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haloperidol and Glioma

haloperidol has been researched along with Glioma in 16 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
" The present study examines the effects of antipsychotic drugs, haloperidol and risperidone, on the expression of HSP70 produced by MK-801 in rat C6 glioma cells."7.74Effects of haloperidol and risperidone on the expression of heat shock protein 70 in MK-801-treated rat C6 glioma cells. ( Chai, YG; Choi, J; Choi, MR; Kim, D; Kim, DJ; Kim, SH; Lee, JS; Park, YC; Roh, K; Roh, S; Yang, BH, 2008)
"We have investigated the expression of neuropeptide Y (NPY) in C6 glioma cells after the glutamatergic stimulation by the in situ RT-PCR and immunocytochemical techniques."7.70Expression of neuropeptide Y by glutamatergic stimulation in rat C6 glioma cells. ( Choe, BK; Kim, SK; Kwon, GY; Shin, SW, 2000)
"In this study, the inhibitory effects of R(-)-NPA (R(-)-Propylnorapomorphine) and haloperidol on voltage-dependent K+ currents in rat C6 glioma cells (C6 cells) were observed by means of the whole-cell patch-clamp recording technique."7.69[Inhibition of voltage-dependent K+ currents in rat C6 glioma cells by haloperidol and R(-)-NPA]. ( He, SF; Xie, Z, 1997)
" We used two-dimensional gel electrophoresis coupled with MALDI-TOF/TOF mass spectrometry protein identification to analyze differentially expressed proteins in haloperidol-, risperidone-, and clozapine-treated C6 glioma cells."3.79Two-dimensional gel electrophoresis revealed antipsychotic drugs induced protein expression modulations in C6 glioma cells. ( Chen, ML, 2013)
" We illustrate our approach by analyzing the effects induced by two sigma-1 receptor ligands (haloperidol and 4-IBP) on the behavior of two glioma cell lines using two in vitro cell models, i."3.74Videomicroscopic extraction of specific information on cell proliferation and migration in vitro. ( Debeir, O; Decaestecker, C; Kiss, R; Mégalizzi, V; Warzée, N, 2008)
" The present study examines the effects of antipsychotic drugs, haloperidol and risperidone, on the expression of HSP70 produced by MK-801 in rat C6 glioma cells."3.74Effects of haloperidol and risperidone on the expression of heat shock protein 70 in MK-801-treated rat C6 glioma cells. ( Chai, YG; Choi, J; Choi, MR; Kim, D; Kim, DJ; Kim, SH; Lee, JS; Park, YC; Roh, K; Roh, S; Yang, BH, 2008)
" Using a microarray approach, we here demonstrate that the antipsychotic drugs clozapine and haloperidol upregulate several genes involved in cholesterol and fatty acid biosynthesis in cultured human glioma cells, including HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase), HMGCS1 (3-hydroxy-3-methylglutaryl-coenzyme A synthase-1), FASN (fatty acid synthase) and SCD (stearoyl-CoA desaturase)."3.73Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? ( Berge, RK; Breilid, H; Fernø, J; Glambek, M; Løvlie, R; Raeder, MB; Skrede, S; Stansberg, C; Steen, VM; Tronstad, KJ; Vik-Mo, AO, 2005)
"We investigated the effects of the atypical antipsychotic drugs quetiapine and clozapine and the typical antipsychotic haloperidol on the secretion of GDNF from rat C6 glioma cells."3.73Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells. ( Dyck, LE; Li, XM; Shao, Z; Wang, H, 2006)
"We have investigated the expression of neuropeptide Y (NPY) in C6 glioma cells after the glutamatergic stimulation by the in situ RT-PCR and immunocytochemical techniques."3.70Expression of neuropeptide Y by glutamatergic stimulation in rat C6 glioma cells. ( Choe, BK; Kim, SK; Kwon, GY; Shin, SW, 2000)
"Haloperidol, a dopamine receptor antagonist and sigma-receptor-active neuroleptic drug, is cytotoxic to primary hippocampal neurones, C6 glioma cells and NCB20 cells."3.69Haloperidol-induced cell death--mechanism and protection with vitamin E in vitro. ( Behl, C; Holsboer, F; Rupprecht, R; Skutella, T, 1995)
"In this study, the inhibitory effects of R(-)-NPA (R(-)-Propylnorapomorphine) and haloperidol on voltage-dependent K+ currents in rat C6 glioma cells (C6 cells) were observed by means of the whole-cell patch-clamp recording technique."3.69[Inhibition of voltage-dependent K+ currents in rat C6 glioma cells by haloperidol and R(-)-NPA]. ( He, SF; Xie, Z, 1997)
"Pretreatment of haloperidol significantly reduced the radiotracer accumulation of [(99m)Tc]23 or [(99m)Tc]24 in the brain."1.40Novel cyclopentadienyl tricarbonyl (99m)tc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors. ( Brust, P; Cui, M; Deuther-Conrad, W; Jia, B; Jia, H; Li, D; Liu, B; Lu, J; Steinbach, J; Wang, X; Xie, Y, 2014)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's4 (25.00)18.2507
2000's5 (31.25)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sozio, P1
Fiorito, J2
Di Giacomo, V2
Di Stefano, A2
Marinelli, L2
Cacciatore, I2
Cataldi, A2
Pacella, S2
Turkez, H1
Parenti, C1
Rescifina, A1
Marrazzo, A2
Wang, X1
Li, D1
Deuther-Conrad, W1
Lu, J1
Xie, Y1
Jia, B1
Cui, M1
Steinbach, J1
Brust, P1
Liu, B1
Jia, H1
Patruno, A1
Rapino, M1
Fornasari, E1
Prezzavento, O1
Debeir, O1
Mégalizzi, V1
Warzée, N1
Kiss, R1
Decaestecker, C1
Roh, K1
Roh, S1
Yang, BH1
Lee, JS1
Chai, YG1
Choi, MR1
Park, YC1
Kim, DJ1
Kim, D1
Choi, J1
Kim, SH1
Chen, ML1
de Souza, DF1
Wartchow, K1
Hansen, F1
Lunardi, P1
Guerra, MC1
Nardin, P1
Gonçalves, CA1
Fernø, J1
Raeder, MB1
Vik-Mo, AO1
Skrede, S1
Glambek, M1
Tronstad, KJ1
Breilid, H1
Løvlie, R1
Berge, RK1
Stansberg, C1
Steen, VM1
Shao, Z1
Dyck, LE1
Wang, H1
Li, XM1
Behl, C1
Rupprecht, R1
Skutella, T1
Holsboer, F1
Kagaya, A1
Motohashi, N1
Kugaya, A1
Yamaji, T1
Hayashi, T1
Okamoto, Y1
Shinno, H1
Takebayashi, M1
Uchitomi, Y1
Yamawaki, S1
Griffon, N1
Pilon, C1
Sautel, F1
Schwartz, JC1
Sokoloff, P1
Xie, Z1
He, SF1
Kim, SK1
Kwon, GY1
Shin, SW1
Choe, BK1
Friedman, SJ1
Skehan, P1
Traber, J1
Reiser, G1
Fischer, K1
Hamprecht, B1

Other Studies

16 other studies available for haloperidol and Glioma

ArticleYear
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.
    European journal of medicinal chemistry, 2015, Jan-27, Volume: 90

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Drug Scr

2015
Novel cyclopentadienyl tricarbonyl (99m)tc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors.
    Journal of medicinal chemistry, 2014, Aug-28, Volume: 57, Issue:16

    Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Glioma; Haloperidol; Ligands; Male; Mice, Inbred

2014
Effect of MRJF4 on C6 Glioma Cells Proliferation and Migration.
    Central nervous system agents in medicinal chemistry, 2017, Volume: 17, Issue:2

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioma; Haloperidol; NF-kappa B; Pheny

2017
Videomicroscopic extraction of specific information on cell proliferation and migration in vitro.
    Experimental cell research, 2008, Oct-01, Volume: 314, Issue:16

    Topics: Animals; Benzamides; Cell Division; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screen

2008
Effects of haloperidol and risperidone on the expression of heat shock protein 70 in MK-801-treated rat C6 glioma cells.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Dec-12, Volume: 32, Issue:8

    Topics: Animals; Cell Line, Tumor; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagoni

2008
Two-dimensional gel electrophoresis revealed antipsychotic drugs induced protein expression modulations in C6 glioma cells.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Jan-10, Volume: 40

    Topics: Animals; Antipsychotic Agents; Cell Line, Tumor; Clozapine; Electrophoresis, Gel, Two-Dimensional; F

2013
Interleukin-6-induced S100B secretion is inhibited by haloperidol and risperidone.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Jun-03, Volume: 43

    Topics: Animals; Antipsychotic Agents; Cell Line, Tumor; Cytokines; Enzyme-Linked Immunosorbent Assay; Glial

2013
Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?
    The pharmacogenomics journal, 2005, Volume: 5, Issue:5

    Topics: Antipsychotic Agents; Cell Line, Tumor; Cholesterol; Clozapine; Fatty Acid Synthases; Fatty Acids; G

2005
Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells.
    Journal of psychiatry & neuroscience : JPN, 2006, Volume: 31, Issue:1

    Topics: Animals; Antipsychotic Agents; Cell Line, Tumor; Clozapine; Dibenzothiazepines; Enzyme-Linked Immuno

2006
Haloperidol-induced cell death--mechanism and protection with vitamin E in vitro.
    Neuroreport, 1995, Dec-29, Volume: 7, Issue:1

    Topics: Animals; Antipsychotic Agents; Apoptosis; Cell Death; Cricetinae; Cricetulus; Dopamine Antagonists;

1995
Cyclic GMP generation mediated by 5-HT-2 receptors via nitric oxide-dependent pathway and its effect on the desensitization of 5-HT-2 receptors in C6 glioma cells.
    Journal of neural transmission. General section, 1995, Volume: 100, Issue:1

    Topics: Animals; Arginine; Calcium; Chelating Agents; Cyclic GMP; Dopamine Antagonists; Edetic Acid; Egtazic

1995
Antipsychotics with inverse agonist activity at the dopamine D3 receptor.
    Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:10

    Topics: Animals; Antipsychotic Agents; Calcium; CHO Cells; Clozapine; Colforsin; Cricetinae; Cyclic AMP; DNA

1996
[Inhibition of voltage-dependent K+ currents in rat C6 glioma cells by haloperidol and R(-)-NPA].
    Sheng li xue bao : [Acta physiologica Sinica], 1997, Volume: 49, Issue:1

    Topics: Animals; Apomorphine; Biological Transport, Active; Brain Neoplasms; Dopamine Agonists; Dopamine Ant

1997
Expression of neuropeptide Y by glutamatergic stimulation in rat C6 glioma cells.
    Neurochemistry international, 2000, Volume: 36, Issue:1

    Topics: Animals; Dopamine; Gene Expression Regulation, Neoplastic; Glioma; Glutamic Acid; Haloperidol; Kaini

2000
The inhibition of sterol synthesis by anesthetics.
    FEBS letters, 1979, Jun-15, Volume: 102, Issue:2

    Topics: Acetates; Anesthetics, Local; Animals; Cell Line; Chlorpromazine; Diphenylacetic Acids; Glioma; Halo

1979
Measurements of adenosine 3':5'-cyclic monophosphate and membrane potential in neuroblastoma times glioma hybrid cells: opiates and adrenergic agonists cause effects opposite to those of prostaglandin E1.
    FEBS letters, 1975, Apr-01, Volume: 52, Issue:2

    Topics: Animals; Cell Line; Clone Cells; Cyclic AMP; Dopamine; Glioma; Haloperidol; Hybrid Cells; Isoprotere

1975