Page last updated: 2024-10-28

haloperidol and Hypertension

haloperidol has been researched along with Hypertension in 36 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"A patient with bipolar I disorder has been treated with lithium and haloperidol for the last 20 years and received an ACE inhibitor for his hypertension since 9 years ago."3.85Hypertensive bipolar: chronic lithium toxicity in patients taking ACE inhibitor. ( Abdul Aziz, MF; Masiran, R, 2017)
" or VTA-injected SB222200 and R-820 (500 pmol) evoked anti-hypertension, which was blocked by raclopride."3.76Blockade of tachykinin NK3 receptor reverses hypertension through a dopaminergic mechanism in the ventral tegmental area of spontaneously hypertensive rats. ( Couture, R; De Brito Gariepy, H, 2010)
"Hypertension is one of the most serious health problems of the modern world with a continuous rise in the number of patients."2.44Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents. ( Bariwal, JB; Chauhan, BS; Jain, KS; Kathiravan, MK; Phoujdar, MS; Sahne, RS; Shah, AK; Yadav, MR, 2008)
"In haloperidol-treated rats on the LSD, both plasma gamma-MSH and NIL gamma-MSH content were greater than in vehicle-treated rats (P<0."1.32Suppression of gamma-melanocyte-stimulating hormone secretion is accompanied by salt-sensitive hypertension in the rat. ( Almog, S; Humphreys, MH; Mayan, H; Ni, XP, 2003)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199024 (66.67)18.7374
1990's5 (13.89)18.2507
2000's4 (11.11)29.6817
2010's3 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jain, KS1
Bariwal, JB1
Kathiravan, MK1
Phoujdar, MS1
Sahne, RS1
Chauhan, BS1
Shah, AK1
Yadav, MR1
Masiran, R1
Abdul Aziz, MF1
Ginwalla, M1
Biblo, LA1
Paydak, H1
Marchione, P1
Vento, C1
Marianetti, M1
Romeo, T1
Amabile, GA1
Giacomini, P1
De Brito Gariepy, H2
Carayon, P1
Ferrari, B1
Couture, R2
Mayan, H1
Ni, XP1
Almog, S1
Humphreys, MH1
Gross, ML1
Hahn, RA1
Farrell, SK1
Masserano, JM1
Weiner, N1
Bloom, FE1
Baetge, G1
Deyo, S1
Ettenberg, A1
Koda, L1
Magistretti, PJ1
Shoemaker, WJ1
Staunton, DA1
Martin, JR2
Quock, RM2
Shipley, JE1
Rowland, N1
Antelman, SM1
Buggy, J1
Edwards, DJ1
Shapiro, AP1
Patel, A1
Getsos, JP1
Moussa, G1
Damato, AN1
Chu, TF1
Lin, MT1
Autelitano, DJ1
van den Buuse, M2
Evenden, J1
Meyerson, B1
Kudrin, AN1
Davydova, ON1
Krendal', FP1
Sowers, JR1
Resch, G1
Tempel, G1
Herzog, J1
Colantino, M1
Wildbolz, A1
Hansson, HA1
Johansson, BB1
Cummingham, DG1
Challapalli, M1
Wallace, ER1
Staton, MA1
Finch, L1
Hersom, A1
Hicks, P1
Thornton, WE1
Hansell, P1
Sjöquist, M1
Barát, E1
Huszár, E1
Vértes, K1
Debreczeni, LA1
de Jong, W1
Ghadirian, AM1
Nair, NP1
Schwartz, G1
Bentley, GA1
Copeland, IW1
Hoyer, I1
Van Zwieten, PA1
Janowsky, DS1
el-Yousef, MK1
Davis, JM1
Fann, WE1
Brindle, GF1
Cocito, E1
Ambrosini, G1
Arata, A1
Bevilacqua, P1
Tortora, E1
Buffa, B1
Cotta Ramusino, M1
Muti, M1

Reviews

4 reviews available for haloperidol and Hypertension

ArticleYear
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.
    Bioorganic & medicinal chemistry, 2008, May-01, Volume: 16, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Age

2008
Tyrosine hydroxylase regulation in the central nervous system.
    Molecular and cellular biochemistry, 1983, Volume: 53-54, Issue:1-2

    Topics: Amphetamine; Animals; Brain; Catecholamines; Central Nervous System; Electric Conductivity; Electros

1983
Chemical and physiological aspects of the actions of lithium and antidepressant drugs.
    Neuropharmacology, 1983, Volume: 22, Issue:3 Spec No

    Topics: Animals; Antidepressive Agents; Apomorphine; Blood Pressure; Brain Chemistry; Diet; Endorphins; Halo

1983
[Diagnostic errors due to unilateral psychiatric or unilateral somatic appreciation (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1979, Nov-06, Volume: 68, Issue:45

    Topics: Adjustment Disorders; Adult; Aged; Brain Neoplasms; Bronchial Neoplasms; Diagnostic Errors; Echinoco

1979

Trials

1 trial available for haloperidol and Hypertension

ArticleYear
Clinical evaluation in 112 psychiatric patients of a butyrophenone neuroleptic, dehydrobenzperidol (R 4749). A controlled study in 45 patients of dehydrobenzperidol versus haloperidol.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:8

    Topics: Adult; Asthenia; Benperidol; Catatonia; Clinical Trials as Topic; Depression; Haloperidol; Humans; H

1970

Other Studies

31 other studies available for haloperidol and Hypertension

ArticleYear
Hypertensive bipolar: chronic lithium toxicity in patients taking ACE inhibitor.
    BMJ case reports, 2017, Aug-28, Volume: 2017

    Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Bipolar Disorder; Delirium; Diagnosis

2017
Torsade de pointes following intravenous haloperidol administration in a patient with complete heart block.
    WMJ : official publication of the State Medical Society of Wisconsin, 2009, Volume: 108, Issue:1

    Topics: Aged; Antipsychotic Agents; Cardiac Catheterization; Electrocardiography; Haloperidol; Heart Block;

2009
Hemiballismus in subthalamic haemorrhage: efficacy of levetiracetam.
    European journal of neurology, 2009, Volume: 16, Issue:6

    Topics: Aged; Anti-Dyskinesia Agents; Anticonvulsants; Antihypertensive Agents; Ataxia; Cerebellum; Dose-Res

2009
Contribution of the central dopaminergic system in the anti-hypertensive effect of kinin B1 receptor antagonists in two rat models of hypertension.
    Neuropeptides, 2010, Volume: 44, Issue:2

    Topics: Analysis of Variance; Animals; Blood Pressure; Bradykinin B1 Receptor Antagonists; Brain; Disease Mo

2010
Blockade of tachykinin NK3 receptor reverses hypertension through a dopaminergic mechanism in the ventral tegmental area of spontaneously hypertensive rats.
    British journal of pharmacology, 2010, Volume: 161, Issue:8

    Topics: Animals; Benzazepines; Blood Pressure; Dopamine; Haloperidol; Heart Rate; Hypertension; Ibotenic Aci

2010
Suppression of gamma-melanocyte-stimulating hormone secretion is accompanied by salt-sensitive hypertension in the rat.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:5

    Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Bromocriptine; Dopamine Agonists; Dopamine Antag

2003
Acute dystonia as idiosyncratic reaction to haloperidol.
    Lancet (London, England), 1980, Aug-30, Volume: 2, Issue:8192

    Topics: Acute Disease; Child; Dystonia; Female; Haloperidol; Humans; Hypertension

1980
Inhibition of peripheral adrenergic neurotransmission by lergotrile in spontaneously hypertensive rats.
    Life sciences, 1981, Jun-01, Volume: 28, Issue:22

    Topics: Animals; Electric Stimulation; Ergolines; Haloperidol; Hemodynamics; Hypertension; Male; Norepinephr

1981
Pharmacological characterization of apomorphine-induced hypothermia in the spontaneously hypertensive rat.
    Life sciences, 1984, Aug-27, Volume: 35, Issue:9

    Topics: Animals; Apomorphine; Blood Pressure; Body Temperature; Haloperidol; Hydralazine; Hypertension; Hypo

1984
Increased amphetamine stereotypy and longer haloperidol catalepsy in spontaneously hypertensive rats.
    Life sciences, 1981, Feb-16, Volume: 28, Issue:7

    Topics: Amphetamines; Animals; Brain; Catalepsy; Catecholamines; Female; Haloperidol; Humans; Hypertension;

1981
The Osborn wave of hypothermia in normothermic patients.
    Clinical cardiology, 1994, Volume: 17, Issue:5

    Topics: Adult; Aged; Angina Pectoris; Body Temperature; Chest Pain; Cocaine; Electrocardiography; Female; Ha

1994
Picrotoxin induces both hypertension and dopamine release in the rat amygdala.
    Neuroscience letters, 1996, Nov-08, Volume: 218, Issue:3

    Topics: Amygdala; Animals; Anticonvulsants; Cardiovascular System; Convulsants; Diazepam; Dopamine; Dopamine

1996
Concomitant up-regulation of proopiomelanocortin and dopamine D2-receptor gene expression in the pituitary intermediate lobe of the spontaneously hypertensive rat.
    Journal of neuroendocrinology, 1997, Volume: 9, Issue:4

    Topics: Alternative Splicing; Animals; beta-Endorphin; Bromocriptine; Cells, Cultured; Dopamine Agonists; Do

1997
The behavior of spontaneously hypertensive and Wistar Kyoto rats under a paced fixed consecutive number schedule of reinforcement.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 63, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Chlordiazepoxide; Conditioning, Opera

1999
[Pharmacologic incompatibility of neuroleptics and tranquilizers with other medicines].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1977, Volume: 77, Issue:4

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anticonvulsants; Antipsychotic Ag

1977
Hyperprolactinaemia in the spontaneously hypertensive rat.
    Acta endocrinologica, 1979, Volume: 90, Issue:1

    Topics: Animals; Haloperidol; Hypertension; Hypothalamus; Immobilization; Levodopa; Male; Prolactin; Rats; S

1979
Prevention of protein extravasation in the brain by an anion transport inhibitor in acute experimental hypertension in rats.
    Acta physiologica Scandinavica, 1979, Volume: 105, Issue:4

    Topics: Acute Disease; Animals; Anions; Bicuculline; Blood Proteins; Blood-Brain Barrier; Cerebrospinal Flui

1979
Hypertension in acute haloperidol poisoning.
    The Journal of pediatrics, 1979, Volume: 95, Issue:3

    Topics: Acute Disease; Female; Haloperidol; Humans; Hypertension; Infant

1979
Influence of dopaminergic agonists upon body temperature and behavior of spontaneously hypertensive and normotensive rats.
    Proceedings of the Western Pharmacology Society, 1978, Volume: 21

    Topics: Animals; Apomorphine; Behavior, Animal; Body Temperature; Carbidopa; Dopamine; Haloperidol; Humans;

1978
Acute hypertension after abrupt withdrawal of antipsychotic medication.
    Southern medical journal, 1977, Volume: 70, Issue:4

    Topics: Adolescent; Benztropine; Fluphenazine; Haloperidol; Humans; Hypertension; Male; Schizophrenia; Subst

1977
Studies on the hypotensive action of alpha-methyldopamine.
    British journal of pharmacology, 1975, Volume: 54, Issue:4

    Topics: Animals; Blood Pressure; Cats; Deoxyepinephrine; Depression, Chemical; Desipramine; Dopamine; Drug I

1975
Dementia induced by methyldopa with haloperidol.
    The New England journal of medicine, 1976, May-27, Volume: 294, Issue:22

    Topics: Adult; Anxiety; Dementia; Drug Synergism; Haloperidol; Humans; Hypertension; Male; Methyldopa; Middl

1976
Dopamine receptor blockade and synthesis inhibition during exaggerated natriuresis in spontaneously hypertensive rats.
    Acta physiologica Scandinavica, 1992, Volume: 144, Issue:3

    Topics: Animals; Benserazide; Dopamine Antagonists; Haloperidol; Hypertension; Isotonic Solutions; Male; Nat

1992
Effects of propranolol, nalorphine and haloperidol on the breathing and on the metabolism of PGI2 and TXA2 of normotensive and spontaneously hypertensive rats.
    Acta physiologica Hungarica, 1989, Volume: 74, Issue:1

    Topics: Animals; Epoprostenol; Haloperidol; Hypertension; Inspiratory Capacity; Nalorphine; Propranolol; Rat

1989
Differential effects of dopaminergic drugs on open-field behavior of spontaneously hypertensive rats and normotensive Wistar-Kyoto rats.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3

    Topics: Amphetamine; Animals; Apomorphine; Benzazepines; Clonidine; Desipramine; Dopamine; Dopamine Agents;

1989
Transmembrane lithium distribution and hypertension in manic depressive patients.
    Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:3-4

    Topics: Adult; Bipolar Disorder; Blood Pressure; Chlorpromazine; Drug Therapy, Combination; Erythrocytes; Fe

1989
The effect of chronic haloperidol treatment on some cardiovascular parameters in cats.
    British journal of pharmacology, 1985, Volume: 86, Issue:3

    Topics: Animals; Blood Pressure; Cats; Drug Administration Schedule; Female; Haloperidol; Heart Rate; Hemody

1985
The central hypotensive action of amphetamine, ephedrine, phentermine, chlorphentermine and fenfluramine.
    The Journal of pharmacy and pharmacology, 1972, Volume: 24, Issue:6

    Topics: Amphetamine; Animals; Appetite Depressants; Blood Pressure; Cats; Chlorphentermine; Depression, Chem

1972
Antagonism of guanethidine by chlorpromazine.
    The American journal of psychiatry, 1973, Volume: 130, Issue:7

    Topics: Blood Pressure; Chlorpromazine; Drug Interactions; Female; Guanethidine; Haloperidol; Humans; Hypert

1973
The use of neuroleptic agents in a neurosurgical unit.
    Clinical neurosurgery, 1969, Volume: 16

    Topics: Benperidol; Cerebral Angiography; Chlorpromazine; Craniocerebral Trauma; Electrodes; Epilepsy; Fenta

1969
[Haloperidol in states of psychomotor excitation and in anxiety states secondary to acute cardiocirculatory insufficiency].
    Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1966, Dec-31, Volume: 90, Issue:6

    Topics: Aged; Anxiety Disorders; Coronary Disease; Dementia; Female; Haloperidol; Heart Diseases; Humans; Hy

1966