halothane has been researched along with Sensitivity and Specificity in 38 studies
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The most commonly used laboratory test for predicting malignant hyperthermia susceptibility is the caffeine halothane contracture test." | 9.07 | Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. The North American Malignant Hyperthermia Registry. ( Bunn, JS; Diaz, M; Landis, JR; Larach, MG, 1992) |
| "Using moxifloxacin and terfenadine, which are known to induce benign and malignant QT interval prolongation, respectively, we analysed whether halothane-anaesthetized microminipigs are an appropriate model for assessing the risk of drug-induced long QT syndrome." | 7.85 | Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| " The center followed the diagnostic protocols of the North America MH Group, in which the contractures of biopsies from the vastus lateralis muscle are analyzed after exposure to caffeine and halothane (CHCT)." | 7.76 | Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil. ( Abreu, AV; Aguiar, MI; Cardoso, LA; Carmo, PL; Cunha, LB; Matos, AR; Sudo, RT; Trachez, MM; Zapata-Sudo, G, 2010) |
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 7.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| "The most commonly used laboratory test for predicting malignant hyperthermia susceptibility is the caffeine halothane contracture test." | 5.07 | Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. The North American Malignant Hyperthermia Registry. ( Bunn, JS; Diaz, M; Landis, JR; Larach, MG, 1992) |
| "Using moxifloxacin and terfenadine, which are known to induce benign and malignant QT interval prolongation, respectively, we analysed whether halothane-anaesthetized microminipigs are an appropriate model for assessing the risk of drug-induced long QT syndrome." | 3.85 | Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| " The center followed the diagnostic protocols of the North America MH Group, in which the contractures of biopsies from the vastus lateralis muscle are analyzed after exposure to caffeine and halothane (CHCT)." | 3.76 | Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil. ( Abreu, AV; Aguiar, MI; Cardoso, LA; Carmo, PL; Cunha, LB; Matos, AR; Sudo, RT; Trachez, MM; Zapata-Sudo, G, 2010) |
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 3.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| "Isoflurane or enflurane was also measured from whole blood samples in which three volunteers inhaled each compound." | 1.31 | Sensitive determination of four general anaesthetics in human whole blood by capillary gas chromatography with cryogenic oven trapping. ( Ishii, A; Katsumata, Y; Kojima, T; Kumazawa, T; Kurihara, R; Seno, H; Suzuki, O; Watanabe-Suzuki, K, 2001) |
| " MHEh muscles revealed a dose-response curve similar to that found in MHN specimens." | 1.30 | Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol. ( Bittner, RE; Fricker, R; Gilly, H; Kress, HG; Musat, I; Steinbereithner, K, 1997) |
| " For halothane, the dose-response curve showed an IC50 concentration of 1." | 1.29 | Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics. ( Franks, NP; Hall, AC; Lieb, WR, 1994) |
| "Halothane was a more potent depressant of cardiac function than isoflurane and developmental differences were more evident with this agent." | 1.29 | Direct myocardial effects of halothane and isoflurane. Comparison between adult and infant rabbits. ( Bosnjak, ZJ; Kampine, JP; Mehner, RW; Palmisano, BW; Stowe, DF, 1994) |
| "6 MAC halothane did not significantly affect the dose-response relationship between isoproterenol and force." | 1.29 | Halothane and pertussis toxin-sensitive G proteins in airway smooth muscle. ( Jones, KA; Morimoto, N; Warner, DO; Yamamoto, K, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.63) | 18.7374 |
| 1990's | 22 (57.89) | 18.2507 |
| 2000's | 13 (34.21) | 29.6817 |
| 2010's | 2 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, X | 1 |
| Wada, T | 1 |
| Nakamura, Y | 1 |
| Matsukura, S | 1 |
| Izumi-Nakaseko, H | 1 |
| Ando, K | 1 |
| Naito, AT | 1 |
| Sugiyama, A | 1 |
| Campbell, JL | 1 |
| Gu, Q | 1 |
| Guo, D | 1 |
| Nash, HA | 1 |
| Sudo, RT | 1 |
| Cunha, LB | 1 |
| Carmo, PL | 1 |
| Matos, AR | 1 |
| Trachez, MM | 1 |
| Cardoso, LA | 1 |
| Aguiar, MI | 1 |
| Abreu, AV | 1 |
| Zapata-Sudo, G | 1 |
| Islander, G | 3 |
| Ording, H | 4 |
| Bendixen, D | 3 |
| Ranklev Twetman, E | 2 |
| Hassoun, W | 1 |
| Le Cavorsin, M | 1 |
| Ginovart, N | 1 |
| Zimmer, L | 1 |
| Gualda, V | 1 |
| Bonnefoi, F | 1 |
| Leviel, V | 1 |
| Wappler, F | 2 |
| Anetseder, M | 1 |
| Baur, CP | 1 |
| Censier, K | 1 |
| Doetsch, S | 1 |
| Felleiter, P | 1 |
| Fiege, M | 1 |
| Fricker, R | 2 |
| Halsall, PJ | 2 |
| Hartung, E | 2 |
| Heffron, JJ | 2 |
| Heytens, L | 2 |
| Hopkins, PM | 1 |
| Klingler, W | 1 |
| Lehmann-Horn, F | 2 |
| Nivoche, Y | 2 |
| Tegazzin, V | 2 |
| Tzanova, I | 1 |
| Urwyler, A | 2 |
| Weisshorn, R | 1 |
| Schulte am Esch, J | 1 |
| Atherley, RJ | 1 |
| Antognini, JF | 2 |
| Austin, VC | 1 |
| Blamire, AM | 1 |
| Allers, KA | 1 |
| Sharp, T | 1 |
| Styles, P | 1 |
| Matthews, PM | 1 |
| Sibson, NR | 1 |
| Chinn, K | 2 |
| Brown, OE | 2 |
| Manning, SC | 2 |
| Brodsky, JB | 1 |
| Lemmens, HJ | 1 |
| Collins, JS | 1 |
| Morton, JM | 1 |
| Curet, MJ | 1 |
| Brock-Utne, JG | 1 |
| Solt, K | 1 |
| Johansson, JS | 1 |
| Raines, DE | 1 |
| Turner, PG | 1 |
| Dugdale, A | 1 |
| Young, IS | 1 |
| Taylor, S | 1 |
| Panev, T | 1 |
| Allison, JM | 1 |
| Gregory, RS | 1 |
| Birch, KP | 1 |
| Crowder, JG | 1 |
| Hall, AC | 1 |
| Lieb, WR | 1 |
| Franks, NP | 1 |
| Palmisano, BW | 1 |
| Mehner, RW | 1 |
| Stowe, DF | 1 |
| Bosnjak, ZJ | 1 |
| Kampine, JP | 1 |
| Tavernier, BM | 1 |
| Adnet, PJ | 1 |
| Imbenotte, M | 1 |
| Etchrivi, TS | 1 |
| Reyford, H | 1 |
| Haudecoeur, G | 1 |
| Scherpereel, P | 1 |
| Krivosic-Horber, RM | 1 |
| Kosk-Kosicka, D | 1 |
| Roszczynska, G | 1 |
| Mikawa, K | 1 |
| Nishina, K | 1 |
| Maekawa, N | 1 |
| Yaku, H | 1 |
| Obara, H | 1 |
| Uetani, Y | 1 |
| Nakamura, H | 1 |
| Morimoto, N | 1 |
| Yamamoto, K | 2 |
| Jones, KA | 1 |
| Warner, DO | 1 |
| el-Maghrabi, EA | 1 |
| Eckenhoff, RG | 1 |
| McCrae, AF | 1 |
| Gallaher, EJ | 1 |
| Winter, PM | 1 |
| Firestone, LL | 1 |
| Johnson, ME | 1 |
| Sill, JC | 1 |
| Uhl, CB | 1 |
| Halsey, TJ | 1 |
| Gores, GJ | 1 |
| Hankins, DC | 1 |
| Kharasch, ED | 1 |
| Gilly, H | 1 |
| Musat, I | 1 |
| Bittner, RE | 1 |
| Steinbereithner, K | 1 |
| Kress, HG | 1 |
| Brancadoro, V | 1 |
| Cozzolino, S | 1 |
| Ellis, FR | 1 |
| Glauber, V | 2 |
| Gonano, EF | 1 |
| Kozak-Ribbens, G | 1 |
| Kress, H | 1 |
| Krivosic-Horber, R | 1 |
| Mortier, W | 1 |
| Ranklev-Twetman, E | 1 |
| Sigurdsson, S | 1 |
| Snoeck, M | 1 |
| Stieglitz, P | 1 |
| Ben Abraham, R | 1 |
| Zweig, A | 1 |
| Perel, A | 1 |
| Fagerlund, TH | 1 |
| Berg, K | 1 |
| Karuri, AR | 1 |
| Agarwal, RK | 1 |
| Engelking, LR | 1 |
| Kumar, MS | 1 |
| Twetman, ER | 1 |
| Tamura, T | 1 |
| Imai, R | 1 |
| Yamamoto, M | 1 |
| Kojima, T | 1 |
| Ishii, A | 1 |
| Watanabe-Suzuki, K | 1 |
| Kurihara, R | 1 |
| Seno, H | 1 |
| Kumazawa, T | 1 |
| Suzuki, O | 1 |
| Katsumata, Y | 1 |
| Rosenberg, H | 1 |
| Muldoon, S | 1 |
| Ochiai, R | 1 |
| Guthrie, RD | 1 |
| Motoyama, EK | 1 |
| Larach, MG | 1 |
| Landis, JR | 1 |
| Bunn, JS | 1 |
| Diaz, M | 1 |
| Silbert, BS | 1 |
| Koumoundouros, E | 1 |
| Davies, MJ | 1 |
| Cronin, KD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Sevoflurane and Propofol on Maximum Muscular Strength, Speed of Contraction and Relaxation, in Humans: A Pilot Study[NCT05615025] | Phase 3 | 48 participants (Actual) | Interventional | 2023-01-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for halothane and Sensitivity and Specificity
| Article | Year |
|---|---|
Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility.
Topics: Biopsy; Caffeine; Cresols; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant | 2003 |
Nitrous oxide and laparoscopic bariatric surgery.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Body Mass Index; | 2005 |
Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. The North American Malignant Hyperthermia Registry.
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Child; Contracture; Disease Susceptibility; Female; Halot | 1992 |
35 other studies available for halothane and Sensitivity and Specificity
| Article | Year |
|---|---|
Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome.
Topics: Anesthetics, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Dose | 2017 |
Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity.
Topics: Anesthetics, Inhalation; Animals; Chromosome Mapping; Dose-Response Relationship, Drug; Drosophila; | 2009 |
Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Biopsy; Caffeine; Child; Child, Preschool; Contrac | 2010 |
Reproducibility of in vitro contracture test results in patients tested for malignant hyperthermia susceptibility.
Topics: Adult; Anesthetics, Inhalation; Biopsy; Caffeine; Disease Susceptibility; Female; Halothane; Humans; | 2002 |
PET study of the [11C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow.
Topics: Anesthetics; Animals; Cats; Cerebellum; Cerebrovascular Circulation; Corpus Striatum; Halothane; Ket | 2003 |
A rapid and simple method for determination of halothane, isoflurane and sevoflurane in blood using gas chromatography.
Topics: Animals; Chromatography, Gas; Halothane; Isoflurane; Methyl Ethers; Rabbits; Reproducibility of Resu | 2004 |
Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and alpha-chloralose anesthesia.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Chloralose; Dominan | 2005 |
Effects of inhalant anesthesia: tympanometry validation (R98/217).
Topics: Acoustic Impedance Tests; Adenoidectomy; Anesthetics, Inhalation; Child; Child, Preschool; False Neg | 2005 |
Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein.
Topics: Anesthetics, Inhalation; Cysteine; Halothane; Ion Channel Gating; Ion Channels; Kinetics; Ligands; M | 2006 |
Portable mass spectrometry for measurement of anaesthetic agents and methane in respiratory gases.
Topics: Anesthesia, General; Animals; Breath Tests; Female; Halothane; Horses; Isoflurane; Male; Mass Spectr | 2008 |
[An infrared spectrophotometric method for determining nitrous oxide and halothane in the air of operating rooms].
Topics: Air Pollutants, Occupational; Halothane; Nitrous Oxide; Operating Rooms; Sensitivity and Specificity | 1993 |
Determination of anaesthetic agent concentration by refractometry.
Topics: Anesthetics, Inhalation; Desflurane; Enflurane; Ethers; Halothane; Isoflurane; Methyl Ethers; Refere | 1995 |
Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics.
Topics: Administration, Inhalation; Anesthesia, General; Anesthetics; Animals; Calcium Channel Blockers; Cal | 1994 |
Direct myocardial effects of halothane and isoflurane. Comparison between adult and infant rabbits.
Topics: Aging; Animals; Animals, Newborn; Atrioventricular Node; Coronary Circulation; Halothane; Heart; Hea | 1994 |
Halothane and isoflurane decrease calcium sensitivity and maximal force in human skinned cardiac fibers.
Topics: Aged; Calcium; Cetomacrogol; Depression, Chemical; Egtazic Acid; Female; Halothane; Heart; Humans; I | 1994 |
Inhibition of plasma membrane Ca(2+)-ATPase activity by volatile anesthetics.
Topics: Administration, Inhalation; Anesthetics; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Erythro | 1993 |
Perioperative changes in superoxide production in neonates and infants.
Topics: Abdomen; Anesthesia, Inhalation; Female; Halothane; Humans; Infant; Infant, Newborn; Intraoperative | 1993 |
Halothane and pertussis toxin-sensitive G proteins in airway smooth muscle.
Topics: Acetylcholine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Depression, Chemical; Dogs; Drug | 1994 |
Effects of inhalant anesthesia on the middle ear as measured by tympanometry.
Topics: Acoustic Impedance Tests; Anesthesia, Inhalation; Child; Child, Preschool; Ear, Middle; Female; Halo | 1993 |
Inhibition of dopamine transport in rat brain synaptosomes by volatile anesthetics.
Topics: Animals; Brain; Carrier Proteins; Dopamine; Dopamine Plasma Membrane Transport Proteins; Extracellul | 1993 |
Volatile anesthetic requirements differ in mice selectively bred for sensitivity or resistance to diazepam: implications for the site of anesthesia.
Topics: Anesthesia, Inhalation; Animals; Diazepam; Drug Resistance; Enflurane; Halothane; Male; Mice; Select | 1993 |
Effect of volatile anesthetics on hydrogen peroxide-induced injury in aortic and pulmonary arterial endothelial cells.
Topics: Anesthetics, Inhalation; Aorta; Calcium; Cell Death; Cells, Cultured; Cytoplasm; Endothelium, Vascul | 1996 |
Determination of the halothane metabolites trifluoroacetic acid and bromide in plasma and urine by ion chromatography.
Topics: Bromides; Chromatography, High Pressure Liquid; Halothane; Humans; Ions; Sensitivity and Specificity | 1997 |
Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Cresols; Disease Susceptibility; Dose-Re | 1997 |
In vitro contracture test for diagnosis of malignant hyperthermia following the protocol of the European MH Group: results of testing patients surviving fulminant MH and unrelated low-risk subjects. The European Malignant Hyperthermia Group.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Biopsy; Caffeine; Child; Child, Preschool; F | 1997 |
The Israeli Diagnostic Center for Malignant Hyperthermia: 7-years' accumulated experience.
Topics: Academies and Institutes; Adult; Aged; Biopsy; Caffeine; Child; Electromyography; Female; Genetic Pr | 1997 |
Discordance between malignant hyperthermia susceptibility and RYR1 mutation C1840T in two Scandinavian MH families exhibiting this mutation.
Topics: Anesthesia; Caffeine; Denmark; Female; Genetic Predisposition to Disease; Halothane; Humans; Male; M | 1997 |
Effects of halothane and methoxyflurane on regional brain and spinal cord substance P-like and beta-endorphin-like immunoreactivities in the rat.
Topics: Analysis of Variance; Animals; beta-Endorphin; Brain; Halothane; Kinetics; Male; Methoxyflurane; Org | 1998 |
Comparison between the European and North American protocols for diagnosis of malignant hyperthermia susceptibility in humans.
Topics: Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Sensitivity and Specificity | 1999 |
Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole.
Topics: Acute Disease; Anesthesia; Anesthetics, Inhalation; Animals; Astemizole; Atrioventricular Node; Cath | 2001 |
Sensitive determination of four general anaesthetics in human whole blood by capillary gas chromatography with cryogenic oven trapping.
Topics: Adult; Anesthetics, Inhalation; Chromatography, Gas; Enflurane; Halothane; Hot Temperature; Humans; | 2001 |
Testing for malignant hyperthermia.
Topics: Anesthesia; Biopsy; Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Sensiti | 2002 |
Sources of variability in halothane and caffeine contracture tests for susceptibility to malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Caffeine; Child; Contracture; Dose-Response Relationship, Drug; Female; Hal | 1992 |
Differential sensitivity to halothane anesthesia of the genioglossus, intercostals, and diaphragm in kittens.
Topics: Aging; Animals; Carbon Dioxide; Cats; Depression, Chemical; Diaphragm; Dose-Response Relationship, D | 1992 |
The use of aperiodic analysis of the EEG during carotid artery surgery.
Topics: Aged; Anesthesia, General; Brain Ischemia; Carotid Arteries; Carotid Artery Diseases; Electroencepha | 1989 |