haloperidol has been researched along with Genetic Predisposition in 14 studies
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a first genome scan on obesity under antipsychotics in SZ and BP, we analyzed 21 multigenerational kindreds (508 family members) including several patients treated for a minimum of 3 years mainly with haloperidol or chlopromazine." | 3.72 | A genome wide linkage study of obesity as secondary effect of antipsychotics in multigenerational families of eastern Quebec affected by psychoses. ( Bouchard, RH; Chagnon, YC; Emond, C; Maziade, M; Mérette, C; Roy, MA, 2004) |
| " Generally, the antipsychotics significantly enhanced NRG1/ErbB signaling with increased expression of NRG1 and phosphorylation of ErbB4 and ErbB2 in the brain and myocardium, except that clozapine partly blocked the cardiac NRG1/ErbB2 activation, which could be associated with its more severe cardiac adverse actions." | 1.43 | Effects of prolonged antipsychotic administration on neuregulin-1/ErbB signaling in rat prefrontal cortex and myocardium: implications for the therapeutic action and cardiac adverse effect. ( Cai, H; Dang, R; Guo, Y; Jiang, P; Liang, D; Lv, C; Yang, R, 2016) |
| "Extrapyramidal symptoms (EPSs) are common adverse effects of antipsychotics." | 1.39 | The association study of polymorphisms in DAT, DRD2, and COMT genes and acute extrapyramidal adverse effects in male schizophrenic patients treated with haloperidol. ( Bozina, N; Mihaljević-Peles, A; Muck-Seler, D; Nikolac-Perkovic, M; Sagud, M; Vuksan-Cusa, B; Zivković, M, 2013) |
| "Schizophrenia has been proposed to be associated with abnormal glutamatergic neurotransmission." | 1.38 | Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia. ( Drummond, JB; Haroutunian, V; Meador-Woodruff, JH; Simmons, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, Y | 1 |
| Giusti-Rodriguez, P | 1 |
| Crowley, JJ | 1 |
| Bryois, J | 1 |
| Nonneman, RJ | 1 |
| Ryan, AK | 1 |
| Quackenbush, CR | 1 |
| Iglesias-Ussel, MD | 1 |
| Lee, PH | 1 |
| Sun, W | 1 |
| de Villena, FP | 1 |
| Sullivan, PF | 1 |
| Zivković, M | 1 |
| Mihaljević-Peles, A | 1 |
| Bozina, N | 1 |
| Sagud, M | 1 |
| Nikolac-Perkovic, M | 1 |
| Vuksan-Cusa, B | 1 |
| Muck-Seler, D | 1 |
| Zheng, M | 1 |
| Zhang, H | 1 |
| Dill, DL | 1 |
| Clark, JD | 1 |
| Tu, S | 1 |
| Yablonovitch, AL | 1 |
| Tan, MH | 1 |
| Zhang, R | 1 |
| Rujescu, D | 1 |
| Wu, M | 1 |
| Tessarollo, L | 1 |
| Vieira, W | 1 |
| Gottesman, MM | 1 |
| Deng, S | 1 |
| Eberlin, LS | 1 |
| Zare, RN | 1 |
| Billard, JM | 1 |
| Gillet, JP | 1 |
| Li, JB | 1 |
| Peltz, G | 1 |
| Peltola, MA | 1 |
| Kuja-Panula, J | 1 |
| Liuhanen, J | 1 |
| Võikar, V | 1 |
| Piepponen, P | 1 |
| Hiekkalinna, T | 1 |
| Taira, T | 1 |
| Lauri, SE | 1 |
| Suvisaari, J | 1 |
| Kulesskaya, N | 1 |
| Paunio, T | 1 |
| Rauvala, H | 1 |
| Dang, R | 1 |
| Guo, Y | 1 |
| Cai, H | 1 |
| Yang, R | 1 |
| Liang, D | 1 |
| Lv, C | 1 |
| Jiang, P | 1 |
| Markianos, M | 1 |
| Panas, M | 1 |
| Kalfakis, N | 1 |
| Hatzimanolis, J | 1 |
| Vassilopoulos, D | 1 |
| Drummond, JB | 1 |
| Simmons, M | 1 |
| Haroutunian, V | 1 |
| Meador-Woodruff, JH | 1 |
| Kano, Y | 1 |
| Chagnon, YC | 1 |
| Mérette, C | 1 |
| Bouchard, RH | 1 |
| Emond, C | 1 |
| Roy, MA | 1 |
| Maziade, M | 1 |
| Matsumoto, C | 1 |
| Shinkai, T | 1 |
| Hori, H | 1 |
| Ohmori, O | 1 |
| Nakamura, J | 1 |
| Ethier, I | 1 |
| Kagechika, H | 1 |
| Shudo, K | 1 |
| Rouillard, C | 1 |
| Lévesque, D | 1 |
| Hess-Röver, J | 1 |
| Crichton, J | 1 |
| Byrne, K | 1 |
| Holland, AJ | 1 |
| Mirnics, K | 1 |
| Middleton, FA | 1 |
| Stanwood, GD | 1 |
| Lewis, DA | 1 |
| Levitt, P | 1 |
| Pletnikov, MV | 1 |
| Rubin, SA | 1 |
| Vogel, MW | 1 |
| Moran, TH | 1 |
| Carbone, KM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Blind, Placebo-Controlled Trial on the Efficacy of Omega-3 Supplementation With Docosahexaenoic Acid (DHA) on Tardive Dyskinesia[NCT00621634] | Phase 2 | 40 participants (Anticipated) | Interventional | 2008-02-29 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for haloperidol and Genetic Predisposition
| Article | Year |
|---|---|
[Chronic tic disorders--chronic mortor or vocal tic disorders and de la Tourette's syndrome].
Topics: Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy | 2003 |
Diagnosis and treatment of a severe psychotic illness in a man with dual severe sensory impairments caused by the presence of Usher syndrome.
Topics: Animals; Antipsychotic Agents; Blindness; Cricetinae; Diagnosis, Differential; Genetic Predispositio | 1999 |
12 other studies available for haloperidol and Genetic Predisposition
| Article | Year |
|---|---|
Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects.
Topics: Animals; Antipsychotic Agents; Brain; Corpus Striatum; Gene Expression Regulation; Genetic Predispos | 2018 |
The association study of polymorphisms in DAT, DRD2, and COMT genes and acute extrapyramidal adverse effects in male schizophrenic patients treated with haloperidol.
Topics: Acute Disease; Adult; Antipsychotic Agents; Basal Ganglia Diseases; Catechol O-Methyltransferase; Ch | 2013 |
The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans.
Topics: Adolescent; Adult; Alleles; Animals; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfami | 2015 |
AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes.
Topics: Adult; Animals; Antipsychotic Agents; Behavior, Animal; Blotting, Western; Brain; Cell Membrane; Clo | 2016 |
Effects of prolonged antipsychotic administration on neuregulin-1/ErbB signaling in rat prefrontal cortex and myocardium: implications for the therapeutic action and cardiac adverse effect.
Topics: Animals; Antipsychotic Agents; Cardiovascular Diseases; Clozapine; Comorbidity; Genetic Predispositi | 2016 |
Neuroendocrine evidence of normal hypothalamus-pituitary dopaminergic function in Huntington's disease.
Topics: Adult; Dopamine; Female; Genetic Predisposition to Disease; Haloperidol; Humans; Huntingtin Protein; | 2010 |
Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia.
Topics: Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Egg Proteins; Female; Frontal Lobe; Gene Exp | 2012 |
A genome wide linkage study of obesity as secondary effect of antipsychotics in multigenerational families of eastern Quebec affected by psychoses.
Topics: Antipsychotic Agents; Bipolar Disorder; Chlorpromazine; Chromosomes, Human, Pair 12; Comorbidity; Ge | 2004 |
Polymorphisms of dopamine degradation enzyme (COMT and MAO) genes and tardive dyskinesia in patients with schizophrenia.
Topics: Antipsychotic Agents; Catechol O-Methyltransferase; Codon; DNA Primers; Dopamine; Dyskinesia, Drug-I | 2004 |
Docosahexaenoic acid reduces haloperidol-induced dyskinesias in mice: involvement of Nur77 and retinoid receptors.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Benzoates; Biphenyl Compounds; Disease Models, | 2004 |
Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia.
Topics: Adult; Animals; Antipsychotic Agents; Chromosomes, Human, Pair 1; Depressive Disorder, Major; Family | 2001 |
Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animal Diseases; Animals; Animals, Newborn; Borna Disease; B | 2002 |