Page last updated: 2024-10-28

haloperidol and Prostatic Neoplasms

haloperidol has been researched along with Prostatic Neoplasms in 13 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Prostatic Neoplasms: Tumors or cancer of the PROSTATE.

Research Excerpts

ExcerptRelevanceReference
"Tamoxifen (TAM) has previously been shown to inhibit growth of the Dunning R3327 rat prostate adenocarcinoma and to elevate serum prolactin levels."7.67Role of prolactin in modulating the effects of tamoxifen on growth of the Dunning R3327 rat prostate adenocarcinoma. ( Ip, MM; Sylvester, PW, 1987)
"Tamoxifen (TAM) has previously been shown to inhibit growth of the Dunning R3327 rat prostate adenocarcinoma and to elevate serum prolactin levels."3.67Role of prolactin in modulating the effects of tamoxifen on growth of the Dunning R3327 rat prostate adenocarcinoma. ( Ip, MM; Sylvester, PW, 1987)
"Prostate cancer is the most frequently diagnosed malignancy and the leading cause of cancer related death in men."1.46Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer. ( Chen, N; Kim, FJ; Lou, R; Oyer, HM; Salvino, JM; Srikanth, YVV, 2017)
"Pretreatment of haloperidol significantly reduced the radiotracer accumulation of [(99m)Tc]23 or [(99m)Tc]24 in the brain."1.40Novel cyclopentadienyl tricarbonyl (99m)tc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors. ( Brust, P; Cui, M; Deuther-Conrad, W; Jia, B; Jia, H; Li, D; Liu, B; Lu, J; Steinbach, J; Wang, X; Xie, Y, 2014)
"Complex mechanisms of prostate cancer progression prompt to novel therapeutic strategies concerning a combination of drugs or of single molecules able to interact with more crucial targets."1.37Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells. ( Bernardini, R; Fiorito, J; Marrazzo, A; Pasquinucci, L; Prezzavento, O; Ronsisvalle, G; Ronsisvalle, S; Scoto, GM; Zappalà, L, 2011)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's3 (23.08)18.2507
2000's2 (15.38)29.6817
2010's6 (46.15)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Marrazzo, A2
Fiorito, J2
Zappalà, L1
Prezzavento, O1
Ronsisvalle, S1
Pasquinucci, L1
Scoto, GM1
Bernardini, R1
Ronsisvalle, G1
Salvino, JM1
Srikanth, YVV1
Lou, R1
Oyer, HM1
Chen, N1
Kim, FJ1
Kopp, N1
Holtschulte, C1
Börgel, F1
Lehmkuhl, K1
Friedland, K1
Civenni, G1
Laurini, E1
Catapano, CV1
Pricl, S1
Humpf, HU1
Schepmann, D1
Wünsch, B1
Wang, X1
Li, D1
Deuther-Conrad, W1
Lu, J1
Xie, Y1
Jia, B1
Cui, M1
Steinbach, J1
Brust, P1
Liu, B1
Jia, H1
Di Giacomo, V1
Di Valerio, V1
Rapino, M1
Bosco, D1
Cacciatore, I1
Ciulla, M1
Di Stefano, A1
Cataldi, A1
Evans, JC1
Malhotra, M1
Fitzgerald, KA1
Guo, J1
Cronin, MF1
Curtin, CM1
O'Brien, FJ1
Darcy, R1
O'Driscoll, CM1
Rhodius-Meester, HF1
Kuper, IM1
Otten, HM1
Hamburger, HL1
Spruce, BA1
Campbell, LA1
McTavish, N1
Cooper, MA1
Appleyard, MV1
O'Neill, M1
Howie, J1
Samson, J1
Watt, S1
Murray, K1
McLean, D1
Leslie, NR1
Safrany, ST1
Ferguson, MJ1
Peters, JA1
Prescott, AR1
Box, G1
Hayes, A1
Nutley, B1
Raynaud, F1
Downes, CP1
Lambert, JJ1
Thompson, AM1
Eccles, S1
Vilner, BJ1
John, CS2
Bowen, WD2
Gulden, ME1
Li, J1
McAfee, JG1
Thakur, ML1
Benítez del Rosario, MA1
Montón, F1
Salinas, A1
Martín, JJ1
Feria, M1
Sylvester, PW1
Ip, MM1
Nishimaki, T1
Furudate, S1

Other Studies

13 other studies available for haloperidol and Prostatic Neoplasms

ArticleYear
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Guinea Pigs; Haloperidol; Histone Deacetylase Inhibit

2011
Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer.
    Bioorganic & medicinal chemistry letters, 2017, 05-15, Volume: 27, Issue:10

    Topics: Animals; ERG1 Potassium Channel; Guanidines; Half-Life; Humans; Male; Mice; Microsomes, Liver; Neopl

2017
Novel σ
    European journal of medicinal chemistry, 2021, Jan-15, Volume: 210

    Topics: Amination; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Human

2021
Novel cyclopentadienyl tricarbonyl (99m)tc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors.
    Journal of medicinal chemistry, 2014, Aug-28, Volume: 57, Issue:16

    Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Glioma; Haloperidol; Ligands; Male; Mice, Inbred

2014
MRJF4, a novel histone deacetylase inhibitor, induces p21 mediated autophagy in PC3 prostate cancer cells.
    Cellular and molecular biology (Noisy-le-Grand, France), 2015, Jun-08, Volume: 61, Issue:3

    Topics: Autophagy; Cell Line, Tumor; Cell Movement; Cyclin-Dependent Kinase Inhibitor p21; Extracellular Sig

2015
Formulation and Evaluation of Anisamide-Targeted Amphiphilic Cyclodextrin Nanoparticles To Promote Therapeutic Gene Silencing in a 3D Prostate Cancer Bone Metastases Model.
    Molecular pharmaceutics, 2017, 01-03, Volume: 14, Issue:1

    Topics: Bone Neoplasms; Cations; Cell Line, Tumor; Chemistry, Pharmaceutical; Cyclodextrins; Gene Silencing;

2017
An unusual presentation of a varicella zoster virus encephalitis in a patient treated for metastatic prostate cancer.
    Journal of the American Geriatrics Society, 2010, Volume: 58, Issue:12

    Topics: Acyclovir; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Antipsychotic Agents;

2010
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo.
    Cancer research, 2004, Jul-15, Volume: 64, Issue:14

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Calcium Signaling; Carbazoles; Caspases

2004
Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.
    Cancer research, 1995, Jan-15, Volume: 55, Issue:2

    Topics: Adenocarcinoma; Animals; Binding, Competitive; Breast Neoplasms; Carcinoma, Ductal, Breast; Glioblas

1995
Synthesis, in vitro binding, and tissue distribution of radioiodinated 2-[125I]N-(N-benzylpiperidin-4-yl)-2-iodo benzamide, 2-[125I]BP: a potential sigma receptor marker for human prostate tumors.
    Nuclear medicine and biology, 1998, Volume: 25, Issue:3

    Topics: Animals; Benzamides; Binding, Competitive; Haloperidol; Humans; Indicators and Reagents; Iodine Radi

1998
Charles Bonnet syndrome and opioids.
    Journal of the American Geriatrics Society, 2001, Volume: 49, Issue:2

    Topics: Aged; Analgesics, Opioid; Antipsychotic Agents; Blindness; Diagnosis, Differential; Fatal Outcome; H

2001
Role of prolactin in modulating the effects of tamoxifen on growth of the Dunning R3327 rat prostate adenocarcinoma.
    The Prostate, 1987, Volume: 10, Issue:1

    Topics: Adenocarcinoma; Animals; Bromocriptine; Cell Line; Drug Therapy, Combination; Haloperidol; Male; Neo

1987
The role of a new liquid-solid scintillator, a mixture of DPO, POPOP and Epon 812, for enhancement of autoradiograms with tritium agents.
    The Journal of veterinary medical science, 1998, Volume: 60, Issue:7

    Topics: Animals; Antineoplastic Agents; Autoradiography; Epoxy Resins; Humans; Indicators and Reagents; Male

1998