halothane has been researched along with Acute Liver Injury, Drug-Induced in 891 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of severe bronchospasm in a one-year old mechanically ventilated girl which in spite of maximal conventional bronchodilatory treatment only responded to halothane inhalation is presented." | 7.69 | [Severe bronchospasm in a 1-year old child treated with halothane]. ( Hansen, TG; Lybecker, H; Pedersen, CM, 1994) |
| "Based on a case report the necessity of including halothane hepatitis in differential diagnosis of postoperative jaundice is described." | 7.68 | [Halothane hepatitis in the differential diagnosis of postoperative jaundice]. ( Gastmeier, K; Güthoff, W; Schiller, WG, 1990) |
| "Exposure of hyperthyroid rats to halothane results in a centrilobular necrosis of the liver and an 11-fold increase in serum glutamate-pyruvate transaminase (SGPT) levels." | 7.67 | Paradoxical effects of perturbation of intracellular levels of glutathione on halothane-induced hepatotoxicity in hyperthyroid rats. ( Berman, ML; Harbison, RD; James, RC; Smith, AC, 1984) |
| "Hypoxia, phenobarbital induction, and halothane anesthesia have been implicated in the pathogenesis of hepatotoxicity in the rat model." | 7.67 | Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes. ( Costa, AK; Heffel, DF; Schieble, TM; Trudell, JR, 1988) |
| "A series of experiments were conducted to examine the potential role of phase I metabolism in halothane-induced liver injury in the hyperthyroid rat." | 7.67 | Effects of piperonyl butoxide on halothane hepatotoxicity and metabolism in the hyperthyroid rat. ( Berman, LM; Harbison, RD; James, RC; Roberts, SM; Smith, AC, 1988) |
| "8% enflurane, or 1% halothane in 21% oxygen (air) for two hours resulted in hepatic centrilobular necrosis." | 7.66 | Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Holaday, DA; Kuhnert, L; Phythyon, JM, 1983) |
| "Factors affecting halothane (H) hepatotoxicity were investigated in two animal models: 1) the phenobarbital-hypoxia model, and 2) the triiodothyronine (T3) model; in the latter we previously have shown that centrilobular necrosis occurs in T3 pretreated rats anesthetized with 1% H, in 21% oxygen for 2 h." | 7.66 | Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications. ( Phythyon, JM; Uetrecht, J; Wood, AJ; Wood, M, 1983) |
| "Foci of necrosis have been observed in the liver of 50% of enzyme-induced rats treated with halothane." | 7.66 | Hepatic necrosis in rats following halothane administration: protective effect of diethyldithiocarbamate. ( Eade, OE; Lucas, K; Millward-Sadler, GH; Mitchell, J; Wright, R, 1980) |
| "Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0." | 7.66 | An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979) |
| "Liver necrosis and an increase of serum sorbitol dehydrogenase activity can be produced in rats by halothane anesthesia (1% v/v in oxygen) following pretreatment with polychlorinated biphenyls." | 7.66 | [Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)]. ( Krüger, R; Nastainczyk, W; Rendic, S; Ullrich, V, 1982) |
| "Administration of anesthetic doses of halothane to hyperthyroid male rats results in the development of hepatic necrosis." | 7.66 | Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity. ( Berman, ML; Harbison, RD; James, RC; Smith, AC, 1983) |
| "Halothane hepatotoxicity was observed after exposing hyperthyroid rats to 0." | 7.66 | Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model. ( Frühling, A; Siegers, CP; Younes, M, 1983) |
| "To evaluate the relative importance of halothane metabolism and liver hypoxia in the occurrence of hepatic injury, the injury produced in hypoxic rats exposed to identical MAC hours of halothane but at various concentrations of halothane was compared." | 7.66 | Hypoxia may be more important than reductive metabolism in halothane-induced hepatic injury. ( Eger, EI; Johnson, BH; Shingu, K, 1982) |
| "Hepatic centrilobular necrosis developed in rats pretreated with triiodothyronine (T3) and then anesthetized with halothane, 1 per cent, for two hours at an ambient oxygen concentration." | 7.66 | Halothane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Harbison, RD; Hoyle, P; Phythyon, JM; Wood, AJ; Wood, M, 1980) |
| "The time interval since previous anaesthesia was compared in a surgical population in South Wales and in patients who developed jaundice after halothane." | 7.65 | Post-halothane jaundice in relation to previous administration of halothane. ( Jones, EV; Mushin, WW; Rosen, M, 1971) |
| "The liver of all rats given halothane (14% O(2)) had extensive centrilobular necrosis and denaturation." | 3.73 | Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats. ( Li, Q; Liu, ZQ; Yang, LQ; Yu, WF; Zhou, MT, 2005) |
| "Halothane as a cause of hepatitis is rare and may be overlooked when evaluating a patient with sudden onset jaundice." | 3.72 | Halothane induced hepatitis: case report. ( Otedo, AE, 2004) |
| "A case of severe bronchospasm in a one-year old mechanically ventilated girl which in spite of maximal conventional bronchodilatory treatment only responded to halothane inhalation is presented." | 3.69 | [Severe bronchospasm in a 1-year old child treated with halothane]. ( Hansen, TG; Lybecker, H; Pedersen, CM, 1994) |
| "Based on a case report the necessity of including halothane hepatitis in differential diagnosis of postoperative jaundice is described." | 3.68 | [Halothane hepatitis in the differential diagnosis of postoperative jaundice]. ( Gastmeier, K; Güthoff, W; Schiller, WG, 1990) |
| "In vivo covalent binding of halothane biotransformation-reactive intermediates to hepatic protein and lipid was examined in association with the subsequent development of hepatic necrosis in the guinea pig." | 3.68 | Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs. ( Gandolfi, AJ; Hall, PD; Lind, RC, 1990) |
| "A 70-year-old woman developed fever accompanied by impairment of liver function and eosinophilia after 2 courses of halothane anaesthesia given within a few days." | 3.68 | [Liver damage after exposure to halothane]. ( Halevy, A; Orda, R; Roznak, D, 1990) |
| "Exposure of hyperthyroid rats to halothane results in a centrilobular necrosis of the liver and an 11-fold increase in serum glutamate-pyruvate transaminase (SGPT) levels." | 3.67 | Paradoxical effects of perturbation of intracellular levels of glutathione on halothane-induced hepatotoxicity in hyperthyroid rats. ( Berman, ML; Harbison, RD; James, RC; Smith, AC, 1984) |
| "Hypoxia, phenobarbital induction, and halothane anesthesia have been implicated in the pathogenesis of hepatotoxicity in the rat model." | 3.67 | Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes. ( Costa, AK; Heffel, DF; Schieble, TM; Trudell, JR, 1988) |
| "A series of experiments were conducted to examine the potential role of phase I metabolism in halothane-induced liver injury in the hyperthyroid rat." | 3.67 | Effects of piperonyl butoxide on halothane hepatotoxicity and metabolism in the hyperthyroid rat. ( Berman, LM; Harbison, RD; James, RC; Roberts, SM; Smith, AC, 1988) |
| " Prompt resolution of her jaundice followed the initiation of methionine therapy." | 3.67 | Halothane hepatitis and prompt resolution with methionine therapy: case report. ( Windsor, JA; Wynne-Jones, G, 1988) |
| "A rat model of enflurane-associated hepatotoxicity was compared with the halothane-hypoxia (HH) model (adult male rats, phenobarbital induction, 1% halothane, 14% O2, for 2 hr)." | 3.67 | Comparison of the requirements for hepatic injury with halothane and enflurane in rats. ( Brown, BR; Gandolfi, AJ; Lind, RC; Sipes, IG, 1985) |
| "A report is given on a 24 year old nurse, who developed two episodes of fever, chills and malaise with high serum enzyme levels and histologic proof of extensive centrolobular hepatic necrosis in association with vocational halothane exposure in the operating theatre." | 3.67 | [Centrolobular liver cell necroses following occupational halothane contact. Association with antibodies to halothane altered liver cell components]. ( Börsch, G; Müller, KM; Neuberger, J; Ricken, D; Schmidt, G, 1985) |
| "Hepatic centrilobular necrosis developed in rats pretreated with triiodothyronine (T3) and then anesthetized with halothane, 1 per cent, for two hours at an ambient oxygen concentration." | 3.66 | Halothane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Harbison, RD; Hoyle, P; Phythyon, JM; Wood, AJ; Wood, M, 1980) |
| "The aetiology of massive liver-cell necrosis which developed in 16 patients following halothane anaesthesia was investigated by means of new serological techniques." | 3.66 | Specific serological markers in the diagnosis of fulminant hepatic failure associated with halothane anaesthesia. ( Davis, M; Gimson, AE; Neuberger, J; Williams, R, 1983) |
| "Foci of necrosis have been observed in the liver of 50% of enzyme-induced rats treated with halothane." | 3.66 | Hepatic necrosis in rats following halothane administration: protective effect of diethyldithiocarbamate. ( Eade, OE; Lucas, K; Millward-Sadler, GH; Mitchell, J; Wright, R, 1980) |
| "Halothane hepatotoxicity was observed after exposing hyperthyroid rats to 0." | 3.66 | Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model. ( Frühling, A; Siegers, CP; Younes, M, 1983) |
| "Administration of anesthetic doses of halothane to hyperthyroid male rats results in the development of hepatic necrosis." | 3.66 | Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity. ( Berman, ML; Harbison, RD; James, RC; Smith, AC, 1983) |
| "Factors affecting halothane (H) hepatotoxicity were investigated in two animal models: 1) the phenobarbital-hypoxia model, and 2) the triiodothyronine (T3) model; in the latter we previously have shown that centrilobular necrosis occurs in T3 pretreated rats anesthetized with 1% H, in 21% oxygen for 2 h." | 3.66 | Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications. ( Phythyon, JM; Uetrecht, J; Wood, AJ; Wood, M, 1983) |
| "For over a decade there has been concern about hepatitis related to halothane anesthesia." | 3.66 | Changes in liver enzyme values after halothane and enflurane for surgical anesthesia. ( Friday, CD; Thompson, DS, 1978) |
| "A case of halothane hepatitis occurring 14 months after jejunoileal bypass for morbid obesity in a 49-year-old woman is described." | 3.66 | Halothane hepatitis after jejunoileal bypass. ( Hüttel, MS, 1979) |
| "To evaluate the importance of hypoxia itself on halothane-induced hepatic injury in the rat, the question of whether hypoxia could injure the liver without causing death was investigated." | 3.66 | Hypoxia per se can produce hepatic damage without death in rats. ( Eger, EI; Johnson, BH; Shingu, K, 1982) |
| "Liver necrosis and an increase of serum sorbitol dehydrogenase activity can be produced in rats by halothane anesthesia (1% v/v in oxygen) following pretreatment with polychlorinated biphenyls." | 3.66 | [Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)]. ( Krüger, R; Nastainczyk, W; Rendic, S; Ullrich, V, 1982) |
| "To evaluate the relative importance of halothane metabolism and liver hypoxia in the occurrence of hepatic injury, the injury produced in hypoxic rats exposed to identical MAC hours of halothane but at various concentrations of halothane was compared." | 3.66 | Hypoxia may be more important than reductive metabolism in halothane-induced hepatic injury. ( Eger, EI; Johnson, BH; Shingu, K, 1982) |
| "8% enflurane, or 1% halothane in 21% oxygen (air) for two hours resulted in hepatic centrilobular necrosis." | 3.66 | Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Holaday, DA; Kuhnert, L; Phythyon, JM, 1983) |
| "Hepatic injury was measured in enzyme-induced rats following ligation of the hepatic artery performed under anesthesia with thiamylal, halothane, enflurane, or isoflurane." | 3.66 | Postanesthetic hepatic injury in rats: influence of alterations in hepatic blood flow, surgery, and anesthesia time. ( Biava, CG; Collins, P; Eger, EI; Harper, MH; Johnson, BH, 1982) |
| "Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0." | 3.66 | An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979) |
| " Halothane hepatotoxic was produced in all rat strains by exposing phenobarbital-pretreated rats to 1 per cent halothane under mild hypoxia (14 per cent oxygen, inspired) for 2 h." | 3.66 | Genetic differences in reductive metabolism and hepatotoxicity of halothane in three rat strains. ( Adams, JF; Cousins, MJ; Gourlay, GK; Hall, P, 1981) |
| "Hepatic necrosis was induced in rats by a single exposure to 1 per cent halothane in oxygen following pretreatment with a single dose of Aroclor 1254, a polychlorinated biphenyl." | 3.65 | An animal model of hepatotoxicity associated with halothane anesthesia. ( Brown, BR; Sipes, IG, 1976) |
| "The authors report a case of postoperative jaundice occurring within 30 days in a patient anesthetized three times with halothane." | 3.65 | [Allergic characteristics of halothane hepatitis. Apropos of a case report]. ( Cavellat, M; Delhumeau, A; Emeriaud, JP; L'Hoste, F, 1976) |
| "After long-term exhibition to halothane (up to 96 hours), centrolobular hepatic damage (fatty degeneration, necrobiosis and necrosis) developed in rats, proportionally to the number of anesthesias and shortening of the intervals." | 3.65 | [Liver-damaging action of halothane--an animal experiment study]. ( Barz, H; Wolf, R, 1975) |
| "Extensive infarction of the liver, initially thought to be halothane hepatitis, is described." | 3.65 | Spontaneous hepatic artery thrombosis with infarction of the liver. ( Balint, JA; Buhac, I; OConnor, PJ, 1976) |
| "Eight pregnant Sprague-Dawley rates were exposed to 10 ppm halothane 8 hours/day and 5 days/week throughout pregnancy." | 3.65 | Ultrastructural evidence of the hepatotoxic effect of halothane in rats following in-utero exposure. ( Chang, LW; Dudley, AW; Katz, J; Lee, YK, 1975) |
| "As an index of delayed hypersensitivity in vitro halothane macrophage migration inhibition factor tests (halothane-MIF tests) were performed on peripheral blood lymphocytes from five patients with halothane hepatitis." | 3.65 | Halothane macrophage migration inhibtiion factor test in halothane-associated hepatitis. ( Gibbs, AR; Price, CD; Williams, WJ, 1977) |
| "142 patients with postoperative jaundice following anaesthesia with halothane were divided into two groups:-group A (76 cases) in which halothane appeared to be the sole responsible agent for jaundice, and- group B (66 cases) in which other causes were detected." | 3.65 | [Relevance of clinical signs of hypersensitivity in cases of halothane hepatitis]. ( Walton, B, 1976) |
| "The time interval since previous anaesthesia was compared in a surgical population in South Wales and in patients who developed jaundice after halothane." | 3.65 | Post-halothane jaundice in relation to previous administration of halothane. ( Jones, EV; Mushin, WW; Rosen, M, 1971) |
| "The volatile inhalation anaesthetics have been implicated in a variety of adverse viscerotoxic reactions." | 2.37 | Adverse effects of volatile anaesthetics. ( Brown, BR; Gandolfi, AJ, 1987) |
| "The otherwise safe and useful anaesthetic halothane has been suspected of producing the occasional complication of hepatic necrosis, ascribed either to a drug allergy or to biotransformation to reactive intermediates." | 2.36 | Halogenated analgesics and hepatotoxicity. ( Brown, BR, 1981) |
| "Most adverse drug reactions affecting the liver and producing jaundice are unpredictable, delayed in onset, and only hypothetically related to microsomal metabolism in some instances." | 2.35 | Hepatic drug metabolism and adverse hepatic drug reactions. ( Schaffner, F, 1975) |
| "In halothane-treated females, plasma concentration of tumor necrosis factor-alpha was greater than in males, and neutrophils were recruited to liver more rapidly and to a greater extent." | 1.36 | A mouse model of severe halothane hepatitis based on human risk factors. ( Dugan, CM; Ganey, PE; MacDonald, AE; Roth, RA, 2010) |
| "The study concludes that zinc has the potential to alleviate the toxic effects of halothane in rat liver." | 1.35 | Protective role of zinc pretreatment in hepatotoxicity induced by halothane. ( Celik, JB; Esen, H; Otelcioglu, S; Toy, H; Unsal, C, 2008) |
| "A rare case of halothane-induced fulminant hepatic failure is reported in a 22 years old male, who developed fever, jaundice, coma and deranged coagulation profile, 2 days after undergoing laparotomy under halothane anaesthesia." | 1.34 | Halothane induced fulminant hepatic failure. ( Hussain, T; Qureshi, MA; Saeed, F, 2007) |
| "Propofol treatment, by inhibiting the NF-kappaB signal transduction pathway, might block the production of noxious mediators involved in the development of halothane-induced injury." | 1.33 | Halothane induces oxidative stress and NF-kappaB activation in rat liver: protective effect of propofol. ( Amaral, JL; Brasil, LJ; González-Gallego, J; Kretzmann, NA; Marroni, N; San-Miguel, B; Tuñón, MJ; Zettler, CG, 2006) |
| "Halothane (Fluothane) is a halogenic volatile anaesthetic used in therapeutic since 1956." | 1.32 | [Halothane-induced hepatitis. 8 case reports]. ( Belkahia, C; Daghfous, M; Daghfous, R; el Aïdli, S; Kastalli, S; Loueslati, MH; Sfaxi, M; Sraïri, S, 2003) |
| " Catechin suppresses lipid peroxidation and increases enzyme activity, therefore it seems to be capable of protecting liver parenchyma against the direct toxic effect of halothane." | 1.31 | Hepatobiliary scintigraphy for evaluating the hepatotoxic effect of halothane and the protective effect of catechin in comparison with histo-chemical analysis of liver tissue. ( Ciftçi, S; Karamanlioğlu, B; Salihoğlu, YS; Temiz, E; Yüksel, M, 2002) |
| "The chloroform-treated rats also developed renal tubular necrosis with large increases in plasma creatinine and urea nitrogen, which were completely ameliorated by DMSO." | 1.30 | Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney. ( Gandolfi, AJ; Lind, RC, 1997) |
| "Once halothane hepatitis has developed, there are no specific treatments and liver replacement may be required." | 1.30 | Halothane hepatitis. ( Neuberger, J, 1998) |
| "Halothane antibodies were negative." | 1.28 | Halothane hepatitis in children. ( Gunasekaran, T; Hassall, E; Israel, DM; Steward, D, 1990) |
| "Isoniazid (INH) is a selective inducer of cytochrome P-450 isozymes that are involved in the biotransformation of organohalogen anesthetics." | 1.28 | Isoniazid potentiation of a guinea pig model of halothane-associated hepatotoxicity. ( Gandolfi, AJ; Hall, PM; Lind, RC, 1990) |
| "Halothane was used on at least five occasions." | 1.28 | Halothane hepatitis: a case report. ( Speedy, H, 1990) |
| "When halothane hepatitis has occurred, treatment is purely supportive with the possibility of transplantation for those in grade IV encephalopathy." | 1.27 | Halothane hepatitis. ( Neuberger, J; Williams, R, 1988) |
| "Isoflurane anesthesia was given for the placement of a catheter into the femoral artery." | 1.27 | Effects of halothane, isoflurane, enflurane, thiopental, and fentanyl on blood gas values in rats exposed to hypoxia. ( Eger, EI; Johnson, BH; Lurz, FW; Shingu, K; Taber, V, 1983) |
| " Furthermore, (+)-catechin seems capable of protecting against the direct toxic effect of halothane metabolites resulting from the reductive pathways." | 1.27 | Halothane hepatotoxicity in glutathione depleted rats. ( Sellin, D; Siegers, CP; Wilhelm, KP; Younes, M, 1987) |
| "Halothane antibodies were detected in 12 of the 16 (75%) patients with hepatic encephalopathy and 16 of the 23 (70%) who did not develop encephalopathy, demonstrating that halothane antibodies are detectable in a wider spectrum of halothane-associated liver damage than previously appreciated." | 1.27 | Specific antibodies to halothane-induced liver antigens in halothane-associated hepatitis. ( Kenna, JG; Neuberger, J; Williams, R, 1987) |
| "Acetaminophen (Tylenol) is a widely used analgesic/antipyretic drug which is enzymatically bioactivated, or toxified, by the cytochromes P-450 to a hepatotoxic reactive intermediary metabolite." | 1.27 | Delayed enhancement of acetaminophen hepatotoxicity by general anesthesia using diethyl ether or halothane. ( Ku, MS; Ramji, P; Wells, PG, 1986) |
| " The LD50 (30 day) for cyclophosphamide without halothane was 251 mg/kg; with 2 h subsequent exposure to halothane it was 152 mg/kg; and with 20 h subsequent exposure to halothane it was 158 mg/kg." | 1.27 | Increased toxicity of the antitumor drug cyclophosphamide in mice in the presence of the volatile anesthetic agent halothane. ( Kooistra, KL; Powis, G; Rosenow, S; Van Dyke, RA, 1986) |
| ""Enflurane hepatitis" has only recently been accepted as a disease entity." | 1.27 | Enflurane hepatitis. A report of a case with a previous history of halothane hepatitis. ( Hreidarsson, AB; Sigurdsson, J; Thjodleifsson, B, 1985) |
| "A 12 year old boy with Burkitt's lymphoma developed severe hepatitis with hepatomegaly, subclinical jaundice, and a small rise in body temperature, associated with an important rise in SGPT and fall in prothrombin titres, 6 days after anticancer chemotherapy and 24 hours after halothane anaesthesia." | 1.27 | [Post-anesthetic hepatitis. The role of halothane and antimitotic combinations]. ( Cottier, M; Freycon, F; Gounot, R; Métafiot, H; Ollagnier, M; Perret-Poulat, H; Pouyau, G, 1984) |
| "Hepatic necrosis was also seen after halothane anesthesia even at ambient oxygen concentrations, although the degree of necrosis was much milder." | 1.27 | Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis. ( Ebihara, Y; Ishii, H; Kato, S; Nagata, S; Okuno, F; Takagi, T; Takahashi, H; Tashiro, M; Tsuchiya, M; Yamauchi, H, 1983) |
| "Halothane hepatitis has been a matter of continuing controversy, but now it seems to be generally accepted as a clinical entity." | 1.26 | Halothane hepatitis. ( Ranek, L, 1978) |
| "A case of acute renal failure associated with halothane-induced hepatitis is reported which responded to treatment." | 1.26 | A case of acute reversible renal failure associated with halothane induced liver disease. ( Auffray, JP; Casanova, P; De Belsunce, M; Henry, JF; Kessali, V; Murisasco, A; Saingra, S, 1981) |
| "During the decade 1968-1978 the Danish Board of Adverse Reactions to Drugs received 572 (6% of the total number) reports on hepatotoxicity." | 1.26 | Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish Board of Adverse Reactions to Drugs. ( Andreasen, PB; Døssing, M, 1982) |
| "3." | 1.25 | Exchange transfusion in hepatic coma: factors affecting results, with long-term follow-up data. ( Darin, JC; Hussey, CV; Lewis, JD; Varma, RR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 743 (83.39) | 18.7374 |
| 1990's | 106 (11.90) | 18.2507 |
| 2000's | 22 (2.47) | 29.6817 |
| 2010's | 18 (2.02) | 24.3611 |
| 2020's | 2 (0.22) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Liu, Z | 2 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Guo, C | 1 |
| Liu, W | 1 |
| Cai, J | 1 |
| Yu, X | 1 |
| Wang, H | 1 |
| Li, X | 1 |
| Zuo, D | 1 |
| Jiang, X | 1 |
| Zhang, B | 1 |
| Liu, J | 1 |
| Sanyal, AJ | 1 |
| Puri, P | 1 |
| Zhou, H | 1 |
| Wang, XY | 1 |
| Mizobe, T | 1 |
| Bakhshaei, MH | 1 |
| Bahrami, A | 1 |
| Mirzakhani, A | 1 |
| Mahjub, H | 1 |
| Assari, MJ | 1 |
| Endo, S | 2 |
| Yano, A | 1 |
| Fukami, T | 3 |
| Nakajima, M | 3 |
| Yokoi, T | 4 |
| Proctor, WR | 3 |
| Chakraborty, M | 3 |
| Fullerton, AM | 3 |
| Korrapati, MC | 1 |
| Ryan, PM | 2 |
| Semple, K | 3 |
| Morrison, JC | 2 |
| Berkson, JD | 3 |
| Chea, LS | 3 |
| Yang, Q | 1 |
| Li, AP | 1 |
| Spolski, R | 1 |
| West, EE | 1 |
| Rochman, Y | 1 |
| Leonard, WJ | 1 |
| Bourdi, M | 5 |
| Pohl, LR | 20 |
| Kurth, MJ | 1 |
| Gershwin, ME | 1 |
| Kleiner, DE | 1 |
| Zeng, X | 1 |
| Dagur, PK | 1 |
| Reilly, TP | 3 |
| Uetrecht, J | 2 |
| Kaplowitz, N | 2 |
| Unsal, C | 1 |
| Celik, JB | 1 |
| Toy, H | 1 |
| Esen, H | 1 |
| Otelcioglu, S | 1 |
| Eghtesadi-Araghi, P | 1 |
| Sohrabpour, A | 1 |
| Vahedi, H | 1 |
| Saberi-Firoozi, M | 1 |
| Antoine, DJ | 2 |
| Williams, DP | 1 |
| Park, BK | 3 |
| Beştaş, A | 1 |
| Kahramanoglu, M | 1 |
| Erhan, OL | 1 |
| Bolat, E | 1 |
| Ozercan, I | 1 |
| Gürsu, F | 1 |
| Gülcü, F | 1 |
| Cheng, L | 4 |
| You, Q | 4 |
| Yin, H | 2 |
| Holt, M | 1 |
| Franklin, C | 1 |
| Ju, C | 4 |
| Altwegg, R | 1 |
| Karamanakos, PN | 1 |
| Kobayashi, E | 1 |
| Kobayashi, M | 1 |
| Tsuneyama, K | 2 |
| Dugan, CM | 2 |
| MacDonald, AE | 1 |
| Roth, RA | 2 |
| Ganey, PE | 2 |
| Holt, MP | 1 |
| Laverty, HG | 1 |
| Benson, C | 1 |
| Chaponda, M | 1 |
| Williams, D | 1 |
| Kevin Park, B | 1 |
| Hunt, CM | 1 |
| Toyoda, Y | 1 |
| Miyashita, T | 1 |
| Abenavoli, L | 1 |
| Libri, E | 1 |
| Bosco, D | 1 |
| Gallo, D | 1 |
| Luzza, F | 1 |
| Mahboobi, N | 1 |
| Esmaeili, S | 1 |
| Safari, S | 1 |
| Habibollahi, P | 1 |
| Dabbagh, A | 1 |
| Alavian, SM | 1 |
| Bortolato, S | 1 |
| Zanovello, A | 1 |
| Rugge, M | 1 |
| Brotto, M | 1 |
| Marini, S | 1 |
| Gervasi, PG | 1 |
| Manno, M | 2 |
| Oropeza-Hernández, LF | 1 |
| Quintanilla-Vega, B | 1 |
| Reyes-Mejía, RA | 1 |
| Serrano, CJ | 1 |
| García-Latorre, EA | 1 |
| Dekant, W | 1 |
| Albores, A | 1 |
| HARRIGAN, WF | 1 |
| GOLDBERG, MH | 1 |
| HEIDENBERG, WJ | 2 |
| TORIO, I | 1 |
| TORIO, IS | 1 |
| CEBULA, J | 1 |
| TORNETTA, FJ | 1 |
| TAMAKI, HT | 1 |
| CHAMBERLAIN, G | 1 |
| KERBEL, NC | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 13C-Methacetin Breath Test for the Prediction of Outcome in in Acute Liver Injury or Acute Liver Failure[NCT02786836] | Phase 2/Phase 3 | 76 participants (Actual) | Interventional | 2016-06-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The relationship between the cPDR (cumulative PDR of metabolized 13C-Methacetin 20 minutes after ingestion) in single time points of MBT measurements and TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT/transplant free survival at Day 21 | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 1.4 | 0.2 |
Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 (normal carbon dioxide) ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS (transplant free survival) and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: Days 1 and 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Mean Peak PDR for TFS subjects at Day 21 | Mean Peak PDR for non-TFS subjects at Day 21 | |
| 13C-Methacetin Breath Test (MBT) | 10.2 | 1.9 |
This outcome is similar to the peak PDR defined in the primary outcome but as a secondary we are looking at Day 1 or Day 2 peak PDR values. Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT & Day 21 TFS | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 9.1 | 2.3 |
124 reviews available for halothane and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Animals; Biotransformation; Chemic | 2008 |
The potential of cytokines as safety biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Anesthetics, Inhalation; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; | 2010 |
Mitochondrial and immunoallergic injury increase risk of positive drug rechallenge after drug-induced liver injury: a systematic review.
Topics: Amoxicillin-Potassium Clavulanate Combination; Antitubercular Agents; Azathioprine; Chemical and Dru | 2010 |
[Drug-induced liver injury].
Topics: Acetaminophen; Algorithms; Amoxicillin; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Anti-Bact | 2012 |
Halothane: how should it be used in a developing country?
Topics: Anesthetics, Inhalation; Attitude of Health Personnel; Chemical and Drug Induced Liver Injury; Costs | 2012 |
[HALOTHANE AND THE LIVER].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Toxicology | 1964 |
[APROPOS OF LIVER DAMAGE BY HALOTHANE. SURVEY OF THE LITERATURE AND PERSONAL INVESTIGATIONS].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Geriatrics; Halothane; Hepatitis; Liver Diseases | 1964 |
Problems of multiple inhalation anaesthetics.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; gamma-Glutamyl | 1981 |
Halogenated hydrocarbon environmental pollution: the special case of halogenated anesthetics.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Ethers; Halothane; Health Occupations; Humans; | 1982 |
Drug induced liver disease.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis | 1983 |
Halothane hepatitis and the anaesthesiologist.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Hu | 1984 |
Reactive metabolites as a cause of hepatotoxicity.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Drug-Related Side | 1983 |
[Halothane hepatitis].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Critical Care; Diagnosis, Dif | 1984 |
Halothane anaesthesia and liver damage.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Anesthetics; Animals; Antibody Formation; Cell Memb | 1984 |
[Halothane hepatitis].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Prospective Studi | 1982 |
Halothane hepatitis: what's new?
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug Interactions; Halothane | 1980 |
Drug-related acute and chronic hepatitis.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypersen | 1980 |
[The physical health of personnel exposed to halothane in operating rooms].
Topics: Anesthesiology; Chemical and Drug Induced Liver Injury; Halothane; Heart Diseases; Humans; Kidney Di | 1980 |
Self-assessment questions true or false?
Topics: Adolescent; Aged; Anesthesia; Anesthesia, Inhalation; Anesthesiology; Anesthetics; Anesthetics, Loca | 1980 |
["Hepatitis" following halothane-anesthesia (author's transl)].
Topics: Adult; Aged; Anesthesia, General; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; D | 1981 |
Halogenated analgesics and hepatotoxicity.
Topics: Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Halothane; Humans; | 1981 |
Drug-induced liver disease.
Topics: Analgesics; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contracep | 1981 |
Anaesthetic gases and health risks to laboratory personnel: a review.
Topics: Abnormalities, Drug-Induced; Anesthesia, Inhalation; Anesthetics; Animals; Chemical and Drug Induced | 1981 |
The organ toxicity of inhaled anesthetics.
Topics: Anesthetics, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Disease Models | 1995 |
Molecular basis of drug-induced immunological liver injury.
Topics: Animals; Antibody Formation; Anticonvulsants; Chemical and Drug Induced Liver Injury; Dihydralazine; | 1995 |
Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens.
Topics: Autoantigens; Chemical and Drug Induced Liver Injury; Cross Reactions; Halothane; Humans; Liver Cirr | 1995 |
The use of volatile agents in southern Africa.
Topics: Chemical and Drug Induced Liver Injury; Drug Costs; Enflurane; Halothane; Humans; Incidence; Informe | 1994 |
Inhalation anaesthetics and liver damage.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Isoflu | 1993 |
[Halothane hepatitis].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver | 1993 |
Mechanisms of halothane toxicity: novel insights.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1993 |
Hepatotoxicity of volatile anaesthetics.
Topics: Anesthetics; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Hepa | 1993 |
[Chemical hepatitis (halothane, toluene)].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Toluene | 1995 |
[Drug induced liver injury].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1995 |
Hepatitis, rash and eosinophilia following trichloroethylene exposure: a case report and speculation on mechanistic similarity to halothane induced hepatitis.
Topics: Adult; Alanine Transaminase; Anesthetics, Inhalation; Aspartate Aminotransferases; Chemical and Drug | 1996 |
Paediatric anaesthesia.
Topics: Anesthesia; Anesthesia, Local; Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Ethe | 1997 |
Hepatic injury associated with halogenated anaesthetics: cross-sensitization and its clinical implications.
Topics: Anesthetics, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver | 1997 |
Selective protein covalent binding and target organ toxicity.
Topics: Acetaminophen; Animals; Binding, Competitive; Chemical and Drug Induced Liver Injury; Halothane; Hex | 1997 |
Immunoallergic drug-induced hepatitis: lessons from halothane.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Lympho | 1997 |
Immunotoxicology of the liver: adverse reactions to drugs.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dihydralazine; Drug Hypersensitivity; Halothane; Hu | 1997 |
[Neurotoxicity of inhalation anesthetics, halothane].
Topics: Anesthetics, Inhalation; Animals; Central Nervous System; Chemical and Drug Induced Liver Injury; Ha | 1999 |
[Metabolism and toxicity of anesthetics].
Topics: Anesthetics, Inhalation; Carbon Monoxide Poisoning; Chemical and Drug Induced Liver Injury; Enfluran | 1999 |
Toxicity of inhalation anaesthetic agents.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersens | 1978 |
Fate of fluorinated metabolites of inhalation anesthetics in man.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Inj | 1979 |
Hepatic drug metabolism and adverse hepatic drug reactions.
Topics: Adaptation, Biological; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poiso | 1975 |
[Hepatitis-like liver disorders caused by infections, poisoning and drugs].
Topics: Alcoholism; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cytomegalovirus Infection | 1976 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
Anesthesia and the liver.
Topics: Adolescent; Adult; Aged; Anesthetics; Chemical and Drug Induced Liver Injury; Female; Halothane; Hum | 1977 |
Drug-induced chronic liver disease.
Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Halothane; Humans; Indoles; Isoniazid; Meth | 1977 |
[Halothane hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1977 |
Biotransformation and hepatotoxicity of halothane.
Topics: Anesthesia; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chemical Phenomena; | 1977 |
Absorption, biotransformation, and storage of halothane.
Topics: Anesthesia, Inhalation; Animals; Biotransformation; Body Fluids; Chemical and Drug Induced Liver Inj | 1977 |
Hepatotoxicity: pathogenesis and therapeutic intervention.
Topics: Acetaminophen; Anabolic Agents; Androgens; Animals; Chemical and Drug Induced Liver Injury; Cysteami | 1979 |
Biochemical and morphological study of the liver injury induced by drugs and chemicals.
Topics: Alkaline Phosphatase; Aspirin; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Halothan | 1979 |
Drug-induced chronic hepatitis and cirrhosis.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adve | 1979 |
Halothane and the liver: coming of age?
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Humans; Liver Diseases; | 1976 |
Acute liver injury.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hepati | 1975 |
Pathologic effects of chronic halothane inhalation: an overview.
Topics: Anesthesia, Inhalation; Animals; Brain; Brain Diseases; Chemical and Drug Induced Liver Injury; Envi | 1976 |
[Anesthesiologists and the environment in the operation room].
Topics: Abortion, Spontaneous; Air Microbiology; Air Pollution; Anesthesiology; Anesthetics; Arrhythmias, Ca | 1975 |
Anaesthesia-related liver disease.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Incidenc | 1992 |
Halothane hepatitis.
Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Haloth | 1991 |
[Halogenated anesthetic agents and the liver].
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Halothane; Hum | 1991 |
The molecular basis of halothane-induced hepatitis.
Topics: Adult; Animals; Antigens; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Child; Female | 1991 |
Hapten carrier conjugates associated with halothane hepatitis.
Topics: Animals; Carrier Proteins; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; | 1991 |
Drug-induced allergic hepatitis.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Hepa | 1990 |
Risk factors for halothane hepatitis.
Topics: Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Risk Factors | 1989 |
Is halothane obsolete? Two standards of judgement.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1989 |
Neoantigens associated with halothane hepatitis.
Topics: Animals; Antigens; Carrier Proteins; Chemical and Drug Induced Liver Injury; Halothane; Humans; Trif | 1989 |
Halothane and liver damage.
Topics: Adult; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver Diseases; Male; Middle Aged; | 1989 |
[Effects of halogenated anesthetic agents on the liver].
Topics: Animals; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Liver; Rats | 1989 |
[Poisoning caused by chronic exposure to volatile anesthetics. Molecular mechanisms and risk anesthetics].
Topics: Air Pollutants, Occupational; Biodegradation, Environmental; Bromides; Chemical and Drug Induced Liv | 1989 |
Halothane hepatitis in children.
Topics: Adolescent; Anesthesia, Inhalation; Antibodies; Chemical and Drug Induced Liver Injury; Child; Child | 1987 |
Mechanism of halothane-induced hepatotoxicity: another step on a long path.
Topics: Animals; Chemical and Drug Induced Liver Injury; Guinea Pigs; Halothane; Humans; Mice; Rats | 1988 |
[Halothane hepatotoxicity and hepatic circulation].
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver Circulation | 1988 |
[30 years of halothane--30 years of halothane hepatitis].
Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Child; Female; Halothane; Humans | 1987 |
[Is halothane obsolete?].
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Guinea Pigs; Halothane; Hum | 1987 |
Immunology of drug and alcohol-induced liver disease.
Topics: Acute Disease; Animals; Antibody Formation; Chemical and Drug Induced Liver Injury; Chronic Disease; | 1987 |
Perspectives in the pathogenesis of halothane-induced hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Hypoxia; Rats | 1986 |
Halothane hepatitis: a model of immune mediated drug hepatotoxicity.
Topics: Adolescent; Animals; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Child; Child, Pres | 1987 |
Adverse effects of volatile anaesthetics.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Inj | 1987 |
Unexplained hepatitis following halothane.
Topics: Adult; Age Factors; Anesthesia, General; Animals; Biotransformation; Chemical and Drug Induced Liver | 1985 |
[Etiology of hepatic injuries and sensitivity of the liver].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Inactivation, Met | 1985 |
[Drug hypersensitivity and the etiology of toxic hepatitis].
Topics: Carrier Proteins; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Haptens; | 1985 |
[Toxic hepatitis induced by contrast media or anesthetics in Japan].
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Contrast Media; Enflurane; Halothane; Humans; I | 1985 |
[Prevention and therapy of severe toxic hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Halothane; Humans; Isoniazid; Methyldopa; Pe | 1985 |
Drugs and the ageing liver.
Topics: Aged; Aging; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syst | 1985 |
[Drug damage to the liver: role of reactive metabolites and pharmacokinetics].
Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adv | 1985 |
[Possibilities of liver damage by foreign substances].
Topics: Aminopyrine; Animals; Antimetabolites; Carcinogens; Chemical and Drug Induced Liver Injury; Chemical | 1985 |
Metabolism of volatile anaesthetics.
Topics: Adipose Tissue; Anesthetics; Animals; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induc | 1972 |
Halothane hepatitis. Current concepts.
Topics: Anesthesia, General; Animals; B-Lymphocytes; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1974 |
[Anesthesia in liver, gallbladder and biliary tract surgery].
Topics: Analgesia; Anesthesia; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Spinal; Biliary Tract | 1974 |
Drug-induced immunological effects on the liver.
Topics: Aminosalicylic Acids; Anaphylaxis; Chemical and Drug Induced Liver Injury; Chlorpromazine; Drug Erup | 1972 |
Halothane and the liver: a review of the epidemiologic, immunologic and metabolic aspects of the relationship.
Topics: Anesthesia, Inhalation; Antidotes; Chemical and Drug Induced Liver Injury; Cyclopropanes; Eosinophil | 1972 |
Advances in medicine.
Topics: Anemia, Macrocytic; Anti-Arrhythmia Agents; Anticoagulants; Azathioprine; Chemical and Drug Induced | 1972 |
Halothane in Britain today.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Enzyme Induct | 1972 |
Halothane in the United States. An appraisal of the literature on "halothane hepatitis" and the American reaction to it.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypers | 1972 |
Postoperative jaundice.
Topics: Bacterial Infections; Bile Pigments; Bilirubin; Chemical and Drug Induced Liver Injury; Cholecystiti | 1973 |
Is halothane hepatotoxicity an allergic reaction to halothane?
Topics: Antigens; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Humans; Hypersensitivity; Li | 1973 |
Halothane hepatitis--fact or fallacy?
Topics: Chemical and Drug Induced Liver Injury; Fever; Halothane; Hepatitis; Hepatitis A; Hepatitis B Antige | 1973 |
Hepatic disease and pregnancy.
Topics: Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; Fatty Liver; Fem | 1973 |
[Chronic exposure to halothane: liver damage in anaesthetists].
Topics: Anesthesiology; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Environmental Expos | 1973 |
[Current problems and comments on the question of chronic liver damage due to halothane in anaesthesia personnel].
Topics: Anesthesiology; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Environmental Exposure; | 1973 |
Halothane anesthesia and hepatitis in a high-risk population.
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Diazepam; Enzyme Induction; Halothane; Human | 1973 |
Immunological liver disease.
Topics: Acidosis, Renal Tubular; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Cholangiograph | 1973 |
[Halothane syndrome. On the possibility of allergy caused by 1,1,1-trifluor-2-brom-2-chlorethane (Halan) (author's transl)].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Environmental | 1973 |
The adverse effects of drugs on the liver.
Topics: Acetaminophen; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; | 1973 |
[Liver damage due to drugs. I].
Topics: Arsenicals; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cholestasis; Coumarins; Drug-Re | 1974 |
The effects of fluorinated anesthetics on the liver and kidneys.
Topics: Acute Kidney Injury; Adult; Anesthesia, Inhalation; Animals; Biotransformation; Chemical and Drug In | 1974 |
Postoperative juandice.
Topics: Aminosalicylic Acids; Anemia, Hemolytic; Bile Ducts; Bilirubin; Chemical and Drug Induced Liver Inju | 1974 |
Biotransformation of halothane.
Topics: Anesthesia, Inhalation; Animals; Biotransformation; Bromides; Chemical and Drug Induced Liver Injury | 1974 |
Halothane: clinical considerations.
Topics: Anesthesia, Inhalation; Antibodies, Anti-Idiotypic; Biotransformation; Chemical and Drug Induced Liv | 1974 |
[Drug induced liver diseases].
Topics: Aminosalicylic Acids; Animals; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; | 1974 |
[Halothane hepatotoxicity and occupational hazards on the operating room (review of the literature)].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Environmental Exposure; Halothane; H | 1974 |
Sensitivity to anaesthetics.
Topics: Anesthesia, Intravenous; Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Humans; Jau | 1974 |
[On the problem of liver damage caused by halothane anesthesia].
Topics: Adult; Aged; Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Dogs; Female; Halothane; H | 1966 |
Effects of halothane on hepatic function.
Topics: Age Factors; Alkaline Phosphatase; Anesthesia, General; Anesthesia, Inhalation; Animal Nutritional P | 1968 |
The management of fulminant hepatic failure.
Topics: Acute Disease; Blood Transfusion; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Hal | 1970 |
[Drug-induced hepatitis].
Topics: Adult; Anti-Bacterial Agents; Antimetabolites; Chemical and Drug Induced Liver Injury; Contraceptive | 1970 |
[Halothane hepatitis and allergy].
Topics: Adult; Bromine; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Li | 1970 |
[Recent progress in the study of liver diseases].
Topics: Adrenal Cortex Hormones; Anesthesia, Inhalation; Bilirubin; Biological Transport; Chemical and Drug | 1971 |
Therapeutic considerations in selected forms of acute and chronic liver disease.
Topics: Acute Disease; Age Factors; Alcoholism; Azathioprine; Chemical and Drug Induced Liver Injury; Chroni | 1971 |
[Toxic liver injury].
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Cholestyramine Resin; Contraceptives, Oral; Dia | 1970 |
Halothane hepatitis.
Topics: Adult; Alkaline Phosphatase; Anesthesia, Inhalation; Bilirubin; Chemical and Drug Induced Liver Inju | 1971 |
The halothane dilemma: a case for the defence.
Topics: Adult; Anesthesia, General; Antigens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; | 1971 |
[Parenchymal damage following Halothane and Methoxyflurane].
Topics: Anesthesia, Inhalation; Biotransformation; Chemical and Drug Induced Liver Injury; Chemical Phenomen | 1971 |
9 trials available for halothane and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Halothane and hepatitis.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Enflurane; | 1980 |
Halothane and hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Halothane; Humans; Liver; Prospect | 1980 |
Controlled prospective study of the effect on liver function of multiple exposures to halothane.
Topics: Aged; Alanine Transaminase; Anesthesia, Inhalation; Anesthetics; Aspartate Aminotransferases; Biopsy | 1975 |
Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium.
Topics: Adult; Aged; Alanine Transaminase; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; C | 1975 |
Halothane hepatitis.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Female; Ha | 1978 |
Proceedings: A controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium.
Topics: Alanine Transaminase; Anesthesia, General; Chemical and Drug Induced Liver Injury; Clinical Trials a | 1975 |
Hepatic glutathione S-transferase release after halothane anaesthesia: open randomised comparison with isoflurane.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Clin | 1987 |
Liver function, histology, and cytochemistry in man following halothane and cyclopropane anaesthesia.
Topics: Adult; Aged; Anesthesia, Inhalation; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced | 1966 |
Prospective and retrospective searches for liver necrosis following halothane anesthesia. Serum enzyme study and case report.
Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Halothane | 1966 |
758 other studies available for halothane and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Scavenger receptor a is a major homeostatic regulator that restrains drug-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Hepatocytes; Homeostasis; | 2023 |
The halothane hepatitis that was not.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans; Sevoflurane | 2020 |
Exposure Assessment, Biological Monitoring, and Liver Function Tests of Operating Room Personnel Exposed to Halothane in Hamedan Hospitals, West of Iran.
Topics: Adult; Alanine Transaminase; Anesthetics, Inhalation; Aspartate Aminotransferases; Biomarkers; Bromi | 2017 |
Involvement of miRNAs in the early phase of halothane-induced liver injury.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Female; Halothane; | 2014 |
Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.
Topics: Anesthetics, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; | 2014 |
Halothane-induced hepatitis: paradigm or paradox for drug-induced liver injury.
Topics: Anesthetics, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Female; Halotha | 2014 |
Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment.
Topics: Alanine Transaminase; Analysis of Variance; Animals; CD11b Antigen; CD8-Positive T-Lymphocytes; Cell | 2015 |
Inhibition of immune tolerance unmasks drug-induced allergic hepatitis.
Topics: Animals; CD11b Antigen; CD8-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; Female; | 2015 |
Protective role of zinc pretreatment in hepatotoxicity induced by halothane.
Topics: Anesthetics, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Halothane; Liver Diseases; | 2008 |
Halothane hepatitis in Iran: a review of 59 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Chemical and Drug Induced Liver | 2008 |
The role of the antioxidants lycopene and vitamin E in the prevention of halothane-induced hepatotoxicity.
Topics: Anesthetics, Inhalation; Animals; Antioxidants; Carotenoids; Chemical and Drug Induced Liver Injury; | 2008 |
Effect of polyI:C cotreatment on halothane-induced liver injury in mice.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Chemical and Drug Induced L | 2009 |
[Acute liver failure due to a treatment by nimesulide].
Topics: Amoxicillin-Potassium Clavulanate Combination; Anesthetics, Inhalation; Anti-Bacterial Agents; Anti- | 2009 |
Could quinacrine prevent 'halothane hepatitis'?
Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibitors; | 2009 |
Halothane-induced liver injury is mediated by interleukin-17 in mice.
Topics: Anesthetics, Inhalation; Animals; Base Sequence; Chemical and Drug Induced Liver Injury; Cytokines; | 2009 |
A mouse model of severe halothane hepatitis based on human risk factors.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Blotting, Western; Chemical and Drug Induced Liver In | 2010 |
Generation of T cell responses targeting the reactive metabolite of halothane in mice.
Topics: Animals; CD40 Antigens; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Halo | 2010 |
Involvement of natural killer T cells in halothane-induced liver injury in mice.
Topics: Anesthetics, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Clodronic Acid; Disease Mo | 2010 |
Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis.
Topics: Anesthetics, Inhalation; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Chemical an | 2011 |
Estradiol and progesterone modulate halothane-induced liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chemokine CXCL1; Chemokine CXCL2; Estradiol; Female | 2011 |
Eosinophils mediate the pathogenesis of halothane-induced liver injury in mice.
Topics: Animals; Cell Movement; Chemical and Drug Induced Liver Injury; Chemokine CCL11; Chemokine CCL24; Co | 2013 |
Trifluoroacetylated proteins in liver and plasma of guinea pigs treated with HCFC-123 and halothane.
Topics: Alanine Transaminase; Anesthetics, Inhalation; Animals; Aspartate Aminotransferases; Azo Compounds; | 2003 |
Trifluoroacetylated adducts in spermatozoa, testes, liver and plasma and CYP2E1 induction in rats after subchronic inhalatory exposure to halothane.
Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Biomarkers; Body Weight; Chemical and | 2003 |
Halothane and hepatic toxicity.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Hepatitis A; Humans | 1963 |
Additional case of halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Humans; Viral Vaccines | 1963 |
Halothane hepatitis. An American disease?
Topics: Anesthesia; Anesthesia, Spinal; Anesthesiology; Chemical and Drug Induced Liver Injury; Halothane; H | 1963 |
Halothane jaundice andhepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Humans; Jaundice | 1963 |
Liver damage after halothane anaesthesia.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Humans; Liver Diseases | 1963 |
HALOTHANE HEPATOTOXICITY.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Obstetrical; Aspartate Aminotransferases; Blood Chem | 1963 |
JAUNDICE AFTER HALOTHANE AND RADIOTHERAPY.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Hepatitis A; Jaundice; Neoplasms; Pelv | 1963 |
LACK OF NECROSIS IN DOG LIVER AFTER ANESTHESIA WITH HALOTHANE.
Topics: Anesthesia; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Dogs; Halothane; Hepatit | 1963 |
EFFECTS OF CHLOROFORM AND HALOTHANE ANESTHESIA ON LIVER FUNCTION IN MAN.
Topics: Alanine Transaminase; Anesthesia; Anesthesia, Inhalation; Aspartate Aminotransferases; Bilirubin; Bl | 1964 |
JAUNDICE AFTER HALOTHANE AND RADIOTHERAPY.
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Hepatitis; Hepatitis A; Humans; Hysterect | 1964 |
[LIVER DAMAGE BY DRUGS].
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Arsphenamine; Chemical and Drug Induced Liver Injury; Chl | 1963 |
MASSIVE HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANESTHESIA.
Topics: Anesthesia; Atropine; Barbiturates; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Halot | 1964 |
MASSIVE HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANAESTHESIA.
Topics: Anesthesia; Anesthesiology; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Injections | 1964 |
POSTOPERATIVE HEPATIC NECROSIS. ITS INCIDENCE AND DIAGNOSTIC VALUE IN ASSOCIATION WITH THE ADMINISTRATION OF HALOTHANE.
Topics: Chemical and Drug Induced Liver Injury; Cyclopropanes; Diagnosis, Differential; Geriatrics; Halothan | 1964 |
EFFECTS OF CHLOROFORM AND HALOTHANE ANAESTHESIA ON LIVER FUNCTION.
Topics: Anesthesia; Anesthesiology; Chemical and Drug Induced Liver Injury; Chloroform; Halothane; Hepatitis | 1964 |
LIVER DAMAGE AND FLUOTHANE.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Liver Diseases; Toxicology; Viral Vacc | 1964 |
MASSIVE HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANAESTHESIA.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Massive Hepatic Necrosis; | 1964 |
[CONTRIBUTION TO THE STUDY OF HEPATIC TOXICITY CAUSED BY HALOTHANE].
Topics: Anesthesia; Anesthesiology; Chemical and Drug Induced Liver Injury; Gastrectomy; Halothane; Hepatiti | 1964 |
[FLUOTHAME ICTERUS IN CHILDHOOD].
Topics: Anesthesia; Anesthesia, Endotracheal; Cardiac Surgical Procedures; Chemical and Drug Induced Liver I | 1964 |
TRANSAMINASE STUDIES FOLLOWING ANESTHESIA.
Topics: Alanine Transaminase; Anesthesia; Anesthetics; Blood Chemical Analysis; Chemical and Drug Induced Li | 1964 |
[EXPERIENCES WITH HALOTHANE IN GYNECOLOGY AND OBSTETRICS].
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Obstetrical; Angiotensins; Cesarean Section; Chemica | 1964 |
SYSTEMIC CANDIDIASIS AND RENAL INVOLVEMENT.
Topics: Anti-Bacterial Agents; Candidiasis; Chemical and Drug Induced Liver Injury; Chloramphenicol; Diagnos | 1964 |
HALOTHANE AND THE LIVER.
Topics: Chemical and Drug Induced Liver Injury; Chloroform; Halothane; Hepatitis; Jaundice; Liver Diseases; | 1964 |
HALOTHANE AND THE LIVER: RETROSPECTIVE STUDIES.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Liver Diseases; Necrosis; Retrospect | 1964 |
CHLOROFORM, HALOTHANE, AND HEPATOTOXICITY.
Topics: Alanine Transaminase; Chemical and Drug Induced Liver Injury; Chloroform; Clinical Enzyme Tests; D-A | 1964 |
HALOTHANE JAUNDICE. REPORT OF A CASE.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Jaundice; Pathology; Toxicology | 1964 |
HALOTHANE AND LIVER DYSFUNCTION: A RETROSPECTIVE STUDY.
Topics: Alanine Transaminase; Alkaline Phosphatase; Anesthesia; Anesthesia, General; Aspartate Aminotransfer | 1964 |
[ACUTE MASSIVE NECROSIS OF THE LIVER AFTER REPEATED HALOTHANE ANESTHESIA].
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Necrosis; Pharmacology; | 1964 |
HEPATITIS ASSOCIATED WITH HALOTHANE.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Hepatitis A; Toxicology; Viral Vaccine | 1964 |
[COMPARATIVE EXPERIMENTAL STUDY OF THE HISTOLOGICAL CHANGES IN THE LIVER AND KIDNEY IN ACUTE POISONING BY CHLOROFORM, FLUOTHANE AND METHOCYFLURANE].
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Chloroform; Halothane; Hepatitis; Kidney; Kidne | 1964 |
[FUNCTIONAL AND BIOPTIC STUDY OF THE LIVER IN PATIENTS EXPOSED TO FLUOTHANE ANESTHESIA].
Topics: Alanine Transaminase; Alkaline Phosphatase; Anesthesia; Aspartate Aminotransferases; Chemical and Dr | 1964 |
[HEPATOTOXICITY OF THE LIVER].
Topics: Anesthetics; Barbiturates; Chemical and Drug Induced Liver Injury; Chloroform; Cyclopropanes; Ethano | 1964 |
THE INCIDENCE OF POSTOPERATIVE JAUNDICE WITH SPECIAL REFERENCE TO HALOTHANE.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Cyclopropanes; Ether; Halothane; Hepatitis; Inci | 1964 |
MASSIVE LIVER CELL NECROSIS; A RETROSPECTIVE STUDY.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Hepatitis A; Isoniazid; M | 1964 |
[APROPOS OF THE LIVER TOXICITY OF FLUOTHANE FROM A CLINICAL VIEWPOINT].
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Halothane; Hepatitis; Hepatitis A; | 1964 |
JAUNDICE AND ITS RELATION TO THERAPEUTIC AGENTS.
Topics: Alkaline Phosphatase; Antidepressive Agents; Aspartate Aminotransferases; Bilirubin; Chemical and Dr | 1965 |
LIVER AND KIDNEY DAMAGE AFTER ANESTHESIA.
Topics: Anesthesia; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Ether; Halothane; | 1965 |
BENIGN POSTOPERATIVE INTRAHEPATIC CHOLESTASIS.
Topics: Alkaline Phosphatase; Anesthesia; Anesthesia, Inhalation; Blood Transfusion; Chemical and Drug Induc | 1965 |
DRUGS AND LIVER DISEASE.
Topics: Androgens; Anti-Bacterial Agents; Antihypertensive Agents; Antineoplastic Agents; Arsphenamine; Chem | 1965 |
POST-OPERATIVE HEPATIC MORBIDITY WITH SPECIAL REFERENCE TO THE ROLE OF HALOTHANE.
Topics: Chemical and Drug Induced Liver Injury; Classification; Drug Hypersensitivity; Halothane; Hepatitis; | 1965 |
HALOTHANE HEPATOTOXICITY; AN INVESTIGATION OF THE EFFECTS OF SHORT EXPOSURE.
Topics: Alanine Transaminase; Anesthesia; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Ch | 1965 |
A COMPARISON OF THE EFFECTS OF CHLOROFORM AND HALOTHANE ON LIVER FUNCTION.
Topics: Alanine Transaminase; Anesthesia; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Ch | 1965 |
HALOTHANE AND JAUNDICE IN PAEDIATRIC ANAESTHESIA.
Topics: Alanine Transaminase; Alkaline Phosphatase; Anesthesia; Aspartate Aminotransferases; Bilirubin; Bloo | 1965 |
POST-OPERATIVE JAUNDICE. A CASE HISTORY.
Topics: Biopsy; Bronchoscopy; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Esophagoscopy | 1965 |
LIVER NECROSIS FOLLOWING ANESTHESIA.
Topics: Anesthesia; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Geriatrics; Halothane; H | 1965 |
POSTOPERATIVE LIVER DAMAGE: IS ANESTHESIA INVOLVED?
Topics: Anesthesia; Anesthetics; Chemical and Drug Induced Liver Injury; Geriatrics; Halogens; Halothane; He | 1965 |
[HALOTHANE AND LIVER DAMAGE].
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Hepatitis A; Liver Disease | 1965 |
[BEHAVIOR OF ORNITHINE CARBAMYLTRANSFERASE (OCT) IN SERUM AFTER NARCOSIS WITH FLUOTHANE IN OBSTETRICS AND GYNECOLOGY].
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Obstetrical; Blood; Cesarean Section; Chemical and D | 1964 |
EFFECTS OF HALOTHANE AND CHLOROFORM ON THE LIVER IN PROTEIN-DEFICIENT MICE.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Chloroform; Halothane; Hepatitis; Mice; Patholog | 1965 |
[ON THE PROBLEM OF THE HEPATOTOXICITY OF HALOTHANE. ANIMAL EXPERIMENTS WITH SPECIAL REFERENCE TO HYPOXIA DOSES].
Topics: Anesthesia; Animal Experimentation; Animals; Chemical and Drug Induced Liver Injury; Dogs; Halothane | 1965 |
[CONTRIBUTION TO THE STUDY OF HEPATIC TOXICITY OF HALOTHANE].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Pharmacology; Research; Toxicology | 1965 |
ACUTE PARENCHYMATOUS HEPATIC DISEASE FOLLOWING GENERAL ANESTHESIA: CLINICAL APPRAISAL OF HEPATOTOXICITY FOLLOWING ADMINISTRATION OF HALOTHANE.
Topics: Alkaline Phosphatase; Anesthesia; Anesthesia, General; Aspartate Aminotransferases; Bilirubin; Blood | 1965 |
[LIVER DISORDERS AFTER HALOTHANE ANESTHESIA--POST OR PROPTER?].
Topics: Anesthesia; Anesthesiology; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Liver Dise | 1964 |
[HALOTHANE AND LIVER DAMAGE].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Liver Diseases; Postoperative Complica | 1964 |
[LIVER DAMAGE CAUSED BY HALOTHANE].
Topics: Abdominal Injuries; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Liver Diseases; To | 1965 |
HALOTHANE AND THE LIVER.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Hepatitis A; Toxicology | 1965 |
FATAL JAUNDICE AFTER HALOTHANE.
Topics: Anesthesia; Anesthesia, General; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Jaund | 1965 |
[Halothane-induced hepatitis. 8 case reports].
Topics: Adult; Aged; Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Hum | 2003 |
Halothane induced hepatitis: case report.
Topics: Adult; Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; J | 2004 |
Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats.
Topics: Alanine Transaminase; Anesthetics, Inhalation; Animals; Calcium; Chemical and Drug Induced Liver Inj | 2005 |
Halothane induces oxidative stress and NF-kappaB activation in rat liver: protective effect of propofol.
Topics: Anesthetics, Inhalation; Animals; Antioxidants; Blotting, Western; Chemical and Drug Induced Liver I | 2006 |
Role of neutrophils in a mouse model of halothane-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Fluoroacetates; Hal | 2006 |
Halothane induced fulminant hepatic failure.
Topics: Adult; Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Fatal Outcome; Halothane; Hu | 2007 |
[Fluothane anesthesia].
Topics: Animals; Barbiturates; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1966 |
[Fatal case of liver damage due to fluothane anesthesia].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Male; Middle Aged | 1966 |
Liver reaction after halothane and diethyl ether anaesthesia.
Topics: 17-Hydroxycorticosteroids; Alanine Transaminase; Anesthesia; Aspartate Aminotransferases; Chemical a | 1967 |
[Jaundices of therapeutic origin].
Topics: Antineoplastic Agents; Antitubercular Agents; Arsenicals; Chemical and Drug Induced Liver Injury; Ch | 1967 |
[Fluothane damage of the stressed liver].
Topics: Alcohols; Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Halothane; Liver; Male; Necro | 1967 |
[Acute postoperative liver lesions with special emphasis on halothane. Comparative morphological and clinical studies].
Topics: Aged; Anesthesia, Inhalation; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Esophagoscopy | 1967 |
Halothane and anicteric hepatitis.
Topics: Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Live | 1980 |
Halothane and anicteric hepatitis.
Topics: Air Pollutants; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1980 |
Prospective study of liver function following repeat halothane and enflurane.
Topics: Adult; Aged; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Enflurane; Female; gamma- | 1981 |
N-acetylcysteine protection against halothane hepatotoxicity:experiments in rats.
Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Halothane; Liver; Male; Rats | 1981 |
Hepatic necrosis in rats following halothane administration: protective effect of diethyldithiocarbamate.
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Ditiocarb; Halothane; Liver | 1980 |
Free radical formation in vivo and hepatotoxicity due to anesthesia with halothane.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclic N-Oxides; Electron Spi | 1982 |
[Exposure to anesthetic gases: risk and prevention].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Air Pollutants, Occupational; Anesthesia, Inhala | 1983 |
Influence of dithiocarb, (+)-catechin and silybine on halothane hepatotoxicity in the hypoxic rat model.
Topics: Animals; Benzopyrans; Catechin; Chemical and Drug Induced Liver Injury; Ditiocarb; Flavonoids; Fluor | 1983 |
An enzyme-linked immunosorbent assay for detection of antibodies against halothane-altered hepatocyte antigens.
Topics: Absorption; Animals; Antibodies; Antigens, Surface; Binding Sites, Antibody; Chemical and Drug Induc | 1984 |
Effects of halothane, isoflurane, enflurane, thiopental, and fentanyl on blood gas values in rats exposed to hypoxia.
Topics: Anesthetics; Animals; Carbon Dioxide; Chemical and Drug Induced Liver Injury; Enflurane; Fentanyl; H | 1983 |
Does halothane cause liver necrosis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis | 1983 |
Does halothane cause liver necrosis?
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Necrosis | 1983 |
Halothane and children: the first quarter century.
Topics: Adolescent; Arrhythmias, Cardiac; Basal Ganglia Diseases; Chemical and Drug Induced Liver Injury; Ch | 1984 |
Is enflurane hepatotoxic?
Topics: Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Postoperative Complications | 1984 |
Untoward side effects and toxicities of inhalational anesthetics.
Topics: Anesthesia, Inhalation; Anesthetics; Carcinogens; Chemical and Drug Induced Liver Injury; Enflurane; | 1984 |
Isoflurane does not prevent hepatic injury produced by halothane in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Enzyme Induction; Halothane; Isoflurane; Male; Meth | 1984 |
The effect of halothane, isoflurane, and blood loss on hepatotoxicity and hepatic oxygen availability in phenobarbital-pretreated hypoxic rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Hemorrhage; Isoflurane; Liver; Liver Cir | 1984 |
[Mechanisms of liver damage during general anesthesia].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Hypoxia; Ischemia | 1984 |
[Postoperative liver damage due to halothane. Should we stop using halothane for adult patients?].
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Huma | 1984 |
Isoflurane: the need for new volatile agents.
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Isoflura | 1983 |
Anesthesia-induced hepatotoxicity.
Topics: Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Halothane; Rats | 1983 |
Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Inj | 1983 |
Anaesthetic deaths.
Topics: Anesthesia, General; Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; History, 19th C | 1983 |
Halothane-associated granulomatous hepatitis.
Topics: Adult; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; Granuloma; Halothane; Humans; | 1983 |
Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis.
Topics: Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Synergism; | 1983 |
Hepatic necrosis associated with use of halothane in a dog.
Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Halothane; | 1984 |
Clinical significance of eosinophilia in the diagnosis of halothane-induced liver injury.
Topics: Adult; Chemical and Drug Induced Liver Injury; Eosinophilia; Female; Halothane; Humans; Male; Middle | 1984 |
Celiac plexus block does not alter hepatic injury in rats.
Topics: Anesthetics; Animals; Bupivacaine; Celiac Plexus; Chemical and Drug Induced Liver Injury; Drug Inter | 1984 |
Paradoxical effects of perturbation of intracellular levels of glutathione on halothane-induced hepatotoxicity in hyperthyroid rats.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Glutathione; | 1984 |
Liver damage after halothane anaesthesia: analysis of cases in Finnish hospitals in 1972-1981.
Topics: Adult; Age Factors; Anesthesia, Inhalation; Autoantibodies; Chemical and Drug Induced Liver Injury; | 1984 |
[Post-anesthetic hepatitis. The role of halothane and antimitotic combinations].
Topics: Anesthesia, Inhalation; Antineoplastic Agents; Burkitt Lymphoma; Chemical and Drug Induced Liver Inj | 1984 |
A nurse with liver injury associated with occupational exposure to halothane in a recovery unit.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Nurses; Occupational Disea | 1984 |
Factors influencing halothane hepatotoxicity in the rat hypoxic model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug Interactions; | 1980 |
[Postoperative hepatitis resulting from halothane?].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Male; Post | 1981 |
Genetics and halothane hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Rats; Rats, Inbred Strains | 1981 |
[Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Halothane; L-Iditol | 1982 |
Hypoxia per se can produce hepatic damage without death in rats.
Topics: Animals; Carbon Dioxide; Chemical and Drug Induced Liver Injury; Halothane; Hypoxia; Liver Diseases; | 1982 |
Specific serological markers in the diagnosis of fulminant hepatic failure associated with halothane anaesthesia.
Topics: Acute Disease; Adolescent; Adult; Aged; Anesthesia, Inhalation; Antibodies; Chemical and Drug Induce | 1983 |
Postoperative jaundice in children. The influence of halothane.
Topics: Adolescent; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; | 1983 |
A perspective on halothane-induced hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1983 |
Etiology of halothane hepatotoxicity.
Topics: Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Disease Models, Animal; Female; Halot | 1983 |
Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Eating; Enflurane; Halothane; Hyperthy | 1983 |
Enflurane hepatotoxicity. A clinicopathologic study of 24 cases.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Enflurane; Female; Halothane; Human | 1983 |
Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorides; Glutathione; Halothane; Hyperthyroidism; | 1983 |
The predictive value of changes in antipyrine pharmacokinetics in halothane and paracetamol induced hepatic necrosis in rats.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Halothane; Ki | 1983 |
Hypoxia and halothane hepatotoxicity.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Female; Halothane; Hypoxia; Male | 1983 |
Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fasting; Fluorides; Halothane; Hypoxia; Liver Disea | 1983 |
[Drug-induced liver damage; new aspects on its mechanism].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contraceptives, Oral; Drug-Re | 1980 |
Metabolism of anesthetic agents: toxic implications.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Enflurane; Enzyme Induction; Fasting; | 1982 |
Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish Board of Adverse Reactions to Drugs.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Urinary; Antidepressive Agents, Tricyclic; Antituber | 1982 |
Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis.
Topics: Adult; Aged; Animals; Antibody Formation; Autoantibodies; Cell Membrane; Chemical and Drug Induced L | 1980 |
Hepatic Injury following halothane, enflurane, and isoflurane anesthesia in rats.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Enflurane; Enzyme Induction; Halothane | 1982 |
Halothane hepatitis in a young child.
Topics: Anesthesia, Inhalation; Antibodies; Chemical and Drug Induced Liver Injury; Child, Preschool; Female | 1982 |
[Halothane hepatitis. Possibilities of prevention].
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Chil | 1982 |
Pharmacogenetics and halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Phenotype | 1982 |
[Hepatic repercussions of halothane in iterative pediatric anaesthesia].
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Halothane; Hep | 1982 |
Halothane hepatitis: a series of case report following podiatric surgery.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Fever; Foot; Halothane; Humans; Middle | 1982 |
A perspective on halothane-induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis; Rats | 1982 |
Hepatic centrilobular necrosis in rats after exposure to halothane, enflurane, or isoflurane.
Topics: Animals; Chemical and Drug Induced Liver Injury; Enflurane; Glutathione; Halothane; Isoflurane; Live | 1982 |
Hypoxia may be more important than reductive metabolism in halothane-induced hepatic injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fasting; Halothane; Hypoxia; Liver; Liver Diseases; | 1982 |
[Hepatitis caused by drugs. 4].
Topics: Adult; Aminosalicylic Acid; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Halothane | 1982 |
Bacteraemia in patients with fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; H | 1982 |
[Toxic hepatitis after halothane (fluothane)].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Male; Middle Aged; Time Factors | 1982 |
[Indication for halothane anesthesia].
Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Ear, Middle; Halothane; Humans; | 1982 |
[Hepatic lesion caused by halogenated anesthetics].
Topics: Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Liver; Male; Middle Aged; Necr | 1982 |
Anesthetic pollution and disease.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Air Pollutants, Occupational; Anesthesiology; An | 1980 |
Postanesthetic hepatic injury in rats: influence of alterations in hepatic blood flow, surgery, and anesthesia time.
Topics: Abdomen; Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Enzyme Induction; Halothane; H | 1982 |
[A study of the effect on liver function of multiple exposures to anesthetics (author's transl)].
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anesthesia, General; Chemical and Drug Induced Liver | 1980 |
Halothane hepatitis in three pairs of closely related women.
Topics: California; Chemical and Drug Induced Liver Injury; Female; Halothane; Hispanic or Latino; Humans; L | 1981 |
A case of acute reversible renal failure associated with halothane induced liver disease.
Topics: Acute Kidney Injury; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; Halothane; Human | 1981 |
Halothane-induced nephrotoxicity.
Topics: Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Kid | 1981 |
Hepatotoxicity of halogenated inhalation anesthetics.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Hydro | 1981 |
Pharmacogenetics and the halothane hepatitis mystery.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Pharmacogenet | 1981 |
Genetic differences in reductive metabolism and hepatotoxicity of halothane in three rat strains.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Enzyme I | 1981 |
[Acute hepatic failure after exposure to halothane -the clinical study of 10 cases- (author's transl)].
Topics: Acute Disease; Adult; Aged; Anesthesia, General; Chemical and Drug Induced Liver Injury; Female; Hal | 1981 |
Oxidative metabolism of halothane in the production of altered hepatocyte membrane antigens in acute halothane-induced hepatic necrosis.
Topics: Animals; Antigens, Surface; Chemical and Drug Induced Liver Injury; Cytotoxicity, Immunologic; Femal | 1981 |
Circulating immune complexes in patients with fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Antigen-Antibody Complex; Chemical and Drug Induced Liver In | 1981 |
Liver injury due to drugs.
Topics: Acetaminophen; Anti-Bacterial Agents; Antitubercular Agents; Cathartics; Chemical and Drug Induced L | 1981 |
Toxic metabolites from biotransformation: major organ damage.
Topics: Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Enflurane; Ether; H | 1981 |
Hepatic damage after exposure to halothane in medical personnel.
Topics: Adult; Antibodies; Chemical and Drug Induced Liver Injury; Cytotoxicity Tests, Immunologic; General | 1981 |
[Four cases of halothane hepatitis after first halothane exposure (author's transl)].
Topics: Adult; Aged; Anesthesia, General; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; | 1981 |
HLA A and B locus antigens in patients with unexplained hepatitis following halothane anaesthesia.
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Gene Frequency; | 1981 |
Halothane-induced hepatic disease.
Topics: Adolescent; Adult; Age Factors; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Differentia | 1981 |
Study relates health problems to anesthetic gases...
Topics: Abortion, Spontaneous; Adult; Anesthesia, Dental; Anesthesia, Inhalation; Chemical and Drug Induced | 1980 |
Time-course of formation of volatile reductive metabolites of halothane in humans and an animal model.
Topics: Adult; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Disease Models, Animal; | 1980 |
Halothane-induced hepatic necrosis in triiodothyronine-pretreated rats.
Topics: Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 1980 |
Halothane hepatitis: allergy or idiosyncrasy?
Topics: Animals; Antibody Formation; Autoantibodies; Chemical and Drug Induced Liver Injury; Drug Hypersensi | 1980 |
[Halothane hepatitis--increased incidence?].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Denmark; Female; Halothane; Humans; Male; Middl | 1980 |
The liver and halothane--again.
Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Enflurane; Enzyme Induction; Halothane; | 1980 |
[Toxic hepatitis and spontaneous abortions in female anesthesiologists: 2 cases].
Topics: Abortion, Spontaneous; Adult; Anesthesia; Anesthesiology; Chemical and Drug Induced Liver Injury; Et | 1980 |
Unexplained hepatitis following halothane: case report.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Jaundice; Middle Age | 1980 |
Comparison of the biotransformation and hepatotoxicity of halothane and deuterated halothane.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Deuterium; Halothane; Male; Rats | 1980 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1980 |
Drug reactions and the liver.
Topics: Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Halothane; Huma | 1980 |
The liver and halothane-again.
Topics: Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Kidney Diseases; Microsomes, L | 1980 |
Lymphocyte cytotoxicity to halothane altered hepatocytes in patients with severe hepatic necrosis following halothane anaesthesia.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cytotoxicity, Immunologic; Female; Halothane; H | 1980 |
[Halothane and obese patients].
Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Obesity; Risk Fa | 1995 |
Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid.
Topics: Acetyltransferases; Amino Acid Sequence; Autoantigens; Autoimmune Diseases; Binding, Competitive; Ch | 1994 |
Time course of 72-kilodalton heat shock protein induction and appearance of trifluoroacetyl adducts in livers of halothane-exposed rats.
Topics: Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Electrophoresis, Polyacrylamide | 1994 |
Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes.
Topics: Animals; Antigens; Carrier Proteins; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; | 1995 |
[Effects of drugs on the liver. A review illustrated with 3 clinical cases].
Topics: Acetaminophen; Adult; Aged; Androgens; Chemical and Drug Induced Liver Injury; Denmark; Disulfiram; | 1994 |
Hepatic necrosis associated with halothane anesthesia in an alpaca.
Topics: Anesthesia, Inhalation; Animals; Camelids, New World; Chemical and Drug Induced Liver Injury; Haloth | 1995 |
Sera from patients with halothane hepatitis contain antibodies to halothane-induced liver antigens which are not detectable by immunoblotting.
Topics: Animals; Antigens; Autoantibodies; Blotting, Western; Chemical and Drug Induced Liver Injury; Enzyme | 1994 |
Possible role of HLA in hepatotoxicity. An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Chlorpromazine; | 1994 |
[Liver transplantation in halothane-induced liver necrosis].
Topics: Adult; Anesthesia, General; Appendectomy; Appendicitis; Chemical and Drug Induced Liver Injury; Halo | 1994 |
A model for fatal halothane hepatitis in the guinea pig.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glu | 1994 |
Absence of anti-trifluoroacetate antibody after halothane anaesthesia in patients exhibiting no or mild liver damage.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anesthesia, Inhalation; Animals; Antibodies; Chemical | 1994 |
Human hepatocytes express trifluoroacetylated neoantigens after in vitro exposure to halothane.
Topics: Antibody Specificity; Antigens; Biotransformation; Cells, Cultured; Chemical and Drug Induced Liver | 1994 |
Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis.
Topics: Adult; Autoantibodies; Carboxylic Ester Hydrolases; Chemical and Drug Induced Liver Injury; Enzyme-L | 1993 |
Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis.
Topics: Adult; Aged; Antipyrine; Chemical and Drug Induced Liver Injury; Complement C3; Female; Halothane; H | 1993 |
Association of anti-58 kDa endoplasmic reticulum antibodies with halothane hepatitis.
Topics: Animals; Antibodies; Antigen-Antibody Reactions; Chemical and Drug Induced Liver Injury; Endoplasmic | 1993 |
Hepatotoxicity of volatile anaesthetic agents.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1993 |
[Severe bronchospasm in a 1-year old child treated with halothane].
Topics: Administration, Inhalation; Bronchial Spasm; Bronchodilator Agents; Chemical and Drug Induced Liver | 1994 |
[Evaluation of hepatic damage in personnel in the anesthesiology- resuscitation department in relation to halothane exposure].
Topics: Adult; Anesthesiology; Chemical and Drug Induced Liver Injury; Female; Halothane; Health Personnel; | 1993 |
Immunity to halothane metabolite-modified proteins in halothane hepatitis.
Topics: Animals; Antibody Formation; Antigens; Biotransformation; Chemical and Drug Induced Liver Injury; Fe | 1993 |
Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase.
Topics: Antibodies; Antigens; Chemical and Drug Induced Liver Injury; Halothane; Humans; Isomerases; Microso | 1993 |
Halothane hepatitis in a renal transplant patient previously exposed to isoflurane.
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Isoflurane | 1993 |
Possible role of thymol in the pathogenesis of 'halothane hepatitis'.
Topics: Antibody Formation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Thymol | 1993 |
[Mechanism of drug-induced hepatitis. A consequence of superposition of two xenobiotic systems].
Topics: Autoantibodies; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme | 1995 |
Suspected isoflurane hepatitis in an obese patient with a history of halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Cross Reactions; Halothane; Humans; Isoflurane; Male; Middle | 1995 |
Hypothesis: halothane hepatitis--has thymol been overlooked?
Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Thymol | 1995 |
Detection of autoantibodies directed against human hepatic endoplasmic reticulum in sera from patients with halothane-associated hepatitis.
Topics: Adult; Autoantibodies; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Female; Haloth | 1995 |
Drug-induced hepatotoxicity.
Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Child; Halothane; Humans | 1996 |
[Halothane-induced hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Isoflurane; Liver | 1996 |
Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis.
Topics: Animals; Antibody Formation; Autoantibodies; Autoantigens; Cell Line; Cell Membrane; Chemical and Dr | 1996 |
Patients must be a virtue.
Topics: Chemical and Drug Induced Liver Injury; Disulfiram; Halothane; Humans; Liver; Oxidation-Reduction | 1996 |
Biotransformation of halothane, enflurane, isoflurane, and desflurane to trifluoroacetylated liver proteins: association between protein acylation and hepatic injury.
Topics: Acylation; Anesthetics, Inhalation; Animals; Antigen-Antibody Reactions; Biotransformation; Chemical | 1997 |
Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney.
Topics: Administration, Inhalation; Administration, Oral; Alanine Transaminase; Allyl Compounds; Animals; Bi | 1997 |
Demonstration of a cellular immune response in halothane-exposed guinea pigs.
Topics: Alanine Transaminase; Anesthetics, Inhalation; Animals; Antigen-Presenting Cells; Cell Division; Cel | 1997 |
A jaundiced look at the management of hepatitis?
Topics: Acetaminophen; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Female; Halothane; Hepatiti | 1997 |
Halothane hepatitis in a South African population--frequency and the influence of gender and ethnicity.
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; | 1997 |
Interaction of lymphocytes with Kupffer cells from halothane-exposed guinea pigs.
Topics: Anesthetics, Inhalation; Animals; Antibodies; Cell Adhesion; Chemical and Drug Induced Liver Injury; | 1997 |
Molecular basis of halothane hepatitis.
Topics: Anesthetics, Inhalation; Animals; Autoantigens; Chemical and Drug Induced Liver Injury; Halothane; H | 1998 |
Anesthesiology.
Topics: Anesthesiology; Anesthetics, Inhalation; Anesthetics, Local; Bupivacaine; Chemical and Drug Induced | 1998 |
Halothane-associated hepatitis in a 6-year-old boy: evidence for native liver regeneration following failed treatment with auxiliary liver transplantation.
Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Child; Halothane; Humans; Liver Reg | 1998 |
Halothane hepatitis.
Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Guideline Adherence; Halothane; Hum | 1998 |
Halothane-induced acute liver failure: continuing occurrence and use of liver transplantation.
Topics: Adult; Aged; Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Child, Preschool; Euro | 1998 |
[Fatal hepatitis in a young child: probable role of halothane].
Topics: Accidents, Traffic; Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Child, Preschoo | 1997 |
Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroacetates; Cysteine; Cytochrome P-450 Enzyme S | 1998 |
Postoperative hepatic dysfunction in perspective. 1970.
Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; History, 20th Century; H | 1998 |
Hepatotoxicity following desflurane anesthesia.
Topics: Adult; Anesthesia; Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Desflurane; Fema | 1999 |
Halothane and post-halothane exposure hepatitis.
Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1999 |
Halothane, children and original sources.
Topics: Adult; Age Factors; Anesthetics, Inhalation; Anesthetics, Intravenous; Anti-Bacterial Agents; Chemic | 1999 |
Halothane: the last word?
Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Child; Halothane; Humans; Infant; M | 2001 |
The uses of error: iatrogenic hepatitis.
Topics: Aged; Anesthetics, Inhalation; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Female | 2001 |
Hepatobiliary scintigraphy for evaluating the hepatotoxic effect of halothane and the protective effect of catechin in comparison with histo-chemical analysis of liver tissue.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Bile Ducts; Catechin; Chemical and Drug Induced Liver | 2002 |
Good news, bad news.
Topics: Adult; Alanine Transaminase; Anesthesiology; Anesthetics, Inhalation; Autoantibodies; Chemical and D | 2002 |
Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists.
Topics: Adult; Age Factors; Alanine Transaminase; Anesthesiology; Anesthetics, Inhalation; Autoantibodies; C | 2002 |
Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Biotransformation; Chemical and Drug Induc | 2002 |
Toxic effects of halogenated anesthetics on human hepatocytes.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Ethers; Female; Halothane; Humans; Liver; | 1975 |
[Allergic characteristics of halothane hepatitis. Apropos of a case report].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Halothane; Humans; Jau | 1976 |
[Experimental study of conjugates of a catabolite common to halothane, enflurane and fluroxene in guinea pigs].
Topics: Animals; Antibodies; Antibody Formation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivi | 1976 |
[Halogen hepatitis].
Topics: Anesthetics; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Hal | 1976 |
Halothane hepatitis.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1978 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Halothane; Hepatitis A; Humans; Jau | 1978 |
Halothane, hypoxia, and hepatitis.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Hypoxia; Liver | 1978 |
Halothane hepatitis.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Evaluation; Female; Halothane; | 1978 |
Sensitisation to halothane-altered liver components in severe hepatic necrosis after halothane anaesthesia.
Topics: Adult; Aged; Anesthesia, Inhalation; Animals; Antigen-Antibody Reactions; Antigens, Heterophile; Aut | 1978 |
Halothane hepatitis.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Ag | 1978 |
A possible interaction of PCB and halothane in man.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Polychlorinated Biphenyls | 1979 |
[Inhibition by diethyldithiocarbamate (DEDTC) of acute hepatotoxic effects induced by polyhalogenated hydrocarbons (PHHC)].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; Ditioca | 1976 |
Studies in clinical liver disease.
Topics: Adult; Autoantibodies; Bacterial Infections; Biopsy; Chemical and Drug Induced Liver Injury; Cholest | 1979 |
Management of halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1977 |
Current status of halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Evaluation Studies as Topic; Halothane; Humans | 1977 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1978 |
[Hepatitis after halothane exposure (author's transl)].
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Huma | 1978 |
Extrahepatic tissue distribution, covalent binding, and toxicity of halothane in control and phenobarbital-pretreated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Kidney; Liver; Lung; Male; Necrosis; Phe | 1978 |
Liver function following repeated anaesthesia--method of study and interim results.
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Human | 1979 |
Acute structural hepatic alteration due to poisons.
Topics: Acetaminophen; Acute Disease; Amanita; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liv | 1977 |
[Halothane hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1979 |
Halothane hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1979 |
Hepatotoxic effects of repeated anaesthetics.
Topics: Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Methyl Ethers | 1979 |
Halothane and the liver: "firm ground" at last?
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Halothane; Humans; Liver | 1979 |
Hepatotoxicity and halothane metabolism in an animal model with application for human toxicity.
Topics: Alanine Transaminase; Anesthetics; Animals; Biotransformation; Carbon Dioxide; Chemical and Drug Ind | 1979 |
Halothane hepatotoxicity and fluoride production in mice and rats.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fluorides; | 1979 |
Hepatitis caused by halothane sniffing.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Substance-Related Disorder | 1979 |
Liver injury, drugs, and popular poisons.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1979 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptiv | 1979 |
[Halothane hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1979 |
Case records of the California Podiatry Hospital: a clinicopathologic exercise. Halothane hepatitis.
Topics: Acute Disease; Aged; Anesthesia, General; Chemical and Drug Induced Liver Injury; Female; Halothane; | 1979 |
[Halothane hepatitis: fact or fiction? (author's transl)].
Topics: Acute Disease; Anesthetics; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane | 1979 |
[Post-operative fulminant hepatitis presumably due to halothane (author's transl)].
Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity; Halot | 1979 |
Leukocyte migration inhibition in halothane-induced hepatitis.
Topics: Adult; Aged; Cell Migration Inhibition; Chemical and Drug Induced Liver Injury; Cholelithiasis; Chol | 1979 |
[Halothane hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans | 1979 |
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytoc | 1979 |
Hepatic necrosis caused by halothane and hypoxia in phenobarbital-treated rats.
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sys | 1979 |
Hepatic reactions to drugs.
Topics: Acetaminophen; Adenoma; Adult; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1979 |
Reductive metabolism of halothane and hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Ethylenes; Halothane; Humans; Hydrocarbons, Halogenated | 1979 |
Halothane hepatitis revisited in women undergoing treatment of carcinoma of the cervix.
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Huma | 1979 |
Halothane hepatotoxicity.
Topics: Anesthesia, Intravenous; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Ha | 1979 |
Liver dysfunction after repeated anaesthesia.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans | 1979 |
What's new in anesthesiology.
Topics: Air Pollution; Anesthesiology; Chemical and Drug Induced Liver Injury; Halothane; Humans; Operating | 1979 |
[Hepatic toxicity of halothane].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Halothane; Humans | 1979 |
Halothane hepatitis after jejunoileal bypass.
Topics: Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Ileum; Immun | 1979 |
Liver failure associated with halothane.
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Labeling; Female; Haloth | 1977 |
[Drug-induced chronic aggressive hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Halothane; Humans; Isoniazid; Methy | 1977 |
[Hepatitis after halothane anesthesia].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans | 1977 |
Halothane hepatotoxicity and the reduced derivative, 1,1,1-trifluoro-2-chloroethane.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Environmental Exposure; Halothan | 1977 |
Pathologic changes following chronic exposures to halothane: a review.
Topics: Animals; Brain; Brain Diseases; Chemical and Drug Induced Liver Injury; Dogs; Environmental Exposure | 1977 |
Conference on comparative metabolism and toxicity of vinyl chloride-related compounds: overview and summary.
Topics: Animals; Chemical and Drug Induced Liver Injury; Environmental Exposure; Halothane; Humans; Hydrocar | 1977 |
[Anesthesia and immunity (author's transl)].
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Immunity; Immunity, | 1978 |
[Halothane hepatitis].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Denmark; Female; Halothane; H | 1978 |
[Toxic hepatitis after halothane. 98 cases reported to the Danish Board on Adverse Reactions to Drugs].
Topics: Age Factors; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Denmark; Female; | 1978 |
[Halothane hepatitis].
Topics: Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Denmark; Female; Haloth | 1978 |
A morphologic study of unexplained hepatitis following halothane anesthesia.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Female; Halothane; Human | 1978 |
[Hepatitis and acute renal failure following halothane anaesthesia in a patient treated with perhexiline maleate (author's transl)].
Topics: Acute Kidney Injury; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Drug Synergism; | 1978 |
Changes in liver enzyme values after halothane and enflurane for surgical anesthesia.
Topics: Adult; Alanine Transaminase; Anesthesia, General; Aspartate Aminotransferases; Chemical and Drug Ind | 1978 |
Halothane hepatitis: benign resolution of a severe lesion.
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Liver; Midd | 1978 |
[Postoperative medical jaundice (author's transl)].
Topics: Bacterial Infections; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hemolysis; Hum | 1978 |
Recurrent hepatitis following halothane exposures.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Liver; Middle Aged; Recur | 1978 |
Drug-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related | 1978 |
[Adverse effects of modern inhalation anesthetics. 2. Control of amounts and elimination of escaping anesthesia gases].
Topics: Air Conditioning; Air Pollutants; Air Pollutants, Occupational; Anesthetics; Chemical and Drug Induc | 1978 |
[Complications following repeated and protracted anesthesias].
Topics: Anesthesia, General; Anesthesia, Inhalation; Anesthetics; Chemical and Drug Induced Liver Injury; Ha | 1975 |
Is halothane hepatitis chronic active hepatitis?
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Humans; Male; Occupational Diseases; | 1977 |
Repeated anaesthesia.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1977 |
The effects of repeated 14C halothane exposure in mice.
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Halothane; Liver; Mice; Mic | 1977 |
[Clinical aspects of halothane hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Leg Injuries; Liver; Middle Aged; | 1977 |
Halothane macrophage migration inhibtiion factor test in halothane-associated hepatitis.
Topics: Adult; Aged; Animals; Cell Migration Inhibition; Chemical and Drug Induced Liver Injury; Female; Gui | 1977 |
Are effects of halothane on hepatocytes "pathologic".
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Liver; Liver Diseases; Rats | 1977 |
Circulating immune complexes after repeated halothane anaesthesia.
Topics: Anesthesia; Antigen-Antibody Complex; Chemical and Drug Induced Liver Injury; Complement System Prot | 1977 |
Halothane hepatitis in children.
Topics: Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Halothane; Humans; Infant; Male | 1977 |
Halothane hepatitis. Case report.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Jaundice | 1977 |
General anesthetics and hepatic toxicity.
Topics: Anesthesia, Inhalation; Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Humans; Live | 1977 |
Halothane hepatitis.
Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Live | 1977 |
Should you use halothane?
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver | 1977 |
[Halothane and antituberculous drugs--a hepatotoxic combination? (author's transl)].
Topics: Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Ethambutol; Female; Halothane; | 1977 |
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse.
Topics: Aminopyrine N-Demethylase; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chlorp | 1976 |
Diminished hepatic arterial flow during halothane administration.
Topics: Adult; Chemical and Drug Induced Liver Injury; Child, Preschool; Female; Halothane; Hepatic Artery; | 1976 |
Unexplained hepatitis following halothane.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1976 |
Halothane hepatitis revisited.
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Aged; Prednisone | 1976 |
An animal model of hepatotoxicity associated with halothane anesthesia.
Topics: Anesthesia, Inhalation; Animals; Aroclors; Biotransformation; Chemical and Drug Induced Liver Injury | 1976 |
[Relevance of clinical signs of hypersensitivity in cases of halothane hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Circadian Rhythm; Drug Hypersensitivity; Eosinophils; Haloth | 1976 |
Hepatitis and halothane.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Halothane | 1976 |
[Cytoplasmic crystals (cholesterol?) in acute and chronic liver lesions. Electron microscopic study].
Topics: Adult; Alcoholism; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; C | 1976 |
[Ultrastructural changes in rat hepatocytes after prolonged exposure to nonanesthtic doses of halothane and enflurane].
Topics: Animals; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Liver; Methyl Ethers; Rats | 1976 |
[Liver disease caused by halothane. Considerations on some clinical cases of halothane-induced jaundice].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Guinea Pigs; Halothane; Humans; Jaundice; Rab | 1976 |
[Liver-damaging action of halothane--an animal experiment study].
Topics: Animals; Bile Pigments; Cell Division; Chemical and Drug Induced Liver Injury; Dose-Response Relatio | 1975 |
Halothane hepatitis with subclinical manifestations: report of case.
Topics: Adult; Chemical and Drug Induced Liver Injury; Halothane; Humans; Male | 1976 |
[Diagnostic tests for hypersensitivity to halogen compounds].
Topics: Autoantibodies; Cell Migration Inhibition; Chemical and Drug Induced Liver Injury; Drug Hypersensiti | 1976 |
Hepatic decompensation following general anesthesia in alpha 1-antitrypsin deficiency.
Topics: alpha 1-Antitrypsin Deficiency; Anesthesia, General; Chemical and Drug Induced Liver Injury; Halotha | 1976 |
Urinary metabolites of halothane in man.
Topics: Binding Sites; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cysteine; Ethanolamines | 1975 |
Letter: Ethics and halothane.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Ethics, Medical; Halothane; Humans | 1975 |
[Letter: Liver lesions due to halothane].
Topics: Air; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Environmental Exposure; Halotha | 1975 |
Serum ferritin in patients with iron overload and with acute and chronic liver diseases.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1975 |
Drug therapy. Drug allergy (second of three parts).
Topics: Allergens; Anaphylaxis; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypers | 1975 |
Letter: Halothane in the guinea pig.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Guinea Pigs; Halothane | 1975 |
Exchange transfusion in hepatic coma: factors affecting results, with long-term follow-up data.
Topics: Adolescent; Adult; Aged; Ammonia; Bilirubin; Biopsy; Chemical and Drug Induced Liver Injury; Child; | 1975 |
Comparative toxicities of halothane, isoflurane, and diethyl ether at subanesthetic concentrations in laboratory animals.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Body Weight; Chemical and Drug Induced Liver Injury; D | 1975 |
Letter: Ethics and halothane.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Ethics, Medical; Halothane; Human Ex | 1975 |
Lymphocyte transformation in halothane-related hepatitis.
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosis, Differential | 1975 |
Ultrastructural evidence of the hepatotoxic effect of halothane in rats following in-utero exposure.
Topics: Animals; Animals, Newborn; Chemical and Drug Induced Liver Injury; Cytoplasm; Environmental Pollutan | 1975 |
Liver disease caused by medicinal agents.
Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contracept | 1975 |
[Is the demand for a 3-month interval between two halothane anesthesias justified?].
Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Halothane; Human | 1975 |
[Halothane hepatitis].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Female; Halothane; Hum | 1975 |
Halothane-related hepatitis. A clinical study of twenty-six cases.
Topics: Adult; Aged; Anesthesia, General; Bilirubin; Chemical and Drug Induced Liver Injury; Diagnosis, Diff | 1975 |
[Rules for the histological evaluation of drug-induced liver lesions].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Contraceptives, Oral; F | 1975 |
Ultrastructural studies of the hepatocytes after chronic exposure to low levels of halothane.
Topics: Animals; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Fe | 1975 |
[Halothane immunity and hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane | 1975 |
[Halothane hepatitis and lymphocyte stimulation test].
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Lymphocyte Activation | 1975 |
[Two cases of hepatic complication from halothane anesthesia following pediatric tonsillectomy (author's transl)].
Topics: Alkaline Phosphatase; Anesthesia, General; Chemical and Drug Induced Liver Injury; Child; Female; Ha | 1975 |
[Fatal effects of halothane anesthesia].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Ag | 1975 |
Proceedings: Further immunological investigations in patients with possible halothane hepatitis.
Topics: Cell Migration Inhibition; Chemical and Drug Induced Liver Injury; Halothane; Humans; Immunity, Cell | 1975 |
Halothane and the liver.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans; Jaundice; Postoperative Compl | 1975 |
[Postoperative icterus].
Topics: Anesthesia, Inhalation; Bacterial Infections; Chemical and Drug Induced Liver Injury; Cholestasis; H | 1975 |
Diagnosis of halothane-related hepatitis.
Topics: Anesthesia; Body Temperature; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Femal | 1975 |
Postoperative fever and the halothane controversy.
Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Fever; Halothane; Humans; Malignant Hyp | 1975 |
[Fulminant hepatitis].
Topics: Acute Disease; Adrenal Cortex Hormones; Alkalosis, Respiratory; Blood Transfusion; Brain Edema; Chem | 1975 |
[Drug-induced liver diseases].
Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; C | 1975 |
Immunological aspects of halothane hepatitis. Possible relevance of biotransformation.
Topics: Biotransformation; Cell Migration Inhibition; Chemical and Drug Induced Liver Injury; Halothane; Hum | 1975 |
[Lymphocyte stimulation test in halothane-induced hepatic injury and its clinical observation].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Lymphocyte Activatio | 1975 |
[Postoperative fever, jaundice and cognition disorder: acute hepatic necrosis caused by halothane].
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Aged | 1975 |
Disturbance of hepatic structure under halothane anaesthesia.
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Halothane; Liver Diseases; | 1975 |
[Occurrence of hepatitis in an anesthesiologist].
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Environmental Exposure; Halothane; Humans; Male; | 1976 |
Spontaneous hepatic artery thrombosis with infarction of the liver.
Topics: Aged; Amputation, Surgical; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosi | 1976 |
Recurrent hepatitis B-negative hepatitis after halothane anesthesia: apparent failure to demonstrate altered sensitivity.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Hepatitis B Antig | 1976 |
Halothane-induced liver damage: an analysis of the material reported to the Swedish Adverse Drug Reaction Committee, 1966-1973.
Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia, Inhalation; Aspartate Aminotransferases; Bilirubin | 1976 |
Absence of cellular hypersensitivity in patients with unexplained hepatitis following halothane.
Topics: Anesthesia, Inhalation; Cell Migration Inhibition; Chemical and Drug Induced Liver Injury; Halothane | 1976 |
A new aspect of the metabolism of halothane.
Topics: Bromides; Chemical and Drug Induced Liver Injury; Halothane; Liver | 1976 |
Hypoxia and halothane metabolism in vivo: release of inorganic fluoride and halothane metabolite binding to cellular constituents.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorides; Halothane; Hypoxia; Lipid Metabolism; Li | 1976 |
Hepatic pathology and skin test reactions to trifluoro-acetylated autologous protein after repeated halothane anaesthesia in the guineapig.
Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Fluoroa | 1976 |
Letter: Unexplained hepatitis following halothane.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1976 |
Letter: Unexplained hepatitis following halothane.
Topics: Chemical and Drug Induced Liver Injury; Halothane | 1976 |
Unexplained hepatitis following halothane.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Hypoxia | 1976 |
Elevation of serum xanthine oxidase following halothane anesthesia in the rat.
Topics: Anesthesia, General; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; F | 1976 |
A national database on hepatitis after exposure to inhaled halothane.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Registries | 1992 |
Chemical hepatitis associated with occupational exposure to halothane in a research laboratory.
Topics: Adult; Chemical and Drug Induced Liver Injury; Halothane; Humans; Laboratories; Male; Occupational E | 1992 |
Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Biopsy; Chemical and Drug Induced Liver Injury; Child, Pres | 1992 |
Immunocytochemical detection of the 72-kDa heat shock protein in halothane--induced hepatotoxicity in rats.
Topics: Animals; Antibodies, Monoclonal; Chemical and Drug Induced Liver Injury; Halothane; Heat-Shock Prote | 1992 |
Subanesthetic halothane is hepatotoxic in the guinea pig.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 1992 |
Halothane hepatitis 28 years after primary exposure.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Male; Middle Aged; | 1992 |
Nalidixic acid-induced hemolytic anemia complicating halothane-induced hepatitis.
Topics: Anemia, Hemolytic; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Mastectomy, Se | 1992 |
Does methionine alter the outcome in halothane hepatitis?
Topics: Administration, Oral; Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; F | 1992 |
Use of structural alterations in the synthesis of halothane metabolite antigens to mimic halothane-induced immunogen.
Topics: Acetates; Acetylation; Aminocaproates; Animals; Antibodies; Chemical and Drug Induced Liver Injury; | 1990 |
Screening for antibodies associated with halothane hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Fluoroacetates; | 1991 |
Halothane hepatitis in children.
Topics: Chemical and Drug Induced Liver Injury; Child; Halothane; Humans; Male | 1991 |
[Mitochondrial changes in the rat liver in hyperthyroidism: a possible explanation for halothane hepatitis?].
Topics: Animals; Calcium; Chemical and Drug Induced Liver Injury; Halothane; Hyperthyroidism; Mitochondria, | 1991 |
[Effect of sho-saiko-to (xiao-chai-hu-tang) on hepatic injury induced by halothane in rats].
Topics: Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Halothane; Male; Rats; Rats, | 1991 |
Aerobic dehalogenation of halothane showing different substrate dependency from anaerobic dehalogenation in liver microsomes of guinea pig.
Topics: Aerobiosis; Animals; Chemical and Drug Induced Liver Injury; Guinea Pigs; Halothane; In Vitro Techni | 1991 |
Release of liver microsomal beta-glucuronidase from hepatocytes in vitro and in vivo by organophosphates and hepatotoxic agents.
Topics: Acetanilides; Amino Acid Sequence; Animals; Carbamates; Carboxylic Ester Hydrolases; Chemical and Dr | 1991 |
Halothane hepatitis revisited.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1991 |
Hepatitis following use of two different fluorinated anesthetic agents.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Emergencies; Enflurane; | 1991 |
Even isoflurane.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Isoflurane | 1991 |
Colchicine to prevent halothane hepatitis?
Topics: Chemical and Drug Induced Liver Injury; Colchicine; Female; Halothane; Humans | 1991 |
[Halothane induced hepatitis: risk related to sickle cell disease].
Topics: Anemia, Sickle Cell; Chemical and Drug Induced Liver Injury; Child; Halothane; Humans; Male | 1991 |
The effect of alcohol and anesthetic metabolites on cell membranes. A possible direct immune mechanism.
Topics: Acetaldehyde; Alcoholism; Animals; Antibody Formation; Cell Membrane; Chemical and Drug Induced Live | 1991 |
S-ethylthiotrifluoroacetate enhancement of the immune response to halothane in the guinea pig.
Topics: Animals; Antibody Formation; Antigens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity | 1991 |
[A revival of inhalation anesthesia. Reduced risk of liver toxicity].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Liver; | 1990 |
[Halothane hepatitis in the differential diagnosis of postoperative jaundice].
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Halothane; Humans; Jaundice; Male; | 1990 |
Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Halothane; Lipid Metabolism; Liv | 1990 |
Halothane hepatitis in children.
Topics: Chemical and Drug Induced Liver Injury; Child; Halothane; Humans; Liver Function Tests; Male | 1990 |
Halothane hepatitis.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1990 |
Antibody assays for the detection of patients sensitized to halothane.
Topics: Animals; Antibodies; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Halo | 1990 |
[Protective effect of calcium channel blockers on the liver against halothane hepatitis in rats].
Topics: Animals; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Halothane; Liver; Male; R | 1990 |
Halothane hepatitis: a case report.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Male; Medical Rec | 1990 |
Cimetidine pretreatment and halothane hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Halothane; Humans; Premedication | 1990 |
[Liver damage after exposure to halothane].
Topics: Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Eosinophilia; Female; Halothan | 1990 |
Seeking an alternative to halothane.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans | 1990 |
Lack of defect in oxidative hydroxylation of debrisoquine in a patient with halothane hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Syst | 1990 |
Isoniazid potentiation of a guinea pig model of halothane-associated hepatotoxicity.
Topics: Alanine Transaminase; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome | 1990 |
Halothane hepatitis: attempt to develop an animal model.
Topics: Animals; Antibody Formation; Antigens, Surface; Chemical and Drug Induced Liver Injury; Cytotoxicity | 1987 |
Early indicators of prognosis in fulminant hepatic failure.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Halothan | 1989 |
Is halothane obsolete? Two standards of judgement.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Middle Aged; Risk | 1989 |
Age and gender influence halothane-associated hepatotoxicity in strain 13 guinea pigs.
Topics: Aging; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Female; Guinea Pigs; | 1989 |
Detection of antibodies to a halothane metabolite hapten in sera from patients with halothane-associated hepatitis.
Topics: Adolescent; Adult; Aged; Antibodies; Chemical and Drug Induced Liver Injury; Child; Child, Preschool | 1989 |
[Should we continue to use halothane clinically?].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1989 |
Halothane associated hepatitis and phenobarbitone.
Topics: Adult; Anesthesia, Obstetrical; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Halo | 1989 |
[Protective effects of ulinastatin on hepatic oxygen metabolism during halothane anesthesia in the presence of graded hypoxic hypoxemia].
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Dogs; Glycoproteins; Haloth | 1989 |
[Is it truly necessary to terminate the clinical use of halothane?].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver | 1989 |
[A case of fulminant hepatitis after reexposure to halothane six years later].
Topics: Acute Kidney Injury; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halotha | 1989 |
The pathology of halothane hepatotoxicity in a guinea-pig model: a comparison with human halothane hepatitis.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Disea | 1989 |
Halothane-associated liver damage.
Topics: Acute Disease; Anesthesia; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Fem | 1986 |
Halothane hepatotoxicity.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1986 |
Guidelines on halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Child; Fever; Halothane; Humans | 1987 |
Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase.
Topics: Animals; Antibodies; Carboxylesterase; Carboxylic Ester Hydrolases; Chemical and Drug Induced Liver | 1989 |
The role of oxidative biotransformation of halothane in the guinea pig model of halothane-associated hepatotoxicity.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Guinea Pigs; Halothane; Liver; M | 1989 |
[Hepatic injury and halogenated anesthetics: preliminary clinical experience].
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Ha | 1985 |
Halothane and the liver.
Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Halothane; Humans; Male | 1986 |
Halothane and the liver.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1986 |
Halothane and the liver.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1986 |
[A clinicopathological study of 11 patients with acute drug-induced hepatic failure].
Topics: Acute Disease; Adult; Aged; Chemical and Drug Induced Liver Injury; Ethionamide; Female; Halothane; | 1986 |
Halothane hepatitis in children.
Topics: Adolescent; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Halothane; Humans | 1987 |
Halothane hepatitis in children.
Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Child; Halothane; Humans | 1987 |
Halothane hepatitis in children.
Topics: Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Halothane; Humans | 1987 |
Hepatocellular damage due to halothane anaesthesia.
Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Child; Female; Halothane; Humans | 1988 |
Comparison of covalent binding from halothane metabolism in hepatic microsomes from phenobarbital-induced and hyperthyroid rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Glutathione; Halothane; Hyperthyroidism; Lipid Meta | 1988 |
[Case reports of postoperative liver dysfunction following halothane anesthesia within a short period after enflurane anesthesia].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Synergism; Enflurane; Fe | 1988 |
Immunological basis of anesthetic-induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Guinea Pigs; Halothane; Huma | 1988 |
Enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Isoantigens; Male; Rats; Rats | 1988 |
Halothane related liver affection in an anaesthetist.
Topics: Anesthesiology; Chemical and Drug Induced Liver Injury; Halothane; Humans; Male; Middle Aged; Occupa | 1988 |
The immunological basis of adverse drug reactions. A report on a symposium held in Liverpool on 6th April 1988.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects an | 1988 |
Unexplained hepatitis following reexposure to halothane at 10-year interval.
Topics: Anesthesia, General; Biopsy; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Male; | 1988 |
Identification by immunoblotting of three halothane-induced liver microsomal polypeptide antigens recognized by antibodies in sera from patients with halothane-associated hepatitis.
Topics: Animals; Antibodies; Antigens; Chemical and Drug Induced Liver Injury; Halothane; Humans; Immunologi | 1987 |
Plasma glutathione S-transferase concentration as a measure of hepatocellular integrity following a single general anaesthetic with halothane, enflurane or isoflurane.
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Enflurane; Female; Glutathion | 1988 |
Halothane hepatitis.
Topics: Adult; Aged; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Female; Guinea | 1988 |
Effects of treatment with phenobarbitone or isoniazid on hepatotoxicity due to prolonged subanaesthetic halothane inhalation.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Halothane; Isoniazid; Liver; Male; Org | 1988 |
Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes.
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Halothane; Hypoxia; In Vitro Techniq | 1988 |
Halothane hepatitis patients generate an antibody response toward a covalently bound metabolite of halothane.
Topics: Adult; Aged; Anesthesia, Inhalation; Antibody Formation; Chemical and Drug Induced Liver Injury; Fem | 1988 |
Diagnostic test for halothane hepatitis.
Topics: Autoantibodies; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1988 |
Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane.
Topics: Animals; Antigens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Haptens | 1988 |
Effects of piperonyl butoxide on halothane hepatotoxicity and metabolism in the hyperthyroid rat.
Topics: Administration, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Cy | 1988 |
[Anesthesia and postoperative hepatic changes].
Topics: Adult; Anesthetics; Chemical and Drug Induced Liver Injury; Child; Female; Halothane; Humans; Liver; | 1988 |
Halothane hepatitis and prompt resolution with methionine therapy: case report.
Topics: Adult; Anesthesia, Inhalation; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Halothane; | 1988 |
[Hepatitis caused by halothane. A clinical case].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Ag | 1987 |
Investigation of the immunological basis of halothane-induced hepatotoxicity.
Topics: Animals; Antigen-Antibody Complex; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimetidine | 1986 |
[Halothane and hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Halothane; Hepatitis, Viral, Human; | 1987 |
Acute renal failure following halothane anesthesia.
Topics: Acute Kidney Injury; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Huma | 1987 |
Clinical report, "Hepatic necrosis following halothane anesthesia in goats," viewed as unacceptable.
Topics: Animals; Chemical and Drug Induced Liver Injury; Goats; Halothane; Liver Diseases; Necrosis | 1987 |
[Halothane and hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1987 |
[Halothane and hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1987 |
Halogenated anesthetics increase oxygen consumption in isolated hepatocytes from phenobarbital-treated rats.
Topics: Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 En | 1987 |
[Unexplained fatal hepatic necrosis following halothane--a case report].
Topics: Aged; Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans; Male; Necrosis | 1987 |
[Halothane-associated liver damage: metabolic, immunologic and genetic mechanisms].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Inactivation, Metabolic; Liver; Risk | 1987 |
Halothane hepatotoxicity in glutathione depleted rats.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syste | 1987 |
[Severe hepatitis following halothane anesthesia in a child].
Topics: Age Factors; Anesthesia, General; Cerebral Hemorrhage; Chemical and Drug Induced Liver Injury; Child | 1987 |
Antibody to halothane-induced liver antigen.
Topics: Animals; Antibodies; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver | 1987 |
Specific antibodies to halothane-induced liver antigens in halothane-associated hepatitis.
Topics: Adolescent; Adult; Aged; Antibodies; Antigens; Chemical and Drug Induced Liver Injury; Child; Child, | 1987 |
[Halothane and the liver. Clinical experience].
Topics: Adolescent; Adult; Age Factors; Aged; Anesthesiology; Antibodies; Chemical and Drug Induced Liver In | 1987 |
[Immunological aspects of halothane hepatoxicity].
Topics: Animals; Antigens; Antigens, Surface; Cell Membrane; Chemical and Drug Induced Liver Injury; Enzyme- | 1987 |
[Halogenic anesthetics. Their current use].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Hydrocarbons, Haloge | 1987 |
[Halothane. Medico-legal considerations].
Topics: Chemical and Drug Induced Liver Injury; England; Female; Halothane; Humans; Informed Consent; Male; | 1987 |
[Etiological factors in halothane hepatoxicity].
Topics: Animals; Chemical and Drug Induced Liver Injury; Genetic Predisposition to Disease; Guinea Pigs; Hal | 1987 |
Halothane and the liver--the present situation.
Topics: Antigen-Antibody Complex; Autoantibodies; Chemical and Drug Induced Liver Injury; Halothane; Humans; | 1987 |
Generation of halothane-induced immune response in a guinea pig model of halothane hepatitis.
Topics: Animals; Antibody Formation; Antigens; Chemical and Drug Induced Liver Injury; Female; Guinea Pigs; | 1987 |
Halothane hepatitis in an animal model: time course of hepatic damage.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Disea | 1987 |
Delayed enhancement of acetaminophen hepatotoxicity by general anesthesia using diethyl ether or halothane.
Topics: Acetaminophen; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Drug Synergi | 1986 |
Halothane hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Male; Rats; Sex Factors | 1986 |
Halothane hepatitis in children.
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Halothane; Humans; Uni | 1986 |
Halothane hepatitis in an 11-month-old child.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Infant; Male; Tim | 1986 |
Halothane hepatotoxicity--again?
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Guinea Pigs; Halothane; Humans; | 1986 |
[The effect of chronic ethanol administration on halothane hepatotoxicity in rats].
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Ethanol; Halothane; Rats | 1986 |
Genetic predisposition to liver damage after halothane anesthesia in guinea pigs.
Topics: Alanine Transaminase; Animals; Breeding; Chemical and Drug Induced Liver Injury; Disease Susceptibil | 1986 |
Prolonged halothane hepatitis. Prompt resolution of severe lesion with corticosteroid therapy.
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Aged; Prednisone; Time Fac | 1986 |
Prospective study of liver function in children following multiple halothane anaesthetics at short intervals.
Topics: Adolescent; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; | 1986 |
Halothane hepatitis in a prospective study of postoperative complications.
Topics: Aged; Alanine Transaminase; Anesthesia, General; Chemical and Drug Induced Liver Injury; Female; Hal | 1986 |
Halothane-associated liver damage and renal failure in a young child.
Topics: Acute Kidney Injury; Alanine Transaminase; Anesthesia; Aspartate Aminotransferases; Chemical and Dru | 1986 |
Halothane hepatitis in a child?
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Infant; Male | 1986 |
Impaired hepatocellular integrity during general anaesthesia, as assessed by measurement of plasma glutathione S-transferase.
Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Female | 1986 |
Unexplained hepatitis following halothane.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1987 |
Halothane hepatotoxicity in guinea pigs.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Guinea Pigs; Haloth | 1987 |
Experimental studies on some effects of repeated halothane anaesthesia.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis, Animal; Male; Rats; Rats, Inb | 1985 |
HLA antigens in patients with unexplained hepatitis following halothane anesthesia.
Topics: Adolescent; Adult; Aged; Anesthetics; Chemical and Drug Induced Liver Injury; Child; Cholestasis, In | 1985 |
Halothane hepatitis: toxicity or hypersensitivity?
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Equipm | 1985 |
Test for halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1985 |
Increased toxicity of the antitumor drug cyclophosphamide in mice in the presence of the volatile anesthetic agent halothane.
Topics: Animals; Brain; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Dose-Resp | 1986 |
Is enflurane hepatotoxic?
Topics: Adult; Chemical and Drug Induced Liver Injury; Enflurane; Female; Halothane; Humans; Liver Diseases; | 1986 |
Postoperative hepatic dysfunction after halothane or enflurane anesthesia in patients with hyperthyroidism.
Topics: Adult; Alanine Transaminase; Anesthesia, Inhalation; Aspartate Aminotransferases; Chemical and Drug | 1986 |
Halothane anesthesia does not exacerbate hepatic dysfunction in cirrhotic rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1985 |
Guinea-pig model of halothane-associated hepatotoxicity in the absence of enzyme induction and hypoxia.
Topics: Animals; Biotransformation; Blood Gas Analysis; Chemical and Drug Induced Liver Injury; Disease Mode | 1985 |
Unexplained hepatitis after podiatric surgery with halothane anesthesia.
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Foot; Halothane | 1985 |
Nitrous oxide does not hinder the repair of halothane-induced hepatic injury in the rat.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Bretylium Compounds; Chemical an | 1985 |
[A case of hepatitis probably induced by the first halothane exposure].
Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Knee; | 1985 |
Sex differences in halothane metabolism and hepatotoxicity in a rat model.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Biotransformation; Breath Tests; Chemical and | 1985 |
Toxicity of volatile anaesthetic agents.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1985 |
Enflurane hepatitis. A report of a case with a previous history of halothane hepatitis.
Topics: Adult; Anesthetics; Biotransformation; Chemical and Drug Induced Liver Injury; Enflurane; Female; Ha | 1985 |
Comparison of the requirements for hepatic injury with halothane and enflurane in rats.
Topics: Anesthesia, Inhalation; Animals; Biotransformation; Body Temperature; Carbon Tetrachloride; Chemical | 1985 |
Halothane hepatitis. Detection of a constitutional susceptibility factor.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Disease Susceptibility; Drug Evaluation, Precli | 1985 |
Halothane hepatitis revisited.
Topics: Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Halothane; Humans; In Vitro Technique | 1985 |
[Centrolobular liver cell necroses following occupational halothane contact. Association with antibodies to halothane altered liver cell components].
Topics: Adult; Autoantibodies; Biopsy; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Li | 1985 |
Hepatic and renal effects of prolonged exposure of rats to 50 p.p.m. methoxyflurane.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Fatty Liver; Fluorides; Halothane; Kid | 1985 |
Is there such thing as halothane-induced hepatitis?
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1985 |
The changing pattern of childhood.
Topics: Acidosis; Adipose Tissue; Alpha-Globulins; Anemia, Aplastic; Biliary Tract Diseases; Brain Diseases; | 1971 |
The effect of the repeated administration of halothane on the liver of the horse.
Topics: Adenosine Triphosphatases; Alcohol Oxidoreductases; Alkaline Phosphatase; Animals; Arginase; Asparta | 1970 |
The liver in mild halothane hepatitis. Light and electron microscopic findings with special reference to the mononuclear cell infiltrate.
Topics: Adult; Anesthesia, Inhalation; Biopsy; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum | 1970 |
Use of Normotest and Thrombotest, coagulation tests in hepatocellular disease.
Topics: Acute Disease; Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin | 1973 |
Fluorocarbon propellants in aerosols.
Topics: Abortion, Spontaneous; Aerosol Propellants; Aerosols; Anesthesia, Inhalation; Chemical and Drug Indu | 1973 |
[Morphology and etiology of halothane-induced liver lesions (author's transl)].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Cholestasis; Fatty Liv | 1972 |
Guidelines for diagnosis of therapeutic drug-induced liver injury in liver biopsies.
Topics: Anabolic Agents; Biopsy; Cathartics; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholest | 1974 |
Letter: Occupational hazard of halothane.
Topics: Adult; Anesthesia; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Occupational D | 1974 |
The effects of multiple anaesthetics on the livers of rats subjected to microsomal enzyme induction. A preliminary report.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Enzyme | 1973 |
The abortive lives of modern inhalation anesthetics.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism | 1973 |
Experimental immunity to a metabolite of halothane and fluroxene: cutaneous delayed-type hypersensitivity.
Topics: Albumins; Animals; Biotransformation; Cattle; Chemical and Drug Induced Liver Injury; Disease Models | 1974 |
Hepatic metabolism of halothane.
Topics: Anesthesia, Inhalation; Anesthesiology; Animals; Biotransformation; Blood Pressure; Chemical and Dru | 1974 |
[Drug-induced damage of the liver].
Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse R | 1973 |
Halothane.
Topics: Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Huma | 1965 |
Halothane.
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Male | 1965 |
Halothane.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Male | 1965 |
Halothane: hepatitis or allergy?
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity; Halothane; H | 1969 |
Halothane.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1969 |
Is halothane hepatotoxic?
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1969 |
[Acute liver failure following repeated halothane anesthesia--related to an accident covered by industrial insurance].
Topics: Accidents, Occupational; Adolescent; Anesthesia, Inhalation; Autopsy; Chemical and Drug Induced Live | 1969 |
The effects of chloroform or halothane on horse liver in the early stage of ragwort poisoning.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Arginase; Bilirubin; Biopsy; Chemical and | 1972 |
Peritoneoscopy during hepatic coma.
Topics: Adolescent; Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Haloth | 1973 |
Hepatitis: drug or viral?
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Halothane; Hepatitis A; Humans; Ipr | 1966 |
The spectrum of hepatotoxicity.
Topics: Aminosalicylic Acids; Anti-Bacterial Agents; Antimetabolites; Benzene Derivatives; Carbon Tetrachlor | 1968 |
Letter: Hepatic necrosis after enflurance anesthesia.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Hydrocarbons, Halogen | 1974 |
Chronic aggressive hepatitis induced by halothane.
Topics: Adult; Anesthesia, Inhalation; Biopsy; Chemical and Drug Induced Liver Injury; Cholecystectomy; Chol | 1974 |
Letter: "Halothane hepatitis".
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Liver | 1974 |
Letter: Ethics and halothane.
Topics: Chemical and Drug Induced Liver Injury; Drug and Narcotic Control; Ethics, Medical; Halothane; Human | 1974 |
Letter: Halothane and liver damage.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Pharmacy and Therapeutics Committee; Unit | 1974 |
Letter: Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Environmental Exposure; Halothane | 1974 |
Letter: Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans | 1974 |
Editorial: Halothane and liver damage.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Jaund | 1974 |
Mechanisms of acute hepatic toxicity: chloroform, halothane, and glutathione.
Topics: Acute Disease; Anesthesia, Inhalation; Aniline Compounds; Animals; Biotransformation; Chemical and D | 1974 |
Letter: Ethics and halothane.
Topics: Chemical and Drug Induced Liver Injury; Ethics, Medical; Halothane; Human Experimentation; Humans; R | 1974 |
Letter: Jaundice after halothane.
Topics: Chemical and Drug Induced Liver Injury; Drug and Narcotic Control; Halothane; Humans; Pharmacy and T | 1974 |
Fluothane (halothane) anesthesia and acute hepatic toxicity.
Topics: Acute Disease; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Hu | 1974 |
Morphological results of the rat liver after the application of halothane and hypoxia.
Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholinesterases; Endop | 1974 |
The incidence and causes of postoperative jaundice. A prospective study.
Topics: Adult; Alanine Transaminase; Bilirubin; Biopsy; Chemical and Drug Induced Liver Injury; Halothane; H | 1974 |
[The isoenzyme pattern of LDH following halothane anaesthesia for choecystectomy (author's transl)].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Cholecystectomy; Halothane; Humans; | 1974 |
Halothane hepatitis with renal failure treated with hemodialysis and exchange transfusion.
Topics: Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Exchange Transfusion, Whole Bloo | 1974 |
Halothane, et al, 1973.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Kidney; Liver; Methoxyflurane | 1973 |
Letter to the editor. Warning for halothane use.
Topics: Anesthesia, Dental; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1972 |
Halothane metabolism and the liver.
Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis; Ret | 1973 |
Halothane hepatitis: fact or fallacy.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1973 |
Fact or fancy--a reasoned view of halothane.
Topics: Anesthesia, Dental; Anesthesia, General; Anesthesia, Inhalation; Chemical and Drug Induced Liver Inj | 1974 |
Halothane anesthesia followed by anicteric hepatitis with complete recovery.
Topics: Anesthesia, Inhalation; Biopsy; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Ma | 1974 |
Post-operative jaundice and halothane anaesthetics.
Topics: Adult; Anesthesia, Dental; Chemical and Drug Induced Liver Injury; Dentigerous Cyst; Female; Halotha | 1974 |
Anaesthesia and the liver--lessons from history?
Topics: Anesthesia, Inhalation; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Chloroform; Ha | 1972 |
Biochemical effects of halothane.
Topics: Adult; Animals; Autoantibodies; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Dr | 1972 |
Autoimmune response in experimental halothan-induced liver injury.
Topics: Animals; Antibody Formation; Autoantibodies; Chemical and Drug Induced Liver Injury; Dose-Response R | 1973 |
Tetracycline hepatotoxicity in the differential diagnosis of postoperative jaundice.
Topics: Ampicillin; Candida albicans; Candidiasis; Chemical and Drug Induced Liver Injury; Child; Child, Pre | 1974 |
A patient with diabetes.
Topics: Acetone; Adult; Autopsy; Bacteriuria; Brain; Chemical and Drug Induced Liver Injury; Cystoscopy; Dia | 1974 |
Relationship of Milan antigen to abnormal serum lipoprotein.
Topics: Centrifugation, Zonal; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Hepatitis B A | 1972 |
A summary of the National Halothane Study.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Necrosis; United States | 1972 |
Halothane hepatitis as seen by the physician.
Topics: Adult; Aged; Anesthesia, Inhalation; Antibodies; Chemical and Drug Induced Liver Injury; Diagnosis, | 1972 |
Anesthesia and hepatic necrosis.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Cyclopropanes; Halothane; Humans; Necrosis | 1972 |
[Drugs and the liver].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Enzyme Induction; Halothane; Humans; Liver; Liver Di | 1972 |
[Early postoperative jaundice and peroperative liver diseases. Point of view of the anatomo-pathologist].
Topics: Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Dogs; Halothane; Jaundice; Liver; Necro | 1972 |
Halothane hepatitis.
Topics: Anesthesia, Inhalation; Anesthesiology; Chemical and Drug Induced Liver Injury; Drug Hypersensitivit | 1972 |
[Halothane and jaundice].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Jaundice | 1972 |
What is a "safe" interval between halothane exposures?
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Liver Dise | 1972 |
[Early postoperative jaundice and peroperative hepatopathy. The anatomo-pathologist's point of view].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Halothane; Humans; Jaundice; Liver; Male; Mid | 1972 |
Depression of lymphocyte reactivity to phytohemagglutinin by serum from patients with liver disease.
Topics: Bile Acids and Salts; Carrier State; Chemical and Drug Induced Liver Injury; Cholelithiasis; Halotha | 1973 |
Halothane hepatitis.
Topics: Adult; Alkaline Phosphatase; Anesthesia, Inhalation; Aspartate Aminotransferases; Autopsy; Bilirubin | 1973 |
Cytotoxic effects of halogenated anaesthetics on cultured human liver and embryonic kidney cells.
Topics: Cell Membrane; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chloroform; Cytoplasm; Embry | 1973 |
Anaesthesia and the liver: history and epidemiology.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Chloroform; Halothane; Humans; Liver; Liver Fun | 1973 |
Anaesthetic contamination.
Topics: Abortion, Spontaneous; Air Conditioning; Air Pollution; Anesthetics; Animals; Chemical and Drug Indu | 1973 |
[Renal and hepatic dysfunction following the use of methoxyflurane as an anesthetic].
Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Cross Reactions; Drug Hypersensitivity; | 1973 |
Halothane hepatitis--fact or fallacy.
Topics: Antibodies; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity; | 1973 |
[Sedatives and liver diseases].
Topics: Barbiturates; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Humans; Hypnotics and | 1973 |
Diagnosis of halothane hepatitis.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Lymphocyte | 1973 |
Lymphocyte transformation. Absence of increased responses in alleged halothane jaundice.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Ethyl Ethers; Halothane; | 1973 |
"Halothane hepatitis".
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1973 |
Ultrastructural pathology of a case of halothane hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Halothane; Humans; Kupffer Cells; Liver; Male; Micros | 1973 |
[Halothane-hepatitis. A case report].
Topics: Acute Disease; Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Haloth | 1973 |
Halothane induced liver damage.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypers | 1973 |
Histological appearances in fulminant hepatic failure with reference to aetiology, time of survival and role of immunological processes.
Topics: Acetaminophen; Adolescent; Adult; Aged; Cell Nucleus; Chemical and Drug Induced Liver Injury; Haloth | 1973 |
[Liver damage after halothane--an analysis of the material of the Committee of Side Effects 1965-1972].
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Huma | 1973 |
[Hepatic disorder associated with halothane anesthesia: diagnosis based on RNA synthesis by the peripheral lymphocytes].
Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Liver | 1973 |
[Case of fulminant hepatitis after the 3d halothane exposure].
Topics: Adult; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Dogs; Halothane; Hum | 1973 |
Letter: Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver | 1973 |
Editorial: Fulminant hepatic failure.
Topics: Age Factors; Aged; Anesthesia; Calcium; Chemical and Drug Induced Liver Injury; Exchange Transfusion | 1973 |
Downstream contamination of in-series vapourizers.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Methoxyflurane; V | 1974 |
Frequency and type of renal and electrolyte disorders in fulminant hepatic failure.
Topics: Acetaminophen; Acute Kidney Injury; Blood Glucose; Chemical and Drug Induced Liver Injury; Creatinin | 1974 |
Liver injury following halothane anesthesia in phenobarbital-pretreated rats.
Topics: Alkadienes; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 1974 |
Postmethoxyflurane hepatitis: a clinical entity.
Topics: Adult; Anesthesia, Inhalation; Anesthesia, Obstetrical; Anti-Bacterial Agents; Bilirubin; Chemical a | 1974 |
The syndrome of methoxyflurane-associated hepatitis.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity; | 1974 |
Letter: Jaundice after halothane.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Jaundice; Postoperative Complications; Ti | 1974 |
Editorial: Silent death.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Muscle Rel | 1974 |
[Halothane hepatitis. 11 cases of hepatitis after repeated halothane anesthesia].
Topics: Adult; Anesthesia; Chemical and Drug Induced Liver Injury; Child; Female; Halothane; Hepatic Encepha | 1974 |
A nearly fatal hepatotoxic reaction to rifampin after halothane anesthesia.
Topics: Aged; Alanine Transaminase; Anesthesia, Inhalation; Aspartate Aminotransferases; Biopsy; Chemical an | 1974 |
Anesthesiology grand rounds. Yale-New Haven hospital: "Halothane Hepatitis".
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Intervertebral Disc Displa | 1974 |
Letter: Hepatitis and halothane sniffing.
Topics: Adult; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Male; Substance-Related Dis | 1974 |
Letter: Jaundice after halothane.
Topics: Air Pollution; Chemical and Drug Induced Liver Injury; Drug Contamination; Ethyl Ethers; Halothane; | 1974 |
"Halothane hepatitis".
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Humans; Immunity, Cellular; Liver; L | 1974 |
[Drug-induced hepatopathies].
Topics: Adult; Age Factors; Bilirubin; Cell Membrane; Chemical and Drug Induced Liver Injury; Cholestasis; D | 1974 |
Hepatocellular dysfunction without jaundice after enflurane anesthesia.
Topics: Anesthesia, Inhalation; Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Humans; Hydr | 1974 |
[Report number 20 from the committee for secondary effects of drugs: a review of 8 years' work].
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Child; Child | 1974 |
Liver disease in pregnancy.
Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptives, Oral; Fatt | 1974 |
Biotransformation of anesthetics: clinical implications. II.
Topics: Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dogs; Dose-Response | 1974 |
Halothane hepatitis--a report of five cases.
Topics: Adult; Anesthesia, General; Biopsy; Chemical and Drug Induced Liver Injury; Female; Halothane; Human | 1974 |
[Microsomal mixed function oxidation and oxygen partial pressure--relationship between hypoxia and liver injuries by halothane].
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Hypoxia; Liver Diseases; Male; Microsome | 1974 |
Electron-microscopic and autoradiographic studies on the effect of halothane and chloroform on liver cells.
Topics: Anesthesia, Inhalation; Animals; Autoradiography; Blood Coagulation Factors; Blood Volume; Carbon Te | 1968 |
Halothane anesthesia, hepatic necrosis, and death: report of a case.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Ag | 1967 |
[Histological, histochemical and electron microscopical findings in foreign substance induced liver hypertrophy in white mice].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Endoplasmic Reticulum; Halothane; Hyper | 1967 |
Histochemical studies on the effect of some anaesthetics on rat liver.
Topics: Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Endoplasmic Reticulum | 1969 |
Influence of a clinical anaesthesia-technique (premedication with tranquillizers and atropine, induction with chloralhydrate, maintenance with halothane in a closed circle system) on liver function tests in the horse.
Topics: Anesthesia, Inhalation; Animals; Atropine; Chemical and Drug Induced Liver Injury; Chloral Hydrate; | 1969 |
The biotransformation of halothane.
Topics: Animals; Autoradiography; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury | 1971 |
[Enzyme histochemical studies on liver damage caused by halothane as compared to diethyl ether and chloroform].
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Citric Acid Cyc | 1971 |
Fatal hepatic necrosis and halothane.
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Aged; Necrosis | 1972 |
Halothane, hepatitis, and dental anaesthesia.
Topics: Anesthesia, Dental; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1972 |
[Sedatives and liver diseases].
Topics: Barbiturates; Chemical and Drug Induced Liver Injury; Halothane; Humans; Hypnotics and Sedatives; Ph | 1972 |
Anaesthesia and the liver.
Topics: Anesthesia; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Dogs; Halothan | 1972 |
The proof of guilt. A study of case reports of postoperative jaundice.
Topics: Adolescent; Adult; Anesthetics; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; J | 1972 |
Hepatic necrosis produced by repeated administration of halothane to guinea pigs.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1972 |
Serious sequelae of general anesthesia.
Topics: Adult; Aged; Anesthesia, General; Chemical and Drug Induced Liver Injury; Circumcision, Male; Cortic | 1972 |
[Hepatitis due to fluothane].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Postoperative Com | 1972 |
Fatal hepatic necrosis associated with halothane anesthesia.
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Hepatitis; | 1972 |
[A comparative evaluation of the effects of different kinds of anesthesia on the liver as judged by sorbitol dehydrogenase activity].
Topics: Adult; Alcohol Oxidoreductases; Anesthesia, General; Chemical and Drug Induced Liver Injury; Chlorof | 1972 |
Effects of phenobarbital pretreatment on the response of rat liver to halothane administration.
Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Enzyme Induction; | 1972 |
The effect of intraperitoneal administration of halothane.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Injections, Intraperitoneal; Male; Perit | 1972 |
Halothane hepatitis--an unsettled issue.
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Male; Middle Aged; Necrosis | 1972 |
Retinal detachment, halothane, and hepatitis.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Postoperative Com | 1972 |
Drugs containing halogen atoms: toxicity and lack of toxicity.
Topics: Chemical and Drug Induced Liver Injury; Ethers; Halothane; Heart Diseases; Humans; Hydrocarbons, Hal | 1972 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Humans; Necrosis | 1971 |
"The halothane dilemma".
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane | 1971 |
[Specific hepato-toxicity or liver blood-flow?].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Drug Hypersensitivity; Halothane; Humans; Liv | 1971 |
Post-halothane jaundice in relation to previous administration of halothane.
Topics: Adult; Age Factors; Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; England; Ha | 1971 |
Acute massive hepatic necrosis with fatal liver failure.
Topics: Acute Disease; Adolescent; Adult; Aged; Anticonvulsants; Antitubercular Agents; Azathioprine; Blood | 1971 |
Possible cross-sensitivity between halothane and methoxyflurane: report of a case.
Topics: Alkaline Phosphatase; Anesthesia, Inhalation; Appendectomy; Aspartate Aminotransferases; Bilirubin; | 1971 |
[Does inhalation anesthesia represent a professional risk to the anesthetizing personnel?].
Topics: Abortion, Threatened; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Environmental | 1971 |
Diagnosis of halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Time Factors | 1971 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Jaundice; Postoperative Complications | 1971 |
[Jaundice after halothane anesthesia].
Topics: Adult; Anesthesia; Aspartate Aminotransferases; Bilirubin; Body Temperature; Chemical and Drug Induc | 1971 |
[Halothane icterus].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans | 1971 |
Doctors McDonald, Climie answer criticism of halothane article.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1971 |
Detroit anesthesiologists challenge statements of halothane article.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver | 1971 |
[Halogenated hydrocarbons and the liver].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Halothane; Humans; | 1971 |
Fatal liver necrosis after repeated halothane anesthesia.
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans; Intestinal Obstruction; Middl | 1971 |
Clinical implications of halothane contamination of the anesthetic circle.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diffusion; Halothane; Humans; Liver; | 1971 |
[Evaluation of anesthetics according to their hepatotoxicity and ornithine carbamoyl-transferase activity].
Topics: Adult; Anesthesia, Inhalation; Anesthetics; Chemical and Drug Induced Liver Injury; Chloroform; Cycl | 1971 |
[Hepatitis after intrauterine radium application in uterine cancer in halothane anesthesia].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Radium; Uterine N | 1971 |
Halothane anesthesia and postoperative liver necrosis.
Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Cholecystectomy; Female; Halothane; Hum | 1968 |
Halothane and the liver: a review.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Liver; Nursing | 1971 |
Fulminant hepatic necrosis following halothane anesthesia.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Aged; Necro | 1970 |
Halothane hepatitis in a laboratory technician.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Laboratories; Occupational | 1971 |
[Halothane icterus].
Topics: Acute Kidney Injury; Blood Coagulation Tests; Chemical and Drug Induced Liver Injury; Diagnosis, Dif | 1970 |
Penthrane for obstetrical anesthesia.
Topics: Anesthesia, Conduction; Anesthesia, Inhalation; Anesthesia, Obstetrical; Chemical and Drug Induced L | 1967 |
Hepatic necrosis associated with halothane anesthesia.
Topics: Anesthesia; Autopsy; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Collagen; Connecti | 1969 |
The halothane controversy.
Topics: Canada; Chemical and Drug Induced Liver Injury; Halothane; Liver | 1969 |
Jaundice after anaesthesia.
Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; H | 1969 |
Halothane hepatotoxicity: a report of six cases receiving radium therapy for carcinoma of the cervix.
Topics: Anesthesia; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Jaundice; | 1969 |
[Experimental studies on the hepatotoxic effect of halothane].
Topics: Anesthesia, Endotracheal; Animals; Chemical and Drug Induced Liver Injury; Cholecystectomy; Dogs; Ha | 1969 |
Haemobilia associated with hepatic necrosis after halothane anaesthesia. A case report.
Topics: Anesthesia, Inhalation; Biliary Tract; Chemical and Drug Induced Liver Injury; Halothane; Hemorrhage | 1969 |
[A report about drug side effects. X].
Topics: Adolescent; Adult; Amenorrhea; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; Erythro | 1969 |
[Effect of anesthesia on the liver (histochemical study)].
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Cyclopropanes; DNA; Ethyl | 1969 |
The halothane controversy.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1970 |
Steroids for halothane hepatitis?
Topics: Adrenal Cortex Hormones; Chemical and Drug Induced Liver Injury; Halothane | 1970 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1970.
Topics: Aged; Autopsy; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Halothane; H | 1970 |
[Hepatitis in connection with halothane anesthesia in irradiation therapy for uterine cancers].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Liver; Ut | 1970 |
[Halothane and liver].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1970 |
Recurrent hepatitis in patients receiving multiple halothane anesthetics for radium treatment of carcinoma of the cervix uteri.
Topics: Aged; Anesthesia, General; Autopsy; Body Temperature; Carcinoma; Chemical and Drug Induced Liver Inj | 1970 |
[Allergic reactions in the liver induced by halothane].
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Liver; Male | 1970 |
Cell-mediated immunity in halothane hypersensitivity.
Topics: Anesthesia, Inhalation; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Drug Hypersensi | 1970 |
Liver necrosis after repeated fluothane anaesthesia. Cause or coincidence?
Topics: Adolescent; Aged; Anesthesia, General; Biopsy; Chemical and Drug Induced Liver Injury; Female; Halot | 1970 |
Postanesthetic hepatic dysfunction.
Topics: Anesthesia, Inhalation; Autopsy; Chemical and Drug Induced Liver Injury; Female; Fever; Halothane; H | 1970 |
Halothane and liver damage.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Halothane; Human | 1970 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1970.
Topics: Aged; Autopsy; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Diagnosis, Diffe | 1970 |
Erythroid aplasia after halothane hepatitis. Report of a case.
Topics: Aged; Anemia, Aplastic; Bone Marrow Cells; Chemical and Drug Induced Liver Injury; Erythrocytes; Fem | 1970 |
Lymphocyte stimulation induced by halothane in patients with hepatitis following exposure to halothane.
Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; DNA; Drug Hypersensitivity; | 1970 |
Fatal halothane hepatitis with transient granulomas.
Topics: Adult; Anesthesia, Inhalation; Autopsy; Biopsy; Chemical and Drug Induced Liver Injury; Drug Hyperse | 1970 |
Effects of prolonged halothane anesthesia on some cetaceans.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Blood C | 1970 |
[Liver toxicity of halothane].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Mal | 1970 |
Hepatic dysfunction without jaundice following administration of halothane.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Fever; Halothane; Hepatitis B | 1970 |
Halothane and liver failure.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Cholecystectomy; Female; Halothane; | 1970 |
Halothane and liver failure.
Topics: Chemical and Drug Induced Liver Injury; Cholecystectomy; Colon; Female; Halothane; Humans; Surgical | 1970 |
Halothane and liver failure.
Topics: Chemical and Drug Induced Liver Injury; Cholecystectomy; Female; Halothane; Humans | 1970 |
Hepatotoxicity and anesthetics.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver | 1970 |
Hypothetical halothane hazards.
Topics: Air Pollution; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Li | 1970 |
[Effects of halogenated anesthetics on the liver, thyroid gland and kidney].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Halothane; Humans; Kidney; Kidney Diseases; Live | 1970 |
The national halothane study.
Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Male; Retros | 1970 |
Multiple halothane administrations.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Male | 1970 |
Halothane: the medicolegal aspects of its use.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Jurisprudence | 1970 |
[Studies of the effect of an inhalation anesthesia and surgery on the liver function with special reference to halothane. 1].
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Aspartate Aminotransferases; Bilirubin; Chemi | 1970 |
[On value of the use of a mixture of ribonucleosides in the prevention of toxic liver damage due to halothane in geriatric surgery].
Topics: Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Preoperativ | 1970 |
Problems in diagnosing halothane hepatitis.
Topics: Adult; Blood Transfusion; Chemical and Drug Induced Liver Injury; Female; Fever; Halothane; Humans; | 1970 |
Hemolytic anemia complicating halothane induced hepatitis.
Topics: Anemia, Hemolytic; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Aged | 1971 |
Current status of halothane.
Topics: Anesthesia, Inhalation; Anesthesia, Obstetrical; Arrhythmias, Cardiac; Blood Circulation; Cardiovasc | 1971 |
Hepatitis following halothane anesthetic.
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; | 1971 |
[Postoperative toxic liver disease].
Topics: Aged; Autopsy; Chemical and Drug Induced Liver Injury; Cholecystectomy; Cholelithiasis; Female; Halo | 1971 |
Halothane jaundice--a case report.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Jaundice; Liver; Liver Fun | 1971 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Humans; Immunosuppressive Agents; Li | 1971 |
Halothane anesthesia. Unsuspected danger for the surgical patient.
Topics: Alkaline Phosphatase; Anesthesia, Inhalation; Aspartate Aminotransferases; Bilirubin; Chemical and D | 1971 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Postoperative Complications | 1971 |
Halothane and liver necrosis.
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Liver; Middle Aged | 1971 |
[Halothane hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Hypersensitivity, Delayed; Liver; | 1971 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Jaundice; Liver; Postoperative Complicati | 1971 |
[Halothane narcosis and the liver].
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver | 1971 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Immunosuppressive Agents | 1971 |
Halothane hepatitis.
Topics: Aged; Ampicillin; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Male; Urinary Tr | 1971 |
[Halothane-induced lesions of the rat liver in comparison to penthrane and ether anesthesia].
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Ethers; Halothane; Methoxyf | 1967 |
[Liver necrosis in consequence of fluothane anesthesia].
Topics: Chemical and Drug Induced Liver Injury; Fatty Liver; Halothane; Hepatic Encephalopathy; Humans; Live | 1967 |
[Effect of various anesthesias on liver function during operations].
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Local; Chemical and Drug Induced Liver Injury; Ethe | 1967 |
Halothane and liver injury.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Liver Dise | 1968 |
[Procaine-splitting esterase activity in rat liver and blood after CCl-4 and halothane administration].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Depression, Chemica | 1968 |
An evaluation of halothane toxicity.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hal | 1968 |
Hepatic coma with renal failure, treated by repeated exchange transfusion.
Topics: Acute Kidney Injury; Adult; Aphasia; Arthrogryposis; Bilirubin; Calcium; Chemical and Drug Induced L | 1968 |
A case of recovery from coma produced by the ingestion of 250 ml of halothane.
Topics: Adult; Chemical and Drug Induced Liver Injury; Coma; Female; Gastric Lavage; Halothane; Heart Arrest | 1968 |
Hepatic necrosis following halothane anesthesia.
Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Necrosis | 1968 |
Fulminant hepatic failure. Presumable contribution to halothane.
Topics: Acute Disease; Adolescent; Adult; Aged; Aminosalicylic Acids; Chemical and Drug Induced Liver Injury | 1968 |
Postoperative hepatic failure and halothane.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Postoperative Complications | 1968 |
Effect of repeated halothane anesthesia on sheep.
Topics: Anesthesia, Inhalation; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury | 1968 |
Multiple halothane anesthesia in the burn patient.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anesthesia, Inhalation; Aspartate Aminotransferases; | 1968 |
[Postoperative liver lesions and halothane anesthesia].
Topics: Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Ethyl Ethers; Female; Halothane; Humans | 1968 |
[Liver damage by halothane and its compensation by necrotropic liver protecting substances].
Topics: Alcohols; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Halothane; Homocy | 1968 |
[Hepatotoxicity of fluothane. (Retrospective critical review and presentation of 2 cases)].
Topics: Adult; Aged; Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans; Jaundice; Male | 1968 |
Recurrent hepatitis attributable to halothane sensitization in an anesthetist.
Topics: Adult; Anesthesiology; Asthma; Biopsy; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity | 1969 |
Halothane-induced liver damage--an entity.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Liver; Liver Disea | 1969 |
Halothane and liver damage.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1969 |
Halothane and liver damage.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1969 |
Halothane and liver damage.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver Diseases | 1969 |
Halothane and liver damage.
Topics: Africa, Southern; Chemical and Drug Induced Liver Injury; Halothane; Humans; Jaundice; Liver Disease | 1969 |
[On fluothane-induced liver damage].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Ja | 1969 |
Effects of halothane, ether, and chloroform on the isolated, perfused, bovine liver. A comparative study.
Topics: Animals; Aspartate Aminotransferases; Cattle; Chemical and Drug Induced Liver Injury; Chloroform; Et | 1969 |
[Halothane and liver toxicity].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Chloroform; Fever; Halothane; Hepati | 1969 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halogens; Halothane; Humans | 1969 |
Halothane hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1969 |
Hepatic sensitization to halothane.
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Haloth | 1969 |
[Acute liver cell necrosis].
Topics: Adult; Barbiturates; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Liver; Liver | 1969 |
Delayed petrol intoxication.
Topics: Accidents, Aviation; Adult; Animals; Chemical and Drug Induced Liver Injury; Embolism, Fat; Halothan | 1969 |
Hepatitis after exposure to halothane.
Topics: Adult; Aged; Alkaline Phosphatase; Anesthesia; Antibodies; Aspartate Aminotransferases; Bilirubin; C | 1969 |
[Effect of anesthesia on the activity of enzymes (GPT, GOT, OCT) in the blood serum. (On the problem of hepatic totoxicity of halothane)].
Topics: Adolescent; Adult; Alanine Transaminase; Anesthesia, Endotracheal; Aspartate Aminotransferases; Chem | 1965 |
Postoperative jaundice associated with halothane anesthesia.
Topics: Adult; Aged; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Huma | 1965 |
[Postanesthesia hepatic complications].
Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Ma | 1965 |
[Halothane and hepatotoxicity].
Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans | 1965 |
[Liver damage caused by halothane].
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver | 1966 |
Was it halothane? A case report.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans | 1966 |
Hepatic function tests: postoperative changes with halothane or diethyl ether anesthesia.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Ethyl Ethers; Halothane; Humans; Liv | 1966 |
Safety of halothane.
Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans | 1966 |
Hepatitis after repeated exposure to halothane. Case report and brief review.
Topics: Adult; Blood Protein Electrophoresis; Chemical and Drug Induced Liver Injury; Eosinophilia; Female; | 1966 |
[Functional changes in the liver following orthopedic surgery under general anesthesia. Evaluation of the hepatotoxicity of Halothane].
Topics: Adolescent; Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Female; Halothane; H | 1966 |
Adverse hepatic reactions to halothane: risks and safeguards.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; In Vitro Techniques; Liver | 1966 |
Concerning hepatotoxicity of halothane.
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Necrosis | 1966 |
[On the problem of the so-called halothane hepatitis].
Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Postoperative Com | 1966 |