halothane has been researched along with Allergy, Drug in 128 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aanalysis of data derived from 170 reports of jaundice developing after anaesthesia with halothane received after January 1974 confirmed the relations between multiple exposure to halothane and jaundice and between the number of exposures and the rapidity with which jaundice develops after exposure." | 7.66 | Jaundice after repeated exposure to halothane: a further analysis of reports to the Committee on Safety of Medicines. ( Inman, WH; Mushin, WW, 1978) |
| " All patients whose jaundice may have had an identifiable cause were excluded, which left 76 patients with unexplained hepatitis following halothane anaesthesia (UHFH)." | 7.65 | Unexplained hepatitis following halothane. ( Appleyard, AJ; Doniach, D; Perrin, J; Simpson, BR; Strunin, L; Walton, B, 1976) |
| "The time interval since previous anaesthesia was compared in a surgical population in South Wales and in patients who developed jaundice after halothane." | 7.65 | Post-halothane jaundice in relation to previous administration of halothane. ( Jones, EV; Mushin, WW; Rosen, M, 1971) |
| " National Halothane Study showed the interval to the onset of jaundice after one exposure to halothane (91 cases) to be slightly shorter than the interval for those having had multiple exposures to the agent." | 5.04 | Onset of postoperative jaundice related to anaesthetic history. ( Gilbert, JP; McPeek, B, 1974) |
| "Aanalysis of data derived from 170 reports of jaundice developing after anaesthesia with halothane received after January 1974 confirmed the relations between multiple exposure to halothane and jaundice and between the number of exposures and the rapidity with which jaundice develops after exposure." | 3.66 | Jaundice after repeated exposure to halothane: a further analysis of reports to the Committee on Safety of Medicines. ( Inman, WH; Mushin, WW, 1978) |
| "The authors report a case of postoperative jaundice occurring within 30 days in a patient anesthetized three times with halothane." | 3.65 | [Allergic characteristics of halothane hepatitis. Apropos of a case report]. ( Cavellat, M; Delhumeau, A; Emeriaud, JP; L'Hoste, F, 1976) |
| "142 patients with postoperative jaundice following anaesthesia with halothane were divided into two groups:-group A (76 cases) in which halothane appeared to be the sole responsible agent for jaundice, and- group B (66 cases) in which other causes were detected." | 3.65 | [Relevance of clinical signs of hypersensitivity in cases of halothane hepatitis]. ( Walton, B, 1976) |
| " All patients whose jaundice may have had an identifiable cause were excluded, which left 76 patients with unexplained hepatitis following halothane anaesthesia (UHFH)." | 3.65 | Unexplained hepatitis following halothane. ( Appleyard, AJ; Doniach, D; Perrin, J; Simpson, BR; Strunin, L; Walton, B, 1976) |
| "The time interval since previous anaesthesia was compared in a surgical population in South Wales and in patients who developed jaundice after halothane." | 3.65 | Post-halothane jaundice in relation to previous administration of halothane. ( Jones, EV; Mushin, WW; Rosen, M, 1971) |
| "Individuals susceptible to malignant hyperpyrexia have muscle with heightened sensitivity to halothane, caffeine, succinylcholine, potassium chloride, and temperature change." | 2.64 | Identification of susceptibility to malignant hyperpyrexia. ( Denborough, MA; Moulds, RF, 1974) |
| "Diclofenac was administered to rats by gastric gavage." | 1.30 | Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions. ( Graf, ML; Lustberg, LR; Martin, BM; Pohl, LR; Ware, JA, 1998) |
| "To determine whether a malignant hyperthermia (MH) episode could nevertheless be provoked by a more rigorous challenge, both genetically MHS (Pietrain) and normal (Yorkshire) 5-wk-old piglets were exposed to a combined halothane-succinylcholine challenge." | 1.28 | Halothane sensitivity of young pigs in vivo and in vitro. ( Fay, RS; Gallant, EM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 115 (89.84) | 18.7374 |
| 1990's | 11 (8.59) | 18.2507 |
| 2000's | 2 (1.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campbell, JL | 1 |
| Gu, Q | 1 |
| Guo, D | 1 |
| Nash, HA | 1 |
| Mutoh, T | 1 |
| Tsubone, H | 1 |
| COLE, WH | 1 |
| READ, AE | 1 |
| VICKERS, MD | 1 |
| DINNICK, OP | 1 |
| Cachin, M | 1 |
| Kamiński, B | 1 |
| Górzyński, J | 1 |
| Karczewski, W | 1 |
| Shipton, EA | 1 |
| Kruger, AE | 1 |
| Ford, DJ | 1 |
| Coyle, DE | 1 |
| Harrington, JF | 1 |
| Cousins, MJ | 1 |
| Maddrey, WC | 1 |
| Kreienbühl, G | 1 |
| Brown, BR | 2 |
| Touloukian, J | 1 |
| Kaplowitz, N | 1 |
| Barna, BP | 1 |
| Gogate, P | 1 |
| Deodhar, SD | 1 |
| Moeder, M | 1 |
| Dienstag, JL | 1 |
| Dujovne, CA | 1 |
| Otsu, K | 1 |
| Nishida, K | 1 |
| Kimura, Y | 1 |
| Kuzuya, T | 1 |
| Hori, M | 1 |
| Kamada, T | 1 |
| Tada, M | 1 |
| Morgan, PG | 1 |
| Sedensky, MM | 1 |
| Beaune, PH | 1 |
| Lecoeur, S | 1 |
| Voigt, MD | 1 |
| Workman, B | 1 |
| Lombard, C | 1 |
| Kirsch, RE | 1 |
| Ware, JA | 1 |
| Graf, ML | 1 |
| Martin, BM | 2 |
| Lustberg, LR | 1 |
| Pohl, LR | 5 |
| Delhumeau, A | 1 |
| Emeriaud, JP | 1 |
| L'Hoste, F | 1 |
| Cavellat, M | 1 |
| Lombard, A | 1 |
| Lamarche, M | 1 |
| Mathieu, A | 3 |
| Di Padua, D | 2 |
| Duheille, J | 1 |
| Cohen, EN | 1 |
| Farmer, BC | 1 |
| Sivarajan, M | 1 |
| Mitchell, JR | 2 |
| Potter, WZ | 1 |
| Eikelenboom, G | 1 |
| Anisimova, IG | 1 |
| Krechkovskiĭ, EA | 1 |
| Rosenoer, VM | 1 |
| Tornay, AS | 1 |
| Reyes, H | 2 |
| Acuña, R | 1 |
| Donoso, S | 1 |
| Nunez-Gornes, JF | 1 |
| Marx, JJ | 1 |
| Motszko, C | 1 |
| Thorén-Tolling, K | 1 |
| Andresen, E | 1 |
| Jensen, P | 1 |
| Lauterburg, BH | 1 |
| Inman, WH | 1 |
| Mushin, WW | 2 |
| Price, HL | 1 |
| Walton, B | 6 |
| Prieto, J | 1 |
| Barry, M | 1 |
| Sherlock, S | 2 |
| Parker, CW | 1 |
| Zimmerman, HJ | 2 |
| Flaherty, G | 1 |
| Aji, T | 1 |
| Shiaku, Y | 1 |
| Kosaka, N | 1 |
| Cibils, LA | 1 |
| Watts, C | 1 |
| Williams, OB | 1 |
| Goldstein, G | 1 |
| Simpson, BR | 6 |
| Strunin, L | 9 |
| Doniach, D | 2 |
| Perrin, J | 1 |
| Appleyard, AJ | 1 |
| Reves, JG | 2 |
| McCracken, LE | 1 |
| Martin, JL | 2 |
| Dubbink, DA | 1 |
| Plevak, DJ | 1 |
| Peronne, A | 1 |
| Taswell, HF | 1 |
| Hay, EJ | 1 |
| Pumford, NR | 2 |
| Heytens, L | 1 |
| Martin, JJ | 1 |
| Van de Kelft, E | 1 |
| Bossaert, LL | 1 |
| Thomassen, D | 1 |
| Butler, LE | 1 |
| Satoh, H | 2 |
| Ferrans, VJ | 1 |
| Perrone, A | 1 |
| Hastings, KL | 1 |
| Schuman, S | 1 |
| Brown, AP | 1 |
| Thomas, C | 1 |
| Gandolfi, AJ | 2 |
| Fay, RS | 1 |
| Gallant, EM | 1 |
| O'Grady, JG | 1 |
| Alexander, GJ | 1 |
| Hayllar, KM | 1 |
| Williams, R | 3 |
| Guldager, H | 1 |
| Hubbard, AK | 1 |
| Park, BK | 1 |
| Coleman, JW | 1 |
| Kenna, JG | 2 |
| Christ, DD | 1 |
| Fossati, C | 1 |
| Neuberger, J | 1 |
| Chapman, BA | 1 |
| Laurenson, VG | 1 |
| Cook, HB | 1 |
| Stock, JG | 1 |
| Nagashima, H | 1 |
| Koide, N | 1 |
| DiPadua, D | 1 |
| Mills, J | 1 |
| Kahan, B | 1 |
| Howard, ER | 1 |
| Winkler, K | 1 |
| Sejersen, P | 1 |
| Rask, H | 1 |
| Kalow, W | 1 |
| Davies, GE | 1 |
| Holmes, JE | 1 |
| Korkor, G | 1 |
| Tempel, G | 1 |
| Dykes, MH | 2 |
| Gilbert, JP | 2 |
| McPeek, B | 2 |
| Schöntube, E | 1 |
| Schöntube, M | 1 |
| Dornette, WH | 1 |
| Morley, TS | 2 |
| Boyd, CH | 1 |
| Reed, WD | 1 |
| Lagas, HM | 1 |
| Waalton, B | 1 |
| Dumonde, DC | 2 |
| Williams, C | 2 |
| Jones, D | 1 |
| Strunin, JM | 2 |
| Layton, JM | 1 |
| Simpson, R | 1 |
| Lund, I | 2 |
| Skulberg, A | 2 |
| Joshi, PH | 1 |
| Conn, HO | 1 |
| Moulds, RF | 1 |
| Denborough, MA | 1 |
| Kirchmayer, S | 1 |
| Trey, C | 1 |
| Davidson, CS | 1 |
| Okumura, F | 1 |
| Bruce, DL | 1 |
| Raymon, F | 1 |
| Byrd, BF | 1 |
| Daniel, RA | 1 |
| Vasudeo, P | 1 |
| Williams, WJ | 1 |
| Pioli, E | 1 |
| Horton, JN | 1 |
| Waldron, A | 1 |
| Jones, DW | 1 |
| Layton, J | 1 |
| Kratholm, S | 1 |
| Rosen, M | 1 |
| Jones, EV | 1 |
| Judson, JA | 1 |
| De Jongh, HJ | 1 |
| Walmsley, JB | 1 |
| Nusbaum, LM | 1 |
| Stone, WA | 1 |
| Hamelberg, W | 1 |
| Campkin, TV | 1 |
| McNeil, WT | 1 |
| Moore, KP | 1 |
| Stovner, J | 1 |
| Endresen, GK | 1 |
| Paronetto, F | 1 |
| Popper, H | 1 |
| Dordal, E | 1 |
| Glagov, S | 1 |
| Orlando, RA | 1 |
| Platz, C | 1 |
| Lecky, JH | 1 |
| Cohen, PJ | 1 |
| Condon, RE | 1 |
| Bombeck, CT | 1 |
| Steigmann, F | 1 |
| Lattey, M | 1 |
| Mendel, EB | 1 |
| Boyett, GT | 1 |
| Cullen, DJ | 1 |
| Klatskin, G | 1 |
| Kimberg, DV | 1 |
| Combes, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 13C-Methacetin Breath Test for the Prediction of Outcome in in Acute Liver Injury or Acute Liver Failure[NCT02786836] | Phase 2/Phase 3 | 76 participants (Actual) | Interventional | 2016-06-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The relationship between the cPDR (cumulative PDR of metabolized 13C-Methacetin 20 minutes after ingestion) in single time points of MBT measurements and TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT/transplant free survival at Day 21 | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 1.4 | 0.2 |
Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 (normal carbon dioxide) ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS (transplant free survival) and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: Days 1 and 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Mean Peak PDR for TFS subjects at Day 21 | Mean Peak PDR for non-TFS subjects at Day 21 | |
| 13C-Methacetin Breath Test (MBT) | 10.2 | 1.9 |
This outcome is similar to the peak PDR defined in the primary outcome but as a secondary we are looking at Day 1 or Day 2 peak PDR values. Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT & Day 21 TFS | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 9.1 | 2.3 |
24 reviews available for halothane and Allergy, Drug
| Article | Year |
|---|---|
Halothane hepatitis and the anaesthesiologist.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Hu | 1984 |
Halothane hepatitis: what's new?
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug Interactions; Halothane | 1980 |
Drug-related acute and chronic hepatitis.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypersen | 1980 |
["Hepatitis" following halothane-anesthesia (author's transl)].
Topics: Adult; Aged; Anesthesia, General; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; D | 1981 |
Immunotoxicology of the liver: adverse reactions to drugs.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dihydralazine; Drug Hypersensitivity; Halothane; Hu | 1997 |
Toxicity of inhalation anaesthetic agents.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersens | 1978 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
Hapten carrier conjugates associated with halothane hepatitis.
Topics: Animals; Carrier Proteins; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; | 1991 |
Drug-induced allergic hepatitis.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Hepa | 1990 |
[Toxicity and hepatotoxicity of halothane].
Topics: Drug Hypersensitivity; Halothane; Hepatic Encephalopathy; Humans; Liver | 1986 |
Halothane hepatitis: a model of immune mediated drug hepatotoxicity.
Topics: Adolescent; Animals; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Child; Child, Pres | 1987 |
Unexplained hepatitis following halothane.
Topics: Adult; Age Factors; Anesthesia, General; Animals; Biotransformation; Chemical and Drug Induced Liver | 1985 |
[Drug hypersensitivity and the etiology of toxic hepatitis].
Topics: Carrier Proteins; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Haptens; | 1985 |
Halothane hepatitis. Current concepts.
Topics: Anesthesia, General; Animals; B-Lymphocytes; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1974 |
Drug-induced immunological effects on the liver.
Topics: Aminosalicylic Acids; Anaphylaxis; Chemical and Drug Induced Liver Injury; Chlorpromazine; Drug Erup | 1972 |
Halothane in Britain today.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Enzyme Induct | 1972 |
Halothane in the United States. An appraisal of the literature on "halothane hepatitis" and the American reaction to it.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypers | 1972 |
[Halothane syndrome. On the possibility of allergy caused by 1,1,1-trifluor-2-brom-2-chlorethane (Halan) (author's transl)].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Environmental | 1973 |
General anesthesia.
Topics: Anesthesia, General; Dentures; Drug Hypersensitivity; Fires; Halothane; Humans; Informed Consent; Ma | 1973 |
Halothane: clinical considerations.
Topics: Anesthesia, Inhalation; Antibodies, Anti-Idiotypic; Biotransformation; Chemical and Drug Induced Liv | 1974 |
The management of fulminant hepatic failure.
Topics: Acute Disease; Blood Transfusion; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Hal | 1970 |
[Halothane hepatitis and allergy].
Topics: Adult; Bromine; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Li | 1970 |
Halothane hepatitis.
Topics: Adult; Alkaline Phosphatase; Anesthesia, Inhalation; Bilirubin; Chemical and Drug Induced Liver Inju | 1971 |
The halothane dilemma: a case for the defence.
Topics: Adult; Anesthesia, General; Antigens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; | 1971 |
2 trials available for halothane and Allergy, Drug
| Article | Year |
|---|---|
Onset of postoperative jaundice related to anaesthetic history.
Topics: Anesthetics; Clinical Trials as Topic; Drug Hypersensitivity; Halothane; Humans; Jaundice; Postopera | 1974 |
Identification of susceptibility to malignant hyperpyrexia.
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Creatine Kinase; Drug Hypersensitivity; Electrocardiograp | 1974 |
102 other studies available for halothane and Allergy, Drug
| Article | Year |
|---|---|
Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity.
Topics: Anesthetics, Inhalation; Animals; Chromosome Mapping; Dose-Response Relationship, Drug; Drosophila; | 2009 |
Hypersensitivity of laryngeal C-fibers induced by volatile anesthetics in young guinea pigs.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Bradykinin; Capsaicin; Drug Hypersensitivity | 2003 |
SEVERE URTICARIA OCCURRING DURING THE ADMINISTRATION OF A GENERAL ANAESTHETIC.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthetics, General; Drug Hypersensitivity; Halothane; Skin Tes | 1964 |
DRUGS AND LIVER DISEASE.
Topics: Androgens; Anti-Bacterial Agents; Antihypertensive Agents; Antineoplastic Agents; Arsphenamine; Chem | 1965 |
POST-OPERATIVE HEPATIC MORBIDITY WITH SPECIAL REFERENCE TO THE ROLE OF HALOTHANE.
Topics: Chemical and Drug Induced Liver Injury; Classification; Drug Hypersensitivity; Halothane; Hepatitis; | 1965 |
[Jaundices of therapeutic origin].
Topics: Antineoplastic Agents; Antitubercular Agents; Arsenicals; Chemical and Drug Induced Liver Injury; Ch | 1967 |
Respiratory response to volatile anaesthetics. I. Effect of halothane in spontaneously breathing rabbits.
Topics: Animals; Drug Hypersensitivity; Female; Halothane; Male; Phrenic Nerve; Rabbits; Respiration | 1967 |
Effects of hypersensitivity to a halothane metabolite on halothane-induced liver damage.
Topics: Animals; Drug Hypersensitivity; Fluoroacetates; Halothane; Liver; Male; Rats; Rats, Inbred F344; Tri | 1984 |
Hepatotoxicity of halogenated inhalation anesthetics.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Hydro | 1981 |
Halothane-induced hepatic disease.
Topics: Adolescent; Adult; Age Factors; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Differentia | 1981 |
Lymphocyte transformation and radioallergosorbent tests in drug hypersensitivity.
Topics: Allopurinol; Ampicillin; Anti-Bacterial Agents; Drug Hypersensitivity; Female; Halothane; Humans; Ly | 1980 |
Halothane hepatitis: allergy or idiosyncrasy?
Topics: Animals; Antibody Formation; Autoantibodies; Chemical and Drug Induced Liver Injury; Drug Hypersensi | 1980 |
Alterations of liver-cell membranes after exposure to halothane.
Topics: Animals; Cell Membrane; Drug Hypersensitivity; Halothane; In Vitro Techniques; Liver; Microscopy, El | 1980 |
The point mutation Arg615-->Cys in the Ca2+ release channel of skeletal sarcoplasmic reticulum is responsible for hypersensitivity to caffeine and halothane in malignant hyperthermia.
Topics: Amino Acid Sequence; Animals; Arginine; Blotting, Western; Caffeine; Calcium; Calcium Channels; Cell | 1994 |
Mutations conferring new patterns of sensitivity to volatile anesthetics in Caenorhabditis elegans.
Topics: Anesthetics; Animals; Caenorhabditis elegans; Chromosome Mapping; Dose-Response Relationship, Drug; | 1994 |
Halothane hepatitis in a South African population--frequency and the influence of gender and ethnicity.
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; | 1997 |
Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions.
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrier Prote | 1998 |
[Allergic characteristics of halothane hepatitis. Apropos of a case report].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Halothane; Humans; Jau | 1976 |
[Experimental study of the sensitizing properties of halothane].
Topics: Anesthesia, Inhalation; Animals; Drug Hypersensitivity; Female; Freund's Adjuvant; Guinea Pigs; Halo | 1976 |
[Experimental study of conjugates of a catabolite common to halothane, enflurane and fluroxene in guinea pigs].
Topics: Animals; Antibodies; Antibody Formation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivi | 1976 |
[Halogen hepatitis].
Topics: Anesthetics; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Hal | 1976 |
An anaphylactoid response to a small dose of d-tubocurarine.
Topics: Adult; Anaphylaxis; Bronchial Spasm; Drug Eruptions; Drug Hypersensitivity; Erythema; Female; Haloth | 1979 |
[Use of neuroleptic agents in modern pig-farming (author's transl)].
Topics: Abattoirs; Acidosis; Animals; Antipsychotic Agents; Butyrophenones; Drug Hypersensitivity; Ethics, P | 1975 |
[Allergenic properties of halothane].
Topics: Allergens; Animals; Drug Hypersensitivity; Guinea Pigs; Halothane; Hypersensitivity, Delayed; Hypers | 1979 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptiv | 1979 |
[Halothane hepatitis: fact or fiction? (author's transl)].
Topics: Acute Disease; Anesthetics; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane | 1979 |
[Post-operative fulminant hepatitis presumably due to halothane (author's transl)].
Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity; Halot | 1979 |
Leukocyte migration inhibition in halothane-induced hepatitis.
Topics: Adult; Aged; Cell Migration Inhibition; Chemical and Drug Induced Liver Injury; Cholelithiasis; Chol | 1979 |
CK isozymes in serum of halothane sensitive and non-reacting pigs.
Topics: Animals; Creatine Kinase; Drug Hypersensitivity; Female; Halothane; Isoenzymes; Male; Stress, Physio | 1979 |
Close linkage established between the HAL locus for halothane sensitivity and the PHI (phosphohexose isomerase) locus in pigs of the Danish Landrace breed.
Topics: Anesthesia, Inhalation; Animals; Drug Hypersensitivity; Genetic Linkage; Genotype; Glucose-6-Phospha | 1977 |
Drug-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related | 1978 |
Jaundice after repeated exposure to halothane: a further analysis of reports to the Committee on Safety of Medicines.
Topics: Anesthesia, Inhalation; Drug Hypersensitivity; Halothane; Humans; Jaundice; Middle Aged; Time Factor | 1978 |
Halothane hepatitis.
Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Live | 1977 |
[Relevance of clinical signs of hypersensitivity in cases of halothane hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Circadian Rhythm; Drug Hypersensitivity; Eosinophils; Haloth | 1976 |
[Diagnostic tests for hypersensitivity to halogen compounds].
Topics: Autoantibodies; Cell Migration Inhibition; Chemical and Drug Induced Liver Injury; Drug Hypersensiti | 1976 |
Serum ferritin in patients with iron overload and with acute and chronic liver diseases.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1975 |
Drug therapy. Drug allergy (second of three parts).
Topics: Allergens; Anaphylaxis; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypers | 1975 |
Liver disease caused by medicinal agents.
Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contracept | 1975 |
Letter: Halothanitis or glandular fever?
Topics: Adult; Anesthesia, Inhalation; Diagnosis, Differential; Drug Hypersensitivity; Halothane; Humans; In | 1975 |
[Halothane immunity and hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane | 1975 |
Anesthesia for coelioscopy.
Topics: Abdomen; Anesthesia; Anesthesia, Conduction; Anesthesia, General; Anesthesia, Local; Arrhythmias, Ca | 1975 |
Sensitivity reactions to intradiscal injection of chymopapain during general anesthesia.
Topics: Adult; Aged; Anesthesia, Inhalation; Chymopapain; Drug Hypersensitivity; Endopeptidases; Female; Hal | 1976 |
Unexplained hepatitis following halothane.
Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia, Inhalation; Autoantibodies; Child; Child, Preschoo | 1976 |
Hepatic pathology and skin test reactions to trifluoro-acetylated autologous protein after repeated halothane anaesthesia in the guineapig.
Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Fluoroa | 1976 |
Halothane hepatitis 28 years after primary exposure.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Male; Middle Aged; | 1992 |
In vitro contracture tests in patients with various neuromuscular diseases.
Topics: Adolescent; Adult; Aged; Caffeine; Child; Child, Preschool; Disease Susceptibility; Drug Hypersensit | 1992 |
S-ethylthiotrifluoroacetate enhancement of the immune response to halothane in the guinea pig.
Topics: Animals; Antibody Formation; Antigens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity | 1991 |
Halothane sensitivity of young pigs in vivo and in vitro.
Topics: Animals; Drug Hypersensitivity; Halothane; Malignant Hyperthermia; Muscle Contraction; Muscles; Succ | 1990 |
Early indicators of prognosis in fulminant hepatic failure.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Halothan | 1989 |
Halothane-associated liver damage.
Topics: Acute Disease; Anesthesia; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Fem | 1986 |
Halothane allergy as cause of acne.
Topics: Acne Vulgaris; Adult; Drug Hypersensitivity; Female; Halothane; Humans | 1987 |
Immunological basis of anesthetic-induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Guinea Pigs; Halothane; Huma | 1988 |
The immunological basis of adverse drug reactions. A report on a symposium held in Liverpool on 6th April 1988.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects an | 1988 |
Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane.
Topics: Animals; Antigens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Haptens | 1988 |
[Halothane and the liver. Clinical experience].
Topics: Adolescent; Adult; Age Factors; Aged; Anesthesiology; Antibodies; Chemical and Drug Induced Liver In | 1987 |
Halothane hepatitis: toxicity or hypersensitivity?
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Equipm | 1985 |
Experimental immunity to a metabolite of halothane and fluroxene: cutaneous delayed-type hypersensitivity.
Topics: Albumins; Animals; Biotransformation; Cattle; Chemical and Drug Induced Liver Injury; Disease Models | 1974 |
Halothane.
Topics: Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Huma | 1965 |
Halothane.
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Male | 1965 |
Halothane.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Male | 1965 |
Halothane: hepatitis or allergy?
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity; Halothane; H | 1969 |
Rigidity and malignant hyperthermia associated with anaesthesia.
Topics: Anesthesia, General; Animals; Calcium; Drug Hypersensitivity; Female; Fever; Halothane; Humans; Hydr | 1970 |
The spectrum of hepatotoxicity.
Topics: Aminosalicylic Acids; Anti-Bacterial Agents; Antimetabolites; Benzene Derivatives; Carbon Tetrachlor | 1968 |
Letter: "Halothane hepatitis".
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Liver | 1974 |
Editorial: Halothane and liver damage.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Jaund | 1974 |
[Anesthesias for ambulatory dental treatment].
Topics: Ambulatory Care; Anesthesia, Dental; Anesthesia, Endotracheal; Anesthesia, General; Anesthesia, Loca | 1974 |
Biochemical effects of halothane.
Topics: Adult; Animals; Autoantibodies; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Dr | 1972 |
Ophthalmic hyper-sensitivity to anaesthetic vapour.
Topics: Anesthesiology; Drug Hypersensitivity; Eye Diseases; Halothane; Humans | 1972 |
Halothane hepatitis as seen by the physician.
Topics: Adult; Aged; Anesthesia, Inhalation; Antibodies; Chemical and Drug Induced Liver Injury; Diagnosis, | 1972 |
Halothane hepatitis.
Topics: Anesthesia, Inhalation; Anesthesiology; Chemical and Drug Induced Liver Injury; Drug Hypersensitivit | 1972 |
[Renal and hepatic dysfunction following the use of methoxyflurane as an anesthetic].
Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Cross Reactions; Drug Hypersensitivity; | 1973 |
Halothane hepatitis--fact or fallacy.
Topics: Antibodies; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity; | 1973 |
Lymphocyte transformation. Absence of increased responses in alleged halothane jaundice.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Ethyl Ethers; Halothane; | 1973 |
Halothane induced liver damage.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypers | 1973 |
The syndrome of methoxyflurane-associated hepatitis.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity; | 1974 |
Editorial: Jaundice and repeated exposure to halothane.
Topics: Drug Hypersensitivity; Halothane; Humans; Jaundice; Legislation, Drug; Liver; United Kingdom | 1974 |
[Drug-induced hepatopathies].
Topics: Adult; Age Factors; Bilirubin; Cell Membrane; Chemical and Drug Induced Liver Injury; Cholestasis; D | 1974 |
Letter: Jaundice after halothane.
Topics: Anesthesiology; Drug Hypersensitivity; Halothane; Humans; Jaundice | 1974 |
Test for halothane sensitivity.
Topics: Drug Hypersensitivity; Halothane; Humans; In Vitro Techniques; Lymphocytes; Male | 1972 |
Serious sequelae of general anesthesia.
Topics: Adult; Aged; Anesthesia, General; Chemical and Drug Induced Liver Injury; Circumcision, Male; Cortic | 1972 |
M.I.F. test in halothane jaundice.
Topics: Cell Migration Inhibition; Drug Hypersensitivity; Female; Halothane; Humans; Jaundice; Macrophages; | 1972 |
Failure to demonstrate increased lymphocyte transformation in patients with postoperative jaundice and physicians with alleged halothane sensitivity.
Topics: Drug Hypersensitivity; Halothane; Humans; Jaundice; Lymphocyte Activation; Postoperative Complicatio | 1972 |
"The halothane dilemma".
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane | 1971 |
[Specific hepato-toxicity or liver blood-flow?].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Drug Hypersensitivity; Halothane; Humans; Liv | 1971 |
Post-halothane jaundice in relation to previous administration of halothane.
Topics: Adult; Age Factors; Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; England; Ha | 1971 |
Possible cross-sensitivity between halothane and methoxyflurane: report of a case.
Topics: Alkaline Phosphatase; Anesthesia, Inhalation; Appendectomy; Aspartate Aminotransferases; Bilirubin; | 1971 |
Unexplained postoperative fever. Its value as a sign of halothane sensitization.
Topics: Anesthesia, General; Bilirubin; Body Temperature; Cholecystectomy; Drug Hypersensitivity; Female; Fe | 1971 |
Halothane and the liver: a review.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Liver; Nursing | 1971 |
Jaundice after anaesthesia.
Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; H | 1969 |
[Allergic reactions in the liver induced by halothane].
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Liver; Male | 1970 |
Cell-mediated immunity in halothane hypersensitivity.
Topics: Anesthesia, Inhalation; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Drug Hypersensi | 1970 |
Halothane and liver damage.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Halothane; Human | 1970 |
Lymphocyte stimulation induced by halothane in patients with hepatitis following exposure to halothane.
Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; DNA; Drug Hypersensitivity; | 1970 |
Fatal halothane hepatitis with transient granulomas.
Topics: Adult; Anesthesia, Inhalation; Autopsy; Biopsy; Chemical and Drug Induced Liver Injury; Drug Hyperse | 1970 |
Hepatic dysfunction without jaundice following administration of halothane.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Fever; Halothane; Hepatitis B | 1970 |
Heterologous bovine liver perfusion therapy of acute hepatic failure.
Topics: Adenosine Triphosphate; Adolescent; Adult; Animals; Cattle; Consciousness; Drug Hypersensitivity; Fe | 1970 |
Halothane sensitization: a case report.
Topics: Anesthesia, Inhalation; Drug Hypersensitivity; Halothane; Heart Diseases; Humans; Male; Middle Aged; | 1970 |
Hepatitis following halothane anesthetic.
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; | 1971 |
Severe anaphylactic reaction to penicillin during halothane anaesthesia. A case report.
Topics: Anaphylaxis; Anesthesia, General; Bronchial Spasm; Debridement; Drug Hypersensitivity; Female; Femur | 1971 |
Recurrent hepatitis attributable to halothane sensitization in an anesthetist.
Topics: Adult; Anesthesiology; Asthma; Biopsy; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity | 1969 |
Halothane-induced liver damage--an entity.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Liver; Liver Disea | 1969 |
Hepatic sensitization to halothane.
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Haloth | 1969 |