Page last updated: 2024-10-28

haloperidol and Inflammatory Response Syndrome, Systemic

haloperidol has been researched along with Inflammatory Response Syndrome, Systemic in 1 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Research Excerpts

Excerpt	Relevance	Reference
"Haloperidol was associated with significantly lower hospital mortality."	1.33	Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. ( Angus, DC; Clermont, G; Fink, MP; Kersten, A; Kong, L; Milbrandt, EB; Weissfeld, LA, 2005)

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Milbrandt, EB	1
Kersten, A	1
Kong, L	1
Weissfeld, LA	1
Clermont, G	1
Fink, MP	1
Angus, DC	1

Clinical Trials (3)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized Prospective Pilot Study Of Haloperidol In Addition To Standard Sedation In Mechanically Ventilated Patients With Delirium[NCT00429676]	Phase 2	20 participants (Anticipated)	Interventional	2005-12-31	Completed
ORIC-I: Optimizing Recovery From Intensive Care: Mechanical Ventilation and Delirium[NCT00300391]	Phase 3	40 participants (Actual)	Interventional	2006-03-31	Terminated (stopped due to Insufficient recruitment to meet aims.)
Randomized Double-Blind Clinical Trial to Compare Haloperidol and Non-Pharmacologic Treatment Versus Non-Pharmacologic Treatment and Placebo, in Elderly Hospitalized Patients With Hypoactive Delirium[NCT02345902]	Phase 3	60 participants (Anticipated)	Interventional	2016-01-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

28-day All-cause Mortality

(NCT00300391)
Timeframe: Daily

Intervention	Participants (Count of Participants)
Delirium	4
Persistent Coma	2
No Delirium	1

90-day All-cause Mortality

(NCT00300391)
Timeframe: 90 Days from enrollment in study

Intervention	Participants (Count of Participants)
Delirium	4
Persistent Coma	2
No Delirium	1

Duration of Mechanical Ventilation

(NCT00300391)
Timeframe: daily

Intervention	day (Median)
Delirium	4.5
Persistent Coma	6
No Delirium	4

ICU Length of Stay

(NCT00300391)
Timeframe: Daily

Intervention	day (Median)
Delirium	9
Persistent Coma	6
No Delirium	7

Other Studies

1 other study available for haloperidol and Inflammatory Response Syndrome, Systemic

Article	Year
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Critical care medicine, 2005, Volume: 33, Issue:1 Topics: Adult; Aged; Antipsychotic Agents; Cohort Studies; Conscious Sedation; Critical Care; Critical Illne	2005
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Critical care medicine, 2005, Volume: 33, Issue:1 Topics: Adult; Aged; Antipsychotic Agents; Cohort Studies; Conscious Sedation; Critical Care; Critical Illne	2005
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Critical care medicine, 2005, Volume: 33, Issue:1 Topics: Adult; Aged; Antipsychotic Agents; Cohort Studies; Conscious Sedation; Critical Care; Critical Illne	2005
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Critical care medicine, 2005, Volume: 33, Issue:1 Topics: Adult; Aged; Antipsychotic Agents; Cohort Studies; Conscious Sedation; Critical Care; Critical Illne	2005
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Critical care medicine, 2005, Volume: 33, Issue:1 Topics: Adult; Aged; Antipsychotic Agents; Cohort Studies; Conscious Sedation; Critical Care; Critical Illne	2005
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Critical care medicine, 2005, Volume: 33, Issue:1 Topics: Adult; Aged; Antipsychotic Agents; Cohort Studies; Conscious Sedation; Critical Care; Critical Illne	2005
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Critical care medicine, 2005, Volume: 33, Issue:1 Topics: Adult; Aged; Antipsychotic Agents; Cohort Studies; Conscious Sedation; Critical Care; Critical Illne	2005
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Critical care medicine, 2005, Volume: 33, Issue:1 Topics: Adult; Aged; Antipsychotic Agents; Cohort Studies; Conscious Sedation; Critical Care; Critical Illne	2005
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Critical care medicine, 2005, Volume: 33, Issue:1 Topics: Adult; Aged; Antipsychotic Agents; Cohort Studies; Conscious Sedation; Critical Care; Critical Illne	2005