT-29 human colon carcinoma cell line. Topics: Alkaloids; Animals; Colonic Neoplasms; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Endothelium; Hawaii; Heterocyclic Compounds, 4 or More Rings; Humans; Inhibitory Concentration 50; Lung Neoplasms; Male; Mice; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Prostatic Neoplasms; Spain; Tumor Cells, Cultured; Urochordata | 2003 |