Page last updated: 2024-10-28

haloperidol and Pyrexia

haloperidol has been researched along with Pyrexia in 46 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Research Excerpts

ExcerptRelevanceReference
" The following case report describes a patient developing neuroleptic malignant syndrome (NMS) secondary to the use of haloperidol given to control the patient's agitation."7.70Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. ( Guin-Renfroe, S; Meythaler, JM; Wilkinson, R, 1999)
"Cocaine-related rhabdomyolysis has a high mortality."5.29Rhabdomyolysis and hyperthermia after cocaine abuse: a variant of the neuroleptic malignant syndrome? ( Daras, M; Kakkouras, L; Koppel, BS; Tuchman, AJ, 1995)
"This suggests that neuroleptic malignant syndrome is caused by a peripheral, not central, effect of haloperidol."5.28Fatal hyperthermia in a quadriplegic man. Possible evidence for a peripheral action of haloperidol in neuroleptic malignant syndrome. ( Downey, JA; Downey, RJ; Newhouse, E; Weissman, C, 1992)
"Methamphetamine abuse remains an alarming public heath challenge, with no approved pharmacotherapies available."3.83Agmatine attenuates the discriminative stimulus and hyperthermic effects of methamphetamine in male rats. ( Li, J; Li, JX; Qiu, Y; Thorn, DA, 2016)
" The following case report describes a patient developing neuroleptic malignant syndrome (NMS) secondary to the use of haloperidol given to control the patient's agitation."3.70Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. ( Guin-Renfroe, S; Meythaler, JM; Wilkinson, R, 1999)
" Both ASP and GLU produced a hyperthermic response in all animals, including those in which hypothermia was induced by reserpine."3.69Effect of aspartate and glutamate on nociception, catalepsy and core temperature in rats. ( Gupta, MC; Singh, J, 1997)
" But 2 days later he developed auditory hallucinations which were interpreted as alcohol hallucinations, for which he was additionally given haloperidol, 15 mg/d."3.68[Central anticholinergic intoxication syndrome. A contribution to the differential diagnosis of exogenous psychoses]. ( Eikmeier, G; Gastpar, M; Kastrup, O, 1991)
" The drug does not possess an antidepressant action proper but activates the aggressive-defensive behaviour in experimental reserpine depression and reduces the provocation-induced aggressive behaviour in experimental haloperidol depression."3.66[Psychopharmacologic spectrum of melanostatin]. ( Klusha, VE; Kozlovskaia, MM; Svirskis, ShV; Val'dman, AV, 1980)
"The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia."3.66New data on lithium and haloperidol incompatibility. ( Frankel, M; Spring, G, 1981)
" Muscle rigidity was not affected by etybenzatropine or diazepam, but dantrolene, a direct-acting skeletal muscle relaxant, provided muscle relaxation with a concomitant decrease of fever and serum creatine kinase."3.66Beneficial effects of dantrolene in the treatment of neuroleptic malignant syndrome: a report of two cases. ( Bismuth, C; Conso, F; de Rohan-Chabot, P; Elkharrat, D; Gajdos, P; Goulon, M, 1983)
" Overall, 25 years of experience have indicated that haloperidol can be used safely and effectively to manage a variety of psychiatric illnesses, so long as dosage and method of administration are adjusted to individual patients' needs."2.65Haloperidol: a quarter century of experience. ( Ayd, FJ; Settle, EC, 1983)
"We report a case of severe neuroleptic malignant syndrome with hyperthermia, rhabdomyolysis and hepatic failure where we applied endovascular cooling in order to reverse hyperthermia."1.35Endovascular cooling in a patient with neuroleptic malignant syndrome. ( Diedler, J; Mellado, P; Veltkamp, R, 2008)
"Cocaine-related rhabdomyolysis has a high mortality."1.29Rhabdomyolysis and hyperthermia after cocaine abuse: a variant of the neuroleptic malignant syndrome? ( Daras, M; Kakkouras, L; Koppel, BS; Tuchman, AJ, 1995)
"Fever is generally considered to be an essential feature of neuroleptic malignant syndrome (NMS)."1.29Case study: neuroleptic malignant syndrome without pyrexia. ( Hynes, AF; Vickar, EL, 1996)
"This suggests that neuroleptic malignant syndrome is caused by a peripheral, not central, effect of haloperidol."1.28Fatal hyperthermia in a quadriplegic man. Possible evidence for a peripheral action of haloperidol in neuroleptic malignant syndrome. ( Downey, JA; Downey, RJ; Newhouse, E; Weissman, C, 1992)
"Haloperidol was ineffective as a fenfluramine antagonist."1.26Fenfluramine-induced hyperthermia and stimulation in the rabbit. ( Beal, GA; Quock, RM, 1976)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199031 (67.39)18.7374
1990's12 (26.09)18.2507
2000's2 (4.35)29.6817
2010's1 (2.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Thorn, DA1
Li, J1
Qiu, Y1
Li, JX1
Pataki, I1
Adamik, A1
Jászberényi, M1
Mácsai, M1
Telegdy, G1
Diedler, J1
Mellado, P1
Veltkamp, R1
Val'dman, AV1
Kozlovskaia, MM1
Klusha, VE1
Svirskis, ShV1
Henderson, VW1
Wooten, GF1
Spring, G1
Frankel, M1
Knezevic, W1
Mastaglia, FL1
Lefroy, RB1
Fisher, A1
Martin, GE1
Bacino, CB1
Papp, NL1
Settle, EC1
Ayd, FJ1
Goulon, M2
de Rohan-Chabot, P1
Elkharrat, D2
Gajdos, P1
Bismuth, C2
Conso, F2
May, DC1
Morris, SW1
Stewart, RM1
Fenton, BJ1
Gaffney, FA1
Dosani, RA1
Samar, RK1
Kaushik, SK1
Garg, AR1
de Rohan Chabot, P1
Daras, M1
Kakkouras, L1
Tuchman, AJ1
Koppel, BS1
Bowyer, JF1
Vybíral, S1
Veselá, R1
Osborne, PG1
Onoe, H1
Watanabe, Y1
Hynes, AF1
Vickar, EL1
Singh, J1
Gupta, MC1
Still, J1
Friedman, B1
Law, E1
Deppe, S1
Epperly, N1
Orlet, H1
Wilkinson, R1
Meythaler, JM1
Guin-Renfroe, S1
Domino, EF1
Gahagan, S1
Adinoff, B1
Kovacic, B1
Rips, R1
Desiles, M1
Puech, AJ1
Bantutova, I2
Heikkila, JJ1
Holbrook, L1
Brown, IR1
Scialli, JV1
Thornton, WE1
Greenblatt, DJ1
Gross, PL1
Harris, J1
Shader, RI1
Ciraulo, DA1
Geller, B1
Greydanus, DE1
Snow, AE1
Horita, A3
Quock, RM2
Beal, GA2
Baastrup, PC1
Hollnagel, P1
Sorensen, R1
Schou, M1
Roszell, DK1
Burks, TF1
VanInwegen, RG1
Carino, MA1
Chesnut, RM1
Weick, BG1
Ottervanger, JP1
Gerbrandy-Colijn, A1
Stricker, BH1
Downey, RJ1
Downey, JA1
Newhouse, E1
Weissman, C1
Kastrup, O1
Eikmeier, G1
Gastpar, M1
Funahashi, M1
Kohda, H1
Hori, O1
Hayashida, H1
Kimura, H1
Lee, S1
Merriam, A1
Kim, TS1
Liebling, M1
Dickson, DW1
Moore, GR1
Iakimova, K1
Koleva, E1
Ovcharova, R1
Bach, DS1
Rybak, MJ1
Cohen, WJ1
Cohen, NH1
de Morsier, G1
Oppenheim, G1
Dillon, JB1

Reviews

1 review available for haloperidol and Pyrexia

ArticleYear
Cerebellar degeneration in neuroleptic malignant syndrome: neuropathologic findings and review of the literature concerning heat-related nervous system injury.
    Journal of neurology, neurosurgery, and psychiatry, 1989, Volume: 52, Issue:3

    Topics: Adult; Cerebellar Diseases; Cerebellum; Chronic Disease; Dose-Response Relationship, Drug; Fever; Ha

1989

Trials

1 trial available for haloperidol and Pyrexia

ArticleYear
Haloperidol: a quarter century of experience.
    The Journal of clinical psychiatry, 1983, Volume: 44, Issue:12

    Topics: Aged; Basal Ganglia Diseases; Bipolar Disorder; Clinical Trials as Topic; Dosage Forms; Drug Adminis

1983

Other Studies

44 other studies available for haloperidol and Pyrexia

ArticleYear
Agmatine attenuates the discriminative stimulus and hyperthermic effects of methamphetamine in male rats.
    Behavioural pharmacology, 2016, Volume: 27, Issue:6

    Topics: Agmatine; Amphetamine-Related Disorders; Animals; Discrimination Learning; Dopamine Antagonists; Dos

2016
Involvement of transmitters in pituitary adenylate cyclase-activating polypeptide-induced hyperthermia.
    Regulatory peptides, 2003, Oct-15, Volume: 115, Issue:3

    Topics: Animals; Apomorphine; Body Temperature; Bromocriptine; Dopamine Antagonists; Dose-Response Relations

2003
Endovascular cooling in a patient with neuroleptic malignant syndrome.
    Journal of the neurological sciences, 2008, Jan-15, Volume: 264, Issue:1-2

    Topics: Antipsychotic Agents; Catheters, Indwelling; Creatine Kinase; Drug Synergism; Female; Fever; Haloper

2008
[Psychopharmacologic spectrum of melanostatin].
    Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:6

    Topics: Aggression; Amantadine; Animals; Behavior, Animal; Biogenic Amines; Brain Chemistry; Catalepsy; Cats

1980
Neuroleptic malignant syndrome: a pathogenetic role for dopamine receptor blockade?
    Neurology, 1981, Volume: 31, Issue:2

    Topics: Antipsychotic Agents; Basal Ganglia Diseases; Body Temperature Regulation; Creatine Kinase; Fever; H

1981
New data on lithium and haloperidol incompatibility.
    The American journal of psychiatry, 1981, Volume: 138, Issue:6

    Topics: Antipsychotic Agents; Bipolar Disorder; Drug Incompatibility; Drug Therapy, Combination; Dyskinesia,

1981
Neuroleptic malignant syndrome.
    The Medical journal of Australia, 1984, Jan-07, Volume: 140, Issue:1

    Topics: Antipsychotic Agents; Basal Ganglia Diseases; Female; Fever; Fluphenazine; Haloperidol; Humans; Male

1984
Action of selected serotonin antagonists on hyperthermia evoked by intracerebrally injected beta-endorphin.
    Peptides, 1981,Summer, Volume: 2, Issue:2

    Topics: Animals; beta-Endorphin; Body Temperature; Body Temperature Regulation; Cinanserin; Endorphins; Feve

1981
Beneficial effects of dantrolene in the treatment of neuroleptic malignant syndrome: a report of two cases.
    Neurology, 1983, Volume: 33, Issue:4

    Topics: Adolescent; Adult; Basal Ganglia Diseases; Dantrolene; Fever; Haloperidol; Humans; Male; Muscle Rigi

1983
Neuroleptic malignant syndrome: response to dantrolene sodium.
    Annals of internal medicine, 1983, Volume: 98, Issue:2

    Topics: Dantrolene; Fever; Haloperidol; Humans; Male; Middle Aged; Muscle Rigidity; Syndrome

1983
Haloperidol-induced neuroleptic malignant syndrome.
    Southern medical journal, 1983, Volume: 76, Issue:4

    Topics: Adult; Catatonia; Fever; Haloperidol; Humans; Male; Psychoses, Substance-Induced; Schizophrenia; Syn

1983
Malignant neuroleptic syndrome due to haloperidol. (A case report).
    Journal of postgraduate medicine, 1983, Volume: 29, Issue:1

    Topics: Adult; Fever; Haloperidol; Humans; Male; Muscle Rigidity; Pallor; Syndrome

1983
[Neuroleptic malignant syndrome. Beneficial effects of dantrolene on hyperthermia and hypertonia (author's transl)].
    La Nouvelle presse medicale, 1982, Mar-27, Volume: 11, Issue:14

    Topics: Adolescent; Basal Ganglia Diseases; Calcium; Dantrolene; Fever; Haloperidol; Humans; Male; Malignant

1982
Rhabdomyolysis and hyperthermia after cocaine abuse: a variant of the neuroleptic malignant syndrome?
    Acta neurologica Scandinavica, 1995, Volume: 92, Issue:2

    Topics: Adult; Antipsychotic Agents; Brain; Cell Death; Cocaine; Diagnosis, Differential; Diazepam; Female;

1995
The role of hyperthermia in amphetamine's interactions with NMDA receptors, nitric oxide, and age to produce neurotoxicity.
    Annals of the New York Academy of Sciences, 1995, Sep-15, Volume: 765

    Topics: Aging; Amphetamine; Animals; Arginine; Brain; Dizocilpine Maleate; Fever; Glutamic Acid; Haloperidol

1995
Can haloperidol disguise fever?
    Physiological research, 1994, Volume: 43, Issue:6

    Topics: Animals; Basal Metabolism; Body Temperature; Body Temperature Regulation; Cold Temperature; Fever; H

1994
GABAergic system inducing hyperthermia in the rat preoptic area: its independence of prostaglandin E2 system.
    Brain research, 1994, Oct-24, Volume: 661, Issue:1-2

    Topics: Analysis of Variance; Animals; Bicuculline; Body Temperature; Dinoprostone; Dose-Response Relationsh

1994
Case study: neuroleptic malignant syndrome without pyrexia.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1996, Volume: 35, Issue:7

    Topics: Antipsychotic Agents; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Fever;

1996
Effect of aspartate and glutamate on nociception, catalepsy and core temperature in rats.
    Indian journal of physiology and pharmacology, 1997, Volume: 41, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Analgesia; Analgesics, Opioid; Animals; Aspartic Acid; Body Temperatur

1997
Neuroleptic malignant syndrome in a burn patient.
    Burns : journal of the International Society for Burn Injuries, 1998, Volume: 24, Issue:6

    Topics: Accidents, Occupational; Adult; Antipsychotic Agents; Bromocriptine; Burns; Dantrolene; Debridement;

1998
Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury.
    Brain injury, 1999, Volume: 13, Issue:12

    Topics: Adolescent; Amantadine; Brain Injuries; Dopamine Agents; Dopamine Antagonists; Fever; Haloperidol; H

1999
Effects of various neuroleptics on rabbit hyperthermia induced by N, N-Dimethyltryptamine (DMT) and d-amphetamine.
    Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 226, Issue:1

    Topics: Animals; Body Temperature; Chlorpromazine; Dextroamphetamine; Dibenzothiepins; Dose-Response Relatio

1977
Is a dopaminergic system involved in thyrotropin releasing hormone induced hyperthermia and in its potentiation by amphetamine?
    Progress in neuro-psychopharmacology, 1979, Volume: 3, Issue:4

    Topics: alpha-Methyltyrosine; Amphetamine; Animals; Apomorphine; Chlorpromazine; Dopamine; Dopamine Agents;

1979
[Effect of pharmacological agents and coagulation of the n. raphe dorsalis on morphine effects].
    Eksperimentalna meditsina i morfologiia, 1979, Volume: 18, Issue:4

    Topics: Animals; Brain Stem; Catalepsy; Cyproheptadine; Dimenhydrinate; Electrocoagulation; Female; Fencloni

1979
Disaggregation of polysomes in fetal organs and maternal brain after administration of d-lysergic acid diethylamide in vivo.
    Journal of neurochemistry, 1979, Volume: 32, Issue:6

    Topics: Amino Acids; Animals; Brain; Female; Fetus; Fever; Haloperidol; Lysergic Acid Diethylamide; Male; Ma

1979
Toxic reactions from a haloperidol overdose in two children. Thermal and cardiac manifestations.
    JAMA, 1978, Jan-02, Volume: 239, Issue:1

    Topics: Accidents, Home; Acute Disease; Age Factors; Bradycardia; Child, Preschool; Female; Fever; Haloperid

1978
Fatal hyperthermia following haloperidol therapy of sedative-hypnotic withdrawal.
    The Journal of clinical psychiatry, 1978, Volume: 39, Issue:8

    Topics: Adult; Barbiturates; Dose-Response Relationship, Drug; Fever; Haloperidol; Humans; Male; Methaqualon

1978
Haloperidol-induced comatose state with hyperthermia and rigidity in adolescence: two case reports with a literature review.
    The Journal of clinical psychiatry, 1979, Volume: 40, Issue:2

    Topics: Adolescent; Child; Child Behavior Disorders; Coma; Female; Fever; Haloperidol; Humans; Male; Muscle

1979
Preliminary studies on the effect of electric foot shock stress on apomorphine induced hyperthermia.
    Proceedings of the Western Pharmacology Society, 1977, Volume: 20

    Topics: Animals; Apomorphine; Behavior, Animal; Diazepam; Electroshock; Fever; Haloperidol; Male; Rabbits; S

1977
Fenfluramine-induced hyperthermia and stimulation in the rabbit.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 13, Issue:3

    Topics: Animals; Behavior, Animal; Body Temperature; Cinanserin; Cyproheptadine; Dose-Response Relationship,

1976
Adverse reactions in treatment with lithium carbonate and haloperidol.
    JAMA, 1976, Dec-06, Volume: 236, Issue:23

    Topics: Affective Symptoms; Bipolar Disorder; Drug Synergism; Female; Fever; Haloperidol; Humans; Lithium; M

1976
The effects of haloperidol and thioridazine on apomorphine- and LSD-induced hyperthermia in the rabbit.
    Journal of psychiatric research, 1975, Volume: 12, Issue:2

    Topics: Animals; Apomorphine; Dose-Response Relationship, Drug; Fever; Haloperidol; Humans; Hypnotics and Se

1975
Phentolamine inhibition of morphine induced hyperthermia in cats.
    Proceedings of the Western Pharmacology Society, 1975, Volume: 18

    Topics: Animals; Cats; Female; Fever; Haloperidol; Hydroxydopamines; Male; Morphine; Phentolamine; Propranol

1975
Apomorphine: antagonism of its hyperthermic action in the rabbit by intracerebrally administered haloperidol.
    Proceedings of the Western Pharmacology Society, 1975, Volume: 18

    Topics: Animals; Apomorphine; Depression, Chemical; Fever; Haloperidol; Hypothalamus; Injections, Intraventr

1975
[Fever caused by neuroleptics].
    Nederlands tijdschrift voor geneeskunde, 1992, Nov-14, Volume: 136, Issue:46

    Topics: Adult; Delayed-Action Preparations; Female; Fever; Haloperidol; Humans; Male; Middle Aged; Neurolept

1992
Fatal hyperthermia in a quadriplegic man. Possible evidence for a peripheral action of haloperidol in neuroleptic malignant syndrome.
    Chest, 1992, Volume: 101, Issue:6

    Topics: Adult; Fever; Haloperidol; Humans; Male; Neuroleptic Malignant Syndrome; Quadriplegia; Spinal Cord I

1992
[Central anticholinergic intoxication syndrome. A contribution to the differential diagnosis of exogenous psychoses].
    Deutsche medizinische Wochenschrift (1946), 1991, Nov-15, Volume: 116, Issue:46

    Topics: Akathisia, Drug-Induced; Biperiden; Diagnosis, Differential; Doxepin; Dysarthria; Dyskinesia, Drug-I

1991
Potentiating effect of morphine upon d-methamphetamine-induced hyperthermia in mice. Effects of naloxone and haloperidol.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:2

    Topics: Animals; Body Temperature Regulation; Drug Synergism; Fever; Haloperidol; Male; Methamphetamine; Mic

1990
[Effect on morphine hyperthermia of dopaminergic agents].
    Eksperimentalna meditsina i morfologiia, 1985, Volume: 24, Issue:4

    Topics: Animals; Apomorphine; Body Temperature; Bromocriptine; Drug Interactions; Fever; Haloperidol; Male;

1985
Haloperidol-associated hyperthermia.
    Drug intelligence & clinical pharmacy, 1985, Volume: 19, Issue:3

    Topics: Body Temperature Regulation; Fever; Haloperidol; Humans; Male; Middle Aged

1985
Lithium carbonate, haloperidol, and irreversible brain damage.
    JAMA, 1974, Dec-02, Volume: 230, Issue:9

    Topics: Acute Disease; Adult; Bipolar Disorder; Brain; Brain Diseases; Carbonates; Chronic Disease; Consciou

1974
[Tic. Study of 11 cases].
    Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie, 1972, Volume: 111, Issue:1

    Topics: Adolescent; Adult; Age Factors; Bronchopneumonia; Child; Female; Fever; Follow-Up Studies; Haloperid

1972
Mutism and hyperthermia in a patient treated with neuroleptics.
    The Medical journal of Australia, 1973, Aug-04, Volume: 2, Issue:5

    Topics: Adult; Antiparkinson Agents; Benztropine; Chlorpromazine; Fever; Haloperidol; Humans; Male; Mutism;

1973
Parenteral long-acting phenothiazines.
    British medical journal, 1972, Mar-25, Volume: 1, Issue:5803

    Topics: Basal Ganglia Diseases; Fever; Fluphenazine; Haloperidol; Humans; Male; Middle Aged

1972