Page last updated: 2024-10-28

haloperidol and Hip Fractures

haloperidol has been researched along with Hip Fractures in 7 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Hip Fractures: Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).

Research Excerpts

ExcerptRelevanceReference
"To study the effectiveness of haloperidol prophylaxis on incidence, severity, and duration of postoperative delirium in elderly hip-surgery patients at risk for delirium."9.11Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. ( Bogaards, MJ; Burger, BJ; de Jonghe, JF; Egberts, TC; Eikelenboom, P; Kalisvaart, KJ; van Gool, WA; Vreeswijk, R, 2005)
"Patients enrolled in a randomized controlled clinical trial of melatonin versus placebo on occurrence of delirium in hip-fracture patients."5.20In-Hospital Haloperidol Use and Perioperative Changes in QTc-Duration. ( Blom, MT; de Boer, A; de Jonghe, A; de Rooij, SE; Jansen, S; Tan, HL; van der Velde, N; van Munster, BC, 2015)
"To study the effectiveness of haloperidol prophylaxis on incidence, severity, and duration of postoperative delirium in elderly hip-surgery patients at risk for delirium."5.11Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. ( Bogaards, MJ; Burger, BJ; de Jonghe, JF; Egberts, TC; Eikelenboom, P; Kalisvaart, KJ; van Gool, WA; Vreeswijk, R, 2005)
"Strategies to prevent and treat delirium during hospitalization for hip fracture have been less studied."1.40[Delirium prevention and treatment in elderly hip fracture]. ( Formiga, F; Robles, MJ; Vidán, MT, 2014)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Robles, MJ1
Formiga, F1
Vidán, MT1
Blom, MT1
Jansen, S1
de Jonghe, A1
van Munster, BC1
de Boer, A1
de Rooij, SE1
Tan, HL1
van der Velde, N1
Freter, S1
Koller, K1
Dunbar, M1
MacKnight, C1
Rockwood, K1
Vochteloo, AJ1
Moerman, S1
van der Burg, BL1
de Boo, M1
de Vries, MR1
Niesten, DD1
Tuinebreijer, WE1
Nelissen, RG1
Pilot, P1
Kalisvaart, KJ2
de Jonghe, JF2
Bogaards, MJ1
Vreeswijk, R2
Egberts, TC1
Burger, BJ1
Eikelenboom, P2
van Gool, WA2
Dijkstra, M1
van Dis, H1
Kat, MG1
van der Ploeg, T1
Grover, M1
Edwards, F1
Hitchcock, K1
Stevens, MM1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block on Postoperative Delirium and Long-term Oucomes in Elderly Patients After Single Knee Arthroplasty[NCT03629483]Phase 4736 participants (Anticipated)Interventional2018-12-10Suspended (stopped due to Trial stopped by the sponsor because of no funding.)
Usefulness of Bright Light Therapy in the Prevention of Delirium in Patients Undergoing Hematopoietic Stem Cell Transplant (HSCT)[NCT01700816]40 participants (Actual)Interventional2012-10-31Terminated (stopped due to Low incidence of delirium.)
Dynamic Light Application to Prevent ICU Acquired Delirium[NCT01274819]1,000 participants (Actual)Interventional2011-07-31Completed
Impact of Dexmedetomidine Supplemented Intravenous Analgesia on Postoperative Delirium and Long-term Outcomes in Elderly After Orthopedic Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial[NCT03629262]Phase 4712 participants (Actual)Interventional2018-10-28Active, not recruiting
Impact of Dexmedetomidine Supplemented Analgesia on Delirium and Long-term Outcomes in Elderly After Hip Fracture Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial[NCT04955249]Phase 41,440 participants (Anticipated)Interventional2021-11-18Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Hematocrit (HCT)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventionvolume percentage (vol%) of red blood ce (Median)
Bright Light Therapy28.20
Sham Light26.70

Hemoglobin (HGB)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventiong/dl (Median)
Bright Light Therapy9.70
Sham Light9.55

Hospital Length of Stay

(NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventiondays (Median)
Bright Light Therapy18
Sham Light18.5

Number of Participants Who Developed Delirium Based on Meeting Criteria on the Delirium Rating Scale and/or Memorial Delirium Assessment Scale

Monday, Wednesday, and Friday assessments will begin after beginning light therapy and include the Delirium Rating Scale-Revised-98 (DRS-98)and Memorial Delirium Assessment Scale (MDAS) (NCT01700816)
Timeframe: From hospital admission until the date of first documented delirium, assessed up to 28 days post-transplant

InterventionParticipants (Count of Participants)
Bright Light Therapy1
Sham Light0

Platelet Count

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventionthousand cells/uL (Median)
Bright Light Therapy39
Sham Light33.5

Red Blood Cells (RBC)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

InterventionM/uL (Median)
Bright Light Therapy3.21
Sham Light2.93

Severity of Delirium Episodes: Memorial Delirium Assessment Scale (MDAS)

"Monday, Wednesday, and Friday assessments of the Memorial Delirium Assessment Scale (MDAS); Patients will receive assessments after beginning light therapy until day 28 post-transplant or discharge, whichever comes first.~10 item scale Items are rated on a four-point scale from 0 (none) to 3 (severe) depending on the level of impairment, rendering a maximum possible score of 30.~A score of 13 has been recommended as a cut-off for establishing the diagnosis of delirium" (NCT01700816)
Timeframe: From first documented episode of delirium until discharge from the hospital, assessed up to 28 days post-transplant

Interventionunits on a scale (Number)
Bright Light Therapy18

White Blood Cells (WBC)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

InterventionK/uL (Median)
Bright Light Therapy2.30
Sham Light4.75

Serum Creatinine and Blood Urea Nitrogen (BUN)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

,
Interventionmg/dl (Median)
Serum CreatinineBlood Urea Nitrogen (BUN)
Bright Light Therapy0.669
Sham Light0.758.5

Sodium (Na), Potassium (K), Chloride (Cl), and Carbon Dioxide (CO2)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT (Hematopoietic Stem Cell Transplantation). (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

,
Interventionmmol/L (Median)
Sodium (Na)Potassium (K)Chloride (Cl)Carbon Dioxide (CO2)
Bright Light Therapy1393.610524.9
Sham Light138.03.80103.025.10

Trials

4 trials available for haloperidol and Hip Fractures

ArticleYear
In-Hospital Haloperidol Use and Perioperative Changes in QTc-Duration.
    The journal of nutrition, health & aging, 2015, Volume: 19, Issue:5

    Topics: Aged, 80 and over; Antipsychotic Agents; Cohort Studies; Delirium; Electrocardiography; Female; Halo

2015
Translating Delirium Prevention Strategies for Elderly Adults with Hip Fracture into Routine Clinical Care: A Pragmatic Clinical Trial.
    Journal of the American Geriatrics Society, 2017, Volume: 65, Issue:3

    Topics: Aged; Aged, 80 and over; Analgesics; Anti-Dyskinesia Agents; Dehydration; Delirium; Female; Haloperi

2017
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:10

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Double-Blind Method; Female; Haloperidol; H

2005
Early symptoms in the prodromal phase of delirium: a prospective cohort study in elderly patients undergoing hip surgery.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2007, Volume: 15, Issue:2

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; APACHE; Cohort Studies; Delirium; Double-Blind Method

2007

Other Studies

3 other studies available for haloperidol and Hip Fractures

ArticleYear
[Delirium prevention and treatment in elderly hip fracture].
    Medicina clinica, 2014, Apr-22, Volume: 142, Issue:8

    Topics: Aged; Anesthesia, Epidural; Anesthesia, General; Benzodiazepines; Cognition Disorders; Combined Moda

2014
Delirium risk screening and haloperidol prophylaxis program in hip fracture patients is a helpful tool in identifying high-risk patients, but does not reduce the incidence of delirium.
    BMC geriatrics, 2011, Aug-11, Volume: 11

    Topics: Aged; Aged, 80 and over; Cohort Studies; Delirium; Female; Haloperidol; Hip Fractures; Humans; Incid

2011
Clinical inquiries. What steps can reduce morbidity and mortality caused by hip fractures?
    The Journal of family practice, 2007, Volume: 56, Issue:11

    Topics: Aged; Analgesics; Antibiotic Prophylaxis; Antipsychotic Agents; Bacterial Infections; Cephalosporins

2007