Page last updated: 2024-10-28

halothane and Aging

halothane has been researched along with Aging in 75 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The authors investigated the cardiovascular and regional hemodynamic changes that occur in the aged rat under unanesthetized control conditions and during the induction of halothane anesthesia."7.66Cardiovascular and regional blood flow changes during halothane anesthesia in the aged rat. ( Albrecht, RF; Hoffman, WE; Miletich, DJ, 1982)
"The cardiovascular effects of halothane anesthesia in a mixture of nitrous oxide and oxygen were studied on piglets 7 hr to 25 days of age."7.65Age-dependent cardiovascular effects of halothane anesthesia in neonatal pigs. ( Crane, L; Gootman, N; Gootman, PM, 1975)
"Anesthesia was induced and maintained with N2O:O2 2:1 and 1 minimum alveolar concentration end-tidal halothane."5.08Pipecuronium revisited: dose-response and maintenance requirement in infants, children, and adults. ( Erkola, O; Meretoja, OA, 1997)
"To define the effect of aging on the pharmacokinetics of volatile anesthetics, we determined the end-tidal and mixed expired anesthetic concentrations of isoflurane, enflurane, halothane, and methoxyflurane during 30 min of simultaneous administration and for 5-12 days of elimination in seven healthy young patients (31 +/- 1."3.68Age affects the pharmacokinetics of inhaled anesthetics in humans. ( Carpenter, RL; Eger, EI; Johnson, BH; Strum, DP; Unadkat, JD, 1991)
"To evaluate the effect of aging on the distribution, clearance, and neuromuscular junction sensitivity to atracurium, the authors determined the pharmacokinetics and pharmacodynamics of atracurium in five healthy elderly subjects (74-76 yr) during halothane-nitrous oxide anesthesia and compared these values to those obtained previously in five healthy young adults (22-44 yr)."3.68Pharmacokinetics and pharmacodynamics of atracurium in the elderly. ( Caldwell, JE; Canfell, PC; Fahey, MR; Fisher, DM; Heier, T; Kitts, JB; Miller, RD; Spellman, MJ, 1990)
"Vecuronium kinetics and dynamics were determined in five infants (3 to 11 months old) and five children (1 to 5 years old) during anesthesia with 70% nitrous oxide and 0."3.67Vecuronium kinetics and dynamics in anesthetized infants and children. ( Castagnoli, K; Fisher, DM; Miller, RD, 1985)
"The authors investigated the cardiovascular and regional hemodynamic changes that occur in the aged rat under unanesthetized control conditions and during the induction of halothane anesthesia."3.66Cardiovascular and regional blood flow changes during halothane anesthesia in the aged rat. ( Albrecht, RF; Hoffman, WE; Miletich, DJ, 1982)
"The cardiovascular effects of halothane anesthesia in a mixture of nitrous oxide and oxygen were studied on piglets 7 hr to 25 days of age."3.65Age-dependent cardiovascular effects of halothane anesthesia in neonatal pigs. ( Crane, L; Gootman, N; Gootman, PM, 1975)
"We determined the cumulative dose-response relations of pipecuronium in infants and children during nitrous oxidehalothane anesthesia."2.67Clinical pharmacology of pipecuronium in infants and children during halothane anesthesia. ( Brandom, BW; Cook, DR; Dong, ML; Pickle, D; Sarner, JB; Weinberger, MJ, 1990)
"Halothane induced a lower negative inotropic effect in senescent rats (1."1.31Myocardial effects of halothane and isoflurane in senescent rats. ( Besse, S; Coriat, P; Riou, B; Rozenberg, S; Vivien, B, 2002)
"Halothane was a more potent depressant of cardiac function than isoflurane and developmental differences were more evident with this agent."1.29Direct myocardial effects of halothane and isoflurane. Comparison between adult and infant rabbits. ( Bosnjak, ZJ; Kampine, JP; Mehner, RW; Palmisano, BW; Stowe, DF, 1994)
"There were 47 episodes of gastro-oesophageal reflux (17."1.29Gastro-oesophageal reflux during anaesthesia in the dog: the effect of age, positioning and type of surgical procedure. ( Galatos, AD; Raptopoulos, D, 1995)
"The dose recommendations for atropine in anesthetized children vary, and the dose-response for heart rate has not been defined."1.28Dose-response for atropine and heart rate in infants and children anesthetized with halothane and nitrous oxide. ( Brown, MP; Palmisano, BW; Setlock, MA; Siker, D; Tripuraneni, R, 1991)
"Bupivacaine was infused at a constant rate while the pigs' ECGs and EEGs were recorded."1.28Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics. ( Badgwell, JM; Heavner, JE; Kytta, J, 1990)
" They then compared these dose-response relationships with values obtained for adults (greater than 18 years old) under comparable anesthetic conditions."1.27Neuromuscular effects of vecuronium (ORG NC45) in infants and children during N2O, halothane anesthesia. ( Fisher, DM; Miller, RD, 1983)
"Alfentanil is a potent short-acting opioid analgesic which depresses respiration and can cause cardiovascular depression."1.27The pharmacokinetics and clinical effects of a low dose of alfentanil in elderly patients. ( Bower, S; Dodson, ME; Kent, AP, 1988)
"05), thus a parallel shift of the dose-response curves was observed."1.27Comparison of the effects of halothane on newborn and adult rabbit myocardium. ( Krane, EJ; Su, JY, 1987)
" The elimination half-life (t beta 1/2) was 174 +/- 60 min in neonates, significantly longer than the values of 90 +/- 23 and 89 +/- 18 min in children and adults, respectively."1.26Pharmacokinetics and pharmacodynamics of d-tubocurarine in infants, children, and adults. ( Cronnelly, R; Fisher, DM; Gregory, GA; Miller, RD; O'Keeffe, C; Stanski, DR, 1982)
"Halothane was tested only at its maximum tolerated dose, and histologic examination was performed only on tumor masses and other grossly abnormal tissues found at necropsy."1.26Carcinogenicity of halothane in Swiss/ICR mice. ( Baden, JM; Kosek, JC; Mazze, RI; Rice, SA; Wharton, RS, 1979)

Research

Studies (75)

TimeframeStudies, this research(%)All Research%
pre-199041 (54.67)18.7374
1990's24 (32.00)18.2507
2000's10 (13.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Johnson, CB1
Sylvester, SP1
Stafford, KJ1
Mitchinson, SL1
Ward, RN1
Mellor, DJ1
Rozenberg, S1
Besse, S1
Vivien, B1
Coriat, P1
Riou, B1
Prakash, YS2
Hunter, LW1
Seckin, I1
Sieck, GC2
Chaves, AA1
Dech, SJ1
Nakayama, T1
Hamlin, RL1
Bauer, JA1
Carnes, CA1
Shumilla, JA1
Sweitzer, SM1
Eger, EI6
Laster, MJ1
Kendig, JJ1
Fisher, DM4
Miller, RD4
Boudreaux, JP1
Schieber, RA1
Cook, DR4
Lerman, J2
Gregory, GA4
Willis, MM2
Rao, CC1
Dierdorf, SF1
Wolfe, TM1
Haselby, KA1
Krishna, G1
Paradise, RR1
Friesen, RH1
Wear, R1
Robinson, S1
Hoffman, WE3
Miletich, DJ3
Albrecht, RF3
O'Keeffe, C1
Stanski, DR1
Cronnelly, R1
Kristoffersen, MB1
Kjaer Hansen, EK1
Jostell, KG1
Stockman, O1
Mirakhur, RK1
Jones, CJ1
Brandom, BW2
Shiu, G1
Wolfson, B1
Gronert, GA1
Handler, SD1
Ream, RS1
Schreiner, MS1
Neff, JD1
McRae, KM1
Jawad, AF1
Scherer, PW1
Neufeld, GR1
Brian, JE1
Slaven, JS1
Kennedy, RH2
Seifen, E2
Patel, R1
Lenczyk, M1
Hannallah, RS1
McGill, WA1
Palmisano, BW2
Mehner, RW1
Stowe, DF1
Bosnjak, ZJ1
Kampine, JP1
Bhattacharyya, BJ1
Tsen, K1
Sokoll, MD1
Peinado, A1
Yuste, R1
Katz, LC1
Galatos, AD1
Raptopoulos, D1
Taguchi, N1
Nishikawa, T1
Inomata, S1
Taguchi, M1
Yamashita, S1
Naito, H1
Wieland, SJ1
Gong, QH1
Fletcher, JE1
Rosenberg, H1
Meretoja, OA1
Erkola, O1
Cody, MJ1
Hannon, JD1
Housmans, PR1
Driessen, JJ1
Robertson, EN1
Van Egmond, J1
Booij, LH1
Erb, C1
Troost, J1
Kopf, S1
Schmitt, U1
Löffelholz, K1
Soreq, H1
Klein, J1
Hartman, PS1
Ishii, N1
Kayser, EB1
Morgan, PG1
Sedensky, MM1
Gip, P1
Hagiwara, G1
Ruby, NF1
Heller, HC1
Baden, JM1
Mazze, RI1
Wharton, RS1
Rice, SA1
Kosek, JC1
Danzmann, E1
Poppelbaum, HF1
Cardan, E1
Crane, L1
Gootman, N1
Gootman, PM2
Drake, WT1
Creighan, M1
Sims, DE1
Ochiai, R1
Guthrie, RD1
Motoyama, EK1
Lynn, AM1
McRorie, TI1
Slattery, JT1
Calkins, DF1
Opheim, KE1
Kalow, W1
Sharer, S1
Britt, B1
Takenoshita, M1
Steinbach, JH1
Setlock, MA1
Brown, MP1
Siker, D1
Tripuraneni, R1
Strum, DP1
Unadkat, JD1
Johnson, BH1
Carpenter, RL1
Dwyer, RC1
Fee, JP1
Howard, PJ1
Clarke, RS1
Murat, I1
Hoerter, J1
Ventura-Clapier, R1
Sarner, JB1
Dong, ML1
Pickle, D1
Weinberger, MJ1
Kitts, JB1
Canfell, PC1
Spellman, MJ1
Caldwell, JE1
Heier, T1
Fahey, MR1
Kitahara, Y1
Kojima, Y1
Nozaki, F1
Badgwell, JM1
Heavner, JE1
Kytta, J1
Loss, GE1
Seifen, AB1
Kurth, CD1
Hutchison, AA1
Caton, DC1
Davenport, PW1
Jorch, G1
Woike, H1
Rabe, H1
Reinhold, P1
Debaene, B1
Meistelman, C1
d'Hollander, A1
Lind, RC1
Gandolfi, AJ1
Hall, PD1
Krane, EJ2
Su, JY2
Yasuda, N1
Targ, AG1
Castagnoli, K1
Kent, AP1
Dodson, ME1
Bower, S1
Baughman, VL1
Grandy, JL1
Steffey, EP1
Miller, M1
Ording, H1
Hansen, U1
Skovgaard, LT1
Levin, ED2
Uemura, E2
DeLuna, R1
Franks, P1
Bowman, RE2
Busoni, P1
Andreuccetti, T1
Schmitt-Bantel, BI1
James, OF1
Martin-Body, RL1
Sinclair, JD1
Eger, RR1
Seals, C1
Mosher, GL1
Robinson, RH1
Crane, LA1
Gootman, NL1
Kitamura, H1
Sawa, T1
Ikezono, E1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Comparison of the Airway Deadspace Associated With the Air-Q® and Endotracheal Tube Using Volumetric Capnography in Young Children[NCT03785977]62 participants (Actual)Observational2019-03-25Completed
Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU[NCT05451953]110 participants (Anticipated)Interventional2022-07-21Recruiting
Influence of Sevoflurane and Propofol on Maximum Muscular Strength, Speed of Contraction and Relaxation, in Humans: A Pilot Study[NCT05615025]Phase 348 participants (Actual)Interventional2023-01-20Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for halothane and Aging

ArticleYear
Newborn anaesthesia: pharmacological considerations.
    Canadian Anaesthetists' Society journal, 1986, Volume: 33, Issue:3 Pt 2

    Topics: Aging; Anesthesia; Anesthesia, Inhalation; Cardiovascular Diseases; Dose-Response Relationship, Drug

1986
Drugs and the ageing liver.
    Journal of hepatology, 1985, Volume: 1, Issue:4

    Topics: Aged; Aging; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syst

1985

Trials

4 trials available for halothane and Aging

ArticleYear
Hemodynamic effects of intravenous ephedrine in infants and children anesthetized with halothane and nitrous oxide.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:3

    Topics: Adolescent; Adrenergic Agonists; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Press

1996
Pipecuronium revisited: dose-response and maintenance requirement in infants, children, and adults.
    Journal of clinical anesthesia, 1997, Volume: 9, Issue:2

    Topics: Adult; Aging; Anesthesia; Anesthetics, Inhalation; Child; Child, Preschool; Dose-Response Relationsh

1997
The time-course of action and recovery of rocuronium 0.3 mg x kg(-1) in infants and children during halothane anaesthesia measured with acceleromyography.
    Paediatric anaesthesia, 2000, Volume: 10, Issue:5

    Topics: Aging; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Child, Preschool; Elective Sur

2000
Clinical pharmacology of pipecuronium in infants and children during halothane anesthesia.
    Anesthesia and analgesia, 1990, Volume: 71, Issue:4

    Topics: Aging; Androstane-3,17-diol; Androstanols; Anesthesia, Inhalation; Child, Preschool; Clinical Trials

1990

Other Studies

69 other studies available for halothane and Aging

ArticleYear
Effects of age on the electroencephalographic response to castration in lambs anaesthetized with halothane in oxygen from birth to 6 weeks old.
    Veterinary anaesthesia and analgesia, 2009, Volume: 36, Issue:3

    Topics: Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Electroencephalography; Halothane;

2009
Myocardial effects of halothane and isoflurane in senescent rats.
    Anesthesiology, 2002, Volume: 97, Issue:6

    Topics: Aging; Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Halothane; Isoflurane; Ma

2002
Volatile anesthetics and regulation of cardiac Na+/Ca2+ exchange in neonates versus adults.
    Annals of the New York Academy of Sciences, 2002, Volume: 976

    Topics: Aging; Anesthetics, Inhalation; Animals; Animals, Newborn; Calcium; Halothane; Heart; Heart Ventricl

2002
Age and anesthetic effects on murine electrocardiography.
    Life sciences, 2003, Apr-11, Volume: 72, Issue:21

    Topics: Aging; Anesthetics, Combined; Anesthetics, Inhalation; Animals; Disease Models, Animal; Electrocardi

2003
Inhibition of spinal protein kinase C-epsilon or -gamma isozymes does not affect halothane minimum alveolar anesthetic concentration in rats.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:1

    Topics: Aging; Anesthetics, Inhalation; Animals; Enzyme Inhibitors; Halothane; Injections, Spinal; Protein K

2004
Neuromuscular effects of vecuronium (ORG NC45) in infants and children during N2O, halothane anesthesia.
    Anesthesiology, 1983, Volume: 58, Issue:6

    Topics: Adolescent; Adult; Aging; Anesthesia, Inhalation; Child; Child, Preschool; Electromyography; Halotha

1983
Hemodynamic effects of halothane in the newborn piglet.
    Anesthesia and analgesia, 1984, Volume: 63, Issue:8

    Topics: Aging; Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug;

1984
Age and solubility of volatile anesthetics in blood.
    Anesthesiology, 1984, Volume: 61, Issue:2

    Topics: Adult; Aged; Aging; Anesthetics; Blood Gas Analysis; Child; Child, Preschool; Cholesterol; Enflurane

1984
Effect of age on epinephrine-induced arrhythmias during halothane anaesthesia in pigs.
    Canadian Anaesthetists' Society journal, 1984, Volume: 31, Issue:1

    Topics: Aging; Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Epinephrine; Halothane; Heart; Hemodyn

1984
The baroresponse and cardiovascular depression by halothane in infants.
    Anesthesiology, 1983, Volume: 58, Issue:4

    Topics: Aging; Halothane; Humans; Infant; Pressoreceptors

1983
The effect of halothane on the baroresponse of adult and baby rabbits.
    Anesthesiology, 1982, Volume: 56, Issue:3

    Topics: Aging; Anesthesia; Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Halothane; Heart Rate;

1982
Cardiovascular and regional blood flow changes during halothane anesthesia in the aged rat.
    Anesthesiology, 1982, Volume: 56, Issue:6

    Topics: Aging; Anesthesia; Animals; Blood Gas Analysis; Blood Pressure; Halothane; Hemodynamics; Male; Micro

1982
Pharmacokinetics and pharmacodynamics of d-tubocurarine in infants, children, and adults.
    Anesthesiology, 1982, Volume: 57, Issue:3

    Topics: Adolescent; Adult; Aging; Anesthesia, General; Child; Child, Preschool; Electromyography; Half-Life;

1982
Chlormethiazole (Heminevrin), pethidine and nitrous oxide as compared to halothane for general anesthesia.
    Acta anaesthesiologica Scandinavica, 1982, Volume: 26, Issue:4

    Topics: Aged; Aging; Anesthesia, General; Chlormethiazole; Halothane; Humans; Kinetics; Meperidine; Middle A

1982
Atropine and glycopyrrolate: changes in cardiac rate and rhythm in conscious and anaesthetised children.
    Anaesthesia and intensive care, 1982, Volume: 10, Issue:4

    Topics: Adolescent; Aging; Anesthesia, General; Arrhythmias, Cardiac; Atropine; Body Weight; Child; Child, P

1982
The inspired median effective dose, brain concentration at anesthesia, and cardiovascular index for halothane in young rats.
    Anesthesia and analgesia, 1981, Volume: 60, Issue:4

    Topics: Aging; Anesthesia, Inhalation; Animals; Brain; Halothane; Heart Diseases; Myocardium; Rats

1981
Contracture responses and energy stores in quadriceps muscle from humans age 7-82 years.
    Human biology, 1980, Volume: 52, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Caffeine; Child; Energy Metabolism; Halothane; Humans; Middle Aged;

1980
Maturational influences on suppression of vocal cord function by anesthesia.
    The Laryngoscope, 1995, Volume: 105, Issue:9 Pt 1

    Topics: Aging; Animals; Dose-Response Relationship, Drug; Halothane; Movement; Rabbits; Respiration; Vocal C

1995
Volumetric capnography in children. Influence of growth on the alveolar plateau slope.
    Anesthesiology, 1995, Volume: 82, Issue:1

    Topics: Adolescent; Aging; Anesthesia; Body Constitution; Carbon Dioxide; Child; Child, Preschool; Halothane

1995
The effect of age on halothane-induced alterations of contractility in isolated rat aorta.
    Mechanisms of ageing and development, 1994, Volume: 74, Issue:1-2

    Topics: Aging; Animals; Aorta; Endothelium, Vascular; Halothane; In Vitro Techniques; Male; Norepinephrine;

1994
Age and the onset of desaturation in apnoeic children.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:9

    Topics: Adolescent; Aging; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Apnea; Body

1994
Direct myocardial effects of halothane and isoflurane. Comparison between adult and infant rabbits.
    Anesthesiology, 1994, Volume: 81, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Atrioventricular Node; Coronary Circulation; Halothane; Heart; Hea

1994
Age-induced alteration of neuromuscular transmission: effect of halothane.
    European journal of pharmacology, 1994, Mar-11, Volume: 254, Issue:1-2

    Topics: Acetylcholine; Aging; Animals; Electrophysiology; Evoked Potentials; Halothane; Iontophoresis; Male;

1994
Extensive dye coupling between rat neocortical neurons during the period of circuit formation.
    Neuron, 1993, Volume: 10, Issue:1

    Topics: Aging; Animals; Biotin; Cerebral Cortex; Dendrites; Electric Conductivity; Halothane; Intercellular

1993
Gastro-oesophageal reflux during anaesthesia in the dog: the effect of age, positioning and type of surgical procedure.
    The Veterinary record, 1995, Nov-11, Volume: 137, Issue:20

    Topics: Abdomen; Aging; Anesthesia; Anesthesia, Inhalation; Animals; Dog Diseases; Dogs; Esophagus; Female;

1995
Altered sodium current response to intracellular fatty acids in halothane-hypersensitive skeletal muscle.
    The American journal of physiology, 1996, Volume: 271, Issue:1 Pt 1

    Topics: Aging; Disease Susceptibility; Electric Conductivity; Fatty Acids; Halothane; Humans; Intracellular

1996
Comparison of volatile anesthetic effects on actin-myosin cross-bridge cycling in neonatal versus adult cardiac muscle.
    Anesthesiology, 2000, Volume: 92, Issue:4

    Topics: Actins; Aging; Algorithms; Anesthetics, Inhalation; Animals; Animals, Newborn; Halothane; Heart; In

2000
Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase.
    Journal of neurochemistry, 2001, Volume: 77, Issue:2

    Topics: Acetylcholine; Acetylcholinesterase; Aging; Anesthetics, Inhalation; Animals; Choline; Cholinesteras

2001
Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans.
    Mechanisms of ageing and development, 2001, Volume: 122, Issue:11

    Topics: Aging; Anesthetics, Inhalation; Animals; Caenorhabditis elegans; Electron Transport Complex I; Elect

2001
Sleep deprivation decreases glycogen in the cerebellum but not in the cortex of young rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 283, Issue:1

    Topics: Aging; Anesthesia; Anesthetics, Inhalation; Animals; Animals, Newborn; Cerebellum; Cerebral Cortex;

2002
Carcinogenicity of halothane in Swiss/ICR mice.
    Anesthesiology, 1979, Volume: 51, Issue:1

    Topics: Adenoma; Aging; Animals; Carcinoma, Hepatocellular; Erythrocyte Count; Female; Halothane; Hemoglobin

1979
[Pathophysiologic considerations on the problem of anesthesia in the aged].
    Zeitschrift fur arztliche Fortbildung, 1979, Oct-01, Volume: 73, Issue:19-20

    Topics: Adrenal Cortex; Adrenal Cortex Hormones; Aged; Aging; Anesthesia; Blood Pressure; Cardiovascular Sys

1979
Pancuronium requirements. With special reference to serum protein pattern.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:6

    Topics: Adult; Aged; Aging; Anesthesia; Blood Proteins; Body Weight; Female; Halothane; Humans; Male; Middle

1979
Age-dependent cardiovascular effects of halothane anesthesia in neonatal pigs.
    Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 214, Issue:2

    Topics: Aging; Anesthesia; Animals; Animals, Newborn; Blood Pressure; Halothane; Heart Rate; Hemodynamics; N

1975
Limitations of monastral blue as a vascular label: rapid rate of clearance is age-dependent, and interactions with anesthetics depress arterial blood pressure in rats.
    Microscopy research and technique, 1992, Nov-01, Volume: 23, Issue:3

    Topics: Aging; Anesthetics; Animals; Blood Pressure; Coloring Agents; Drug Interactions; Halothane; Indoles;

1992
Differential sensitivity to halothane anesthesia of the genioglossus, intercostals, and diaphragm in kittens.
    Anesthesia and analgesia, 1992, Volume: 74, Issue:3

    Topics: Aging; Animals; Carbon Dioxide; Cats; Depression, Chemical; Diaphragm; Dose-Response Relationship, D

1992
Age-dependent morphine partitioning between plasma and cerebrospinal fluid in monkeys.
    Developmental pharmacology and therapeutics, 1991, Volume: 17, Issue:3-4

    Topics: Aging; Animals; Animals, Newborn; Blood-Brain Barrier; Central Nervous System; Halothane; Infusions,

1991
Pharmacogenetics of caffeine and caffeine-halothane contractures in biopsies of human skeletal muscle.
    Pharmacogenetics, 1991, Volume: 1, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Caffeine; Child; Child, Preschool; Female; Genetic Variation; Haloth

1991
Halothane blocks low-voltage-activated calcium current in rat sensory neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1991, Volume: 11, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Calcium Channels; Evoked Potentials; Ganglia, Spinal; Halothane; I

1991
Dose-response for atropine and heart rate in infants and children anesthetized with halothane and nitrous oxide.
    Anesthesiology, 1991, Volume: 75, Issue:2

    Topics: Aging; Anesthesia, Inhalation; Atropine; Blood Pressure; Child; Child, Preschool; Dose-Response Rela

1991
Age affects the pharmacokinetics of inhaled anesthetics in humans.
    Anesthesia and analgesia, 1991, Volume: 73, Issue:3

    Topics: Adipose Tissue; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, Inhalation; Anesthetics; Body Wei

1991
Arterial washin of halothane and isoflurane in young and elderly adult patients.
    British journal of anaesthesia, 1991, Volume: 66, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthesia, Inhalation; Fema

1991
Developmental changes in effects of halothane and isoflurane on contractile properties of rabbit cardiac skinned fibers.
    Anesthesiology, 1990, Volume: 73, Issue:1

    Topics: Adenosine Triphosphatases; Aging; Animals; Animals, Newborn; Calcium; Embryonic and Fetal Developmen

1990
Pharmacokinetics and pharmacodynamics of atracurium in the elderly.
    Anesthesiology, 1990, Volume: 72, Issue:2

    Topics: Adult; Aged; Aging; Anesthesia, Inhalation; Atracurium; Halothane; Humans; Neuromuscular Junction; N

1990
[Aperiodic analysis of EEG in children during halothane anesthesia].
    Masui. The Japanese journal of anesthesiology, 1990, Volume: 39, Issue:3

    Topics: Aging; Anesthesia, Inhalation; Child; Child, Preschool; Electroencephalography; Female; Halothane; H

1990
Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics.
    Anesthesiology, 1990, Volume: 73, Issue:2

    Topics: Aging; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Cardiac Output; Drug Interactions

1990
Aging: effects on minimum alveolar concentration (MAC) for halothane in Fischer-344 rats.
    Anesthesia and analgesia, 1989, Volume: 68, Issue:3

    Topics: Aging; Animals; Body Temperature; Carbon Dioxide; Dose-Response Relationship, Drug; Halothane; Male;

1989
Maturational and anesthetic effects on apneic thresholds in lambs.
    Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 67, Issue:2

    Topics: Aging; Anesthesia; Animals; Carbon Dioxide; Halothane; Laryngeal Nerves; Respiration; Respiratory Ph

1989
Influence of anesthetic induction with halothane and isoflurane on internal carotid blood flow velocity in early infancy.
    Developmental pharmacology and therapeutics, 1989, Volume: 13, Issue:2-4

    Topics: Aging; Anesthesia; Blood Pressure; Carbon Dioxide; Carotid Arteries; Cerebrovascular Circulation; Fe

1989
Recovery from vecuronium neuromuscular blockade following neostigmine administration in infants, children, and adults during halothane anesthesia.
    Anesthesiology, 1989, Volume: 71, Issue:6

    Topics: Adult; Aged; Aging; Anesthesia, Inhalation; Child; Child, Preschool; Halothane; Humans; Infant; Midd

1989
Age and gender influence halothane-associated hepatotoxicity in strain 13 guinea pigs.
    Anesthesiology, 1989, Volume: 71, Issue:6

    Topics: Aging; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Female; Guinea Pigs;

1989
Comparison of the effects of halothane on skinned myocardial fibers from newborn and adult rabbit: II. Effects on sarcoplasmic reticulum.
    Anesthesiology, 1989, Volume: 71, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Halothane; Heart; In Vitro Techniques; Male; My

1989
Solubility of I-653, sevoflurane, isoflurane, and halothane in human tissues.
    Anesthesia and analgesia, 1989, Volume: 69, Issue:3

    Topics: Aged; Aging; Anesthetics; Chromatography, Gas; Desflurane; Ethers; Halothane; Humans; Isoflurane; Me

1989
Vecuronium kinetics and dynamics in anesthetized infants and children.
    Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:4

    Topics: Aging; Anesthesia; Child, Preschool; Female; Halothane; Humans; Infant; Infusions, Parenteral; Kinet

1985
The pharmacokinetics and clinical effects of a low dose of alfentanil in elderly patients.
    Acta anaesthesiologica Belgica, 1988, Volume: 39, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Alfentanil; Analgesics, Opioid; Anesthesia, Inhalation; Female; Fent

1988
Effects of phenobarbital on cerebral blood flow and metabolism in young and aged rats.
    Anesthesiology, 1986, Volume: 65, Issue:5

    Topics: Aging; Anesthesia, Inhalation; Animals; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circu

1986
Arterial blood PO2 and PCO2 in horses during early halothane-oxygen anaesthesia.
    Equine veterinary journal, 1987, Volume: 19, Issue:4

    Topics: Aging; Anesthesia, General; Animals; Blood Gas Analysis; Carbon Dioxide; Halothane; Horses; Oxygen

1987
Age, fiber type composition and in vitro contracture responses in human malignant hyperthermia.
    Acta anaesthesiologica Scandinavica, 1988, Volume: 32, Issue:2

    Topics: Adolescent; Adult; Aging; Caffeine; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia;

1988
Neurobehavioral effects of chronic halothane exposure during developmental and juvenile periods in the rat.
    Experimental neurology, 1987, Volume: 98, Issue:3

    Topics: Aging; Animals; Behavior, Animal; Female; Halothane; Hippocampus; Male; Pregnancy; Rats; Rats, Inbre

1987
Comparison of the effects of halothane on newborn and adult rabbit myocardium.
    Anesthesia and analgesia, 1987, Volume: 66, Issue:12

    Topics: Aging; Animals; Female; Halothane; In Vitro Techniques; Male; Myocardial Contraction; Rabbits

1987
The spread of caudal analgesia in children: a mathematical model.
    Anaesthesia and intensive care, 1986, Volume: 14, Issue:2

    Topics: Aging; Analgesia; Anesthesia, Caudal; Anesthesia, Epidural; Body Weight; Child; Child, Preschool; Ha

1986
Effect of age on the solubility of volatile anesthetics in human tissues.
    Anesthesiology, 1986, Volume: 65, Issue:3

    Topics: Adipose Tissue; Adult; Aged; Aging; Anesthesia, Inhalation; Brain; Enflurane; Halothane; Humans; Inf

1986
Analysis of respiratory patterns in the awake and in the halothane anaesthetised rat.
    Respiration physiology, 1985, Volume: 61, Issue:1

    Topics: Aging; Anesthesia, General; Animals; Carbon Dioxide; Consciousness; Female; Halothane; Rats; Rats, I

1985
Effect of temperature and age on the solubility of enflurane, halothane, isoflurane, and methoxyflurane in human blood.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:6

    Topics: Adult; Aged; Aging; Chromatography, Gas; Enflurane; Halothane; Humans; Isoflurane; Methoxyflurane; M

1985
Plasma and myocardial catecholamine levels in young and aged rats during halothane anesthesia.
    Neurobiology of aging, 1985,Summer, Volume: 6, Issue:2

    Topics: Aging; Anesthesia, General; Animals; Blood Pressure; Catecholamines; Halothane; Heart Rate; Myocardi

1985
Effects of halothane on synaptogenesis and learning behavior in rats.
    Experimental neurology, 1985, Volume: 89, Issue:3

    Topics: Aging; Animals; Behavior, Animal; Female; Halothane; Learning; Pregnancy; Prenatal Exposure Delayed

1985
Anesthesia for fractured hips. Innovar versus halothane.
    The Journal of the Kansas Medical Society, 1972, Volume: 73, Issue:12

    Topics: Adult; Aged; Aging; Benperidol; Drug Combinations; Female; Fentanyl; Fractures, Bone; Halothane; Hip

1972
The effects of decamethonium (C-10) on blood pressure and heart rate in newborn piglets.
    Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 208, Issue:1

    Topics: Acetylcholine; Aging; Anesthesia; Animals; Animals, Newborn; Blood Pressure; Carbon Dioxide; Decamet

1974
Postoperative hypoxemia: The contribution of age to the maldistribution of ventilation.
    Anesthesiology, 1972, Volume: 36, Issue:3

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aging; Anesthesia, General; Child; Female; Halothane

1972