halothane has been researched along with Contracture in 38 studies
Contracture: Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The most commonly used laboratory test for predicting malignant hyperthermia susceptibility is the caffeine halothane contracture test." | 9.07 | Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. The North American Malignant Hyperthermia Registry. ( Bunn, JS; Diaz, M; Landis, JR; Larach, MG, 1992) |
| " The center followed the diagnostic protocols of the North America MH Group, in which the contractures of biopsies from the vastus lateralis muscle are analyzed after exposure to caffeine and halothane (CHCT)." | 7.76 | Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil. ( Abreu, AV; Aguiar, MI; Cardoso, LA; Carmo, PL; Cunha, LB; Matos, AR; Sudo, RT; Trachez, MM; Zapata-Sudo, G, 2010) |
| "5 g contracture for 3% halothane, > or = 0." | 7.70 | The sensitivity and specificity of the caffeine-halothane contracture test: a report from the North American Malignant Hyperthermia Registry. The North American Malignant Hyperthermia Registry of MHAUS. ( Allen, GC; Kunselman, AR; Larach, MG, 1998) |
| "Contracture responses of intact cut masseter and vastus bundles (non-skinned) do not differ with respect to caffeine and halothane." | 7.70 | Caffeine- or halothane-induced contractures of masseter muscle are similar to those of vastus muscle in normal humans. ( Antognini, JF; Gronert, GA; Melton, AT, 1999) |
| " We evaluated whether toxic concentrations of cocaine altered the in vitro muscle response to halothane during contracture tests for MH." | 7.69 | Effect of cocaine on the contracture response to 1% halothane in patients undergoing diagnostic muscle biopsy for malignant hyperthermia. ( Brum, JM; DeBoer, GE; Mitsumoto, H; Sato, N, 1995) |
| "The most commonly used laboratory test for predicting malignant hyperthermia susceptibility is the caffeine halothane contracture test." | 5.07 | Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. The North American Malignant Hyperthermia Registry. ( Bunn, JS; Diaz, M; Landis, JR; Larach, MG, 1992) |
| " However, experts worldwide agree that the only reference test to this day remains the in vitro halothane caffeine contracture tests." | 4.77 | [Screening tests for malignant hyperthermia susceptibility]. ( Adnet, P; Krivosic-Horber, R, 1989) |
| " The center followed the diagnostic protocols of the North America MH Group, in which the contractures of biopsies from the vastus lateralis muscle are analyzed after exposure to caffeine and halothane (CHCT)." | 3.76 | Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil. ( Abreu, AV; Aguiar, MI; Cardoso, LA; Carmo, PL; Cunha, LB; Matos, AR; Sudo, RT; Trachez, MM; Zapata-Sudo, G, 2010) |
| " Genetic screening of a 5-generation Brazilian family with a history of MH-related deaths and a previous MH diagnosis by the caffeine halothane contracture test (CHCT) in some individuals was performed using restriction and sequencing analysis." | 3.75 | Multigenerational Brazilian family with malignant hyperthermia and a novel mutation in the RYR1 gene. ( Amoedo, ND; Cunha, LB; Matos, AR; Rumjanek, FD; Sambuughin, N; Sudo, RT; Zapata-Sudo, G, 2009) |
| "5 g contracture for 3% halothane, > or = 0." | 3.70 | The sensitivity and specificity of the caffeine-halothane contracture test: a report from the North American Malignant Hyperthermia Registry. The North American Malignant Hyperthermia Registry of MHAUS. ( Allen, GC; Kunselman, AR; Larach, MG, 1998) |
| "Contracture responses of intact cut masseter and vastus bundles (non-skinned) do not differ with respect to caffeine and halothane." | 3.70 | Caffeine- or halothane-induced contractures of masseter muscle are similar to those of vastus muscle in normal humans. ( Antognini, JF; Gronert, GA; Melton, AT, 1999) |
| " Diagnosis is based on in vitro muscle contracture in response to halothane and/or caffeine exposure." | 3.70 | [Malignant hyperthermia susceptibility in 3 patients with malignant neuroleptic syndrome]. ( Bahia, VS; Marchiori, PE; Oliveira, RA; Scaff, M; Silva, HC; Tsanaclis, AM, 2000) |
| " We evaluated whether toxic concentrations of cocaine altered the in vitro muscle response to halothane during contracture tests for MH." | 3.69 | Effect of cocaine on the contracture response to 1% halothane in patients undergoing diagnostic muscle biopsy for malignant hyperthermia. ( Brum, JM; DeBoer, GE; Mitsumoto, H; Sato, N, 1995) |
| " The halothane/caffeine contracture test was performed on the biopsied muscle." | 3.69 | Incidence of malignant hyperthermia reactions in 2,214 patients undergoing muscle biopsy. ( Britt, BA; Carr, AS; Cunliffe, M; Lerman, J; McLeod, ME, 1995) |
| " In vitro, human MHS muscle samples were exposed to propofol and changes in (a) baseline tension and (b) contracture tension on exposure to halothane and caffeine were measured." | 3.68 | Propofol is a 'safe' anaesthetic agent in malignant hyperthermia susceptible patients. ( Couchman, KG; McKenzie, AJ; Pollock, N, 1992) |
| "The in vitro contracture test determines the sensitivity of freshly obtained skeletal muscle specimens to caffeine or halothane applied to a bathing solution." | 3.68 | In vitro contracture testing for determination of susceptibility to malignant hyperthermia: a methodologic update. ( Gallagher, WJ; Iaizzo, PA; Wedel, DJ, 1991) |
| " In the present study the cytoplasmic Ca2+ concentrations of lymphocytes were monitored with indo-1 in 14 control subjects (nine fasted and five nonfasted) and five fasted MH susceptible and three fasted nonsusceptible patients, diagnosed by the halothane and caffeine contracture tests." | 3.68 | Importance of fasting in the lymphocyte calcium test for malignant hyperthermia. ( Allen, GC; Conner, GE; Fletcher, JE; Huggins, FJ; Rosenberg, H, 1990) |
| "In vitro contracture tests for susceptibility to malignant hyperthermia (MH) were performed with halothane and caffeine in 34 patients, according to the protocol of the European MH Group." | 3.68 | Influence of salbutamol on the in vitro muscle response to caffeine and halothane in malignant hyperthermia. ( Bendixen, D; Ording, H, 1990) |
| " In order to provide additional evidence, all eight patients had vastus lateralis muscle biopsies with subsequent caffeine-halothane contracture studies performed." | 3.68 | Malignant hyperthermia in the otolaryngologic patient: prospective anesthetic and surgical management of eight children. ( Dubrow, TJ; Dudley, JP; Reynolds, R, 1990) |
| " The in vitro halothane-caffeine contracture tests are the most reliable method of identifying individuals susceptible to MH." | 3.67 | The association between the neuroleptic malignant syndrome and malignant hyperthermia. ( Adamantidis, MM; Adnet, PJ; Adnet-Bonte, CA; Dupuis, BA; Haudecoeur, G; Krivosic-Horber, RM; Saulnier, F, 1989) |
| "The results are reported of the contracture test obtained by using the calcium ionophore A 23187 (Calcimycin) in two patients, the son (A) and the mother (B)." | 3.67 | [Contracture test with ionophore A 23187 for the diagnosis of malignant hyperthermia]. ( Gascard, JP; Kozak-Reiss, G; Laxenaire, MC; Moeller, R, 1986) |
| " Halothane-caffeine contracture tests, interpreted in accordance with the criteria of the European Group on Malignant Hyperthermia, yielded the following results: 13 positive (MHS), 10 negative (MHN), 4 equivocal (MHE)." | 3.67 | [Tests of contracture and sensitivity to malignant hyperthermia in 27 patients]. ( Adamantidis, M; Adnet, P; Guévart, E; Krivosic, I; Krivosic-Horber, R; Theunynck, D, 1988) |
| "In a study of human malignant hyperpyrexia-susceptible muscle a comparison between pancuronium and methylprednisolone showed that both drugs produced qualitatively similar depression of the halothane-induced muscle contracture." | 3.65 | Anaesthesia for patients susceptible to malignant hyperpyrexia. A study of pancuronium and methylprednisolone. ( Cain, PA; Ellis, FR, 1977) |
| " Using muscle from patients susceptible to malignant hyperpyrexia in vitro, it has been demonstrated that muscle contracture can occur with procaine on its own, and in one patient the halothane-induced contracture was potentiated by procaine." | 3.65 | An evaluation of procaine in the treatment of malignant hyperpyrexia. ( Clarke, IM; Ellis, FR, 1975) |
| "Halothane-induced contractures in isolated muscle fibers from swine susceptible to malignant hyperthermia (MHS) were significantly less when fibers were incubated in KRB plus 6." | 3.65 | Porcine malignant hyperthermia: effect of dantrolene sodium on in-vitro halothane-induced contraction of susceptible muscle. ( Anderson, IL; Jones, EW, 1976) |
| "Masseter spasm is often associated with severe rhabdomyolysis in patients with muscle dystrophy, especially Duchenne's dystrophy." | 2.38 | [Clinical features of malignant hyperthermia crisis]. ( Cornet, C; Laxenaire, MC; Moeller, R, 1989) |
| " In six MH(-) patients with previous masseter muscle rigidity, no adverse reactions occurred in response to volatile anesthetic agents." | 1.28 | Safety of general anesthesia in patients previously tested negative for malignant hyperthermia susceptibility. ( Allen, GC; Fletcher, JE; Rosenberg, H, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (34.21) | 18.7374 |
| 1990's | 20 (52.63) | 18.2507 |
| 2000's | 2 (5.26) | 29.6817 |
| 2010's | 3 (7.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dirksen, RT | 1 |
| Allen, PD | 1 |
| Lopez, JR | 1 |
| Sagui, E | 1 |
| Montigon, C | 1 |
| Abriat, A | 1 |
| Jouvion, A | 1 |
| Duron-Martinaud, S | 1 |
| Canini, F | 1 |
| Zagnoli, F | 1 |
| Bendahan, D | 2 |
| Figarella-Branger, D | 1 |
| Brégigeon, M | 1 |
| Brosset, C | 1 |
| Matos, AR | 2 |
| Sambuughin, N | 1 |
| Rumjanek, FD | 1 |
| Amoedo, ND | 1 |
| Cunha, LB | 2 |
| Zapata-Sudo, G | 2 |
| Sudo, RT | 2 |
| Carmo, PL | 1 |
| Trachez, MM | 1 |
| Cardoso, LA | 1 |
| Aguiar, MI | 1 |
| Abreu, AV | 1 |
| Flewellen, EH | 1 |
| Nelson, TE | 1 |
| Sato, N | 1 |
| Brum, JM | 1 |
| Mitsumoto, H | 1 |
| DeBoer, GE | 1 |
| Bello, N | 1 |
| Adnet, P | 3 |
| Saulnier, F | 2 |
| Lestavel, P | 1 |
| Adnet-Bonte, C | 1 |
| Reyford, H | 1 |
| Etchrivi, T | 1 |
| Tavernier, B | 1 |
| Krivosic-Horber, R | 3 |
| Deufel, T | 1 |
| Sudbrak, R | 1 |
| Feist, Y | 1 |
| Rübsam, B | 1 |
| Du Chesne, I | 1 |
| Schäfer, KL | 1 |
| Roewer, N | 1 |
| Grimm, T | 1 |
| Lehmann-Horn, F | 1 |
| Hartung, EJ | 1 |
| Carr, AS | 1 |
| Lerman, J | 1 |
| Cunliffe, M | 1 |
| McLeod, ME | 1 |
| Britt, BA | 3 |
| Kozak-Ribbens, G | 1 |
| Confort-Gouny, S | 1 |
| Cozzone, PJ | 1 |
| Hopkins, PM | 1 |
| Ellis, FR | 4 |
| Halsall, PJ | 1 |
| Stewart, AD | 1 |
| Medina, KA | 1 |
| Mayhew, JF | 1 |
| Allen, GC | 3 |
| Larach, MG | 2 |
| Kunselman, AR | 1 |
| Melton, AT | 1 |
| Antognini, JF | 1 |
| Gronert, GA | 1 |
| Silva, HC | 1 |
| Bahia, VS | 1 |
| Oliveira, RA | 1 |
| Marchiori, PE | 1 |
| Scaff, M | 1 |
| Tsanaclis, AM | 1 |
| Cain, PA | 1 |
| Clarke, IM | 1 |
| Endrenyi, L | 1 |
| Barclay, RL | 1 |
| Cadman, DL | 1 |
| Anderson, IL | 1 |
| Jones, EW | 1 |
| Ording, H | 2 |
| Bendixen, D | 2 |
| McKenzie, AJ | 1 |
| Couchman, KG | 1 |
| Pollock, N | 1 |
| Landis, JR | 1 |
| Bunn, JS | 1 |
| Diaz, M | 1 |
| Iaizzo, PA | 1 |
| Wedel, DJ | 1 |
| Gallagher, WJ | 1 |
| Patel, VK | 1 |
| Dierdorf, SF | 1 |
| Krishna, G | 1 |
| Bonsett, C | 1 |
| Fletcher, JE | 4 |
| Huggins, FJ | 2 |
| Rosenberg, H | 4 |
| Conner, GE | 1 |
| Dudley, JP | 1 |
| Reynolds, R | 1 |
| Dubrow, TJ | 1 |
| Hildebrand, SV | 1 |
| Arpin, D | 1 |
| Cardinet, G | 1 |
| Cornet, C | 1 |
| Moeller, R | 2 |
| Laxenaire, MC | 2 |
| Adnet, PJ | 1 |
| Krivosic-Horber, RM | 1 |
| Adamantidis, MM | 1 |
| Haudecoeur, G | 1 |
| Adnet-Bonte, CA | 1 |
| Dupuis, BA | 1 |
| Lizzo, FH | 1 |
| Kozak-Reiss, G | 1 |
| Gascard, JP | 1 |
| Krivosic, I | 1 |
| Theunynck, D | 1 |
| Guévart, E | 1 |
| Adamantidis, M | 1 |
| Kalow, W | 1 |
| Terreau, ME | 1 |
| Haist, C | 1 |
| Harriman, DG | 1 |
| Keaney, NP | 1 |
| Kyei-Mensah, K | 1 |
| Tyrrell, JH | 1 |
2 reviews available for halothane and Contracture
| Article | Year |
|---|---|
[Clinical features of malignant hyperthermia crisis].
Topics: Adolescent; Adult; Anesthesia, General; Arrhythmias, Cardiac; Carbon Dioxide; Child; Child, Preschoo | 1989 |
[Screening tests for malignant hyperthermia susceptibility].
Topics: Animals; Caffeine; Calcium; Cholinesterases; Contracture; Creatine Kinase; Cyclic AMP; Disease Susce | 1989 |
1 trial available for halothane and Contracture
| Article | Year |
|---|---|
Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. The North American Malignant Hyperthermia Registry.
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Child; Contracture; Disease Susceptibility; Female; Halot | 1992 |
35 other studies available for halothane and Contracture
| Article | Year |
|---|---|
Understanding malignant hyperthermia: each move forward opens our eyes to the distance left to travel.
Topics: Caffeine; Calcium; Contracture; Halothane; Humans; Malignant Hyperthermia | 2019 |
Is there a link between exertional heat stroke and susceptibility to malignant hyperthermia?
Topics: Adult; Anesthetics, Inhalation; Caffeine; Contracture; Disease Susceptibility; Female; Halothane; He | 2015 |
Multigenerational Brazilian family with malignant hyperthermia and a novel mutation in the RYR1 gene.
Topics: Brazil; Caffeine; Contracture; Family; Female; Genetic Testing; Halothane; Humans; Male; Malignant H | 2009 |
Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Biopsy; Caffeine; Child; Child, Preschool; Contrac | 2010 |
In vivo and in vitro responses to magnesium sulphate in porcine malignant hyperthermia.
Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Body Temperature; Carbon Dioxide; Contracture; Halo | 1980 |
Effect of cocaine on the contracture response to 1% halothane in patients undergoing diagnostic muscle biopsy for malignant hyperthermia.
Topics: Adult; Biopsy; Caffeine; Cocaine; Contracture; Disease Susceptibility; Female; Halothane; Humans; Ma | 1995 |
[Lack of sensitivity to per-anesthetic malignant hyperthermia in 32 patients who developed neuroleptic malignant syndrome].
Topics: Adolescent; Adult; Aged; Anesthesia, General; Caffeine; Contracture; Creatine Kinase; Dantrolene; Di | 1994 |
Discordance, in a malignant hyperthermia pedigree, between in vitro contracture-test phenotypes and haplotypes for the MHS1 region on chromosome 19q12-13.2, comprising the C1840T transition in the RYR1 gene.
Topics: Calcium Channels; Chromosomes, Human, Pair 19; Contracture; Disease Susceptibility; Female; Genetic | 1995 |
Incidence of malignant hyperthermia reactions in 2,214 patients undergoing muscle biopsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia Recovery Period; Anesthesia, Conduction; Anes | 1995 |
[Definition of a diagnostic score of malignant hyperthermia using P-31 magnetic resonance spectroscopy].
Topics: Caffeine; Contracture; Disease Susceptibility; Halothane; Humans; Magnetic Resonance Spectroscopy; M | 1996 |
An analysis of the predictive probability of the in vitro contracture test for determining susceptibility to malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Child; Contracture; Disease Susceptibility; Halothane; Hu | 1997 |
Generalized muscle rigidity and hypercarbia with halothane and isoflurane.
Topics: Carbon Dioxide; Child, Preschool; Contracture; Female; Halothane; Humans; Isoflurane; Malignant Hype | 1998 |
The sensitivity and specificity of the caffeine-halothane contracture test: a report from the North American Malignant Hyperthermia Registry. The North American Malignant Hyperthermia Registry of MHAUS.
Topics: Adult; Caffeine; Contracture; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hypert | 1998 |
Caffeine- or halothane-induced contractures of masseter muscle are similar to those of vastus muscle in normal humans.
Topics: Aged; Aged, 80 and over; Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Contr | 1999 |
[Malignant hyperthermia susceptibility in 3 patients with malignant neuroleptic syndrome].
Topics: Adult; Caffeine; Contracture; Disease Susceptibility; Female; Halothane; Humans; Male; Malignant Hyp | 2000 |
Anaesthesia for patients susceptible to malignant hyperpyrexia. A study of pancuronium and methylprednisolone.
Topics: Anesthesia; Contracture; Dose-Response Relationship, Drug; Halothane; Humans; In Vitro Techniques; M | 1977 |
An evaluation of procaine in the treatment of malignant hyperpyrexia.
Topics: Anesthesia, General; Animals; Caffeine; Contracture; Dose-Response Relationship, Drug; Drug Evaluati | 1975 |
Total calcium content of skeletal muscle isolated from humans and pigs susceptible to malignant hyperthermia.
Topics: Animals; Calcium; Contracture; Halothane; Humans; Male; Malignant Hyperthermia; Mitochondria, Muscle | 1975 |
Porcine malignant hyperthermia: effect of dantrolene sodium on in-vitro halothane-induced contraction of susceptible muscle.
Topics: Animals; Caffeine; Calcium; Contracture; Dantrolene; Halothane; Hydantoins; In Vitro Techniques; Mal | 1976 |
Sources of variability in halothane and caffeine contracture tests for susceptibility to malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Caffeine; Child; Contracture; Dose-Response Relationship, Drug; Female; Hal | 1992 |
Propofol is a 'safe' anaesthetic agent in malignant hyperthermia susceptible patients.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Caffeine; Contracture; Disease Susceptibility; Halothane | 1992 |
In vitro contracture testing for determination of susceptibility to malignant hyperthermia: a methodologic update.
Topics: Caffeine; Chromatography, Gas; Contracture; Diffusion Chambers, Culture; Disease Susceptibility; Ele | 1991 |
Negative halothane-caffeine contracture test in mdx (dystrophin-deficient) mice.
Topics: Abdomen; Animals; Caffeine; Contracture; Drug Combinations; Dystrophin; Halothane; Mice; Mice, Mutan | 1991 |
The importance of calcium ions for in vitro malignant hyperthermia testing.
Topics: Caffeine; Calcium; Contracture; Drug Interactions; Halothane; Humans; In Vitro Techniques; Malignant | 1990 |
Importance of fasting in the lymphocyte calcium test for malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Caffeine; Calcium; Contracture; Cytoplasm; Fasting; Female; Halothane; Huma | 1990 |
Influence of salbutamol on the in vitro muscle response to caffeine and halothane in malignant hyperthermia.
Topics: Adult; Albuterol; Caffeine; Contracture; Dose-Response Relationship, Drug; Drug Interactions; Female | 1990 |
Safety of general anesthesia in patients previously tested negative for malignant hyperthermia susceptibility.
Topics: Anesthesia, General; Caffeine; Contracture; Disease Susceptibility; Halothane; Humans; Malignant Hyp | 1990 |
Malignant hyperthermia in the otolaryngologic patient: prospective anesthetic and surgical management of eight children.
Topics: Adenoidectomy; Anesthesia, General; Anxiety; Caffeine; Child; Child, Preschool; Contracture; Female; | 1990 |
Contracture test and histologic and histochemical analyses of muscle biopsy specimens from horses with exertional rhabdomyolysis.
Topics: Anesthesia; Animals; Biopsy, Needle; Caffeine; Contracture; Female; Fever; Halothane; Horse Diseases | 1990 |
The association between the neuroleptic malignant syndrome and malignant hyperthermia.
Topics: Adult; Caffeine; Chlorpromazine; Contracture; Disease Susceptibility; Female; Halothane; Humans; Mal | 1989 |
Effects of droperidol, haloperidol and ketamine on halothane, succinylcholine and caffeine contractures: implications for malignant hyperthermia.
Topics: Animals; Caffeine; Contracture; Droperidol; Haloperidol; Halothane; Humans; Ketamine; Male; Malignan | 1989 |
[Contracture test with ionophore A 23187 for the diagnosis of malignant hyperthermia].
Topics: Adolescent; Adult; Caffeine; Calcimycin; Contracture; Female; Halothane; Humans; Male; Malignant Hyp | 1986 |
[Tests of contracture and sensitivity to malignant hyperthermia in 27 patients].
Topics: Adolescent; Adult; Anesthesia, General; Biopsy; Caffeine; Child; Child, Preschool; Contracture; Crea | 1988 |
Metabolic error of muscle metabolism after recovery from malignant hyperthermia.
Topics: Adolescent; Adult; Anesthesia, General; Caffeine; Calcium; Contracture; Female; Fever; Halothane; Hu | 1970 |
Halothane-induced muscle contracture as a cause of hyperpyrexia.
Topics: Adolescent; Contracture; Creatine Kinase; Female; Fever; Halothane; Humans; Male; Muscle Contraction | 1971 |