halothane and Hyperventilation studies

Hyperventilation: A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.

Research Excerpts

Excerpt	Relevance	Reference
"Energy metabolism of the cat brain was studied using phosphorous-31 nuclear magnetic resonance (31P-NMR) during sevoflurane/halothane anesthesia with normo- and hyperventilation."	7.68	[The effects of sevoflurane/halothane anesthesia during normo- and hyperventilation on the energy metabolism of the cat brain]. ( Fujibayashi, T; Goto, Y; Harada, J; Sugiura, Y; Yanagimoto, M, 1992)
" Rats were divided into four groups as follows: normokalemic control (group I, n = 10), acute hypokalemia with furosemide (group II, n = 16), acute hypokalemia with hyperventilation (group III, n = 18), and chronic hypokalemia induced by a low potassium (K+) diet (group IV, n = 22)."	7.67	Hypokalemia in rats produces resistance to dysrhythmias under halothane anesthesia. ( Farina, JP; Kwon, NJ; Stolte, AL, 1989)
"The effect of hypocapnia (PCO2ET 25 vs 40 torr) on specialized atrioventricular (AV) conduction, supraventricular refractory periods, and experimental atrial arrhythmias provoked by premature atrial stimulation (atrial echoes-echoes, repetitive atrial firing (RAF)) was assessed in dogs anesthetized with pentobarbital or pentobarbital-halothane (1."	7.66	Mechanical hyperventilation: effect on specialized atrioventricular conduction, supraventricular refractoriness, and experimental atrial arrhythmias in dogs anesthetized with pentobarbital or pentobarbital-halothane. ( Ammendrup, P; Atlee, JL, 1980)
" Rats were divided into four groups as follows: normokalemic control (group I, n = 10), acute hypokalemia with furosemide (group II, n = 16), acute hypokalemia with hyperventilation (group III, n = 18), and chronic hypokalemia induced by a low potassium (K+) diet (group IV, n = 22)."	3.67	Hypokalemia in rats produces resistance to dysrhythmias under halothane anesthesia. ( Farina, JP; Kwon, NJ; Stolte, AL, 1989)
"The effect of hypocapnia (PCO2ET 25 vs 40 torr) on specialized atrioventricular (AV) conduction, supraventricular refractory periods, and experimental atrial arrhythmias provoked by premature atrial stimulation (atrial echoes-echoes, repetitive atrial firing (RAF)) was assessed in dogs anesthetized with pentobarbital or pentobarbital-halothane (1."	3.66	Mechanical hyperventilation: effect on specialized atrioventricular conduction, supraventricular refractoriness, and experimental atrial arrhythmias in dogs anesthetized with pentobarbital or pentobarbital-halothane. ( Ammendrup, P; Atlee, JL, 1980)
"In 35 patients carotid angiography was performed under general anaesthesia (Halothane or NLA) under hyper- and hypoventilation conditions."	3.65	[The effect of different ventilation under anaesthesia upon intracerebral x-ray findings (author's transl)]. ( Bradac, GB; Dramburg, M; Heidsieck, CH; Simon, RS, 1976)
"Adductor laryngospasm was defined as continuous tonic TA EMG activity, silent PCA EMG, and vocal cord adduction."	1.28	Continuous positive airway pressure as a promoter of laryngospasm during halothane anesthesia. ( Sanders, I; Silva, DA, 1992)
"However, hyperventilation is advocated after operation in patients with marked brain swelling."	1.25	Intracranial pressure during recovery from nitrous oxide and halothane anaesthesia in neurosurgical patients. ( Jorgensen, PB; Misfeldt, BB, 1975)

Research

Studies (51)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Number of Participants Experiencing Side Effects (Nausea, Dizziness)

Number of Participants Needing Intervention to Treat Blood Loss (a Composite of Use of Uterotonics, Re-aspiration, and Bimanual Massage)

Timeframe	Studies, this research(%)	All Research%
pre-1990	48 (94.12)	18.7374
1990's	2 (3.92)	18.2507
2000's	1 (1.96)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
ROLLASON, WN	1
LATHAM, JW	1
BACKMAN, LE	1
LOEFSTROEM, B	1
WIDEN, L	1
MCHENRY, LC	2
SLOCUM, HC	2
BIVENS, HE	1
MAYES, HA	1
HAYES, GJ	2
Conway, CF	1
Hoffmann, RJ	1
Ammendrup, P	1
Atlee, JL	1
Chong, KY	1
Craen, RA	1
Murkin, JM	1
Lee, D	1
Eliasziw, M	1
Gelb, AW	1
Cunitz, G	1
Soerensen, N	1
Ladegaard-Pedersen, HJ	1
Wagner, PD	1
Dantzker, DR	1
Iacovoni, VE	1
Tomlin, WC	1
West, JB	1
Heidsieck, CH	1
Simon, RS	1
Bradac, GB	1
Dramburg, M	1
Jorgensen, PB	1
Misfeldt, BB	1
Silva, DA	1
Sanders, I	1
Fujibayashi, T	1
Sugiura, Y	1
Yanagimoto, M	1
Harada, J	1
Goto, Y	1
Kwon, NJ	1
Stolte, AL	1
Farina, JP	1
Frei, FJ	1
Thomson, DA	1
Zbinden, AM	1
Kreuscher, H	1
Desmond, J	1
Gordon, RA	1
Feldman, SA	1
Tyrrell, MF	1
Cullen, BF	1
Margolis, AJ	1
Eger, EI	2
Matsuda, I	1
Plötz, J	1
Widdicombe, JG	1
Glogowska, M	1
MacMillan, V	1
Siesjö, BK	2
Darbinyan, TM	1
Short, CE	1
Moya, F	1
Spicer, AR	1
Baraka, A	1
Brandstater, B	1
Muallem, M	1
Seraphim, C	1
Philbin, DM	1
Baratz, RA	1
Patterson, RW	1
Johnston, RR	1
Way, WL	1
Miller, RD	1
Miyazaki, H	1
Yamanaka, I	1
Sato, M	1
Nilsson, L	1
Casaer, J	1
Kodama, K	1
Cullen, DJ	1
Gregory, GA	1
Michenfelder, JD	2
Theye, RA	2
Harrison, GG	1
Saunders, SJ	1
Biebuyck, JF	1
Hickman, R	1
Dent, DM	1
Weaver, V	1
Terblanche, J	1
Vapalahti, M	1
Troupp, H	1
Lahdensuu, M	1
Lipecz, J	1
Harbauer, G	1
Harmsen, P	1
Bay, J	1
Woo, SW	1
Berlin, D	1
Büch, U	1
Hedley-Whyte, J	1
Kelman, GR	1
Prys-Roberts, C	1
Chamberlain, JH	1
Lis, MT	1
Nikki, P	1
Tammisto, T	1
Nagano, J	1
Shimoji, K	1
Watanabe, T	1
Cosmi, EV	1
Marx, GF	1
Potter, DR	1
Paddle, JS	1
Edelist, G	1
Osorio, A	1
Fowler, WS	1
Wynands, JE	1
Fox, GS	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures: Does it Increase Blood Loss and Interventions for Blood Loss and Why Do Anesthesiologists Choose to Use It?[NCT01048658]	Phase 4	160 participants (Actual)	Interventional	2009-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Participants (Count of Participants)
Sevoflurane	13
No Sevoflurane	11

Provider report for need to intervene due to blood loss (yes/no) (NCT01048658)
Timeframe: At time of uterine evacuation and immediately post-operatively, an average of 7.1 minutes

Number of Participants With Estimated Blood Loss Greater Than 300 mL (Yes/no)

Intervention	Participants (Count of Participants)
Sevoflurane	20
No Sevoflurane	13

Procedural blood loss greater than 300 mL. Blood loss was measured in a standardized fashion (amniotic fluid was discarded, blood was separated from tissue, and all gauze surgical drapes weighed). (NCT01048658)
Timeframe: At time of uterine evacuation, an average of 7.1 minutes

Procedure Time: T-test (Time of Speculum Placement to Time Speculum Removed)

Intervention	Participants (Count of Participants)
Sevoflurane	12
No Sevoflurane	6

Length of procedure from time of speculum placement to time of speculum removal, in minutes. (NCT01048658)
Timeframe: Time of speculum place to time of speculum removal, an average of 7.1 minutes

Patient and Provider Satisfaction With Anesthesia

Intervention	minutes (Mean)
Sevoflurane	7.0
No Sevoflurane	7.3

Scores reported on 10-cm Visual Analog Scale (VAS anchors: 0= not satisfied at all, 10= completely satisfied) . Reported as mean +/- standard deviation. Subjects and providers were blinded to anesthesia method. Subjects and providers completed post-operative questionnaire within 30 minutes of procedure completion. (NCT01048658)
Timeframe: Post-procedure, within 30 minutes

Article	Year
A new steroid muscle relaxant. Dacuronium-NB.68 (Organon). Anaesthesia, 1970, Volume: 25, Issue:3 Topics: Androstanes; Anesthesia; Atropine; Clinical Trials as Topic; Gallamine Triethiodide; Halothane; Huma	1970
The effects of anesthesia and pulmonary ventilation on blood loss during elective therapeutic abortion. Anesthesiology, 1970, Volume: 32, Issue:2 Topics: Abortion, Therapeutic; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Obstetric	1970
Observations of blood lactate and pyruvate levels and excess lactate production during and after anaesthesia with and without hyperventilation. British journal of anaesthesia, 1968, Volume: 40, Issue:5 Topics: Acid-Base Equilibrium; Adult; Anesthesia, Inhalation; Blood Gas Analysis; Citric Acid Cycle; Female;	1968

Article	Year
ANAESTHESIA FOR INTRACRANIAL ANEURYSMS. Anaesthesia, 1963, Volume: 18 Topics: Anesthesia; Anesthesia, Inhalation; Anesthesiology; Halothane; Humans; Hyperventilation; Hypotension	1963
ELECTRO-ENCEPHALOGRAPHY IN HALOTHANE ANAESTHESIA. Acta anaesthesiologica Scandinavica, 1964, Volume: 8 Topics: Anesthesia; Anesthesia, Inhalation; Atropine; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; El	1964
HYPERVENTILATION IN AWAKE AND ANESTHETIZED MAN. EFFECTS ON CEREBRAL BLOOD FLOW AND CEREBRAL METABOLISM. Archives of neurology, 1965, Volume: 12 Topics: Anesthesia; Anesthesia, Inhalation; Blood Flow Velocity; Blood Gas Analysis; Carbon Dioxide; Cerebro	1965
Tetany during deep halothane anaesthesia. Anaesthesia, 1967, Volume: 22, Issue:1 Topics: Adult; Anesthesia, General; Atropine; Female; Halothane; Humans; Hyperventilation; Succinylcholine;	1967
Mechanical hyperventilation: effect on specialized atrioventricular conduction, supraventricular refractoriness, and experimental atrial arrhythmias in dogs anesthetized with pentobarbital or pentobarbital-halothane. Anesthesia and analgesia, 1980, Volume: 59, Issue:11 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Dogs; Halothane; Heart Conduction System; Hyperventilatio	1980
Rate of change of cerebral blood flow velocity with hyperventilation during anesthesia in humans. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2000, Volume: 47, Issue:2 Topics: Adult; Anesthesia, Inhalation; Blood Flow Velocity; Cerebrovascular Circulation; Female; Halothane;	2000
Control of intracranial pressure during pediatric neurosurgery anesthesia. Child's brain, 1978, Volume: 4, Issue:4 Topics: Anesthesia; Barbiturates; Brain; Child; Enflurane; Halothane; Humans; Hyperventilation; Intracranial	1978
A circle system without carbon dioxide absorption. Acta anaesthesiologica Scandinavica, 1978, Volume: 22, Issue:3 Topics: Absorption; Anesthesia, Inhalation; Carbon Dioxide; Halothane; Humans; Hyperventilation; Neuroleptan	1978
Ventilation-perfusion inequality in asymptomatic asthma. The American review of respiratory disease, 1978, Volume: 118, Issue:3 Topics: Acetone; Adult; Aerosols; Asthma; Cyclopropanes; Ethane; Ether; Female; Halothane; Humans; Hypervent	1978
[The effect of different ventilation under anaesthesia upon intracerebral x-ray findings (author's transl)]. Der Anaesthesist, 1976, Volume: 25, Issue:10 Topics: Adult; Aged; Anesthesia, General; Cerebral Angiography; Cerebral Arteries; Female; Halothane; Humans	1976
Intracranial pressure during recovery from nitrous oxide and halothane anaesthesia in neurosurgical patients. British journal of anaesthesia, 1975, Volume: 47, Issue:9 Topics: Adult; Anesthesia, Inhalation; Female; Halothane; Humans; Hyperventilation; Intracranial Pressure; M	1975
Continuous positive airway pressure as a promoter of laryngospasm during halothane anesthesia. The Annals of otology, rhinology, and laryngology, 1992, Volume: 101, Issue:11 Topics: Airway Obstruction; Anesthesia, Inhalation; Animals; Biomechanical Phenomena; Disease Models, Animal	1992
[The effects of sevoflurane/halothane anesthesia during normo- and hyperventilation on the energy metabolism of the cat brain]. Masui. The Japanese journal of anesthesiology, 1992, Volume: 41, Issue:1 Topics: Anesthesia, Inhalation; Anesthetics; Animals; Brain; Cats; Energy Metabolism; Ethers; Halothane; Hyp	1992
Hypokalemia in rats produces resistance to dysrhythmias under halothane anesthesia. Journal of cardiothoracic anesthesia, 1989, Volume: 3, Issue:5 Topics: Acute Disease; Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Cardiac Complexes, Premature;	1989
Influence of ventilatory and circulatory changes on the pharmacokinetics of halothane and isoflurane. Experientia, 1988, Feb-15, Volume: 44, Issue:2 Topics: Animals; Blood Circulation; Dogs; Halothane; Hemodynamics; Hyperventilation; Hypotension; Isoflurane	1988
Cerebral circulation during gereral anesthesia. Zeitschrift fur Neurologie, 1974, Feb-27, Volume: 206, Issue:2 Topics: Anesthesia, General; Anesthetics; Brain Neoplasms; Carbon Dioxide; Cerebral Angiography; Cerebral Ve	1974
Ventilation in patients anaesthetized for laparoscopy. Canadian Anaesthetists' Society journal, 1970, Volume: 17, Issue:4 Topics: Acidosis; Acidosis, Respiratory; Adolescent; Adult; Anesthesia, General; Carbon Dioxide; Electrocard	1970
[The effects of hyperventilation during nitrous oxide-oxygen anesthesia with and without halothane on human cerebral metabolism (author's transl)]. Kokyu to junkan. Respiration & circulation, 1974, Volume: 22, Issue:5 Topics: Anesthesia, Inhalation; Brain; Carbon Dioxide; Electric Stimulation; Electroencephalography; Halotha	1974
[Muscle relaxation through relaxants, hyperventilation and narcotics]. Anasthesiologische und intensivmedizinische Praxis, 1974, Volume: 9, Issue:1 Topics: Anesthetics; Carbon Dioxide; Diaphragm; Drug Synergism; Halothane; Humans; Hyperventilation; Male; M	1974
Relative roles of irritant, type-J and pulmonary stretch receptors in lung reflexes. Acta neurobiologiae experimentalis, 1973, Volume: 33, Issue:1 Topics: Aerosols; Animals; Halothane; Histamine; Hyperventilation; Irritants; Lung; Mechanoreceptors; Nerve	1973
The effect of phenobarbitone anaesthesia upon some organic phosphates, glycolytic metabolites and citric acid cycle-associated intermediates of the rat brain. Journal of neurochemistry, 1973, Volume: 20, Issue:6 Topics: Adenine Nucleotides; Anesthesia, General; Animals; Brain; Carbon Dioxide; Citric Acid Cycle; Depress	1973
The use of neuroleptanalgesia for induction of anesthesia. International anesthesiology clinics, 1973,Fall, Volume: 11, Issue:3 Topics: Acid-Base Equilibrium; Adolescent; Adult; Aged; Blood Pressure; Calcium Chloride; Cardiac Output; Ch	1973
Anesthetic complications. Modern veterinary practice, 1974, Volume: 55, Issue:8 Topics: Acidosis; Alkalosis; Anesthesia, Inhalation; Anesthetics; Animals; Arrhythmias, Cardiac; Barbiturate	1974
Rebreathing in a double T-piece system. British journal of anaesthesia, 1969, Volume: 41, Issue:1 Topics: Anesthesia, Inhalation; Carbon Dioxide; Child; Child, Preschool; Halothane; Humans; Hyperventilation	1969
The effect of carbon dioxide on plasma antidiuretic hormone levels during intermittent positive-pressure breathing. Anesthesiology, 1970, Volume: 33, Issue:3 Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Cardiac Output; Diuresis; Dogs; Female; Halothane; Hype	1970
Alteration of anesthetic requirement by amphetamine. Anesthesiology, 1972, Volume: 36, Issue:4 Topics: Alkalosis, Respiratory; Anesthesia, Inhalation; Blood Pressure; Body Temperature; Carbon Dioxide; De	1972
[Hyperventilation syndrome during general anesthesia]. Masui. The Japanese journal of anesthesiology, 1972, Volume: 21, Issue:3 Topics: Adult; Alkalosis, Respiratory; Anesthesia, General; Female; Halothane; Humans; Hyperventilation; Mal	1972
The effect of deep halothane hypotension upon labile phosphates and upon extra- and intracellular lactate and pyruvate concentrations in the rat brain. Acta physiologica Scandinavica, 1971, Volume: 81, Issue:4 Topics: Adenine Nucleotides; Animals; Brain; Brain Chemistry; Carbon Dioxide; Carbonates; Cerebrovascular Ci	1971
[Anesthesia in otology]. Acta oto-rhino-laryngologica Belgica, 1971, Volume: 25, Issue:4 Topics: Anesthesia, Inhalation; Arteries; Blood Pressure; Ear Diseases; Epinephrine; Halothane; Humans; Hype	1971
[Metabolic effects of hyperventilation and carbon dioxide inhalation during halothane anesthesia]. Masui. The Japanese journal of anesthesiology, 1971, Volume: 20, Issue:12 Topics: Anesthesia, Inhalation; Animals; Blood Glucose; Carbon Dioxide; Citrates; Dogs; Electrolytes; Fatty	1971
The cardiovascular effects of carbon dioxide in man, conscious and during cyclopropane anesthesia. Anesthesiology, 1969, Volume: 31, Issue:5 Topics: Adult; Blood Flow Velocity; Blood Pressure; Carbon Dioxide; Cardiovascular System; Curare; Cycloprop	1969
The effects of profound hypocapnia and dilutional anemia on canine cerebral metabolism and blood flow. Anesthesiology, 1969, Volume: 31, Issue:5 Topics: Anemia; Animals; Blood Pressure; Brain; Carbon Dioxide; Cerebrospinal Fluid; Cerebrovascular Circula	1969
Anaesthetic-induced malignant hyperpyrexia and a method for its prediction. British journal of anaesthesia, 1969, Volume: 41, Issue:10 Topics: Acidosis; Adenosine Triphosphate; Anesthesia, General; Animals; Cyanosis; Fever; Halothane; Hyperven	1969
[The effect of halothane on intracranial pressure]. Duodecim; laaketieteellinen aikakauskirja, 1969, Volume: 85, Issue:13 Topics: Anesthesia, Inhalation; Brain Edema; Brain Injuries; Brain Neoplasms; Halothane; Hyperventilation; I	1969
[Studies on the effect of halothane and pentothal on the adrenaline tolerance of the heart]. Der Anaesthesist, 1969, Volume: 18, Issue:8 Topics: Animals; Arrhythmias, Cardiac; Dogs; Drug Synergism; Epinephrine; Halothane; Heart; Hypercapnia; Hyp	1969
Cerebrospinal fluid oxygen tension in man during halothane anaesthesia and hyperventilation. Acta neurologica Scandinavica, 1970, Volume: 46, Issue:4 Topics: Aged; Anesthesia, Inhalation; Arteries; Brain Neoplasms; Carbon Dioxide; Craniotomy; Female; Frontal	1970
Altered perfusion, ventilation, anesthesia and lung-surface forces in dogs. Anesthesiology, 1970, Volume: 33, Issue:4 Topics: Acid-Base Equilibrium; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Cardiac	1970
Variation of alveolar-to-arterial oxygen tension difference with changes of Pa,CO2 in anaesthetized man. The Journal of physiology, 1968, Volume: 194, Issue:1 Topics: Anesthesia, Inhalation; Carbon Dioxide; Cardiac Output; Halothane; Humans; Hypercapnia; Hyperventila	1968
Halothane-induced heat loss and shivering in rats. Acta anaesthesiologica Scandinavica, 1968, Volume: 12, Issue:3 Topics: Adaptation, Physiological; Animals; Body Temperature Regulation; Carbon Dioxide; Cold Temperature; C	1968
[Resumption of respiration after hyperventilation during anesthesia]. Masui. The Japanese journal of anesthesiology, 1968, Volume: 17, Issue:11 Topics: Adolescent; Adult; Aged; Anesthesia, Spinal; Blood Gas Analysis; Chemoreceptor Cells; Female; Haloth	1968
[Effect of anesthetics and the methods of hyperventilation on the apneic point]. Masui. The Japanese journal of anesthesiology, 1968, Volume: 17, Issue:13 Topics: Adolescent; Adult; Aged; Apnea; Carbon Dioxide; Ethyl Ethers; Female; Halothane; Humans; Hydrogen-Io	1968
The effect of anesthesia on the acid-base status of the fetus. Anesthesiology, 1969, Volume: 30, Issue:2 Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Anesthesia, Inhalation; Anesthesia, Obstetrical; Anest	1969
The effect of passive hyperventilation during halothane anaesthesia on the ventilatory response to carbon dioxide. British journal of anaesthesia, 1969, Volume: 41, Issue:2 Topics: Adolescent; Adult; Anesthesia, Inhalation; Carbon Dioxide; Halothane; Humans; Hyperventilation; Midd	1969
Postanesthetic initiation of spontaneous ventilation after passive hyperventilation. Anesthesiology, 1969, Volume: 31, Issue:3 Topics: Anesthesia, Inhalation; Animals; Bicarbonates; Carbon Dioxide; Dogs; Halothane; Humans; Hydrogen-Ion	1969
The effects of hyperventilation on the cerebral circulation and metabolism. Transactions of the American Neurological Association, 1964, Volume: 89 Topics: Anesthesia, Inhalation; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Halothane; Humans;	1964
CO2 levels and pulmonary shunting in anesthetized man. Journal of applied physiology, 1966, Volume: 21, Issue:5 Topics: Adult; Anesthesia, Endotracheal; Carbon Dioxide; Ethyl Ethers; Halothane; Humans; Hyperventilation;	1966
A clinical comparison of propanidid and thiopentone as induction agents to general anaesthesia. Canadian Anaesthetists' Society journal, 1966, Volume: 13, Issue:5 Topics: Adolescent; Adult; Aged; Anesthetics; Apnea; Blood Pressure; Child; Female; Halothane; Humans; Hyper	1966

halothane and Hyperventilation