halothane has been researched along with Genetic Predisposition in 40 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a child who developed a malignant hyperthermia-like syndrome after exposure to succinylcholine and halothane." | 3.75 | Malignant hyperthermia-like syndrome and carnitine palmitoyltransferase II deficiency with heterozygous R503C mutation. ( Hogan, KJ; Vladutiu, GD, 2009) |
| "The basis for susceptibility to halothane-induced liver necrosis in guinea-pigs was examined." | 3.69 | Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow. ( Farrell, GC; Field, J; Frost, L; Mahoney, J; Tapner, M; Weltman, M, 1996) |
| "DNA-based diagnosis for malignant hyperthermia (MH) is an attractive proposition, because it could replace the invasive and morbid caffeine-halothane/in vitro contracture tests of skeletal muscle biopsy tissue." | 2.50 | DNA testing for malignant hyperthermia: the reality and the dream. ( Stowell, KM, 2014) |
| "The problem of malignant hyperthermia may become worse in the near future due to changes in the population brought about by immigration." | 2.44 | [Anesthesia in malignant hyperthermia]. ( Ortiz Gómez, JR, 2008) |
| "Individuals genetically susceptible to malignant hyperthermia (MH) exhibit hypermetabolic reactions when exposed to volatile anaesthetics." | 1.51 | Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. ( Allen, PD; Boyle, JP; Chang, L; Daly, C; Hopkins, PM; Miller, DM; Shaw, MA, 2019) |
| "Sevoflurane is a known triggering agent of malignant hyperthermia (MH)." | 1.39 | Sevoflurane is less sensitive than halothane for in vitro detection of malignant hyperthermia susceptibility. ( Heiderich, S; Johannsen, S; Klingler, W; Roewer, N; Schneiderbanger, D; Schuster, F, 2013) |
| "Identifying patients predisposed to malignant hyperthermia is done through the Ca-induced Ca release test in Japan." | 1.37 | Analysis of human cultured myotubes responses mediated by ryanodine receptor 1. ( Hamada, H; Kawamoto, M; Kobayashi, M; Migita, T; Mukaida, K; Yuge, O, 2011) |
| "In halothane-treated females, plasma concentration of tumor necrosis factor-alpha was greater than in males, and neutrophils were recruited to liver more rapidly and to a greater extent." | 1.36 | A mouse model of severe halothane hepatitis based on human risk factors. ( Dugan, CM; Ganey, PE; MacDonald, AE; Roth, RA, 2010) |
| "The halothane-induced increase in [Ca(2+)](i) differed significantly between the three diagnostic groups." | 1.31 | Phenotyping malignant hyperthermia susceptibility by measuring halothane-induced changes in myoplasmic calcium concentration in cultured human skeletal muscle cells. ( Censier, K; Girard, T; Mueller, CR; Treves, S; Urwyler, A; Zorzato, F, 2002) |
| "The diagnostic outcomes of tests for malignant hyperthermia susceptibility were compared between two laboratories by using muscle tissue from the same patients." | 1.31 | Between-center variability of results of the in vitro contracture test for malignant hyperthermia susceptibility. ( Bendixen, D; Islander, G; Ording, H; Ranklev-Twetman, E, 2000) |
| "Anesthetic-induced malignant hyperthermia (MH) in humans and pigs is associated with dramatic alterations in cardiac function." | 1.31 | Altered expression of cardiac myosin isozymes associated with the malignant hyperthermia genotype in swine. ( Jiang, MJ; Liou, YM; Wu, MC, 2000) |
| "Central core disease (CCD) and nemaline myopathy (NM) are congenital myopathies for which differential diagnosis is often based on the presence either of cores or rods." | 1.31 | An autosomal dominant congenital myopathy with cores and rods is associated with a neomutation in the RYR1 gene encoding the skeletal muscle ryanodine receptor. ( Fardeau, M; Lerale, J; Lunardi, J; MacLennan, DH; Monnier, N; Nivoche, Y; Qi, D; Romero, NB, 2000) |
| "Xenon 70% did not cause an increase in baseline tension of any MH-susceptible muscle specimen in contrast to halothane and caffeine." | 1.31 | Xenon does not induce contracture in human malignant hyperthermia muscle. ( Baur, CP; Froeba, G; Georgieff, M; Jurkat-Rott, K; Klingler, W; Lehmann-Horn, F; Marx, T; Schoch, E, 2000) |
| "The determination of susceptibility to malignant hyperthermia (MH) by genetic investigation is a controversial issue because of the genetic heterogeneity of this disorder." | 1.31 | Homozygous and heterozygous Arg614Cys mutations (1840C-->T) in the ryanodine receptor gene co-segregate with malignant hyperthermia susceptibility in a German family. ( Deutrich, C; Froster, UG; Olthoff, D; Rueffert, H; Thamm, B, 2001) |
| "Xenon is a noble gas with anesthetic properties currently under investigation for use in humans." | 1.30 | Xenon does not trigger malignant hyperthermia in susceptible swine. ( Baeder, S; Baur, C; Calzia, E; Eichinger, HM; Froeba, G; Georgieff, M; Marx, T; Pazhur, J; Radermacher, P, 1999) |
| "The inheritance of malignant hyperthermia susceptibility is thought to be autosomal dominant and the incidence could be as high as 1:10,000." | 1.28 | [Diagnosis of susceptibility for malignant hyperthermia using in-vitro muscle contraction testing in Switzerland]. ( Censier, K; Drewe, J; Frei, F; Rothenbühler, JM; Seeberger, MD; Urwyler, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.00) | 18.7374 |
| 1990's | 12 (30.00) | 18.2507 |
| 2000's | 17 (42.50) | 29.6817 |
| 2010's | 9 (22.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schiemann, AH | 1 |
| Bjorksten, AR | 1 |
| Gillies, RL | 1 |
| Hockey, BM | 1 |
| Ball, C | 1 |
| Pollock, N | 1 |
| Bulger, T | 1 |
| Stowell, KM | 2 |
| Chang, L | 1 |
| Daly, C | 1 |
| Miller, DM | 1 |
| Allen, PD | 2 |
| Boyle, JP | 1 |
| Hopkins, PM | 3 |
| Shaw, MA | 3 |
| Orlov, D | 1 |
| Keith, J | 1 |
| Rosen, D | 1 |
| Croul, S | 1 |
| Kraeva, N | 1 |
| Riazi, S | 1 |
| Johannsen, S | 2 |
| Klingler, W | 2 |
| Schneiderbanger, D | 2 |
| Heiderich, S | 1 |
| Roewer, N | 2 |
| Schuster, F | 2 |
| Treves, S | 3 |
| Müller, CR | 1 |
| Mögele, S | 1 |
| Carpenter, D | 2 |
| Robinson, RL | 2 |
| Quinnell, RJ | 1 |
| Ringrose, C | 2 |
| Hogg, M | 1 |
| Casson, F | 1 |
| Booms, P | 1 |
| Iles, DE | 1 |
| Halsall, PJ | 2 |
| Steele, DS | 1 |
| Hogan, KJ | 1 |
| Vladutiu, GD | 1 |
| Leo, V | 1 |
| Morris, A | 1 |
| Dugan, CM | 1 |
| MacDonald, AE | 1 |
| Roth, RA | 1 |
| Ganey, PE | 1 |
| Kobayashi, M | 1 |
| Mukaida, K | 1 |
| Migita, T | 1 |
| Hamada, H | 1 |
| Kawamoto, M | 1 |
| Yuge, O | 1 |
| Yuen, B | 1 |
| Boncompagni, S | 1 |
| Feng, W | 1 |
| Yang, T | 1 |
| Lopez, JR | 1 |
| Matthaei, KI | 1 |
| Goth, SR | 1 |
| Protasi, F | 1 |
| Franzini-Armstrong, C | 1 |
| Pessah, IN | 1 |
| Girard, T | 4 |
| Censier, K | 4 |
| Mueller, CR | 2 |
| Zorzato, F | 2 |
| Urwyler, A | 5 |
| Wehner, M | 1 |
| Rueffert, H | 2 |
| Koenig, F | 1 |
| Olthoff, D | 2 |
| Ginz, HF | 1 |
| Allison, CP | 1 |
| Marr, AL | 1 |
| Berry, NL | 1 |
| Anderson, DB | 1 |
| Ivers, DJ | 1 |
| Richardson, LF | 1 |
| Keffaber, K | 1 |
| Johnson, RC | 1 |
| Doumit, ME | 1 |
| Islander, G | 4 |
| Rydenfelt, K | 1 |
| Ranklev, E | 1 |
| Bodelsson, M | 1 |
| Ortiz Gómez, JR | 1 |
| Farrell, GC | 1 |
| Frost, L | 1 |
| Tapner, M | 1 |
| Field, J | 1 |
| Weltman, M | 1 |
| Mahoney, J | 1 |
| Owen, VJ | 1 |
| Taske, NL | 1 |
| Lamb, GD | 1 |
| Fagerlund, TH | 2 |
| Ranklev Twetman, E | 2 |
| Berg, K | 2 |
| Glauber, V | 1 |
| Ben Abraham, R | 1 |
| Zweig, A | 1 |
| Perel, A | 1 |
| Ording, H | 2 |
| Bendixen, D | 2 |
| Montes, A | 1 |
| Ramos, R | 1 |
| Trillo, L | 1 |
| Silva, T | 1 |
| Puig, MM | 1 |
| Froeba, G | 2 |
| Marx, T | 2 |
| Pazhur, J | 1 |
| Baur, C | 1 |
| Baeder, S | 1 |
| Calzia, E | 1 |
| Eichinger, HM | 1 |
| Radermacher, P | 1 |
| Georgieff, M | 2 |
| Ranklev-Twetman, E | 1 |
| Liou, YM | 1 |
| Jiang, MJ | 1 |
| Wu, MC | 1 |
| Monnier, N | 1 |
| Romero, NB | 1 |
| Lerale, J | 1 |
| Nivoche, Y | 1 |
| Qi, D | 1 |
| MacLennan, DH | 1 |
| Fardeau, M | 1 |
| Lunardi, J | 1 |
| Baur, CP | 1 |
| Jurkat-Rott, K | 1 |
| Schoch, E | 1 |
| Lehmann-Horn, F | 1 |
| Deutrich, C | 1 |
| Thamm, B | 1 |
| Froster, UG | 1 |
| Kindler, CH | 1 |
| Gong, D | 1 |
| Bourdi, M | 1 |
| Reilly, TP | 1 |
| Elkahloun, AG | 1 |
| George, JW | 1 |
| Pohl, LR | 1 |
| Kalow, W | 1 |
| Britt, BA | 1 |
| Chan, FY | 1 |
| Richter, A | 1 |
| Gerdes, C | 1 |
| Löscher, W | 1 |
| Cosgrove, SB | 1 |
| Eisele, PH | 1 |
| Martucci, RW | 1 |
| Gronert, GA | 1 |
| Brenig, B | 2 |
| Jürs, S | 2 |
| Brem, G | 2 |
| Seeberger, MD | 1 |
| Drewe, J | 1 |
| Rothenbühler, JM | 1 |
| Frei, F | 1 |
| Cousins, MJ | 1 |
3 reviews available for halothane and Genetic Predisposition
| Article | Year |
|---|---|
DNA testing for malignant hyperthermia: the reality and the dream.
Topics: Biopsy; Caffeine; Calcium Channels; Calcium Channels, L-Type; Computational Biology; Genetic Predisp | 2014 |
[Anesthesia in malignant hyperthermia].
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Calcium Signaling; Child; Child, Prescho | 2008 |
Epidemiology and inheritance of malignant hyperthermia.
Topics: Adenosine Triphosphate; Caffeine; Creatine Kinase; Female; Genetic Predisposition to Disease; Haloth | 1979 |
2 trials available for halothane and Genetic Predisposition
| Article | Year |
|---|---|
Effects of halothane sensitivity on mobility status and blood metabolites of HAL-1843-normal pigs after rigorous handling.
Topics: Anesthetics, Inhalation; Animals; Genetic Predisposition to Disease; Halothane; Motor Activity; Stre | 2006 |
Genotype-phenotype comparison of the Swiss malignant hyperthermia population.
Topics: Caffeine; DNA Mutational Analysis; Gene Frequency; Genetic Heterogeneity; Genetic Predisposition to | 2001 |
35 other studies available for halothane and Genetic Predisposition
| Article | Year |
|---|---|
A genetic mystery in malignant hyperthermia 'solved'?
Topics: Anesthetics, Inhalation; Genetic Predisposition to Disease; Genetic Testing; Halothane; Humans; Male | 2018 |
Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Biopsy; Child; Electron Transport; Female; Genetic | 2019 |
Analysis of histomorphology in malignant hyperthermia-susceptible patients.
Topics: Adult; Caffeine; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Halothane; | 2013 |
Sevoflurane is less sensitive than halothane for in vitro detection of malignant hyperthermia susceptibility.
Topics: Anesthetics, Inhalation; Biopsy; Disease Susceptibility; Dose-Response Relationship, Drug; Genetic P | 2013 |
Functional characterization of the RYR1 mutation p.Arg4737Trp associated with susceptibility to malignant hyperthermia.
Topics: Anesthetics; Arginine; B-Lymphocytes; Caffeine; Cell Line, Transformed; Cresols; Family Health; Fema | 2016 |
Genetic variation in RYR1 and malignant hyperthermia phenotypes.
Topics: Anesthetics, Inhalation; Caffeine; Creatine Kinase; DNA Mutational Analysis; DNA, Complementary; Fem | 2009 |
Malignant hyperthermia-like syndrome and carnitine palmitoyltransferase II deficiency with heterozygous R503C mutation.
Topics: Amino Acid Substitution; Anesthetics, Inhalation; Arginine; Carnitine O-Palmitoyltransferase; Child, | 2009 |
The role of CACNA1S in predisposition to malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Caffeine; Calcium Channels; Calcium Channels, L-Type; | 2009 |
A mouse model of severe halothane hepatitis based on human risk factors.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Blotting, Western; Chemical and Drug Induced Liver In | 2010 |
Analysis of human cultured myotubes responses mediated by ryanodine receptor 1.
Topics: Adolescent; Adult; Aged; Caffeine; Calcium; Cells, Cultured; Child; Child, Preschool; Cresols; Dose- | 2011 |
Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage.
Topics: Amino Acid Substitution; Anesthetics, Inhalation; Animals; Body Temperature; Female; Gene Expression | 2012 |
Phenotyping malignant hyperthermia susceptibility by measuring halothane-induced changes in myoplasmic calcium concentration in cultured human skeletal muscle cells.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Calcium; Cell Culture Techniques; Child; Dose-Response R | 2002 |
Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.
Topics: Adult; Aged; Caffeine; Calcium; Child; Child, Preschool; Cresols; Female; Genetic Predisposition to | 2003 |
Similar susceptibility to halothane, caffeine and ryanodine in vitro reflects pharmacogenetic variability of malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Biopsy; Caffeine; Central Nervo | 2004 |
Male preponderance of patients testing positive for malignant hyperthermia susceptibility.
Topics: Caffeine; Family; Female; Genetic Predisposition to Disease; Halothane; Humans; Male; Malignant Hype | 2007 |
Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow.
Topics: Animals; Arteries; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fomepizole; Genetic Pred | 1996 |
Reduced Mg2+ inhibition of Ca2+ release in muscle fibers of pigs susceptible to malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Genetic Predisposition to Disease; | 1997 |
Malignant hyperthermia susceptibility, an autosomal dominant disorder?
Topics: Adolescent; Adult; Caffeine; Calcium Channels; Child; Child, Preschool; Female; Genes, Dominant; Gen | 1997 |
The Israeli Diagnostic Center for Malignant Hyperthermia: 7-years' accumulated experience.
Topics: Academies and Institutes; Adult; Aged; Biopsy; Caffeine; Child; Electromyography; Female; Genetic Pr | 1997 |
Discordance between malignant hyperthermia susceptibility and RYR1 mutation C1840T in two Scandinavian MH families exhibiting this mutation.
Topics: Anesthesia; Caffeine; Denmark; Female; Genetic Predisposition to Disease; Halothane; Humans; Male; M | 1997 |
[Malignant hyperthermia: difficulty in diagnosing susceptibility in Spain].
Topics: Anesthetics, Inhalation; Caffeine; Europe; Genetic Predisposition to Disease; Halothane; Humans; Inf | 1999 |
Xenon does not trigger malignant hyperthermia in susceptible swine.
Topics: Amino Acid Substitution; Anesthesia, General; Anesthetics, Inhalation; Animals; Arginine; Blood Pres | 1999 |
Between-center variability of results of the in vitro contracture test for malignant hyperthermia susceptibility.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Biopsy; Caffeine; Female; Genetic Predisposition t | 2000 |
Altered expression of cardiac myosin isozymes associated with the malignant hyperthermia genotype in swine.
Topics: Adenosine Triphosphatases; Anesthetics, Inhalation; Animals; Calcium; Gene Expression; Genetic Predi | 2000 |
An autosomal dominant congenital myopathy with cores and rods is associated with a neomutation in the RYR1 gene encoding the skeletal muscle ryanodine receptor.
Topics: Amino Acid Substitution; Caffeine; Calcium; Cell Line; DNA Mutational Analysis; Female; France; Gene | 2000 |
Xenon does not induce contracture in human malignant hyperthermia muscle.
Topics: Anesthetics, Inhalation; Caffeine; Culture Techniques; Dose-Response Relationship, Drug; Drug Evalua | 2000 |
Homozygous and heterozygous Arg614Cys mutations (1840C-->T) in the ryanodine receptor gene co-segregate with malignant hyperthermia susceptibility in a German family.
Topics: Adult; Anesthetics, Inhalation; Caffeine; DNA Mutational Analysis; Female; Genetic Predisposition to | 2001 |
The differential effect of halothane and 1,2-dichlorohexafluorocyclobutane on in vitro muscle contractures of patients susceptible to malignant hyperthermia.
Topics: Adult; Aged; Anesthetics; Anesthetics, Inhalation; Chlorofluorocarbons; Cyclobutanes; Female; Geneti | 2002 |
Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Biotransformation; Chemical and Drug Induc | 2002 |
Atypical reactions to halothane in a subgroup of homozygous malignant hyperthermia(MH)-susceptible pigs: indication of a heterogenous genetic basis for the porcine syndrome.
Topics: Animals; Female; Genetic Predisposition to Disease; Halothane; Homozygote; Male; Malignant Hyperther | 1992 |
Evaluation of greyhound susceptibility to malignant hyperthermia using halothane-succinylcholine anesthesia and caffeine-halothane muscle contractures.
Topics: Anesthesia, Inhalation; Animals; Caffeine; Disease Susceptibility; Dog Diseases; Dogs; Genetic Predi | 1992 |
The porcine PHIcDNA linked to the halothane gene detects a NotI RFLP in normal and malignant hyperthermia susceptible pigs.
Topics: Animals; Deoxyribonucleases, Type II Site-Specific; Genes; Genetic Linkage; Genetic Predisposition t | 1990 |
The porcine PHIcDNA linked to the halothane gene detects a HindIII and XbaI RFLP in normal and malignant hyperthermia susceptible pigs.
Topics: Animals; Deoxyribonuclease HindIII; Deoxyribonucleases, Type II Site-Specific; Genes; Genetic Linkag | 1990 |
[Diagnosis of susceptibility for malignant hyperthermia using in-vitro muscle contraction testing in Switzerland].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Caffeine; Child; Female; Genetic Predisposition | 1991 |
[Etiological factors in halothane hepatoxicity].
Topics: Animals; Chemical and Drug Induced Liver Injury; Genetic Predisposition to Disease; Guinea Pigs; Hal | 1987 |