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haloperidol and Pituitary Neoplasms

haloperidol has been researched along with Pituitary Neoplasms in 25 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.

Research Excerpts

ExcerptRelevanceReference
"The effect of cyproheptadine on growth hormone (GH) and prolactin (Prl) secretion from cultured pituitary adenoma cells of acromegaly and pituitary gigantism was studied."7.67Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture. ( Fukushima, T; Ishibashi, M; Yamaji, T, 1985)
"Both normal pituitary fragments and pituitary adenomatous cells (from all types of adenomas studied) spontaneously released TRH in vitro."5.28Normal and adenomatous human pituitaries secrete thyrotropin-releasing hormone in vitro: modulation by dopamine, haloperidol, and somatostatin. ( Barret, A; Brandi, AM; Feinstein, MC; Le Dafniet, M; Lefebvre, P; Mechain, C; Peillon, F, 1990)
" Risperidone had the highest adjusted reporting ratios for hyperprolactinemia (EBGM 34."3.73Atypical antipsychotics and pituitary tumors: a pharmacovigilance study. ( Doraiswamy, PM; Levine, JG; Szarfman, A; Tonning, JM, 2006)
"The effect of cyproheptadine on growth hormone (GH) and prolactin (Prl) secretion from cultured pituitary adenoma cells of acromegaly and pituitary gigantism was studied."3.67Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture. ( Fukushima, T; Ishibashi, M; Yamaji, T, 1985)
"Both normal pituitary fragments and pituitary adenomatous cells (from all types of adenomas studied) spontaneously released TRH in vitro."1.28Normal and adenomatous human pituitaries secrete thyrotropin-releasing hormone in vitro: modulation by dopamine, haloperidol, and somatostatin. ( Barret, A; Brandi, AM; Feinstein, MC; Le Dafniet, M; Lefebvre, P; Mechain, C; Peillon, F, 1990)
"Treatment with bromocriptine further diminished the anterior lobe PRL content, whereas haloperidol partially inhibited this tumor-mediated diminution."1.27Hyperprolactinemia exerts a negative effect on the beta-endorphin content of the rat neurointermediate pituitary lobe. ( Bons, EG; Hackeng, WH; Lamberts, SW; Oosterom, R; Uitterlinden, P; Verleun, T; Zuiderwijk, JM, 1984)
"An ectopic ACTH secreting lung carcinoid was non-responsive to doses of bromocriptine up to 13 microM."1.26Bromocriptine suppresses ACTH secretion from human pituitary tumour cells in culture by a dopaminergic mechanism. ( Adams, EF; Ashby, MJ; Brown, SM; Mashiter, K; White, MC, 1981)
"Rats treated with haloperidol or bearing subcutaneous implants of prolactin-secreting tumors had elevated CSF prolactin levels compared to those observed in control rats."1.26Prolactin in human and rat serum and cerebrospinal fluid. ( Login, IS; MacLeod, RM, 1977)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199017 (68.00)18.7374
1990's4 (16.00)18.2507
2000's2 (8.00)29.6817
2010's2 (8.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lertxundi, U1
Erezuma, I1
Hernandez, R1
Medrano, J1
Garcia, M1
Aguirre, C1
Madhusoodanan, S1
Steinberg, LR1
Coleman, A1
Bavli, S1
Szarfman, A1
Tonning, JM1
Levine, JG1
Doraiswamy, PM1
Konopelska, S1
Quinkler, M1
Strasburger, CJ1
Ventz, M1
Ishibashi, M3
Yamaji, T3
Adams, EF1
Ashby, MJ1
Brown, SM1
White, MC1
Mashiter, K1
Lamberts, SW3
Uitterlinden, P1
Bons, EG1
Zuiderwijk, JM1
Verleun, T1
Oosterom, R1
Hackeng, WH1
de Quijada, M1
Timmermans, HA1
MacLeod, RM7
Canonico, PL1
Valdenegro, CA1
Login, IS3
Nagy, I1
Florio, T1
Pan, MG1
Newman, B1
Hershberger, RE1
Civelli, O1
Stork, PJ1
Scholten-Sloof, BE1
Knol, BW1
Rijnberk, A1
Mol, JA1
Middleton, DJ1
Ubbink, GJ1
Lew, JY1
Zawadzka, H1
Feigenblum, D1
Tang, D1
Filer, D1
Benedetto, P1
Goldstein, M1
Le Dafniet, M1
Lefebvre, P1
Barret, A1
Mechain, C1
Feinstein, MC1
Brandi, AM1
Peillon, F1
Judd, AM1
Kovacs, K1
Ross, PC1
Spangelo, BL1
Jarvis, WD1
Teramoto, A1
Fukushima, T2
Shukla, S1
Turner, WJ1
Newman, G1
Israel, JM1
Jaquet, P1
Vincent, JD1
Takeda, M1
Tanino, S1
Nishinuma, K1
Matsubayashi, T1
Yamashita, S1
Nishimura, T1
Lehmeyer, JE1
McLachlan, MS2
Lavender, JP1
Edwards, CR1

Reviews

2 reviews available for haloperidol and Pituitary Neoplasms

ArticleYear
Hyperprolactinemia Secondary to Pituitary Microadenoma Versus Haloperidol- A Diagnostic Enigma. A Case Report and Brief Review.
    Current drug safety, 2017, Volume: 12, Issue:1

    Topics: Adenoma; Antipsychotic Agents; Diagnosis, Differential; Haloperidol; Humans; Hyperprolactinemia; Mal

2017
Difficulties in the medical treatment of prolactinoma in a patient with schizophrenia--a case report with a review of the literature.
    Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:1

    Topics: Adult; Antipsychotic Agents; Bromocriptine; Clozapine; Dopamine Agonists; Dopamine Antagonists; Drug

2008

Other Studies

23 other studies available for haloperidol and Pituitary Neoplasms

ArticleYear
Antipsychotics and pituitary tumors: an analysis of the European pharmacovigilance database (EudraVigilance).
    International clinical psychopharmacology, 2019, Volume: 34, Issue:2

    Topics: Adolescent; Adult; Aged; Amisulpride; Antipsychotic Agents; Child; Databases, Factual; Female; Halop

2019
Atypical antipsychotics and pituitary tumors: a pharmacovigilance study.
    Pharmacotherapy, 2006, Volume: 26, Issue:6

    Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Amenorrhea; Antipsychotic Agents; Aripiprazole;

2006
Direct effects of catecholamines, thyrotropin-releasing hormone, and somatostatin on growth hormone and prolactin secretion from adenomatous and nonadenomatous human pituitary cells in culture.
    The Journal of clinical investigation, 1984, Volume: 73, Issue:1

    Topics: Acromegaly; Adenoma; Adult; Bromocriptine; Cells, Cultured; Dopamine; Endorphins; Female; Growth Hor

1984
Bromocriptine suppresses ACTH secretion from human pituitary tumour cells in culture by a dopaminergic mechanism.
    Clinical endocrinology, 1981, Volume: 15, Issue:5

    Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Bromocriptine; Carcinoid Tumor; Cells, Cultured; Dopami

1981
Hyperprolactinemia exerts a negative effect on the beta-endorphin content of the rat neurointermediate pituitary lobe.
    Endocrinology, 1984, Volume: 114, Issue:6

    Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; beta-Lipotropin; Bromocriptine; Cell Line; End

1984
Tamoxifen enhances the sensitivity of dispersed prolactin-secreting pituitary tumor cells to dopamine and bromocriptine.
    Endocrinology, 1980, Volume: 106, Issue:3

    Topics: Animals; Bromocriptine; Dopamine; Estradiol; Female; Haloperidol; Neoplasms, Experimental; Pituitary

1980
The inhibition of phosphatidylinositol turnover: a possible postreceptor mechanism for the prolactin secretion-inhibiting effect of dopamine.
    Endocrinology, 1983, Volume: 113, Issue:1

    Topics: Animals; Bromocriptine; Dopamine; Female; Haloperidol; Male; Phosphates; Phosphatidylinositols; Pimo

1983
Restoration of pituitary prolactin synthesis and release by the administration of morphine to rats bearing a transplanted prolactin-secreting tumor.
    Neuroendocrinology, 1981, Volume: 33, Issue:2

    Topics: Animals; Female; Haloperidol; Morphine; Neoplasms, Experimental; Pituitary Gland, Anterior; Pituitar

1981
Effects of cyproheptadine on prolactin synthesis and release by normal and suppressed pituitary glands and by dispersed pituitary tumor cells.
    Endocrinology, 1978, Volume: 103, Issue:5

    Topics: Animals; Cyproheptadine; Female; Haloperidol; Male; Methysergide; Perphenazine; Pimozide; Pituitary

1978
Prolactin in human and rat serum and cerebrospinal fluid.
    Brain research, 1977, Sep-02, Volume: 132, Issue:3

    Topics: Adenoma; Animals; Female; Haloperidol; Humans; Neoplasm Transplantation; Pituitary Neoplasms; Prolac

1977
Dopaminergic inhibition of DNA synthesis in pituitary tumor cells is associated with phosphotyrosine phosphatase activity.
    The Journal of biological chemistry, 1992, Dec-05, Volume: 267, Issue:34

    Topics: Adenylyl Cyclases; Animals; Biological Transport; DNA Replication; DNA, Neoplasm; Dopamine; Haloperi

1992
Pituitary-dependent hyperadrenocorticism in a family of Dandie Dinmont terriers.
    The Journal of endocrinology, 1992, Volume: 135, Issue:3

    Topics: Adenocarcinoma; Adrenal Cortex; Adrenal Cortex Diseases; Animals; Corticotropin-Releasing Hormone; D

1992
Regulation and molecular characterization of dopamine D2 receptors in a prolactin-secreting 7315a anterior pituitary tumor.
    European journal of pharmacology, 1990, Jun-12, Volume: 188, Issue:6

    Topics: Animals; Azides; Blotting, Northern; Butaclamol; Corpus Striatum; Female; Haloperidol; In Vitro Tech

1990
Normal and adenomatous human pituitaries secrete thyrotropin-releasing hormone in vitro: modulation by dopamine, haloperidol, and somatostatin.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 71, Issue:2

    Topics: Adenoma; Chromatography, High Pressure Liquid; Dopamine; Female; Haloperidol; Humans; In Vitro Techn

1990
Characterization of the MMQ cell, a prolactin-secreting clonal cell line that is responsive to dopamine.
    Endocrinology, 1988, Volume: 123, Issue:5

    Topics: Calcium; Cholera Toxin; Colforsin; Cyclic AMP; Dopamine; Enzyme Activation; Estradiol; Haloperidol;

1988
Prolactin secretion by mixed ACTH-prolactin pituitary adenoma cells in culture.
    Acta endocrinologica, 1985, Volume: 108, Issue:4

    Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Cells, Cultured; Corticotropin-Releasing Hormone; Cushi

1985
Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture.
    Acta endocrinologica, 1985, Volume: 109, Issue:4

    Topics: Acromegaly; Adenoma, Acidophil; Adenoma, Chromophobe; Adult; Cells, Cultured; Child; Cyproheptadine;

1985
Bromocriptine-related psychosis and treatment.
    Biological psychiatry, 1985, Volume: 20, Issue:3

    Topics: Adult; Bromocriptine; Female; Haloperidol; Humans; Pituitary Neoplasms; Prolactin; Psychoses, Substa

1985
The electrical properties of isolated human prolactin-secreting adenoma cells and their modification by dopamine.
    Endocrinology, 1985, Volume: 117, Issue:4

    Topics: Adenoma; Bromocriptine; Domperidone; Dopamine; Dose-Response Relationship, Drug; Electrophysiology;

1985
A case of hypophyseal prolactinoma with treatable delusions of dermatozoiasis.
    Acta psychiatrica Scandinavica, 1985, Volume: 72, Issue:5

    Topics: Aged; Bromocriptine; Delusions; Female; Haloperidol; Humans; Hypochondriasis; Insecta; Pituitary Neo

1985
Restoration of prolactin synthesis and release by the administration of monoaminergic blocking agents to pituitary tumor-bearing rats.
    Cancer research, 1974, Volume: 34, Issue:2

    Topics: Animals; Dopamine; Dopamine Antagonists; Female; Haloperidol; In Vitro Techniques; Leucine; Male; Ne

1974
Polytome encephalography in investigation of pituitary tumours.
    Proceedings of the Royal Society of Medicine, 1970, Volume: 63, Issue:5

    Topics: Analgesics; Cerebral Ventriculography; Haloperidol; Humans; Isonipecotic Acids; Phenoperidine; Pitui

1970
Polytome-encephalography in the investigation of pituitary tumours.
    Clinical radiology, 1971, Volume: 22, Issue:3

    Topics: Acromegaly; Adenoma, Chromophobe; Adolescent; Adult; Aged; Cerebral Ventriculography; Craniopharyngi

1971