haloperidol has been researched along with Neuroblastoma in 24 studies
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, the aim of the present study was to examine in the human neuroblastoma SH-SY5Y cell line the impact of a typical (haloperidol) and an atypical (quetiapine) antipsychotic on the expression of genes encoding the key enzymes of the antioxidant metabolism (Cu, Zn superoxide dismutase; Mn superoxide dismutase; glutathione peroxidase; catalase) and enzymes of the glutathione metabolism (gamma-glutamyl cysteine synthetase, glutathione-S-transferase, gamma-glutamyltranspeptidase, glutathione reductase)." | 7.75 | Impact of haloperidol and quetiapine on the expression of genes encoding antioxidant enzymes in human neuroblastoma SH-SY5Y cells. ( Heiser, P; Hemmeter, UM; Krieg, JC; Schmidt, AJ; Vedder, H, 2009) |
| " The aim of this study was to investigate whether haloperidol treatment affects the composition and functionality of lipid rafts in SH-SY5Y neuroblastoma cells." | 7.75 | Effects of the antipsychotic drug haloperidol on the somastostatinergic system in SH-SY5Y neuroblastoma cells. ( Arilla-Ferreiro, E; Busto, R; Cano, S; Dávalos, A; de la Peña, G; Hernández-Pinto, AM; Lasunción, MA; Puebla-Jiménez, L; Sánchez-Wandelmer, J, 2009) |
| "Haloperidol has recently been found to be metabolized to its pyridinium ion (HP+)." | 5.29 | Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells. ( Fang, J; Yu, PH; Zuo, D, 1995) |
| " Therefore, the aim of the present study was to examine in the human neuroblastoma SH-SY5Y cell line the impact of a typical (haloperidol) and an atypical (quetiapine) antipsychotic on the expression of genes encoding the key enzymes of the antioxidant metabolism (Cu, Zn superoxide dismutase; Mn superoxide dismutase; glutathione peroxidase; catalase) and enzymes of the glutathione metabolism (gamma-glutamyl cysteine synthetase, glutathione-S-transferase, gamma-glutamyltranspeptidase, glutathione reductase)." | 3.75 | Impact of haloperidol and quetiapine on the expression of genes encoding antioxidant enzymes in human neuroblastoma SH-SY5Y cells. ( Heiser, P; Hemmeter, UM; Krieg, JC; Schmidt, AJ; Vedder, H, 2009) |
| " In the present study, we compared the SGA aripiprazole with the FGA haloperidol in SH-SY5Y human neuroblastoma cells via brain-derived neurotrophic factor (BDNF)-mediated signaling, notably BDNF, glycogen synthase kinase-3beta (GSK-3beta), and B cell lymphoma protein-2 (Bcl-2)." | 3.75 | Differential effects of aripiprazole and haloperidol on BDNF-mediated signal changes in SH-SY5Y cells. ( Cho, HY; Choi, SM; Ha, EK; Kim, YH; Lee, JG; Park, SW; Seo, MK, 2009) |
| " In the present study we have used high performance liquid chromatography to determine the effects of the antipsychotic drugs haloperidol and clozapine on NAA and NAAG levels in SH-SY5Y human neuroblastoma cells, a model system used to test the responses of dopaminergic neurons in vitro." | 3.74 | Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells. ( Arun, P; Madhavarao, CN; Moffett, JR; Namboodiri, AM, 2008) |
| " We investigated the mechanisms of action of olanzapine and haloperidol, on serum withdrawal apoptosis in human neuroblastoma SH-SY5Y cells." | 3.74 | Protective effects of olanzapine and haloperidol on serum withdrawal-induced apoptosis in SH-SY5Y cells. ( Kim, NR; Kim, YH; Lee, JG; Park, SW, 2008) |
| "In this study we investigated the effects of sigma receptor ligands and neurosteroids on bradykinin-induced intracellular calcium concentration ([Ca2+]i) changes in SH-SY5Y neuroblastoma cells." | 3.72 | Modulation of bradykinin-induced calcium changes in SH-SY5Y cells by neurosteroids and sigma receptor ligands via a shared mechanism. ( Hong, W; Nuwayhid, SJ; Werling, LL, 2004) |
| " [3H](+)-pentazocine binding in BE(2)-C human neuroblastoma cells is high affinity (KD 3." | 3.69 | Sigma binding in a human neuroblastoma cell line. ( Chien, CC; Pasternak, GW; Ryan-Moro, J; Standifer, KM, 1996) |
| " Similar results were obtained with other intact cells, fibroblasts, hepatocytes and neuroblastoma cells using [3H]spiperone and other ligands, such as [3H]haloperidol, [3H]pyrilamine and [3H]ketanserin." | 3.66 | Trapping of labelled ligands in intact cells: a pitfall in binding studies. ( Gossuin, A; Laduron, PM; Maloteaux, JM; Waterkeyn, C, 1983) |
| "1) activity was stimulated by low concentrations of dopamine and apomorphine, but not by low concentrations of norepinephrine in homogenates of malignant mouse neuroblastoma cells." | 3.65 | Demonstration of dopamine-sensitive adenylate cyclase in malignant neuroblastoma cells and change in sensitivity of adenylate cyclase to catecholamines in "differentiated" cells. ( Gilmer, KN; Prasad, KN, 1974) |
| " The aim of this research is to estimate the influence of lithium (alone and in combination with haloperidol) on the parameters of oxidative stress and viability of SH-SY5Y cell lines in neutral and pro-oxidative conditions." | 1.43 | Impact of lithium alone or in combination with haloperidol on oxidative stress parameters and cell viability in SH-SY5Y cell culture. ( Gawlik-Kotelnicka, O; Lazarek, J; Mielicki, W; Rabe-Jabłońska, J; Strzelecki, D, 2016) |
| " Melatonin, a free radical scavenger, blocks tau hyperphosphorylation, and microtubule disorganization caused by haloperidol in a dose-response mode." | 1.36 | Haloperidol causes cytoskeletal collapse in N1E-115 cells through tau hyperphosphorylation induced by oxidative stress: Implications for neurodevelopment. ( Benítez-King, G; Jiménez-Rubio, G; Ortíz-López, L; Ramírez-Rodríguez, G, 2010) |
| "Haloperidol has recently been found to be metabolized to its pyridinium ion (HP+)." | 1.29 | Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells. ( Fang, J; Yu, PH; Zuo, D, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.83) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gawlik-Kotelnicka, O | 1 |
| Mielicki, W | 1 |
| Rabe-Jabłońska, J | 1 |
| Lazarek, J | 1 |
| Strzelecki, D | 1 |
| Arun, P | 1 |
| Madhavarao, CN | 1 |
| Moffett, JR | 1 |
| Namboodiri, AM | 1 |
| Schmidt, AJ | 1 |
| Hemmeter, UM | 1 |
| Krieg, JC | 1 |
| Vedder, H | 1 |
| Heiser, P | 1 |
| Park, SW | 2 |
| Lee, JG | 2 |
| Ha, EK | 1 |
| Choi, SM | 1 |
| Cho, HY | 1 |
| Seo, MK | 1 |
| Kim, YH | 2 |
| Bernstein, HG | 1 |
| Ernst, T | 1 |
| Lendeckel, U | 1 |
| Bukowska, A | 1 |
| Ansorge, S | 1 |
| Stauch, R | 1 |
| Have, ST | 1 |
| Steiner, J | 1 |
| Dobrowolny, H | 1 |
| Bogerts, B | 1 |
| Sánchez-Wandelmer, J | 1 |
| Hernández-Pinto, AM | 1 |
| Cano, S | 1 |
| Dávalos, A | 1 |
| de la Peña, G | 1 |
| Puebla-Jiménez, L | 1 |
| Arilla-Ferreiro, E | 1 |
| Lasunción, MA | 1 |
| Busto, R | 1 |
| Benítez-King, G | 1 |
| Ortíz-López, L | 1 |
| Jiménez-Rubio, G | 1 |
| Ramírez-Rodríguez, G | 1 |
| Gassó, P | 1 |
| Mas, S | 1 |
| Molina, O | 1 |
| Bernardo, M | 1 |
| Lafuente, A | 1 |
| Parellada, E | 1 |
| Hong, W | 1 |
| Nuwayhid, SJ | 1 |
| Werling, LL | 1 |
| Skoblenick, KJ | 1 |
| Castellano, JM | 1 |
| Rogoza, RM | 1 |
| Dyck, BA | 1 |
| Thomas, N | 1 |
| Gabriele, JP | 1 |
| Chong, VZ | 1 |
| Mishra, RK | 1 |
| Kim, NR | 1 |
| Maloteaux, JM | 1 |
| Gossuin, A | 1 |
| Waterkeyn, C | 1 |
| Laduron, PM | 1 |
| Vilner, BJ | 1 |
| John, CS | 1 |
| Bowen, WD | 1 |
| Morio, Y | 1 |
| Tanimoto, H | 1 |
| Yakushiji, T | 1 |
| Morimoto, Y | 1 |
| Silver, MA | 1 |
| Yang, ZW | 1 |
| Ganguli, R | 1 |
| Nimgaonkar, VL | 1 |
| Fang, J | 1 |
| Zuo, D | 1 |
| Yu, PH | 1 |
| Ryan-Moro, J | 1 |
| Chien, CC | 1 |
| Standifer, KM | 1 |
| Pasternak, GW | 1 |
| Griffon, N | 1 |
| Pilon, C | 1 |
| Sautel, F | 1 |
| Schwartz, JC | 1 |
| Sokoloff, P | 1 |
| Volonté, M | 1 |
| Monferini, E | 1 |
| Cerutti, M | 1 |
| Fodritto, F | 1 |
| Borsini, F | 1 |
| Hwang, CK | 1 |
| D'Souza, UM | 1 |
| Eisch, AJ | 1 |
| Yajima, S | 1 |
| Lammers, CH | 1 |
| Yang, Y | 1 |
| Lee, SH | 1 |
| Kim, YM | 1 |
| Nestler, EJ | 1 |
| Mouradian, MM | 1 |
| Richelson, E | 1 |
| Traber, J | 1 |
| Reiser, G | 1 |
| Fischer, K | 1 |
| Hamprecht, B | 1 |
| Bräutigam, M | 1 |
| Laschinski, G | 1 |
| Kittner, B | 1 |
| Herken, H | 1 |
| Prasad, KN | 1 |
| Gilmer, KN | 1 |
24 other studies available for haloperidol and Neuroblastoma
| Article | Year |
|---|---|
Impact of lithium alone or in combination with haloperidol on oxidative stress parameters and cell viability in SH-SY5Y cell culture.
Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Cell Death; Cell Line, Tumor; Cell Survival; Halope | 2016 |
Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.
Topics: Antipsychotic Agents; Aspartic Acid; Cell Line, Tumor; Clozapine; Dipeptides; Dose-Response Relation | 2008 |
Impact of haloperidol and quetiapine on the expression of genes encoding antioxidant enzymes in human neuroblastoma SH-SY5Y cells.
Topics: Antioxidants; Antipsychotic Agents; Catalase; Cell Line, Tumor; Dibenzothiazepines; Down-Regulation; | 2009 |
Differential effects of aripiprazole and haloperidol on BDNF-mediated signal changes in SH-SY5Y cells.
Topics: Analysis of Variance; Antipsychotic Agents; Aripiprazole; Brain-Derived Neurotrophic Factor; Cell Li | 2009 |
Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia.
Topics: Adult; Aged; Animals; Antipsychotic Agents; Cell Line, Tumor; Chronic Disease; Down-Regulation; Fema | 2009 |
Effects of the antipsychotic drug haloperidol on the somastostatinergic system in SH-SY5Y neuroblastoma cells.
Topics: Antipsychotic Agents; Cell Line, Tumor; Haloperidol; Humans; Membrane Microdomains; Membrane Protein | 2009 |
Haloperidol causes cytoskeletal collapse in N1E-115 cells through tau hyperphosphorylation induced by oxidative stress: Implications for neurodevelopment.
Topics: Animals; Antioxidants; Antipsychotic Agents; Cell Line, Tumor; Cytoskeleton; Dose-Response Relations | 2010 |
Neurotoxic/neuroprotective activity of haloperidol, risperidone and paliperidone in neuroblastoma cells.
Topics: Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Huma | 2012 |
Modulation of bradykinin-induced calcium changes in SH-SY5Y cells by neurosteroids and sigma receptor ligands via a shared mechanism.
Topics: Binding Sites; Bradykinin; Calcium; Calcium Signaling; Cell Line, Tumor; Dehydroepiandrosterone; Dop | 2004 |
Translocation of AIF in the human and rat striatum following protracted haloperidol, but not clozapine treatment.
Topics: Animals; Antipsychotic Agents; Apoptosis; Apoptosis Inducing Factor; Case-Control Studies; Cell Line | 2006 |
Protective effects of olanzapine and haloperidol on serum withdrawal-induced apoptosis in SH-SY5Y cells.
Topics: Analysis of Variance; Antipsychotic Agents; Apoptosis; Benzodiazepines; beta Catenin; Cell Line, Tum | 2008 |
Trapping of labelled ligands in intact cells: a pitfall in binding studies.
Topics: Animals; Binding, Competitive; Cell Line; Haloperidol; Humans; Kinetics; Lymphocytes; Mice; Neurobla | 1983 |
Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.
Topics: Adenocarcinoma; Animals; Binding, Competitive; Breast Neoplasms; Carcinoma, Ductal, Breast; Glioblas | 1995 |
Characterization of the currents induced by sigma ligands in NCB20 neuroblastoma cells.
Topics: Animals; Antipsychotic Agents; Brain Neoplasms; Cricetinae; Electrophysiology; Haloperidol; Ligands; | 1994 |
An inhibitory effect of psychoactive drugs on a human neuroblastoma cell line.
Topics: Antipsychotic Agents; Cell Division; Cell Line; Dose-Response Relationship, Drug; Flupenthixol; Flup | 1994 |
Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Line; Dose- | 1995 |
Sigma binding in a human neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Binding, Competitive; Brain; Carbachol | 1996 |
Antipsychotics with inverse agonist activity at the dopamine D3 receptor.
Topics: Animals; Antipsychotic Agents; Calcium; CHO Cells; Clozapine; Colforsin; Cricetinae; Cyclic AMP; DNA | 1996 |
BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; CHO Cells; Clozapine; Corpus Striatum; COS Cells; Cr | 1997 |
Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Sequence; Animals; Autoradiography; Brain; | 2001 |
Tricyclic antidepressants and histamine H1 receptors.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Cl | 1979 |
Measurements of adenosine 3':5'-cyclic monophosphate and membrane potential in neuroblastoma times glioma hybrid cells: opiates and adrenergic agonists cause effects opposite to those of prostaglandin E1.
Topics: Animals; Cell Line; Clone Cells; Cyclic AMP; Dopamine; Glioma; Haloperidol; Hybrid Cells; Isoprotere | 1975 |
Effect of apomorphine, alpha-methylparatyrosine, haloperidol and reserpine on DOPA production in clonal cell lines (PC-12 and N1E-115).
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Animals; Apomorphine; Cell Line; Dihydroxyphenylalani | 1985 |
Demonstration of dopamine-sensitive adenylate cyclase in malignant neuroblastoma cells and change in sensitivity of adenylate cyclase to catecholamines in "differentiated" cells.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Catecholamines; Cell Line; Cyclic AMP; Dopamine; Haloperido | 1974 |