halothane has been researched along with Long QT Syndrome in 19 studies
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using moxifloxacin and terfenadine, which are known to induce benign and malignant QT interval prolongation, respectively, we analysed whether halothane-anaesthetized microminipigs are an appropriate model for assessing the risk of drug-induced long QT syndrome." | 7.85 | Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| "In vivo antiarrhythmic effects of diltiazem hydrochloride and nifekalant hydrochloride, a pure class III antiarrhythmic drug (Vaughan Williams' classification), on adrenaline induced ventricular arrhythmias were examined in halothane anesthetized guinea pigs." | 7.72 | Development of a halothane-adrenaline arrhythmia model using in vivo Guinea pigs. ( Hashimoto, K; Noda, Y, 2004) |
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 7.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| "Torsade de pointes (TdP) occurred in a long QT syndrome type 3 (LQT3) patient after switching perospirone to blonanserin." | 3.96 | Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin-dopamine antagonists against insomnia and nocturnal delirium. ( Chiba, K; Goto, A; Hagiwara-Nagasawa, M; Izumi-Nakaseko, H; Kambayashi, R; Matsumoto, A; Naito, AT; Sugiyama, A, 2020) |
| "Using moxifloxacin and terfenadine, which are known to induce benign and malignant QT interval prolongation, respectively, we analysed whether halothane-anaesthetized microminipigs are an appropriate model for assessing the risk of drug-induced long QT syndrome." | 3.85 | Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| "In vivo antiarrhythmic effects of diltiazem hydrochloride and nifekalant hydrochloride, a pure class III antiarrhythmic drug (Vaughan Williams' classification), on adrenaline induced ventricular arrhythmias were examined in halothane anesthetized guinea pigs." | 3.72 | Development of a halothane-adrenaline arrhythmia model using in vivo Guinea pigs. ( Hashimoto, K; Noda, Y, 2004) |
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 3.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| "Memantine hydrochloride was intravenously administered in doses of 0." | 1.72 | Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study. ( Goto, A; Hagiwara-Nagasawa, M; Izumi-Nakaseko, H; Kambayashi, R; Kawai, S; Matsumoto, A; Shinozaki, M; Sugiyama, A; Takei, Y, 2022) |
| "Mitemcinal (GM-611) is a novel erythromycin-derived prokinetic agent that acts as an agonist at the motilin receptor." | 1.34 | Hemodynamic and electrophysiological effects of mitemcinal (GM-611), a novel prokinetic agent derived from erythromycin in a halothane-anesthetized canine model. ( Itoh, Z; Kato, A; Kimura, K; Mizoguchi, K; Omura, S; Suzuki, M; Tabo, M; Takanashi, H, 2007) |
| "Halothane was discontinued and the surgery proceeded without further incident." | 1.32 | Ventricular tachycardia during general anesthesia in a patient with congenital long QT syndrome. ( Barcelon, N; Biancaniello, T; Katz, RI; Quijano, I, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Kambayashi, R | 2 |
| Goto, A | 2 |
| Hagiwara-Nagasawa, M | 2 |
| Izumi-Nakaseko, H | 4 |
| Shinozaki, M | 1 |
| Kawai, S | 1 |
| Matsumoto, A | 2 |
| Takei, Y | 1 |
| Sugiyama, A | 9 |
| Chiba, K | 2 |
| Naito, AT | 2 |
| Nagasawa, Y | 1 |
| Sakai, K | 1 |
| Kurimoto, R | 1 |
| Kawakami, S | 1 |
| Aimoto, M | 1 |
| Takahara, A | 6 |
| Cao, X | 1 |
| Wada, T | 2 |
| Nakamura, Y | 3 |
| Matsukura, S | 1 |
| Ando, K | 2 |
| Matsuo, K | 1 |
| Fujiwara, K | 1 |
| Omuro, N | 2 |
| Kimura, I | 1 |
| Kobayashi, K | 2 |
| Yoshio, T | 1 |
| Yokoyama, H | 1 |
| Saito, H | 1 |
| Nagayama, Y | 1 |
| Hoshiai, K | 1 |
| Akie, Y | 2 |
| Sakaguchi, Y | 1 |
| Yoshida, H | 1 |
| Satoh, Y | 1 |
| Ishida, Y | 1 |
| Kugiyama, K | 1 |
| Hashimoto, K | 5 |
| Katz, RI | 1 |
| Quijano, I | 1 |
| Barcelon, N | 1 |
| Biancaniello, T | 1 |
| Hagiwara, T | 1 |
| Takahashi, S | 1 |
| Takasuna, K | 1 |
| Noda, Y | 1 |
| Kimura, K | 1 |
| Tabo, M | 1 |
| Mizoguchi, K | 1 |
| Kato, A | 1 |
| Suzuki, M | 1 |
| Itoh, Z | 1 |
| Omura, S | 1 |
| Takanashi, H | 1 |
| Michaloudis, D | 1 |
| Fraidakis, O | 1 |
| Lefaki, T | 1 |
| Kanakoudis, F | 1 |
| Askitopoulou, H | 1 |
| Weissenburger, J | 1 |
| Nesterenko, VV | 1 |
| Antzelevitch, C | 1 |
| Yamamoto, K | 1 |
| Tamura, T | 1 |
| Imai, R | 1 |
| Yamamoto, M | 1 |
| Adu-Gyamfi, Y | 1 |
| Said, A | 1 |
| Chowdhary, UM | 1 |
| Abomelha, A | 1 |
| Sanyal, SK | 1 |
1 trial available for halothane and Long QT Syndrome
| Article | Year |
|---|---|
Anaesthesia and the QT interval in humans: effects of halothane and isoflurane in premedicated children.
Topics: Anesthetics, Inhalation; Blood Pressure; Child, Preschool; Electrocardiography; Female; Halothane; H | 1998 |
18 other studies available for halothane and Long QT Syndrome
| Article | Year |
|---|---|
Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study.
Topics: Animals; Arrhythmias, Cardiac; Dogs; Halothane; Heart Ventricles; Humans; Long QT Syndrome; Memantin | 2022 |
Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin-dopamine antagonists against insomnia and nocturnal delirium.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Calcium Channel Agonists; Cardiac Conduction Sy | 2020 |
Sensitivity of inhalation anesthetics isoflurane and sevoflurane for the drug-induced QT-interval prolongation in guinea pigs.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Electrocardiography; Fluoroquinolones; Guinea P | 2020 |
Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome.
Topics: Anesthetics, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Dose | 2017 |
Effects of the fluoroquinolone antibacterial drug ciprofloxacin on ventricular repolarization in the halothane-anesthetized Guinea pig.
Topics: Action Potentials; Anesthesia; Animals; Anti-Bacterial Agents; Calcium Channel Blockers; Ciprofloxac | 2013 |
The conventional antihistamine drug cyproheptadine lacks QT-interval-prolonging action in halothane-anesthetized guinea pigs: comparison with hydroxyzine.
Topics: Action Potentials; Anesthesia; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Electrocar | 2014 |
Pharmacological characterization of microminipig as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics, Inhalation; Animals; Electrocardiography; Halo | 2017 |
Halothane-anaesthetized, closed-chest, guinea-pig model for assessment of drug-induced QT-interval prolongation.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Calcium Channel Bl | 2009 |
Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac | 2002 |
Ventricular tachycardia during general anesthesia in a patient with congenital long QT syndrome.
Topics: Anesthesia, General; Anesthetics, Inhalation; Child; Female; Halothane; Humans; Long QT Syndrome; Ni | 2003 |
In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome.
Topics: Administration, Oral; Animals; Aza Compounds; Blood Pressure; Chloralose; Disease Models, Animal; Do | 2004 |
Development of a halothane-adrenaline arrhythmia model using in vivo Guinea pigs.
Topics: Adrenergic alpha-Agonists; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Arrhythmias, Ca | 2004 |
Reduction of repolarization reserve by halothane anaesthesia sensitizes the guinea-pig heart for drug-induced QT interval prolongation.
Topics: Action Potentials; Adrenergic beta-Antagonists; Algorithms; Anesthetics, Inhalation; Animals; Chroma | 2005 |
Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K+ channel blocker-induced QT-interval prolongation.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Chromans; Electroc | 2006 |
Hemodynamic and electrophysiological effects of mitemcinal (GM-611), a novel prokinetic agent derived from erythromycin in a halothane-anesthetized canine model.
Topics: Action Potentials; Anesthesia, General; Anesthetics, Inhalation; Animals; Blood Pressure; Cardiac Pa | 2007 |
Transmural heterogeneity of ventricular repolarization under baseline and long QT conditions in the canine heart in vivo: torsades de pointes develops with halothane but not pentobarbital anesthesia.
Topics: Action Potentials; Anesthesia, General; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Di | 2000 |
Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole.
Topics: Acute Disease; Anesthesia; Anesthetics, Inhalation; Animals; Astemizole; Atrioventricular Node; Cath | 2001 |
Anaesthetic-induced ventricular tachyarrhythmia in Jervell and Lange-Nielsen syndrome.
Topics: Anesthesia, Inhalation; Child, Preschool; Diagnosis, Differential; Electrocardiography; Epilepsy; Fe | 1991 |