Page last updated: 2024-10-28

halothane and Seizures

halothane has been researched along with Seizures in 42 studies

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Toxic systemic reactions to bupivacaine usually involve a number of factors, including hypoxia and acidosis."7.68Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs. ( Badgwell, JM; Bessire, A; Dryden, CF; Heavner, JE; Huemer, G; Sanghani, V, 1992)
"We conducted a prospective study to examine the effect of pentobarbital administration on the development of seizures in dogs that had undergone cervical myelography with metrizamide while anesthetized with halothane."7.67Use of pentobarbital sodium to reduce seizures in dogs after cervical myelography with metrizamide. ( Gray, PR; Indrieri, RJ; Lowrie, CT, 1987)
"infusion of 1."5.29Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat. ( Dexter, F; McFarlane, C; Todd, MM; Warner, DS, 1994)
" Fatal cardiac arrhythmias occurred in, respectively, 3 of 11, 2 of 12, and 2 of 13 conscious sheep infused with bupivacaine, levobupivacaine, and ropivacaine; in 1 of 9 with prilocaine, electromechanical dissociation (followed by polymorphic ventricular tachycardia) caused death."3.74The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. ( Copeland, SE; Gu, XQ; Ladd, LA; Mather, LE, 2008)
" Induction doses of ketamine 1 hour after HD exposure resulted in periods of profound apnea, with continued respiratory distress for the next 2 hours."3.70Domestic swine model for the assessment of chemical warfare agent-anesthetic interactions: some effects of sulfur mustard. ( Conley, J; Hamilton, M; Hunter, K; Lundy, P; Sawyer, TW, 2000)
"Toxic systemic reactions to bupivacaine usually involve a number of factors, including hypoxia and acidosis."3.68Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs. ( Badgwell, JM; Bessire, A; Dryden, CF; Heavner, JE; Huemer, G; Sanghani, V, 1992)
"We conducted a prospective study to examine the effect of pentobarbital administration on the development of seizures in dogs that had undergone cervical myelography with metrizamide while anesthetized with halothane."3.67Use of pentobarbital sodium to reduce seizures in dogs after cervical myelography with metrizamide. ( Gray, PR; Indrieri, RJ; Lowrie, CT, 1987)
" Isoniazide and picrotoxin were used to increase motor activity and induce seizures associated with an increase in cerebellar cGMP content."3.66Halothane effect on cGMP and control of motor activity in mouse cerebellum. ( Alpert, M; Triner, L; Verosky, M; Vulliemoz, Y, 1981)
" Local coupling of blood flow and metabolism was studied under different types of anesthesia (barbiturate, halothane), following experimental tumor implantation, and during penicillin seizures or spreading depression."3.66A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats. ( Hossmann, KA; Mies, G; Niebuhr, I, 1981)
"The effect was most pronounced in seizure-prone animals, and subsequent to anaesthetic-induced behavioural immobility, these animals also showed a regional resistance to the depression of spontaneous slow potential shift oscillations."1.30Large slow potential shifts occur during halothane anaesthesia in gerbils. ( Laming, PR; Roughan, JV, 1998)
"infusion of 1."1.29Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat. ( Dexter, F; McFarlane, C; Todd, MM; Warner, DS, 1994)
"Bupivacaine was infused at a constant rate while the pigs' ECGs and EEGs were recorded."1.28Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics. ( Badgwell, JM; Heavner, JE; Kytta, J, 1990)
"D-halothane and halothane were equipotent on both parameters."1.27Deuterated halothane--anesthetic potency, anticonvulsant activity, and effect on cerebellar cyclic guanosine 3',5'-monophosphate. ( Hamm, MW; Krishna, G; Triner, L; Verosky, M; Vulliemoz, Y, 1984)
"The rise in seizure threshold still occurred when animals were pretreated with alpha-methyl-p-tyrosine (200 mg ."1.26Studies on the post-ictal rise in seizure threshold. ( Cowen, PJ; Green, AR; Nutt, DJ, 1981)
"Tonic and clonic convulsions and death induced by electric shock were inhibited more by E."1.26[Pharmacological comparison between enflurane and halothane]. ( Inoki, R; Iwatsubo, K; Kitagawa, J; Shigenaga, Y, 1976)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199032 (76.19)18.7374
1990's7 (16.67)18.2507
2000's3 (7.14)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
MILLAR, TW1
Elsen, FP1
Liljelund, P1
Werner, DF1
Olsen, RW1
Homanics, GE1
Harrison, NL1
Copeland, SE1
Ladd, LA1
Gu, XQ1
Mather, LE1
Nutt, DJ1
Cowen, PJ1
Green, AR1
Triner, L2
Vulliemoz, Y2
Verosky, M2
Alpert, M1
Hamm, MW1
Krishna, G1
Mies, G1
Niebuhr, I1
Hossmann, KA1
Guedj, P1
Payraudeau-Schreiber, P1
McFarlane, C1
Warner, DS1
Dexter, F1
Todd, MM1
Roughan, JV1
Laming, PR1
Holzki, J1
Kretz, FJ1
Conley, J1
Hunter, K1
Lundy, P1
Hamilton, M1
Sawyer, TW1
Fisher, RS1
Prince, DA1
Huck, S1
Scarnati, E2
Forchetti, C2
Pacitti, C1
De Angelis, C2
Leonardis, G4
Wasterlain, CG1
Kryzhanovskiĭ, GN1
Makul'kin, RF1
Shandra, AA1
Harper, MH1
Winter, PM1
Johnson, BH1
Eger, EI2
Turnbull, MJ1
Watkins, JW1
Kitagawa, J1
Iwatsubo, K1
Shigenaga, Y1
Inoki, R1
Ogawa, T1
Shingu, K1
Shibata, M1
Osawa, M1
Mori, K1
Heavner, JE2
Dryden, CF1
Sanghani, V1
Huemer, G1
Bessire, A1
Badgwell, JM2
Kytta, J1
LaManna, JC1
McCracken, KA1
Patil, M1
Prohaska, OJ1
Lanier, WL1
Sharbrough, FW1
Michenfelder, JD1
Gray, PR1
Indrieri, RJ1
Lowrie, CT1
Komatsu, H1
Ogli, K1
De Jong, RH1
Robles, R1
Corbin, RW1
Joas, TA1
Stevens, WC1
Shim, CY1
Andersen, NB1
Myers, RR1
Stockard, JJ1
Fleming, NI1
France, CJ1
Bickford, RG1
Kilman, JW1
Williams, TE1
Kakos, GS1
Craenen, J1
Hosier, DM1
Bennett, DR1
Madsen, JA1
Jordan, WS1
Wiser, WC1
Sakabe, T1
Maekawa, T1
Ishikawa, T1
Takeshita, H1
Gattiker, R1
Lever, MJ1
Miller, KW1
Paton, WD1
Smith, EB1
Raventós, J1
Lemon, PG1
Splendiani, G2
Krenn, J1
Porges, P1
Steinbereithner, K1
Smith, PA1
Macdonald, TR1
Jones, CS1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429]Phase 4144 participants (Anticipated)Interventional2019-04-05Recruiting
Prospective Cohort Study Evaluating Incidence and Correlation Between Pain and Emergence Delirium After Adenotonsillectomy in Preschool Children[NCT01096797]Phase 4150 participants (Actual)Interventional2009-11-30Completed
Lidocaine For Neuroprotection During Cardiac Surgery[NCT00938964]550 participants (Actual)Interventional2009-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Center for Epidemiological Studies Depression Scale (CES-D)

"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-1.27
Placebo-0.89

Change in Center for Epidemiological Studies Depression Scale (CES-D)

"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.57
Placebo0.16

Change in Cognitive Function From Baseline

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 1 year cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement (NCT00938964)
Timeframe: 1 year after surgery

Interventionunits on a scale (Mean)
Lidocaine0.09
Placebo0.07

Change in Cognitive Function From Baseline Characterized as Continuous Cognitive Change

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 6-week cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery

Interventionunits on a scale (Mean)
Lidocaine0.07
Placebo0.07

Change in Duke Activity Status Index (DASI)

"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine6.3
Placebo6.96

Change in Duke Activity Status Index (DASI)

"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-10.98
Placebo-11.67

Change in Neurological Function, as Measured by the National Institutes of Health Stroke Scale (NIHSS)

The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine0.05
Placebo0.07

Change in Neurological Function, as Measured by the National Institutes of Health Stroke Scale (NIHSS)

The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.05
Placebo0.04

Change in Neurological Function, as Measured by the Western Perioperative Neurologic Scale (WPNS)

The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine0.02
Placebo-0.02

Change in Neurological Function, as Measured by the Western Perioperative Neurologic Scale (WPNS)

The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.04
Placebo-0.01

Change in Perceived Social Support

"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine0.71
Placebo-1.16

Change in Perceived Social Support

"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine1.23
Placebo-0.49

Change in Social Activity

"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-0.20
Placebo0.03

Change in Social Activity

"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.95
Placebo1.59

Change in Spielberger State Anxiety Inventory (STAI)

"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-6.70
Placebo-6.39

Change in Spielberger State Anxiety Inventory (STAI)

"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-7.12
Placebo-6.31

Change in Symptom Limitations

Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-1.39
Placebo-1.48

Change in Symptom Limitations

Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-0.67
Placebo-0.8

Change in the Cognitive Difficulties Scale

"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-0.46
Placebo-1.02

Change in the Cognitive Difficulties Scale

"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-3
Placebo-3.21

Change in the Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL)

"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-0.15
Placebo-0.31

Change in the Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL)

"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine2.46
Placebo2.1

Count of Participants With a Decline of Greater Than or Equal to One Standard Deviation in One or More of Five Cognitive Domain Scores Reported as a Dichotomous Post-operative Cognitive Deficit (POCD) Outcome

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. Each domain score is normally distributed with a mean of zero. A change score was calculated for each domain by subtracting the baseline from the 6-week score. A dichotomous outcome variable of post-operative cognitive deficit was defined as a decline of ≥1 standard deviation in 1 or more of the 5 domains. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery

InterventionParticipants (Count of Participants)
Lidocaine87
Placebo83

Change in Study 36-Item Short Form Health Survey (SF-36)

The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 1-year

,
Interventionunits on a scale (Mean)
1 year Change Work Activities1 year Change General health perception
Lidocaine-1.37-0.28
Placebo-1.42-0.43

Change in Study 36-Item Short Form Health Survey (SF-36)

The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 6-weeks

,
Interventionunits on a scale (Mean)
6-Week Change Work activities6-Week Change General health perception
Lidocaine2.71-0.004
Placebo3-0.03

Transcerebral Activation Gradient of Platelet-neutrophil Conjugates

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-0.150.02-0.73-0.10
Placebo-0.43-0.73-0.400.19

Transcerebral Activation Gradients of Monocytes

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-4.22-2.46-0.341.21
Placebo-0.041.832.640.54

Transcerebral Activation Gradients of Neutrophils

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removal and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-2.020.560.581.04
Placebo-0.080.171.19-0.68

Transcerebral Activation Gradients of Platelets

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-0.030.030.330.37
Placebo0.350.430.050.27

Other Studies

42 other studies available for halothane and Seizures

ArticleYear
Convulsions following halothane anaesthesia.
    Anaesthesia, 1958, Volume: 13, Issue:3

    Topics: Anesthesia; Anesthetics; Halothane; Humans; Seizures

1958
GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice.
    Brain research, 2006, Mar-17, Volume: 1078, Issue:1

    Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography

2006
The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:5

    Topics: Acid-Base Equilibrium; Amides; Anesthetics, Inhalation; Anesthetics, Local; Animals; Arrhythmias, Ca

2008
Studies on the post-ictal rise in seizure threshold.
    European journal of pharmacology, 1981, May-08, Volume: 71, Issue:2-3

    Topics: Animals; Anticonvulsants; Bicuculline; Brain; Convulsants; Electroshock; GABA Antagonists; Halothane

1981
Halothane effect on cGMP and control of motor activity in mouse cerebellum.
    Anesthesiology, 1981, Volume: 54, Issue:3

    Topics: Animals; Cerebellum; Cyclic GMP; Halothane; Isoniazid; Male; Mice; Motor Activity; Picrotoxin; Seizu

1981
Deuterated halothane--anesthetic potency, anticonvulsant activity, and effect on cerebellar cyclic guanosine 3',5'-monophosphate.
    Anesthesia and analgesia, 1984, Volume: 63, Issue:5

    Topics: Animals; Cerebellum; Cyclic GMP; Deuterium; Drug Evaluation, Preclinical; Gas Chromatography-Mass Sp

1984
A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats.
    European neurology, 1981, Volume: 20, Issue:3

    Topics: Animals; Antipyrine; Autoradiography; Brain; Brain Neoplasms; Cerebrovascular Circulation; Cortical

1981
[An unusual cause of "post-critical" coma].
    Annales francaises d'anesthesie et de reanimation, 1994, Volume: 13, Issue:2

    Topics: Adult; Brain; Coma; Dose-Response Relationship, Drug; Female; Halothane; Humans; Obstetric Labor Com

1994
Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat.
    Anesthesia and analgesia, 1994, Volume: 79, Issue:4

    Topics: Animals; Electroencephalography; Excitatory Amino Acid Antagonists; Halothane; Lidocaine; Male; Pipe

1994
Large slow potential shifts occur during halothane anaesthesia in gerbils.
    Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 1998, Volume: 182, Issue:6

    Topics: Anesthesia; Animals; Behavior, Animal; Cerebral Cortex; Disease Susceptibility; Electrophysiology; G

1998
Changing aspects of sevoflurane in paediatric anaesthesia: 1975-99.
    Paediatric anaesthesia, 1999, Volume: 9, Issue:4

    Topics: Akathisia, Drug-Induced; Anesthesia, Inhalation; Anesthetics, Inhalation; Arrhythmias, Cardiac; Chil

1999
Domestic swine model for the assessment of chemical warfare agent-anesthetic interactions: some effects of sulfur mustard.
    Military medicine, 2000, Volume: 165, Issue:8

    Topics: Anesthesia, General; Anesthetics; Animals; Apnea; Chemical Warfare; Disease Models, Animal; Drug Eva

2000
Spike-wave rhythms in cat cortex induced by parenteral penicillin. I. Electroencephalographic features.
    Electroencephalography and clinical neurophysiology, 1977, Volume: 42, Issue:5

    Topics: Animals; Barbiturates; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Haloth

1977
The estimation of the survival rate of tetanus-intoxicated mice. A model for screening anti-tetanus drugs.
    Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 308, Issue:1

    Topics: Animals; Chlorpromazine; Diazepam; Drug Evaluation, Preclinical; Halothane; Male; Mice; Phenobarbita

1979
Modifications of penicillin-induced paroxystic hippocampal activity caused by ethrane and fluothane.
    Acta neurologica, 1979, Volume: 1, Issue:4

    Topics: Animals; Anticonvulsants; Convulsants; Drug Interactions; Enflurane; Halothane; Male; Penicillins; R

1979
Effects of epileptic seizures on brain ribosomes: mechanism and relationship to cerebral energy metabolism.
    Journal of neurochemistry, 1977, Volume: 29, Issue:4

    Topics: Age Factors; Animals; Brain; Energy Metabolism; Female; Halothane; Male; Methods; Mice; Nerve Tissue

1977
[Principle of the determinant and formation of complexes of epileptic activity].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1978, Volume: 78, Issue:4

    Topics: Animals; Bemegride; Cats; Cerebral Cortex; Electrophysiology; Ether; Halothane; Seizures; Strychnine

1978
Naloxone does not antagonize general anesthesia in the rat.
    Anesthesiology, 1978, Volume: 49, Issue:1

    Topics: Anesthesia, Inhalation; Animals; Dose-Response Relationship, Drug; Enkephalins; Halothane; Naloxone;

1978
[Fluothane and experimental epilepsy. A neurophysiological study].
    Minerva anestesiologica, 1977, Volume: 43, Issue:6

    Topics: Animals; Anticonvulsants; Cerebral Cortex; Evoked Potentials; Female; Halothane; Male; Rats; Seizure

1977
Determination of halothane-induced sleeping time in the rat: effect of prior administration of centrally active drugs.
    British journal of pharmacology, 1976, Volume: 58, Issue:1

    Topics: Animals; Bemegride; Brain Chemistry; Circadian Rhythm; Drug Interactions; Female; Halothane; Injecti

1976
[Pharmacological comparison between enflurane and halothane].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1976, Volume: 72, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Electroencephalography; Enflurane; Evoked Potentials; Fem

1976
The divergent actions of volatile anaesthetics on background neuronal activity and reactive capability in the central nervous system in cats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:8

    Topics: Amygdala; Animals; Brain; Cats; Electric Stimulation; Electroencephalography; Enflurane; Evoked Pote

1992
Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs.
    Anesthesiology, 1992, Volume: 77, Issue:1

    Topics: Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Electroencephalo

1992
Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics.
    Anesthesiology, 1990, Volume: 73, Issue:2

    Topics: Aging; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Cardiac Output; Drug Interactions

1990
Stimulus-activated changes in brain tissue temperature in the anesthetized rat.
    Metabolic brain disease, 1989, Volume: 4, Issue:4

    Topics: Anesthesia; Animals; Body Temperature; Brain; Chloral Hydrate; Electric Stimulation; Electroencephal

1989
Effects of atracurium, vecuronium or pancuronium pretreatment on lignocaine seizure thresholds in cats.
    British journal of anaesthesia, 1988, Volume: 60, Issue:1

    Topics: Anesthesia, Inhalation; Animals; Atracurium; Cats; Electroencephalography; Halothane; Lidocaine; Pan

1988
Use of pentobarbital sodium to reduce seizures in dogs after cervical myelography with metrizamide.
    Journal of the American Veterinary Medical Association, 1987, Jun-01, Volume: 190, Issue:11

    Topics: Anesthesia, General; Animals; Body Weight; Dog Diseases; Dogs; Halothane; Metrizamide; Myelography;

1987
Opisthotonus during exposure to isoflurane, enflurane, and halothane in mice.
    Anesthesiology, 1987, Volume: 67, Issue:5

    Topics: Animals; Enflurane; Halothane; Isoflurane; Male; Mice; Mice, Inbred Strains; Seizures; Species Speci

1987
Central actions of lidocaine--synaptic transmission.
    Anesthesiology, 1969, Volume: 30, Issue:1

    Topics: Action Potentials; Anesthesia, Endotracheal; Animals; Blood Pressure; Cats; Halothane; Injections, I

1969
Electroencephalographic seizure activity in dogs during anaesthesia.
    British journal of anaesthesia, 1971, Volume: 43, Issue:8

    Topics: Anesthetics; Animals; Carbon Dioxide; Chloroform; Cyclopropanes; Dogs; Electroencephalography; Ether

1971
Minimal alveolar concentration (MAC) and dose-response curves in anesthesia.
    Anesthesiology, 1972, Volume: 36, Issue:2

    Topics: Anesthesia, Inhalation; Anesthetics; Animals; Anura; Biological Assay; Brain; Chloroform; Cyclopropa

1972
The use of on-line telephonic computer analysis of the E.E.G. in anaesthesia.
    British journal of anaesthesia, 1973, Volume: 45, Issue:7

    Topics: Anesthesia; Anesthesia, Inhalation; Animals; Cerebrovascular Circulation; Communication; Computers;

1973
Surgical correction of the transposition complex in infancy.
    The Journal of thoracic and cardiovascular surgery, 1973, Volume: 66, Issue:3

    Topics: Anesthesia, Inhalation; Child, Preschool; Edema; Extracorporeal Circulation; Female; Halothane; Hear

1973
Ketamine anesthesia in brain-damaged epileptics. Electroencephalographic and clinical observations.
    Neurology, 1973, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Anesthesia, Dental; Brain Damage, Chronic; Carbon Dioxide; Child; Child, Preschoo

1973
The effects of lidocaine on canine cerebral metabolism and circulation related to the electroencephalogram.
    Anesthesiology, 1974, Volume: 40, Issue:5

    Topics: Analysis of Variance; Animals; Blood Glucose; Blood Specimen Collection; Brain; Carbon Dioxide; Cere

1974
[Anesthesia problems in clinical kidney transplantation].
    Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimentelle Chirurgie, 1967, Volume: 143, Issue:3

    Topics: Adult; Anesthesia, Endotracheal; Atropine; Coma; Female; Halothane; Humans; Kidney Transplantation;

1967
Pressure reversal of anaesthesia.
    Nature, 1971, Jun-11, Volume: 231, Issue:5302

    Topics: Alcohols; Anesthesia, General; Anesthetics; Animals; Cell Membrane Permeability; Chemical Phenomena;

1971
The impurities in Fluothane: their biological properties.
    British journal of anaesthesia, 1965, Volume: 37, Issue:10

    Topics: Adrenal Glands; Animals; Blood Chemical Analysis; Dogs; Halothane; Haplorhini; Heart; Hydrocarbons,

1965
[Resuscitation of patients with convulsions].
    Minerva anestesiologica, 1966, Volume: 32, Issue:9

    Topics: Barbiturates; Eclampsia; Epilepsies, Partial; Epilepsy; Female; Halothane; Humans; Oxygen Inhalation

1966
[Convulsions in infants. Problems of resuscitation].
    Minerva pediatrica, 1972, Mar-03, Volume: 24, Issue:7

    Topics: Halothane; Humans; Infant; Infant, Newborn; Respiratory Tract Diseases; Resuscitation; Seizures

1972
[Case of anesthesia convulsions under nitrous oxide-halothane anesthesia].
    Der Anaesthesist, 1967, Volume: 16, Issue:3

    Topics: Anesthesia, General; Child; Electroencephalography; Halothane; Humans; Male; Nitrous Oxide; Seizures

1967
Convulsions associated with halothane anaesthesia. Two case reports.
    Anaesthesia, 1966, Volume: 21, Issue:2

    Topics: Anesthesia, Inhalation; Halothane; Humans; Infant; Male; Seizures

1966