Page last updated: 2024-10-28

haloperidol and Impotence

haloperidol has been researched along with Impotence in 8 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Research Excerpts

ExcerptRelevanceReference
"Polydipsia was the most prevalent (24, 60."1.51Adverse drug reactions experienced by out-patients taking chlorpromazine or haloperidol at Zomba Mental Hospital, Malawi. ( Chikowe, I; Domingo, M; Kampira, E; Mafuta, C; Mwakaswaya, V; Parveen, S, 2019)
" In addition, adverse events were also evaluated."1.34[A naturalistic, observational study of outpatients with schizophrenia: efficacy and safety results after 6 months. The International Schizophrenia Outpatient Health Outcomes study, IC-SOHO]. ( Agoston, T; István, S; Tamás, T; Zoltán, J, 2007)
" New dopamine D4 receptor agonists, exemplified by (E)-1-(4-chlorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)propan-1-one O-methyloxime (59a) and (E)-1-(3-chloro-4-fluorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)propan-1-one O-methyloxime (64a), exhibited favorable pharmacokinetic profiles and showed oral bioavailability in rat and dog."1.331-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. ( Bhatia, P; Brioni, JD; Chang, R; Donnelly-Roberts, DL; El Kouhen, O; Hakeem, AA; Henry, R; Hollingsworth, PR; Hsieh, GC; Kolasa, T; Marsh, KC; Martino, B; Matulenko, MA; Miller, LN; Moreland, RB; Mortell, K; Nakane, M; Namovic, MT; Patel, MV; Stewart, AO; Terranova, MA; Uchic, ME; Wetter, JM, 2006)
"The goal of this study was to identify a structurally distinct D(4)-selective agonist with superior oral bioavailability to our first-generation clinical candidate 1a (ABT-724) for the potential treatment of erectile dysfunction."1.33Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. ( Brioni, JD; Chang, R; Cowart, MD; Darbyshire, JF; Donnelly-Roberts, DL; El-Kouhen, OF; Gintant, G; Hakeem, AA; Hollingsworth, PR; Hsieh, GC; Kolasa, T; Marsh, KC; Martin, R; Martino, BR; Matulenko, MA; Miller, LN; Moreland, RB; Mortell, K; Nakane, M; Namovic, MT; Nelson, SL; Patel, MV; Rohde, JJ; Stewart, AO; Sullivan, JP; Terranova, MA; Uchic, ME; Wetter, JM, 2006)
"The novel antipsychotic medications offer a more favorable extrapyramidal side effect profile than conventional agents."1.31Sexual side effects of novel antipsychotic medications. ( Marder, SR; Pierre, JM; Saunders, CS; Wirshing, DA; Wirshing, WC, 2002)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's0 (0.00)18.2507
2000's6 (75.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Enguehard-Gueiffier, C1
Hübner, H1
El Hakmaoui, A1
Allouchi, H1
Gmeiner, P1
Argiolas, A1
Melis, MR1
Gueiffier, A1
Kolasa, T2
Matulenko, MA2
Hakeem, AA2
Patel, MV2
Mortell, K2
Bhatia, P1
Henry, R1
Nakane, M2
Hsieh, GC2
Terranova, MA2
Uchic, ME2
Miller, LN2
Chang, R2
Donnelly-Roberts, DL2
Namovic, MT2
Hollingsworth, PR2
Martino, B1
El Kouhen, O1
Marsh, KC2
Wetter, JM2
Moreland, RB2
Brioni, JD2
Stewart, AO2
Rohde, JJ1
Nelson, SL1
Cowart, MD1
El-Kouhen, OF1
Martino, BR1
Martin, R1
Darbyshire, JF1
Gintant, G1
Sullivan, JP1
Chikowe, I1
Domingo, M1
Mwakaswaya, V1
Parveen, S1
Mafuta, C1
Kampira, E1
István, S1
Agoston, T1
Tamás, T1
Zoltán, J1
Lare, SB1
Labbate, LA1
Wirshing, DA1
Pierre, JM1
Marder, SR1
Saunders, CS1
Wirshing, WC1
Meco, G1
Falaschi, P1
Casacchia, M1
Rocco, A1
Petrini, P1
Rosa, M1
Agnoli, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Survey of Sexual Function in Schizophrenic Patients[NCT01835522]0 participants (Actual)Observational2009-07-31Withdrawn
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

8 other studies available for haloperidol and Impotence

ArticleYear
2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.
    Journal of medicinal chemistry, 2006, Jun-29, Volume: 49, Issue:13

    Topics: Animals; Cattle; CHO Cells; Cricetinae; Cricetulus; Erectile Dysfunction; Guanosine 5'-O-(3-Thiotrip

2006
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
    Journal of medicinal chemistry, 2006, Aug-24, Volume: 49, Issue:17

    Topics: Animals; Benzamides; Binding Sites; Cell Line; Crystallography, X-Ray; Disease Models, Animal; Drug

2006
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
    Journal of medicinal chemistry, 2006, Dec-14, Volume: 49, Issue:25

    Topics: Action Potentials; Administration, Oral; Animals; Benzamides; Biological Availability; Cell Line; Cy

2006
Adverse drug reactions experienced by out-patients taking chlorpromazine or haloperidol at Zomba Mental Hospital, Malawi.
    BMC research notes, 2019, Jul-01, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Antipsychotic Agents; Chlorpromazine; Cross-Sectional Studies; Erectile Dysfuncti

2019
[A naturalistic, observational study of outpatients with schizophrenia: efficacy and safety results after 6 months. The International Schizophrenia Outpatient Health Outcomes study, IC-SOHO].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2007, Volume: 9, Issue:3

    Topics: Adult; Aggression; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Dibenzo

2007
Sildenafil and erectile dysfunction.
    The American journal of psychiatry, 2000, Volume: 157, Issue:12

    Topics: Antipsychotic Agents; Erectile Dysfunction; Haloperidol; Humans; Male; Middle Aged; Phosphodiesteras

2000
Sexual side effects of novel antipsychotic medications.
    Schizophrenia research, 2002, Jul-01, Volume: 56, Issue:1-2

    Topics: Adult; Antipsychotic Agents; Clozapine; Erectile Dysfunction; Fluphenazine; Haloperidol; Humans; Mal

2002
Neuroendocrine effects of haloperidol decanoate in patients with chronic schizophrenia.
    Advances in biochemical psychopharmacology, 1985, Volume: 40

    Topics: Adolescent; Adult; Chronic Disease; Drug Tolerance; Erectile Dysfunction; Female; Haloperidol; Human

1985