Page last updated: 2024-10-28

haloperidol and Hypoxia

haloperidol has been researched along with Hypoxia in 37 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"We aimed to investigate the hypothesis that sigma receptor ligands, haloperidol and ifenprodil, attenuate hypoxia-induced striatal dopamine release in vitro and determine the possible mechanisms."8.12Sigma receptor ligands haloperidol and ifenprodil attenuate hypoxia induced dopamine release in rat striatum. ( Buyukuysal, RL; Gul, Z; Gursoy, M, 2022)
" The aim of the study was to compare the effects of blocking D2's with haloperidol and DA synthesis with alpha methyl paratyrosine (AMPT) on the in vitro carotid body DA response to hypoxia."7.69Carotid body dopamine content and release by short-term hypoxia: effect of haloperidol and alpha methyl paratyrosine. ( Bairam, A; Basson, H; Cottet-Emard, JM; Marchal, F; Pequignot, JM, 1997)
"In haloperidol-induced catalepsy in rats (1."5.30Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders. ( Cohen, S; Levy, R; Speiser, Z, 1998)
"We aimed to investigate the hypothesis that sigma receptor ligands, haloperidol and ifenprodil, attenuate hypoxia-induced striatal dopamine release in vitro and determine the possible mechanisms."4.12Sigma receptor ligands haloperidol and ifenprodil attenuate hypoxia induced dopamine release in rat striatum. ( Buyukuysal, RL; Gul, Z; Gursoy, M, 2022)
"We examined the effects of the dopamine blocker haloperidol (H) on the ventilatory response to sustained hypoxia in awake cats."3.69Dopaminergic influence on the ventilatory response to sustained hypoxia in the cat. ( Anthonisen, NR; Long, W, 1995)
" The aim of the study was to compare the effects of blocking D2's with haloperidol and DA synthesis with alpha methyl paratyrosine (AMPT) on the in vitro carotid body DA response to hypoxia."3.69Carotid body dopamine content and release by short-term hypoxia: effect of haloperidol and alpha methyl paratyrosine. ( Bairam, A; Basson, H; Cottet-Emard, JM; Marchal, F; Pequignot, JM, 1997)
" In one series, we simultaneously measured carotid chemoreceptor and ventilatory responses to hypoxia and hypercapnia before and after a saturation dose of intravenous domperidone, a peripheral dopamine (D2) receptor antagonist."3.67Peripheral and central dopamine receptors in respiratory control. ( Hsiao, C; Lahiri, S; Mokashi, A, 1989)
"The effects of apomorphine on survival time of mice during lethal anoxic hypoxia were studied."3.67Survival time in hypoxic mice: differentiation between apomorphine-induced hypothermia and antihypoxic properties. ( Boismare, F; Chretien, P; Daoust, M; Moore, N; Saligaut, C, 1986)
"Domperidone treatment in intact animals evoked a significant increase in normoxic tidal volume, while haloperidol potentiated tidal volume increase in response to hypoxia."1.43Hypoxic ventilatory response after dopamine D2 receptor blockade in unilateral rat model of Parkinson's disease. ( Andrzejewski, K; Budzińska, K; Kaczyńska, K; Zaremba, M, 2016)
"In haloperidol-induced catalepsy in rats (1."1.30Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders. ( Cohen, S; Levy, R; Speiser, Z, 1998)
"Doxapram is a respiratory stimulant which acts on peripheral chemoreceptors and central respiratory neurons in a dose-dependent fashion in the adult cat."1.29Effects of doxapram on carotid chemoreceptor activity in newborn kittens. ( Bairam, A; Crance, JP; Lahiri, S; Marchal, F; Vert, P, 1993)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199014 (37.84)18.7374
1990's12 (32.43)18.2507
2000's7 (18.92)29.6817
2010's3 (8.11)24.3611
2020's1 (2.70)2.80

Authors

AuthorsStudies
Gursoy, M1
Gul, Z1
Buyukuysal, RL1
Andrzejewski, K1
Budzińska, K1
Zaremba, M1
Kaczyńska, K1
Pichon, A1
Zhenzhong, B1
Favret, F1
Jin, G1
Shufeng, H1
Marchant, D1
Richalet, JP1
Ge, RL1
Wang, JZ1
Cai, CY1
Zhang, YM1
Zheng, JH1
Chen, YC1
Li, WQ1
Shi, GG2
Xiao, JF1
Wang, CY1
Huang, YP1
Shen, JX1
Gao, FF1
Huang, ZQ1
Zheng, YS1
Barros, RC2
Branco, LG2
Cárnio, EC1
Schlenker, EH1
Lahiri, S4
Smatresk, N1
Pokorski, M2
Barnard, P1
Mokashi, A2
McGregor, KH1
Lundberg, D1
Mueller, RA1
Breese, GR1
Smatresk, NJ1
von Essen, C2
Zervas, NT1
Brown, DR1
Koltun, WA1
Pickren, KS1
Bisgard, GE1
Forster, HV1
Klein, JP1
Manohar, M1
Bullard, VA1
Long, W1
Anthonisen, NR1
Morelli, L1
Iturriaga, R1
Spergel, D1
Data, PG1
Trippenbach, T1
Kelly, G1
Bairam, A2
Marchal, F2
Crance, JP1
Vert, P1
Tatsumi, K2
Pickett, CK2
Weil, JV2
Basson, H1
Cottet-Emard, JM1
Pequignot, JM1
Pedersen, ME1
Dorrington, KL1
Robbins, PA1
Speiser, Z1
Levy, R1
Cohen, S1
Osanai, S1
Akiba, Y1
Matsumoto, H1
Nakano, H2
Kikuchi, K1
Huey, KA1
Brown, IP1
Jordan, MC1
Powell, FL1
Lee, SD1
Farkas, GA1
Güner, I1
Yelmen, N1
Sahin, G1
Oruç, T1
Ekström-Jodal, B1
Elfverson, J1
Pontecorvo, MJ1
Karbon, EW1
Goode, S1
Clissold, DB1
Borosky, SA1
Patch, RJ1
Ferkany, JW1
Delpiano, MA1
Acker, H1
Hsiao, C1
Bonora, M1
Gautier, H1
Saligaut, C1
Moore, N1
Chretien, P1
Daoust, M1
Boismare, F1
Olson, LG1
Saunders, NA1
Himwich, WA1
Davis, JM1
Ramdohr, B1
Schröder, R1
Hedeman, LS1
Sil, R1
Temkov, I1
Michailov, SH1
Bojkov, B1

Reviews

1 review available for haloperidol and Hypoxia

ArticleYear
Response of brain amino acids to drugs and environmental conditions.
    Advances in psychobiology, 1972, Volume: 1

    Topics: Amino Acids; Aminobutyrates; Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Chl

1972

Trials

1 trial available for haloperidol and Hypoxia

ArticleYear
Effects of haloperidol on ventilation during isocapnic hypoxia in humans.
    Journal of applied physiology (Bethesda, Md. : 1985), 1997, Volume: 83, Issue:4

    Topics: Adult; Blood Gas Analysis; Dopamine Antagonists; Female; Haloperidol; Humans; Hypoxia; Male; Middle

1997

Other Studies

35 other studies available for haloperidol and Hypoxia

ArticleYear
Sigma receptor ligands haloperidol and ifenprodil attenuate hypoxia induced dopamine release in rat striatum.
    Neurological research, 2022, Volume: 44, Issue:10

    Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dopamine Plasma Membr

2022
Hypoxic ventilatory response after dopamine D2 receptor blockade in unilateral rat model of Parkinson's disease.
    Neuroscience, 2016, Mar-01, Volume: 316

    Topics: Adrenergic Agents; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Disease Mode

2016
Long-term ventilatory adaptation and ventilatory response to hypoxia in plateau pika (Ochotona curzoniae): role of nNOS and dopamine.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:4

    Topics: Acclimatization; Animals; Citrulline; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; Exhalation;

2009
N-n-Butyl haloperidol iodide protects against hypoxia/reoxygenation-induced cardiomyocyte injury by modulating protein kinase C activity.
    Biochemical pharmacology, 2010, May-15, Volume: 79, Issue:10

    Topics: Animals; Apoptosis; Blotting, Western; Cardiotonic Agents; Cells, Cultured; Early Growth Response Pr

2010
N-n-butyl haloperidol iodide preserves cardiomyocyte calcium homeostasis during hypoxia/ischemia.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011, Volume: 27, Issue:5

    Topics: Aniline Compounds; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Fluorescent

2011
Evidence for thermoregulation by dopamine D1 and D2 receptors in the anteroventral preoptic region during normoxia and hypoxia.
    Brain research, 2004, Dec-31, Volume: 1030, Issue:2

    Topics: Analysis of Variance; Animals; Benzazepines; Body Temperature Regulation; Dopamine Antagonists; Halo

2004
In hamsters dopamine D2 receptors affect ventilation during and following intermittent hypoxia.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2007, Volume: 148, Issue:3

    Topics: Animals; Body Temperature; Carbon Dioxide; Carotid Body; Cricetinae; Disease Models, Animal; Domperi

2007
Dopaminergic efferent inhibition of carotid body chemoreceptors in chronically hypoxic cats.
    The American journal of physiology, 1984, Volume: 247, Issue:1 Pt 2

    Topics: Animals; Carotid Body; Carotid Sinus; Cats; Efferent Pathways; Feedback; Haloperidol; Hypoxia; Oxyge

1984
Effects of vagotomy and glossopharyngectomy on respiratory response to dopamine-agonists.
    Acta physiologica Scandinavica, 1982, Volume: 114, Issue:1

    Topics: Animals; Apomorphine; Blood Circulation; Carbon Dioxide; Dopamine; Dose-Response Relationship, Drug;

1982
Opposing effects of dopamine receptor blockade on ventilation and carotid chemoreceptor activity.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1983, Volume: 54, Issue:6

    Topics: Animals; Carotid Sinus; Cats; Chemoreceptor Cells; Dopamine Antagonists; Female; Haloperidol; Hyperc

1983
Local cerebral blood flow in the dog during intravenous infusion of dopamine.
    Surgical neurology, 1980, Volume: 13, Issue:3

    Topics: Adenosine; Animals; Apomorphine; Cerebral Arteries; Cerebrovascular Circulation; Dogs; Dopamine; Dop

1980
Depression of ventilation by dopamine in goats--effects of carotid body excision.
    Respiration physiology, 1980, Volume: 40, Issue:3

    Topics: Animals; Carotid Body; Dopamine; Goats; Haloperidol; Hypoventilation; Hypoxia; Infusions, Parenteral

1980
Dopaminergic influence on the ventilatory response to sustained hypoxia in the cat.
    Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 78, Issue:4

    Topics: Animals; Cats; Chemoreceptor Cells; Dopamine; Haloperidol; Hypoxia; Injections, Intramuscular; Mass

1995
Effects of haloperidol on cat carotid body chemoreception in vitro.
    Advances in experimental medicine and biology, 1993, Volume: 337

    Topics: Animals; Carbon Dioxide; Carotid Body; Cats; Chemoreceptor Cells; Dopamine; Haloperidol; Hypoxia; In

1993
Effects of acute and chronic cocaine on breathing and chemosensitivity in awake rats.
    The American journal of physiology, 1994, Volume: 266, Issue:3 Pt 2

    Topics: Animals; Cocaine; Haloperidol; Hypercapnia; Hypoxia; Injections, Intraperitoneal; Male; Rats; Rats,

1994
Effects of doxapram on carotid chemoreceptor activity in newborn kittens.
    Biology of the neonate, 1993, Volume: 64, Issue:1

    Topics: Animals; Animals, Newborn; Arteries; Carotid Sinus; Cats; Chemoreceptor Cells; Doxapram; Gases; Halo

1993
Decreased carotid body hypoxic sensitivity in chronic hypoxia: role of dopamine.
    Respiration physiology, 1995, Volume: 101, Issue:1

    Topics: Anesthesia; Animals; Carotid Body; Carotid Sinus; Cats; Chronic Disease; Domperidone; Dopamine; Dopa

1995
Carotid body dopamine content and release by short-term hypoxia: effect of haloperidol and alpha methyl paratyrosine.
    Archives of physiology and biochemistry, 1997, Volume: 105, Issue:1

    Topics: alpha-Methyltyrosine; Analysis of Variance; Animals; Carotid Body; Dopamine; Dopamine Antagonists; D

1997
Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders.
    Journal of neural transmission. Supplementum, 1998, Volume: 52

    Topics: Aging; alpha-Methyltyrosine; Animals; Avoidance Learning; Catalepsy; Cognition; Cognition Disorders;

1998
[Effect of dopamine receptor on hypoxic ventilatory response].
    Nihon Kyobu Shikkan Gakkai zasshi, 1997, Volume: 35, Issue:12

    Topics: Animals; Apomorphine; Central Nervous System; Chemoreceptor Cells; Dopamine Agonists; Dopamine Antag

1997
Changes in dopamine D(2)-receptor modulation of the hypoxic ventilatory response with chronic hypoxia.
    Respiration physiology, 2000, Volume: 123, Issue:3

    Topics: Animals; Carbon Dioxide; Carotid Body; Central Nervous System; Domperidone; Dopamine Antagonists; Do

2000
Dopaminergic modulation of ventilation in obese Zucker rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:1

    Topics: Animals; Body Temperature; Domperidone; Dopamine; Dopamine Antagonists; Haloperidol; Hypercapnia; Hy

2002
Central dopamine modulates anapyrexia but not hyperventilation induced by hypoxia.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:3

    Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Dopamine; Dopamine Antagonists; Halop

2002
The effect of intracerebroventricular dopamine administration on the respiratory response to hypoxia.
    The Tohoku journal of experimental medicine, 2002, Volume: 196, Issue:4

    Topics: Animals; Cerebrovascular Circulation; Domperidone; Dopamine; Dopamine Antagonists; Haloperidol; Hypo

2002
Studies on the influence of monoamines on the cerebrovascular response to arterial hypoxia.
    Acta neurologica Scandinavica, 1978, Volume: 57, Issue:2

    Topics: Animals; Cerebrovascular Circulation; Dogs; Dopamine; Haloperidol; Hemodynamics; Hypoxia; Injections

1978
Effects of haloperidol and domperidone on ventilatory roll off during sustained hypoxia in cats.
    Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 72, Issue:5

    Topics: Animals; Carotid Sinus; Cats; Domperidone; Dopamine Antagonists; Electrophysiology; Female; Haloperi

1992
Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents.
    Brain research bulletin, 1991, Volume: 26, Issue:3

    Topics: Animals; Anticonvulsants; Brain Diseases; Electroshock; Haloperidol; Hypoxia; Male; Mice; Mice, Inbr

1991
Hypoxia increases the cyclic AMP content of the cat carotid body in vitro.
    Journal of neurochemistry, 1991, Volume: 57, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Anima

1991
Peripheral and central dopamine receptors in respiratory control.
    Respiration physiology, 1989, Volume: 76, Issue:3

    Topics: Animals; Carotid Body; Cats; Domperidone; Dopamine; Female; Haloperidol; Hypercapnia; Hypoxia; Recep

1989
Influence of dopamine and norepinephrine on the central ventilatory response to hypoxia in conscious cats.
    Respiration physiology, 1988, Volume: 71, Issue:1

    Topics: Animals; Apomorphine; Carbon Dioxide; Cats; Dopamine; Female; Haloperidol; Hypoxia; Lung; Male; Nore

1988
Survival time in hypoxic mice: differentiation between apomorphine-induced hypothermia and antihypoxic properties.
    Methods and findings in experimental and clinical pharmacology, 1986, Volume: 8, Issue:4

    Topics: Animals; Apomorphine; Body Temperature; Domperidone; Drug Interactions; Female; Haloperidol; Hypoxia

1986
The effect of central and peripheral dopamine-agonists on ventilation in the mouse.
    Respiration physiology, 1985, Volume: 61, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brain; Carbidopa; Chemoreceptor Cells; Dopamine; Drug Interactions; Ha

1985
[Inhibition of dopamine-induced arterial hypoxemia by haloperidol].
    Klinische Wochenschrift, 1973, Jun-01, Volume: 51, Issue:11

    Topics: Arteriovenous Anastomosis; Blood Pressure; Carbon Dioxide; Cardiac Output; Coronary Disease; Dopamin

1973
Studies in experimental spinal cord trauma. 2. Comparison of treatment with steroids, low molecular weight dextran, and catecholamine blockade.
    Journal of neurosurgery, 1974, Volume: 40, Issue:1

    Topics: Animals; Dextrans; Disease Models, Animal; Dogs; Edema; Glucocorticoids; Haloperidol; Hypoxia; Methy

1974
[Protective effect of some neuroleptics and of p-diphenol:O2-oxidoreductase (ceruloplasmin) against intoxication hypoxia].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1966, Volume: 18, Issue:10

    Topics: Animals; Central Nervous System; Ceruloplasmin; Chlorpromazine; Cyanides; Haloperidol; Hypoxia; Inse

1966