halothane has been researched along with Myocardial Ischemia in 34 studies
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to assess the efficacy and safety of intravenous diltiazem to prevent myocardial ischemia during surgery on patients with ischemic heart disease undergoing non cardiac surgery under general anesthesia." | 9.08 | [Diltiazem compared with placebo in the prevention of myocardial ischemia during non-cardiac surgery]. ( Costa, A; García-Guasch, R; Llubià, C; Preciado, MJ; Sust, M; Vidal, F, 1998) |
| "Neither halothane nor sevoflurane protected the heart against the effects of acute and severe regional myocardial ischemia." | 7.70 | Anesthetic modulation of myocardial ischemia and reperfusion injury in pigs: comparison between halothane and sevoflurane. ( Coetzee, A; Coetzee, J; Conradie, S, 1999) |
| "The present results provide indirect support for other studies which showed that halothane inhibited the Ca2+ accumulation associated with myocardial ischemia in isolated guinea pig hearts (6), demonstrating a potentially beneficial effect of the anesthetic on the ischemic heart." | 7.69 | Effect of halothane on sarcolemmal calcium channels during myocardial ischemia and reperfusion. ( Drenger, B; Ginosar, Y; Gozal, Y, 1994) |
| "The aim of this study was to assess the efficacy and safety of intravenous diltiazem to prevent myocardial ischemia during surgery on patients with ischemic heart disease undergoing non cardiac surgery under general anesthesia." | 5.08 | [Diltiazem compared with placebo in the prevention of myocardial ischemia during non-cardiac surgery]. ( Costa, A; García-Guasch, R; Llubià, C; Preciado, MJ; Sust, M; Vidal, F, 1998) |
| "Neither halothane nor sevoflurane protected the heart against the effects of acute and severe regional myocardial ischemia." | 3.70 | Anesthetic modulation of myocardial ischemia and reperfusion injury in pigs: comparison between halothane and sevoflurane. ( Coetzee, A; Coetzee, J; Conradie, S, 1999) |
| "The present results provide indirect support for other studies which showed that halothane inhibited the Ca2+ accumulation associated with myocardial ischemia in isolated guinea pig hearts (6), demonstrating a potentially beneficial effect of the anesthetic on the ischemic heart." | 3.69 | Effect of halothane on sarcolemmal calcium channels during myocardial ischemia and reperfusion. ( Drenger, B; Ginosar, Y; Gozal, Y, 1994) |
| "To gain a better understanding of the direct actions of halothane on myocardial function in ischaemia, we studied the effects of increasing extracellular potassium concentration and decreasing extracellular pH (acidosis), alone or in combination with halothane, on the contractile force and resting tension in isolated atria." | 3.69 | Contractile force and resting tension in the presence of halothane and increased extracellular potassium or decreased extracellular pH in isolated guinea pig atria. ( Fujiwara, Y; Oshita, S; Sakabe, T; Takeshita, H; Tamura, H, 1994) |
| "Ca(2+) loading occurs during myocardial reperfusion injury." | 1.31 | Sevoflurane before or after ischemia improves contractile and metabolic function while reducing myoplasmic Ca(2+) loading in intact hearts. ( An, J; Novalija, E; Stowe, DF; Varadarajan, SG, 2002) |
| "Atracurium was given to facilitate tracheal intubation." | 1.30 | Anaesthetic considerations in a patient with lepromatous leprosy. ( Gombar, KK; Gombar, S; Mitra, S, 1998) |
| "Hydroxyl radicals were identified by their reaction with salicylic acid to yield dihydroxybenzoic acids (DHBAs)." | 1.30 | Hydroxyl radical formation during inhalation anesthesia in the reperfused working rat heart. ( Kashimoto, S; Kumazawa, T; Nakamura, T; Oguchi, T, 1999) |
| "Regional myocardial ischemia is associated with a decrease in distensibility of both the ischemic and the remote nonischemic myocardium." | 1.29 | Graded myocardial ischemia is associated with a decrease in diastolic distensibility of the remote nonischemic myocardium in the anesthetized dog. ( Foëx, P; Marsch, SC; Ryder, WA; Wanigasekera, VA; Wong, LS, 1993) |
| "Trimetazidine (TMZ) has been described as a new antiischemic agent." | 1.29 | Effect of trimetazidine on postischemic regional myocardial stunning in the halothane-anesthetized dog. ( Arvieux, C; Cannet, E; de Lorgeril, M; Ferrera, R; Forrat, R; Guidollet, J; Hadour, G; Lehot, JJ; Sebbag, L; Vedrinne, C, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.94) | 18.7374 |
| 1990's | 28 (82.35) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pagel, PS | 1 |
| Crystal, GJ | 1 |
| Warltier, DC | 1 |
| Xia, Z | 1 |
| Herijgers, P | 1 |
| Nishida, T | 1 |
| Ozaki, S | 1 |
| Wouters, P | 1 |
| Flameng, W | 2 |
| Mergner, GW | 1 |
| Zakaria, M | 1 |
| Mergner, WJ | 1 |
| Swann, LW | 1 |
| Stolte, AL | 1 |
| Braswell, ME | 1 |
| Farina, JP | 1 |
| Hursey, TL | 1 |
| Landoni, G | 1 |
| Fochi, O | 1 |
| Zangrillo, A | 1 |
| Cason, BA | 1 |
| Gordon, HJ | 1 |
| Avery, EG | 1 |
| Hickey, RF | 1 |
| Louvier, N | 1 |
| Lançon, JP | 1 |
| Oguchi, T | 2 |
| Kashimoto, S | 2 |
| Yamaguchi, T | 1 |
| Nakamura, T | 2 |
| Kumazawa, T | 2 |
| Sahlman, L | 1 |
| Waagstein, L | 1 |
| Haljamäe, H | 1 |
| Ricksten, SE | 1 |
| Drenger, B | 3 |
| Ginosar, Y | 3 |
| Gozal, Y | 3 |
| Hohner, P | 1 |
| Nancarrow, C | 1 |
| Backman, C | 1 |
| Häggmark, S | 1 |
| Johansson, G | 1 |
| Fridén, H | 1 |
| Diamond, G | 1 |
| Friedman, A | 1 |
| Reiz, S | 1 |
| White, JL | 1 |
| Myers, AK | 1 |
| Analouei, A | 1 |
| Kim, YD | 1 |
| Reitan, JA | 1 |
| Kien, ND | 1 |
| Moore, PG | 1 |
| White, DA | 1 |
| Chandra, M | 1 |
| Reches, A | 1 |
| Oshita, S | 1 |
| Fujiwara, Y | 1 |
| Tamura, H | 1 |
| Sakabe, T | 1 |
| Takeshita, H | 1 |
| Spahn, DR | 1 |
| Hu, WC | 1 |
| Smith, LR | 1 |
| Leone, BJ | 1 |
| Nathan, HJ | 1 |
| Smallman, B | 1 |
| Marsch, SC | 1 |
| Wanigasekera, VA | 1 |
| Ryder, WA | 1 |
| Wong, LS | 1 |
| Foëx, P | 1 |
| Mattheussen, M | 1 |
| Rusy, BF | 1 |
| Van Aken, H | 1 |
| Turner, LA | 2 |
| Polic, S | 2 |
| Hoffmann, RG | 2 |
| Kampine, JP | 2 |
| Bosnjak, ZJ | 2 |
| Coetzee, A | 3 |
| Moolman, J | 1 |
| Vedrinne, C | 1 |
| Sebbag, L | 1 |
| Arvieux, C | 1 |
| Cannet, E | 1 |
| Forrat, R | 1 |
| Hadour, G | 1 |
| Ferrera, R | 1 |
| Guidollet, J | 1 |
| Lehot, JJ | 1 |
| de Lorgeril, M | 1 |
| Boutros, A | 1 |
| Wang, J | 1 |
| Capuano, C | 1 |
| Glantz, L | 1 |
| Chevion, M | 1 |
| Elami, A | 1 |
| Navot, N | 1 |
| Kitrossky, N | 1 |
| García-Guasch, R | 1 |
| Llubià, C | 1 |
| Preciado, MJ | 1 |
| Costa, A | 1 |
| Sust, M | 1 |
| Vidal, F | 1 |
| Mitra, S | 1 |
| Gombar, KK | 1 |
| Gombar, S | 1 |
| Conradie, S | 1 |
| Coetzee, J | 1 |
| Rieke, H | 1 |
| Kazmaier, S | 1 |
| Lange, H | 1 |
| Weyland, A | 1 |
| Sonntag, H | 1 |
| Varadarajan, SG | 1 |
| An, J | 1 |
| Novalija, E | 1 |
| Stowe, DF | 1 |
| Arvieux, CC | 1 |
| Pernin, C | 1 |
| Drouet, N | 1 |
| Mathieu, JP | 1 |
| Hamant, S | 1 |
| Dubois, F | 1 |
| Cuchet, P | 1 |
| Stieglitz, P | 1 |
| Comet, M | 1 |
| Stühmeier, KD | 1 |
| Mainzer, B | 1 |
| Sandmann, W | 1 |
| Tarnow, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Remote Ischemic Preconditioning on Brain Injury in Carotid Endarterectomy[NCT03027011] | 40 participants (Anticipated) | Interventional | 2017-03-01 | Recruiting | |||
| Effect of Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery[NCT03016182] | 60 participants (Anticipated) | Interventional | 2017-02-07 | Recruiting | |||
| Sevoflurane and Cardiac Protection in High Risk Patients Undergoing Cardiac Surgery. A Randomized Controlled Study.[NCT00821262] | Phase 4 | 200 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for halothane and Myocardial Ischemia
| Article | Year |
|---|---|
The Discovery of Myocardial Preconditioning Using Volatile Anesthetics: A History and Contemporary Clinical Perspective.
Topics: Anesthetics, Inhalation; Animals; Cardiac Surgical Procedures; Halothane; Humans; Ischemic Precondit | 2018 |
The role of ATP sensitive potassium channels in myocardial protection.
Topics: Adenosine Triphosphate; Animals; Barbiturates; Halothane; Humans; Isoflurane; Myocardial Ischemia; P | 1995 |
[Do halogenated anesthetics protect from ischemic and reperfusion myocardial injuries?].
Topics: Animals; Calcium Channels; Cats; Dogs; Enflurane; Free Radicals; Halothane; Heart; Isoflurane; Myoca | 1994 |
4 trials available for halothane and Myocardial Ischemia
| Article | Year |
|---|---|
Anaesthesia for abdominal vascular surgery in patients with coronary artery disease (CAD), Part I: Isoflurane produces dose-dependent coronary vasodilation.
Topics: Abdomen; Aged; Aged, 80 and over; Anesthesia; Coronary Circulation; Coronary Disease; Dose-Response | 1994 |
[Diltiazem compared with placebo in the prevention of myocardial ischemia during non-cardiac surgery].
Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Atracurium; Calcium Ch | 1998 |
[Does method of anesthesia modify postoperative ischemia incidence? A study of patients after aortocoronary bypass operations].
Topics: Adult; Aged; Anesthesia, General; Coronary Artery Bypass; Electrocardiography; Enflurane; Fentanyl; | 1999 |
Isoflurane does not increase the incidence of intraoperative myocardial ischaemia compared with halothane during vascular surgery.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Female; Halothane; Hemodynamics; Humans; In | 1992 |
27 other studies available for halothane and Myocardial Ischemia
| Article | Year |
|---|---|
Classic Papers Revisited: An Early Study of Cardioprotection by Volatile Anesthetics: A Behind-the-scenes Look.
Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Dogs; Halothane; Humans; Isoflurane; Myocardia | 2018 |
Remote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Coronary Circulation; Co | 2003 |
Remote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Coronary Circulation; Co | 2003 |
Remote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Coronary Circulation; Co | 2003 |
Remote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Coronary Circulation; Co | 2003 |
The effect of arterial pressure alterations during halothane anesthesia on residual flow and infarct size with transient regional ischemia of the dog.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Blood Pressure; Coronary Circulation; Corona | 1988 |
Cardioprotection by volatile anesthetics in noncardiac surgery? No, not yet at least.
Topics: Anesthetics, Inhalation; Cardiotonic Agents; Enflurane; Evidence-Based Medicine; Halothane; Humans; | 2008 |
Comparative effects of halothane, enflurane, isoflurane and sevoflurane on function and metabolism in the ischaemic rat heart.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Cardiac Output; Coronary Circulation; Enfl | 1995 |
Protective effects of halothane but not isoflurane against global ischaemic injury in the isolated working rat heart.
Topics: Animals; Halothane; Heart; In Vitro Techniques; Isoflurane; Lactates; Lactic Acid; Myocardial Contra | 1995 |
Effect of halothane on sarcolemmal calcium channels during myocardial ischemia and reperfusion.
Topics: Animals; Calcium Channels; Dogs; Halothane; Isradipine; Myocardial Ischemia; Myocardial Reperfusion; | 1994 |
Functional recovery of stunned myocardium is greater with halothane than fentanyl anaesthesia in dogs.
Topics: Anesthesia, General; Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Dogs; Fentanyl; | 1994 |
Regional myocardial function during contiguous ischaemia in an anaesthetized canine model: comparison of six methods of measurement.
Topics: Animals; Disease Models, Animal; Dogs; Dopamine; Epinephrine; Female; Halothane; Heart; Heart Functi | 1994 |
Halothane modifies ischemia-associated injury to the voltage-sensitive calcium channels in canine heart sarcolemma.
Topics: Animals; Binding Sites; Calcium Channels; Dogs; Electrophysiology; Halothane; Isradipine; Kinetics; | 1994 |
Contractile force and resting tension in the presence of halothane and increased extracellular potassium or decreased extracellular pH in isolated guinea pig atria.
Topics: Acidosis; Animals; Arrhythmias, Cardiac; Depression, Chemical; Dose-Response Relationship, Drug; Fem | 1994 |
Pacing-induced left ventricular asynchronies in dogs with critical coronary stenosis: mechanisms and effect of anesthetics.
Topics: Anesthetics; Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Cardiac Pacing, Artifici | 1993 |
Isoflurane, compared to halothane or enflurane, causes increased lactate production but no transmural coronary steal during myocardial ischemia in swine.
Topics: Animals; Coronary Vessels; Enflurane; Halothane; Isoflurane; Lactates; Myocardial Ischemia; Stimulat | 1993 |
Graded myocardial ischemia is associated with a decrease in diastolic distensibility of the remote nonischemic myocardium in the anesthetized dog.
Topics: Analysis of Variance; Anesthesia; Animals; Diastole; Disease Models, Animal; Dogs; Female; Halothane | 1993 |
Recovery of function and adenosine triphosphate metabolism following myocardial ischemia induced in the presence of volatile anesthetics.
Topics: Adenosine Triphosphate; Animals; Halothane; Heart; Hemodynamics; Isoflurane; Myocardial Ischemia; My | 1993 |
Actions of halothane and isoflurane on Purkinje fibers in the infarcted canine heart: conduction, regional refractoriness, and reentry.
Topics: Animals; Disease Models, Animal; Dogs; Electric Stimulation; Electrophysiology; Halothane; Heart Con | 1993 |
Actions of volatile anesthetics on ischemic and nonischemic Purkinje fibers in the canine heart: regional action potential characteristics.
Topics: Action Potentials; Anesthetics; Animals; Dogs; Enflurane; Halothane; Isoflurane; Myocardial Infarcti | 1993 |
Halothane and the reperfusion injury in the intact animal model.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Dose-Response Relationship, Drug; Halothane; | 1993 |
Comparison of the effects of propofol and halothane on acute myocardial ischaemia and myocardial reperfusion injury.
Topics: Anesthetics, Inhalation; Animals; Free Radical Scavengers; Halothane; Myocardial Ischemia; Propofol; | 1996 |
Effect of trimetazidine on postischemic regional myocardial stunning in the halothane-anesthetized dog.
Topics: Adenine Nucleotides; Anesthetics, Inhalation; Animals; Coronary Circulation; Disease Models, Animal; | 1996 |
Isoflurane and halothane increase adenosine triphosphate preservation, but do not provide additive recovery of function after ischemia, in preconditioned rat hearts.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Halothane; Hemodynamics; Isoflurane; Male; Myocardi | 1997 |
Halothane prevents postischemic production of hydroxyl radicals in the canine heart.
Topics: Anesthetics, Inhalation; Animals; Dogs; Gentisates; Halothane; Hydroxybenzoates; Hydroxyl Radical; M | 1997 |
Anaesthetic considerations in a patient with lepromatous leprosy.
Topics: Adjuvants, Anesthesia; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Atrac | 1998 |
Anesthetic modulation of myocardial ischemia and reperfusion injury in pigs: comparison between halothane and sevoflurane.
Topics: Adjuvants, Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Fentanyl; Halotha | 1999 |
Hydroxyl radical formation during inhalation anesthesia in the reperfused working rat heart.
Topics: Anesthetics, Inhalation; Animals; Halothane; Hydroxyl Radical; Isoflurane; Male; Methyl Ethers; Myoc | 1999 |
Sevoflurane before or after ischemia improves contractile and metabolic function while reducing myoplasmic Ca(2+) loading in intact hearts.
Topics: Anesthetics, Inhalation; Animals; Calcium; Guinea Pigs; Halothane; In Vitro Techniques; Ischemic Pre | 2002 |
Comparative effects of halothane associated with verapamil and ischaemia on myocardial metabolism in isolated perfused rat hearts.
Topics: Animals; Blood Pressure; Drug Combinations; Halothane; Heart Rate; Iodine Radioisotopes; Lipids; Mal | 1992 |