Page last updated: 2024-10-28

haloperidol and Emesis

haloperidol has been researched along with Emesis in 87 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Research Excerpts

ExcerptRelevanceReference
"We randomized cannabis users with active emesis to either haloperidol (with a nested randomization to either 0."9.41Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial. ( Crawford, FM; Day, AG; Forrester, S; Hall, AK; Ruberto, AJ; Sivilotti, MLA, 2021)
"The purpose of the study was to compare efficacy and toxicity of olanzapine (OLN; a higher-cost drug) and haloperidol (HAL; a lower-cost drug) in the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients who receive highly emetogenic chemotherapy (HEC)."9.30Randomized Phase II Trial to Compare the Efficacy of Haloperidol and Olanzapine in the Control of Chemotherapy-Induced Nausea and Vomiting in Nepal. ( Acharya, B; Dulal, S; Neupane, P; Paudel, BD; Poudyal, BS; Shah, A; Shilpakar, R; Wood, LA, 2019)
"Haloperidol as an adjunctive therapy is superior to placebo for acute gastroparesis symptoms."9.24Randomized Controlled Double-blind Trial Comparing Haloperidol Combined With Conventional Therapy to Conventional Therapy Alone in Patients With Symptomatic Gastroparesis. ( Cardenas-Turanzas, M; Chambers, KA; Chathampally, Y; Paniagua, L; Patel, S; Roldan, CJ, 2017)
"Haloperidol is used commonly for the control of nausea and vomiting (N/V) in palliative care patients, but there is very little evidence to support its use."9.14The efficacy of haloperidol in the management of nausea and vomiting in patients with cancer. ( Douglas, C; Gilshenan, K; Hardy, JR; O'Shea, A; Welch, L; White, C, 2010)
" This study compared ziprasidone with the conventional antipsychotic haloperidol in outpatients with stable schizophrenia."9.10A 28-week comparison of ziprasidone and haloperidol in outpatients with stable schizophrenia. ( Bäuml, J; Hirsch, SR; Kissling, W; O'Connor, R; Power, A, 2002)
"Tropisetron is a novel antiserotoninergic drug with potent and specific activity against cancer chemotherapy-induced emesis."9.07Tropisetron plus haloperidol to ameliorate nausea and vomiting associated with high-dose alkylating agent cancer chemotherapy. ( Bonadonna, G; Bregni, M; Di Nicola, M; Gianni, AM; Siena, S, 1991)
"The antiemetic effectiveness of haloperidol plus dexamethasone was compared with that of prochlorperazine plus dexamethasone in a prospective study of patients receiving chemotherapy for breast cancer."9.06A randomized comparison of haloperidol plus dexamethasone versus prochlorperazine plus dexamethasone in preventing nausea and vomiting in patients receiving chemotherapy for breast cancer. ( Carpenter, JT; Conolley, C; Lee, J; Silvey, L; Wheeler, RH, 1988)
"0 mg) of haloperidol with that of placebo for the relief of vomiting and nausea due to gastrointestinal disorders."9.04Haloperidol parenterally for treatment of vomiting and nausea from gastrointestinal disorders in a group of geriatric patients: double-blind, placebo-controlled study. ( Nagel, JD; Robbins, EL, 1975)
"Sixty-two postoperative patients were admitted to a double-blind study to compare the therapeutic effectiveness of a single intramuscular injection of 1 mg of haloperidol with that of a placebo for the relief of vomiting and nausea following surgical procedures."9.04The use of haloperidol for treatment of postoperative nausea and vomiting--a double-blind placebo-controlled trial. ( Barton, MD; Cohen, PJ; Libonati, M, 1975)
"To evaluate the efficacy and adverse events associated with the use of haloperidol for the treatment of nausea and vomiting in palliative care patients."8.91Haloperidol for the treatment of nausea and vomiting in palliative care patients. ( Dorman, S; Murray-Brown, F, 2015)
"The primary objective of the review was to evaluate the efficacy and adverse events associated with the use of haloperidol for the treatment of nausea and vomiting in palliative care patients."8.85Haloperidol for the treatment of nausea and vomiting in palliative care patients. ( Dorman, S; Perkins, P, 2009)
"Haloperidol (HL) has successfully been used for nausea and abdominal pain in emergency departments (EDs)."8.02Haloperidol Use in the Emergency Department for Gastrointestinal Symptoms: Nausea, Vomiting, and Abdominal Pain. ( Jehangir, A; Malik, Z; Parkman, HP; Repanshek, ZD; Reznick-Lipina, K; Shahsavari, D; Weiner, M, 2021)
"A short-cut review was carried out to establish whether haloperidol is effective at treating the symptoms of cannabinoid hyperemesis syndrome (CHS)."7.88BET 1: Haloperidol in cannabinoid hyperemesis syndrome. ( Dida, J; Walji, N, 2018)
" From October 1995 to January 1997, prevention of emesis with granisetron 3 mg/12 h i."7.70The antiemetic efficacy of granisetron plus dexamethasone, haloperidol and loracepam in breast cancer patients treated with high-dose chemotherapy with peripheral blood stem-cell support. ( Aznar, E; Climent, MA; Guillem, V; Olmos, T; Palau, J; Ruiz, A; Soriano, V, 1998)
"Haloperidol (HP) has been shown to have analgesic & antiemetic properties."5.46Haloperidol undermining gastroparesis symptoms (HUGS) in the emergency department. ( Croft, B; Darracq, MA; Ramirez, R; Stalcup, P, 2017)
"We randomized cannabis users with active emesis to either haloperidol (with a nested randomization to either 0."5.41Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial. ( Crawford, FM; Day, AG; Forrester, S; Hall, AK; Ruberto, AJ; Sivilotti, MLA, 2021)
"The purpose of the study was to compare efficacy and toxicity of olanzapine (OLN; a higher-cost drug) and haloperidol (HAL; a lower-cost drug) in the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients who receive highly emetogenic chemotherapy (HEC)."5.30Randomized Phase II Trial to Compare the Efficacy of Haloperidol and Olanzapine in the Control of Chemotherapy-Induced Nausea and Vomiting in Nepal. ( Acharya, B; Dulal, S; Neupane, P; Paudel, BD; Poudyal, BS; Shah, A; Shilpakar, R; Wood, LA, 2019)
"Haloperidol as an adjunctive therapy is superior to placebo for acute gastroparesis symptoms."5.24Randomized Controlled Double-blind Trial Comparing Haloperidol Combined With Conventional Therapy to Conventional Therapy Alone in Patients With Symptomatic Gastroparesis. ( Cardenas-Turanzas, M; Chambers, KA; Chathampally, Y; Paniagua, L; Patel, S; Roldan, CJ, 2017)
"The topical gel known as "ABH gel," comprising lorazepam (Ativan(®)), diphenhydramine (Benadryl(®)), and haloperidol (Haldol(®)), is frequently used to treat nausea because of its perceived efficacy, relatively low cost, and ease of use in the home setting."5.19A randomized trial of the effectiveness of topical "ABH Gel" (Ativan(®), Benadryl(®), Haldol(®)) vs. placebo in cancer patients with nausea. ( Coyne, PJ; Dodson, PW; Fletcher, DS; Parker, GG; Smith, TJ; Wan, W, 2014)
"Haloperidol is used commonly for the control of nausea and vomiting (N/V) in palliative care patients, but there is very little evidence to support its use."5.14The efficacy of haloperidol in the management of nausea and vomiting in patients with cancer. ( Douglas, C; Gilshenan, K; Hardy, JR; O'Shea, A; Welch, L; White, C, 2010)
" This study compared ziprasidone with the conventional antipsychotic haloperidol in outpatients with stable schizophrenia."5.10A 28-week comparison of ziprasidone and haloperidol in outpatients with stable schizophrenia. ( Bäuml, J; Hirsch, SR; Kissling, W; O'Connor, R; Power, A, 2002)
"Tropisetron is a novel antiserotoninergic drug with potent and specific activity against cancer chemotherapy-induced emesis."5.07Tropisetron plus haloperidol to ameliorate nausea and vomiting associated with high-dose alkylating agent cancer chemotherapy. ( Bonadonna, G; Bregni, M; Di Nicola, M; Gianni, AM; Siena, S, 1991)
"The antiemetic effectiveness of haloperidol plus dexamethasone was compared with that of prochlorperazine plus dexamethasone in a prospective study of patients receiving chemotherapy for breast cancer."5.06A randomized comparison of haloperidol plus dexamethasone versus prochlorperazine plus dexamethasone in preventing nausea and vomiting in patients receiving chemotherapy for breast cancer. ( Carpenter, JT; Conolley, C; Lee, J; Silvey, L; Wheeler, RH, 1988)
"Sixty-four patients receiving cancer chemotherapy known to induce severe emesis entered a randomized double-blind study of the antiemetic efficacy of haloperidol (Haldol) and benzquinamide (Emetecon)."5.05Specific antiemetics for specific cancer chemotherapeutic agents: haloperidol versus benzquinamide. ( Gagen, M; Neidhart, JA; Wilson, HE; Young, D, 1981)
"Metoclopramide is an effective antiemetic for cisplatin-induced vomiting when given in parenteral high-dose regimens but not oral low-dose regimens."5.05Comparison of the antiemetic effect of high-dose intravenous metoclopramide and high-dose intravenous haloperidol in a randomized double-blind crossover study. ( Cariffe, P; Gala, KV; Grunberg, SM; Jamin, D; Johnson, K; Krailo, M; Lampenfeld, M; Strych, D, 1984)
"0 mg) of haloperidol with that of placebo for the relief of vomiting and nausea due to gastrointestinal disorders."5.04Haloperidol parenterally for treatment of vomiting and nausea from gastrointestinal disorders in a group of geriatric patients: double-blind, placebo-controlled study. ( Nagel, JD; Robbins, EL, 1975)
"Sixty-two postoperative patients were admitted to a double-blind study to compare the therapeutic effectiveness of a single intramuscular injection of 1 mg of haloperidol with that of a placebo for the relief of vomiting and nausea following surgical procedures."5.04The use of haloperidol for treatment of postoperative nausea and vomiting--a double-blind placebo-controlled trial. ( Barton, MD; Cohen, PJ; Libonati, M, 1975)
"To evaluate the efficacy and adverse events associated with the use of haloperidol for the treatment of nausea and vomiting in palliative care patients."4.91Haloperidol for the treatment of nausea and vomiting in palliative care patients. ( Dorman, S; Murray-Brown, F, 2015)
" In postoperative nausea and vomiting (PONV), two randomized controlled trials found treatment with haloperidol comparable to ondansetron."4.89Using haloperidol as an antiemetic in palliative care: informing practice through evidence from cancer treatment and postoperative contexts. ( Bennett, MI; Blenkinsopp, A; McLean, SL, 2013)
"The primary objective of the review was to evaluate the efficacy and adverse events associated with the use of haloperidol for the treatment of nausea and vomiting in palliative care patients."4.85Haloperidol for the treatment of nausea and vomiting in palliative care patients. ( Dorman, S; Perkins, P, 2009)
"Haloperidol (HL) has successfully been used for nausea and abdominal pain in emergency departments (EDs)."4.02Haloperidol Use in the Emergency Department for Gastrointestinal Symptoms: Nausea, Vomiting, and Abdominal Pain. ( Jehangir, A; Malik, Z; Parkman, HP; Repanshek, ZD; Reznick-Lipina, K; Shahsavari, D; Weiner, M, 2021)
"A short-cut review was carried out to establish whether haloperidol is effective at treating the symptoms of cannabinoid hyperemesis syndrome (CHS)."3.88BET 1: Haloperidol in cannabinoid hyperemesis syndrome. ( Dida, J; Walji, N, 2018)
"Settings were postoperative nausea or vomiting (1,994 patients), gastroenterology (261), chemotherapy (189), and radiation therapy (24)."3.81Is low-dose haloperidol a useful antiemetic?: A meta-analysis of published and unpublished randomized trials. ( Büttner, M; Tramèr, MR; von Elm, E; Walder, B, 2004)
" From October 1995 to January 1997, prevention of emesis with granisetron 3 mg/12 h i."3.70The antiemetic efficacy of granisetron plus dexamethasone, haloperidol and loracepam in breast cancer patients treated with high-dose chemotherapy with peripheral blood stem-cell support. ( Aznar, E; Climent, MA; Guillem, V; Olmos, T; Palau, J; Ruiz, A; Soriano, V, 1998)
"A new benzamide, cis-N-(1-benzyl-2-methylpyrrolidin - 3 - yl) - 5 - chloro - 2 - methoxy - 4 - methylaminobenzamide (YM-09151-2) exhibited more potent and longer-lasting inhibitory effects on apomorphine-induced behaviours (stereotyped behaviour, emesis and hypothermia), and methamphetamine-induced stereotyped behaviour, conditioned avoidance response and open field behaviour, conditioned avoidance response and open field behaviour than either structurally similar benzamides (YM-0850 and sulpiride) or classical neuroleptics [chlorpromazine (CPZ) and haloperidol(HPD)]."3.66Neuroleptic properties of cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide (YM-09151-2) with selective antidopaminergic activity. ( Maeno, H; Nishikori, K; Noshiro, O; Usuda, S, 1981)
"5 mg intravenous haloperidol in an effort to improve patient tolerance of cytotoxic chemotherapy and decrease nausea and vomiting."3.66Lorazepam as an adjunct to antiemetic therapy with haloperidol in patients receiving cytotoxic chemotherapy. ( Coates, A; Fox, RM; Friedlander, ML; Hedley, D; Kearsley, JH; Raghavan, D; Sims, K; Tattersall, MH, 1983)
" Compound 2e was much less active than haloperidol in antagonizing apomorphine-induced emesis in dogs, apomorphine-induced stereotypy in rats, and amphetamine-induced circling in lesioned rats."3.66Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 4. Central nervous system depressants. ( Allen, RC; Bauer, VJ; Cornfeldt, ML; Fielding, S; Geyer, HM; Kosley, RW; McFadden, AR; Shutske, GM; Wilker, JC, 1978)
" Ironically, chronic use of cannabis can result in paradoxical effects, including a condition known as cannabinoid hyperemesis syndrome."2.61Cannabinoid hyperemesis syndrome: An unrecognized cause of nausea and vomiting. ( Forest, CP; Smith, TN; Walsh, A, 2019)
"Haloperidol is a butyrophenone neuroleptic agent characterized as a high-affinity dopamine antagonist, originally used for the treatment of schizophrenia."2.48Role of haloperidol in palliative medicine: an update. ( Prommer, E, 2012)
"Haloperidol (HP) has been shown to have analgesic & antiemetic properties."1.46Haloperidol undermining gastroparesis symptoms (HUGS) in the emergency department. ( Croft, B; Darracq, MA; Ramirez, R; Stalcup, P, 2017)
"Vomiting was controlled in all patients, with the exception of three patients with upper abdomen obstruction who required nasogastric tube placement."1.28The management of inoperable gastrointestinal obstruction in terminal cancer patients. ( Caraceni, A; De Conno, F; Messina, L; Ripamonti, C; Spoldi, E; Ventafridda, V, 1990)
"Severe vomiting was evoked by Apo in dogs, but not by Eph even when lethal dose (20 mg."1.28[Comparison of central stimulating effects between ephedrine and apomorphine]. ( Li, BH; Li, Q, 1991)
"The neuroleptic malignant syndrome is a serious and potentially fatal complication of neuroleptic and other dopamine antagonist drugs that are commonly used in symptom control in advanced cancer."1.28The neuroleptic malignant syndrome. ( O'Neill, WM, 1990)
"Sixty patients with Hodgkin's disease were treated with a polychemotherapy regimen including very emetic dacarbazine and adriamycin in addition to bleomycin and vincristine on 622 treatment days during the last 10 years."1.28[Management of vomiting induced by polychemotherapy in Hodgkin's disease]. ( Berényi, E; Kiss, E, 1989)
"Remoxipride was shown to be a selective dopamine D2 receptor antagonist since it displaced [3H]spiperone (IC50 = 1570 nM) but not [3H]flupentixol (IC50 greater than 100 000 nM) in rat striatum, and did not inhibit striatal DA-sensitive adenylate cyclase in vitro (IC50 greater than 100 000 nM)."1.27Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain. ( Angeby, K; Florvall, L; Hall, H; Köhler, C; Lindbom, LO; Magnusson, O; Ogren, SO, 1984)
"Prochlorperazine has an intermediate onset of action and droperidol is the slowest of the three compounds but the only one to provide significant anti-emesis 4-24 hours following administration."1.26Comparison of droperidol, haloperidol and prochlorperazine as postoperative anti-emetics. ( Bennett, G; Loeser, EA; Machin, R; Stanley, TH, 1979)

Research

Studies (87)

TimeframeStudies, this research(%)All Research%
pre-199042 (48.28)18.7374
1990's12 (13.79)18.2507
2000's11 (12.64)29.6817
2010's15 (17.24)24.3611
2020's7 (8.05)2.80

Authors

AuthorsStudies
Allen, RC1
Bauer, VJ1
Kosley, RW1
McFadden, AR1
Shutske, GM1
Cornfeldt, ML1
Fielding, S1
Geyer, HM1
Wilker, JC1
Brown, JM1
Wilsey, MJ1
Dhana, L1
Lonsdale, H1
Ruberto, AJ2
Sivilotti, MLA2
Forrester, S1
Hall, AK2
Crawford, FM2
Day, AG1
Trajkovski, A1
Lang, E1
Moussa, G1
Genest, M1
Villeneuve, E1
Wang, JJ1
Shahsavari, D1
Reznick-Lipina, K1
Malik, Z1
Weiner, M1
Jehangir, A1
Repanshek, ZD1
Parkman, HP1
Rosenthal, J1
Howell, M1
Earl, V1
Malik, M1
Ramirez, R1
Stalcup, P1
Croft, B1
Darracq, MA1
Roldan, CJ1
Chambers, KA1
Paniagua, L1
Patel, S1
Cardenas-Turanzas, M1
Chathampally, Y1
Dida, J1
Walji, N1
Smith, TN1
Walsh, A1
Forest, CP1
Dulal, S1
Paudel, BD1
Neupane, P1
Shah, A1
Acharya, B1
Poudyal, BS1
Shilpakar, R1
Wood, LA1
Hernández-Ramos, I1
Parra-Esquivel, P1
López-Hernández, Á1
Burillo-Putze, G1
Hickey, JL1
Witsil, JC1
Mycyk, MB1
McLean, SL1
Blenkinsopp, A1
Bennett, MI1
Kishi, T1
Mukai, T1
Matsuda, Y1
Iwata, N1
Silvestris, N1
Brunetti, AE1
Russano, M1
Nardulli, P1
Fletcher, DS1
Coyne, PJ1
Dodson, PW1
Parker, GG1
Wan, W1
Smith, TJ1
Murray-Brown, F1
Dorman, S2
Inayat, F1
Virk, HU1
Ullah, W1
Hussain, Q1
Perkins, P1
Marchione, P1
Vento, C1
Marianetti, M1
Romeo, T1
Amabile, GA1
Giacomini, P1
Hardy, JR1
O'Shea, A1
White, C2
Gilshenan, K1
Welch, L1
Douglas, C1
Prommer, E1
APPIANI, L1
CUOCOLO, R1
MESSINA, N1
CIPRIANI, G1
GIORDANO, GB1
DYRBERG, V1
WEAVER, LC1
RAHDERT, E1
RICHARDS, AB1
ABREU, BE1
Vella-Brincat, J1
Macleod, AD1
Büttner, M1
Walder, B1
von Elm, E1
Tramèr, MR1
Krakauer, EL1
Zhu, AX1
Bounds, BC1
Sahani, D1
McDonald, KR1
Brachtel, EF1
Weschules, DJ1
McPherson, A1
McCann, MA1
Sadler, A1
Fyvie, J1
Bleicher, J1
Bhaskara, A1
Huyck, T1
Constantino, S1
Bardia, A1
Loprinzi, CL1
Silberstein, PT1
Usuda, S1
Nishikori, K1
Noshiro, O1
Maeno, H1
Schaffer, CB1
Shahid, A1
Javaid, JI1
Davis, JM1
Friedlander, ML2
Kearsley, JH2
Sims, K2
Coates, A1
Hedley, D1
Raghavan, D1
Fox, RM1
Tattersall, MH1
Ogren, SO1
Hall, H1
Köhler, C1
Magnusson, O1
Lindbom, LO1
Angeby, K1
Florvall, L1
Grunberg, SM1
Gala, KV1
Lampenfeld, M1
Jamin, D1
Johnson, K1
Cariffe, P1
Strych, D1
Krailo, M1
Chacón, RD1
Bruera, ED1
Roca, E1
Neidhart, JA1
Gagen, M1
Young, D1
Wilson, HE1
Uvnäs-Wallensten, K1
Goiny, M2
Uvnäs-Moberg, K1
Posloncec, B1
Blomquist, L1
Luthra, YK1
Mattsson, JL1
Yochmowitz, MG1
Keith, JC1
Wilson, RC1
Booth, NH1
Kemppainen, RJ1
Davis, LE1
Cole, RM1
Robinson, F1
Harvey, L1
Trethowan, K1
Murdoch, V1
Hudzik, TJ2
De Costa, BR1
McMillan, DE1
Climent, MA1
Palau, J1
Ruiz, A1
Soriano, V1
Aznar, E1
Olmos, T1
Guillem, V1
Critchley, P1
Plach, N1
Grantham, M1
Marshall, D1
Taniguchi, A1
Latimer, E1
Jadad, AR1
Rabin, BM2
Joseph, JA2
Hunt, WA1
Dalton, TB1
Kandasamy, SB1
Harris, AH1
Ludewigt, B1
Erat, S1
Hirsch, SR1
Kissling, W1
Bäuml, J1
Power, A1
O'Connor, R1
Ono, H1
Taira, N1
Hashimoto, K1
Lal, H1
Gianutsos, G1
Puri, SK1
Gylys, JA1
Doran, KM1
Buyniski, JP1
Loeser, EA1
Bennett, G1
Stanley, TH1
Machin, R1
Lefebvre, RA1
Willems, JL1
Kalman, T1
Warner, GM1
Robbins, EL1
Nagel, JD1
Barton, MD1
Libonati, M1
Cohen, PJ1
Corsini, GU1
Zompo, MD1
Cianchetti, C1
Mangoni, A1
Montastruc, JL1
Rascol, O1
Montastruc, P1
Ventafridda, V1
Ripamonti, C1
Caraceni, A1
Spoldi, E1
Messina, L1
De Conno, F1
Li, Q1
Li, BH1
Bregni, M1
Siena, S1
Di Nicola, M1
Bonadonna, G1
Gianni, AM1
Francom, M1
O'Neill, WM1
Lang, IM1
Marvig, J1
Backonja, M1
Beinlich, B1
Dulli, D1
Schutta, HS1
Berényi, E1
Kiss, E1
Murakami, M1
Ota, K1
Silvey, L1
Carpenter, JT1
Wheeler, RH1
Lee, J1
Conolley, C1
Grob, CS1
Saller, R1
Hellenbrecht, D1
Plotkin, DA1
Plotkin, D1
Okun, R1
Christman, RS1
Weinstein, RA1
Larose, JB1
De Vries, PM1
Cole, DR1
Duffy, DF1
Rotrosen, J1
Wallach, MB1
Angrist, B1
Gershon, S1
Wolff, JD1
Lionarons, HB1
Mesdag, MJ1
Niemegeers, CJ1
Janssen, PA1
Valena, V1
Young, WG1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Droperidol on Prevention of Emesis From Cannabinoid Hyperemesis Syndrome[NCT05244460]Phase 345 participants (Anticipated)Interventional2021-12-02Recruiting
Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized Controlled Trial[NCT03056482]Phase 433 participants (Actual)Interventional2017-05-21Completed
Haloperidol vs Conventional Therapy for Gastroparesis[NCT02057549]Phase 436 participants (Actual)Interventional2012-11-30Terminated (stopped due to PI left institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Emergency Department Length of Stay (EDLOS)

"The time frame starts from the moment of receiving the study drug to the time when the decision for final disposition is made. Usually after symptoms are controlled, patients are given a PO challenge (food or drink) in order to establish if they are OK to go home. If symptoms return, additional medications are given, the treatment is consider failed and they are admitted to the Hospital.~Patients will not be followed up if admitted to any service. The study ends when final disposition is made.~Patients follow up after final disposition is not part of the study and will not be done." (NCT02057549)
Timeframe: at the time the decision for final disposition is made (about 8 hours)

Interventionhours (Median)
Haloperidol Plus Conventional Therapy4.8
Conventional Therapy9

Nausea Relief as Indicated by Number of Participants Not Requesting Additional Antiemetic Medication

(NCT02057549)
Timeframe: 1 hour after study medication given

InterventionParticipants (Count of Participants)
Haloperidol Plus Conventional Therapy11
Conventional Therapy13

Nausea Score as Measured by a Visual Analogue Scale (VAS)

The Visual Analogue Scale (VAS) ranges from 1-5, with 1 being minimal nausea and 5 being severe nausea. (NCT02057549)
Timeframe: 1 hour after study medication given

Interventionunits on a scale (Mean)
Haloperidol Plus Conventional Therapy1.83
Conventional Therapy3.39

Nausea Score as Measured by a Visual Analogue Scale (VAS)

The Visual Analogue Scale (VAS) ranges from 1-5, with 1 being minimal nausea and 5 being severe nausea. (NCT02057549)
Timeframe: before study medication given

Interventionunits on a scale (Mean)
Haloperidol Plus Conventional Therapy4.53
Conventional Therapy4.11

Number of Participants Admitted to the Hospital After Emergency Department Visit

(NCT02057549)
Timeframe: 2 hours after study medication given

InterventionParticipants (Count of Participants)
Haloperidol Plus Conventional Therapy4
Conventional Therapy13

Pain Relief as Indicated by Number of Participants Not Requesting Additional Pain Medication

(NCT02057549)
Timeframe: 1 hour after study medication given

InterventionParticipants (Count of Participants)
Haloperidol Plus Conventional Therapy11
Conventional Therapy5

Pain Score as Measured by a Visual Analogue Scale (VAS)

The Visual Analogue Scale (VAS) ranges from 0-10, with 0 being the absence of pain and 10 the worst imaginable pain. (NCT02057549)
Timeframe: 1 hour after study medication given

Interventionunits on a scale (Mean)
Haloperidol Plus Conventional Therapy3.13
Conventional Therapy7.17

Pain Score as Measured by a Visual Analogue Scale (VAS)

The Visual Analogue Scale (VAS) ranges from 0-10, with 0 being the absence of pain and 10 the worst imaginable pain. (NCT02057549)
Timeframe: before study medication given

Interventionunits on a scale (Mean)
Haloperidol Plus Conventional Therapy8.50
Conventional Therapy8.28

Reviews

10 reviews available for haloperidol and Emesis

ArticleYear
Cannabinoid hyperemesis syndrome: An unrecognized cause of nausea and vomiting.
    JAAPA : official journal of the American Academy of Physician Assistants, 2019, Volume: 32, Issue:4

    Topics: Acute Disease; Antiemetics; Cannabinoids; Haloperidol; Humans; Lorazepam; Nausea; Syndrome; Vomiting

2019
Using haloperidol as an antiemetic in palliative care: informing practice through evidence from cancer treatment and postoperative contexts.
    Journal of pain & palliative care pharmacotherapy, 2013, Volume: 27, Issue:2

    Topics: Antiemetics; Antineoplastic Agents; Haloperidol; Humans; Nausea; Ondansetron; Palliative Care; Posto

2013
Selective serotonin 3 receptor antagonist treatment for schizophrenia: meta-analysis and systematic review.
    Neuromolecular medicine, 2014, Volume: 16, Issue:1

    Topics: Antipsychotic Agents; Constipation; Double-Blind Method; Drug Therapy, Combination; Granisetron; Hal

2014
Haloperidol for the treatment of nausea and vomiting in palliative care patients.
    The Cochrane database of systematic reviews, 2015, Nov-02, Issue:11

    Topics: Antiemetics; Diphenhydramine; Gels; Haloperidol; Humans; Lorazepam; Nausea; Palliative Care; Randomi

2015
Haloperidol for the treatment of nausea and vomiting in palliative care patients.
    The Cochrane database of systematic reviews, 2009, Apr-15, Issue:2

    Topics: Antiemetics; Haloperidol; Humans; Nausea; Palliative Care; Vomiting

2009
Role of haloperidol in palliative medicine: an update.
    The American journal of hospice & palliative care, 2012, Volume: 29, Issue:4

    Topics: Delirium; Dopamine Antagonists; Haloperidol; Humans; Nausea; Palliative Care; Vomiting

2012
Haloperidol in palliative care.
    Palliative medicine, 2004, Volume: 18, Issue:3

    Topics: Antipsychotic Agents; Conscious Sedation; Delirium; Haloperidol; Humans; Long QT Syndrome; Nausea; V

2004
Is low-dose haloperidol a useful antiemetic?: A meta-analysis of published and unpublished randomized trials.
    Anesthesiology, 2004, Volume: 101, Issue:6

    Topics: Antiemetics; Antineoplastic Agents; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Hal

2004
Efficacy of haloperidol in the treatment of nausea and vomiting in the palliative patient: a systematic review.
    Journal of pain and symptom management, 2001, Volume: 22, Issue:2

    Topics: Antiemetics; Haloperidol; Humans; Nausea; Neoplasms; Palliative Care; Vomiting

2001
[Recent advances in the management of chemotherapy-induced emesis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:3 Pt 1

    Topics: Antiemetics; Antineoplastic Agents; Cisplatin; Dexamethasone; Domperidone; Dronabinol; Drug Therapy,

1986

Trials

19 trials available for haloperidol and Emesis

ArticleYear
Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial.
    Annals of emergency medicine, 2021, Volume: 77, Issue:6

    Topics: Administration, Intravenous; Adult; Antiemetics; Female; Haloperidol; Humans; Male; Marijuana Abuse;

2021
Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial.
    Annals of emergency medicine, 2021, Volume: 77, Issue:6

    Topics: Administration, Intravenous; Adult; Antiemetics; Female; Haloperidol; Humans; Male; Marijuana Abuse;

2021
Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial.
    Annals of emergency medicine, 2021, Volume: 77, Issue:6

    Topics: Administration, Intravenous; Adult; Antiemetics; Female; Haloperidol; Humans; Male; Marijuana Abuse;

2021
Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial.
    Annals of emergency medicine, 2021, Volume: 77, Issue:6

    Topics: Administration, Intravenous; Adult; Antiemetics; Female; Haloperidol; Humans; Male; Marijuana Abuse;

2021
Randomized Controlled Double-blind Trial Comparing Haloperidol Combined With Conventional Therapy to Conventional Therapy Alone in Patients With Symptomatic Gastroparesis.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2017, Volume: 24, Issue:11

    Topics: Abdominal Pain; Adult; Analgesics; Antiemetics; Double-Blind Method; Drug Therapy, Combination; Fema

2017
Randomized Phase II Trial to Compare the Efficacy of Haloperidol and Olanzapine in the Control of Chemotherapy-Induced Nausea and Vomiting in Nepal.
    Journal of global oncology, 2019, Volume: 5

    Topics: Administration, Intravenous; Administration, Oral; Adult; Antiemetics; Antineoplastic Combined Chemo

2019
Optimal control of nausea and vomiting with a three-drug antiemetic regimen with aprepitant in metastatic pancreatic cancer patients treated with first-line modified FOLFIRINOX.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013, Volume: 21, Issue:11

    Topics: Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Aprepitant; Benztropine; Camptoth

2013
A randomized trial of the effectiveness of topical "ABH Gel" (Ativan(®), Benadryl(®), Haldol(®)) vs. placebo in cancer patients with nausea.
    Journal of pain and symptom management, 2014, Volume: 48, Issue:5

    Topics: Administration, Topical; Adolescent; Adult; Aged; Antiemetics; Cross-Over Studies; Diphenhydramine;

2014
The efficacy of haloperidol in the management of nausea and vomiting in patients with cancer.
    Journal of pain and symptom management, 2010, Volume: 40, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antiemetics; Antineoplastic Agents; Female; Ha

2010
Is low-dose haloperidol a useful antiemetic?: A meta-analysis of published and unpublished randomized trials.
    Anesthesiology, 2004, Volume: 101, Issue:6

    Topics: Antiemetics; Antineoplastic Agents; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Hal

2004
Impairment of recall improves tolerance of cytotoxic chemotherapy.
    Lancet (London, England), 1983, Sep-17, Volume: 2, Issue:8351

    Topics: Anti-Anxiety Agents; Antineoplastic Agents; Clinical Trials as Topic; Double-Blind Method; Drug Tole

1983
Comparison of the antiemetic effect of high-dose intravenous metoclopramide and high-dose intravenous haloperidol in a randomized double-blind crossover study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:7

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Double-Blind Method; Drug Evaluati

1984
Specific antiemetics for specific cancer chemotherapeutic agents: haloperidol versus benzquinamide.
    Cancer, 1981, Mar-15, Volume: 47, Issue:6

    Topics: Adult; Antineoplastic Agents; Cisplatin; Clinical Trials as Topic; Double-Blind Method; Doxorubicin;

1981
A 28-week comparison of ziprasidone and haloperidol in outpatients with stable schizophrenia.
    The Journal of clinical psychiatry, 2002, Volume: 63, Issue:6

    Topics: Adolescent; Adult; Antipsychotic Agents; Female; Haloperidol; Humans; Male; Middle Aged; Nausea; Pip

2002
Haloperidol parenterally for treatment of vomiting and nausea from gastrointestinal disorders in a group of geriatric patients: double-blind, placebo-controlled study.
    Journal of the American Geriatrics Society, 1975, Volume: 23, Issue:1

    Topics: Age Factors; Aged; Antiemetics; Clinical Trials as Topic; Drug Evaluation; Female; Gastrointestinal

1975
The use of haloperidol for treatment of postoperative nausea and vomiting--a double-blind placebo-controlled trial.
    Anesthesiology, 1975, Volume: 42, Issue:4

    Topics: Abdomen; Adolescent; Adult; Aged; Anesthesia, Inhalation; Anesthetics; Clinical Trials as Topic; Col

1975
Tropisetron plus haloperidol to ameliorate nausea and vomiting associated with high-dose alkylating agent cancer chemotherapy.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:5

    Topics: Adult; Antiemetics; Antineoplastic Agents; Drug Therapy, Combination; Haloperidol; Humans; Indoles;

1991
A randomized comparison of haloperidol plus dexamethasone versus prochlorperazine plus dexamethasone in preventing nausea and vomiting in patients receiving chemotherapy for breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1988, Volume: 6, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Cyclopho

1988
[Benefit and risk of high-dose metoclopramide in comparison to high-dose haloperidol or triflupromazine in cisplatin-induced vomiting].
    Klinische Wochenschrift, 1985, May-02, Volume: 63, Issue:9

    Topics: Cisplatin; Dose-Response Relationship, Drug; Haloperidol; Humans; Metoclopramide; Neoplasms; Risk; T

1985
Low-dose haloperidol as antiemetic treatment in gastrointestinal disorders: a double-blind study.
    Current therapeutic research, clinical and experimental, 1974, Volume: 16, Issue:11

    Topics: Antiemetics; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Gastrointestinal Di

1974
A double-blind cross-over clinical valuation of metoclopramide and a combination of haloperidol and isopropamide iodide in gastroenterology.
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:10

    Topics: Adolescent; Adult; Antiemetics; Clinical Trials as Topic; Colonic Diseases; Constipation; Crohn Dise

1969
Haloperidol for radiation sickness: Control of associated nausea, vomiting, and anorexia.
    New York state journal of medicine, 1974, Volume: 74, Issue:9

    Topics: Adult; Aged; Clinical Trials as Topic; Feeding and Eating Disorders; Female; Haloperidol; Humans; Ma

1974

Other Studies

59 other studies available for haloperidol and Emesis

ArticleYear
Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 4. Central nervous system depressants.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:11

    Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Central Nervous System

1978
Acute Treatment of Adolescent Cannabinoid Hyperemesis Syndrome With Haloperidol, Lorazepam, and/or Capsaicin: A Single Institution Case Series.
    Journal of psychiatric practice, 2023, 09-01, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Cannabinoids; Capsaicin; Child; Haloperidol; Humans; Lorazepam; Nausea; Syndrome;

2023
Haloperidol as an anti-emetic for Cannabis Hyperemesis Syndrome in the ED.
    CJEM, 2021, Volume: 23, Issue:3

    Topics: Antiemetics; Cannabis; Haloperidol; Humans; Nausea; Vomiting

2021
    Annals of emergency medicine, 2021, Volume: 77, Issue:5

    Topics: Cannabis; Haloperidol; Humans; Ondansetron; Syndrome; Vomiting

2021
Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial.
    Annals of emergency medicine, 2021, Volume: 77, Issue:5

    Topics: Antiemetics; Cannabis; Female; Haloperidol; Humans; Hyperemesis Gravidarum; Ondansetron; Pregnancy;

2021
Haloperidol Use in the Emergency Department for Gastrointestinal Symptoms: Nausea, Vomiting, and Abdominal Pain.
    Clinical and translational gastroenterology, 2021, 06-01, Volume: 12, Issue:6

    Topics: Abdominal Pain; Adult; Antiemetics; Diabetes Mellitus; Emergency Service, Hospital; Female; Florida;

2021
Cannabinoid Hyperemesis Syndrome Secondary to Delta-8 THC Use.
    The American journal of medicine, 2021, Volume: 134, Issue:12

    Topics: Administration, Cutaneous; Adult; Antiemetics; Cannabinoid Receptor Agonists; Capsaicin; Dopamine An

2021
Haloperidol undermining gastroparesis symptoms (HUGS) in the emergency department.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:8

    Topics: Abdominal Pain; Adult; Antiemetics; California; Diabetes Mellitus, Type 1; Emergency Service, Hospit

2017
BET 1: Haloperidol in cannabinoid hyperemesis syndrome.
    Emergency medicine journal : EMJ, 2018, Volume: 35, Issue:11

    Topics: Adult; Antiemetics; Cannabinoids; Haloperidol; Humans; Male; Vomiting

2018
[Spontaneuos pneumomediastinum secondary to cannabinoid hyperemesis syndrome].
    Anales del sistema sanitario de Navarra, 2019, Aug-23, Volume: 42, Issue:2

    Topics: Antiemetics; Cannabinoids; Capsaicin; Haloperidol; Humans; Male; Marijuana Abuse; Mediastinal Emphys

2019
Haloperidol for treatment of cannabinoid hyperemesis syndrome.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:6

    Topics: Abdominal Pain; Adult; Antiemetics; Cannabinoids; Haloperidol; Humans; Male; Marijuana Abuse; Nausea

2013
Is haloperidol the wonder drug for cannabinoid hyperemesis syndrome?
    BMJ case reports, 2017, Jan-04, Volume: 2017

    Topics: Adult; Antiemetics; Cannabinoids; Haloperidol; Humans; Male; Marijuana Abuse; Nausea; Syndrome; Trea

2017
Hemiballismus in subthalamic haemorrhage: efficacy of levetiracetam.
    European journal of neurology, 2009, Volume: 16, Issue:6

    Topics: Aged; Anti-Dyskinesia Agents; Anticonvulsants; Antihypertensive Agents; Ataxia; Cerebellum; Dose-Res

2009
[R 1625 in the treatment of postoperative vomiting].
    Minerva anestesiologica, 1961, Volume: 27

    Topics: Anesthesia; Haloperidol; Humans; Hypnotics and Sedatives; Postoperative Nausea and Vomiting; Vomitin

1961
[R-1625 in the prevention and therapy of vomiting in surgery].
    Rassegna internazionale di clinica e terapia, 1961, May-31, Volume: 41

    Topics: Antiemetics; Biomedical Research; Haloperidol; Surgical Procedures, Operative; Vomiting

1961
[1st observations on the preventive action of haloperidol in vomiting in gaseous encephalography].
    Giornale di psichiatria e di neuropatologia, 1961, Volume: 89

    Topics: Anesthesia; Haloperidol; Hypnotics and Sedatives; Pneumoencephalography; Vectorcardiography; Vomitin

1961
Haloperidol (Serenase) in the prevention of postoperative nausea and vomiting.
    Acta anaesthesiologica Scandinavica, 1962, Volume: 6

    Topics: Anesthesia; Haloperidol; Humans; Hypnotics and Sedatives; Nausea; Postoperative Nausea and Vomiting;

1962
EFFECT OF ANTIEMETICS AND OTHER COMPOUNDS ON PROTOVERATRINE INDUCED EMESIS IN DOGS.
    Journal of pharmaceutical sciences, 1964, Volume: 53

    Topics: Antiemetics; Atropine; Benzamides; Dogs; Haloperidol; Meclizine; Niacin; Perphenazine; Pharmacology;

1964
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 6-2005. A 58-year-old man with esophageal cancer and nausea, vomiting, and intractable hiccups.
    The New England journal of medicine, 2005, Feb-24, Volume: 352, Issue:8

    Topics: Adenocarcinoma; Anti-Inflammatory Agents; Antiemetics; Antineoplastic Agents, Hormonal; Barrett Esop

2005
Tolerability of the compound ABHR in hospice patients.
    Journal of palliative medicine, 2005, Volume: 8, Issue:6

    Topics: Aged; Antiemetics; Cohort Studies; Diphenhydramine; Drug Combinations; Female; Haloperidol; Hospice

2005
Prolonged extra-pyramidal side effects after discontinuation of haloperidol as an antiemetic.
    Palliative medicine, 2006, Volume: 20, Issue:3

    Topics: Aged; Antiemetics; Dopamine Antagonists; Female; Haloperidol; Humans; Nausea; Parkinsonian Disorders

2006
Lorazepam, diphenhydramine, and haloperidol transdermal gel for rescue from chemotherapy-induced nausea/vomiting: results of two pilot trials.
    The journal of supportive oncology, 2008, Volume: 6, Issue:1

    Topics: Administration, Cutaneous; Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Clini

2008
Neuroleptic properties of cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide (YM-09151-2) with selective antidopaminergic activity.
    Psychopharmacology, 1981, Volume: 73, Issue:2

    Topics: Animals; Antipsychotic Agents; Apomorphine; Benzamides; Chlorpropamide; Dogs; Drug Evaluation, Precl

1981
A case report of vomiting related to the interactions of antipsychotics and benztropine.
    The American journal of psychiatry, 1981, Volume: 138, Issue:6

    Topics: Adolescent; Antipsychotic Agents; Benztropine; Drug Interactions; Fluphenazine; Haloperidol; Humans;

1981
Lorazepam as an adjunct to antiemetic therapy with haloperidol in patients receiving cytotoxic chemotherapy.
    Australian and New Zealand journal of medicine, 1983, Volume: 13, Issue:1

    Topics: Anti-Anxiety Agents; Antiemetics; Antineoplastic Agents; Drug Therapy, Combination; Female; Haloperi

1983
Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain.
    European journal of pharmacology, 1984, Jul-20, Volume: 102, Issue:3-4

    Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzamides; Binding

1984
[Emesis due to cytostatic drugs. Update and review of our experiences].
    Medicina, 1983, Volume: 43, Issue:6 Pt 1

    Topics: Antineoplastic Agents; Dexamethasone; Haloperidol; Humans; Metoclopramide; Prochlorperazine; Vomitin

1983
Effect of apomorphine on peripheral venous gastrin and insulin levels in conscious dogs.
    Acta physiologica Scandinavica, 1981, Volume: 112, Issue:2

    Topics: Animals; Apomorphine; Dogs; Dose-Response Relationship, Drug; Female; Gastrins; Haloperidol; Insulin

1981
Increased levels of VIP (vasoactive intestinal polypeptide)-like immunoreactivity in peripheral venous blood of dogs following injections of apomorphine and bromocriptine. Do dopaminergic agents induce gastric relaxation and hypotension by a release of en
    Acta physiologica Scandinavica, 1982, Volume: 115, Issue:3

    Topics: Animals; Apomorphine; Bromocriptine; Dogs; Gastrointestinal Hormones; Gastrointestinal Motility; Hal

1982
Inhibition of radioemesis by disruption of catecholamines in dogs.
    Radiation research, 1981, Volume: 85, Issue:3

    Topics: Animals; Catecholamines; Dogs; Haloperidol; Hydroxydopamines; Male; Methyltyrosines; Neurons; Probab

1981
Failure of naloxone to prevent the emetic activity of apomorphine in dogs.
    Journal of veterinary pharmacology and therapeutics, 1981, Volume: 4, Issue:4

    Topics: Animals; Apomorphine; Dogs; Droperidol; Female; Fentanyl; Haloperidol; Injections, Intravenous; Male

1981
Pharmacologic control of vomiting.
    Journal of the American Veterinary Medical Association, 1980, Feb-01, Volume: 176, Issue:3

    Topics: Animals; Antiemetics; Benzamides; Cats; Dogs; Haloperidol; Motion Sickness; Phenothiazines; Swine; V

1980
Successful control of intractable nausea and vomiting requiring combined ondansetron and haloperidol in a patient with advanced cancer.
    Journal of pain and symptom management, 1994, Volume: 9, Issue:1

    Topics: Analgesics; Bone Neoplasms; Breast Neoplasms; Drug Therapy, Combination; Female; Haloperidol; Humans

1994
Sigma receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers.
    European journal of pharmacology, 1993, May-19, Volume: 236, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Antiemetics; Binding Sites; Columbidae; Drug Interactions; Emetics; Gu

1993
The antiemetic efficacy of granisetron plus dexamethasone, haloperidol and loracepam in breast cancer patients treated with high-dose chemotherapy with peripheral blood stem-cell support.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1998, Volume: 6, Issue:3

    Topics: Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dexamethasone;

1998
Behavioral endpoints for radiation injury.
    Advances in space research : the official journal of the Committee on Space Research (COSPAR), 1994, Volume: 14, Issue:10

    Topics: Amphetamine; Animals; Argon; Avoidance Learning; Behavior, Animal; Central Nervous System Stimulants

1994
Effects of exposure to different types of radiation on behaviors mediated by peripheral or central systems.
    Advances in space research : the official journal of the Committee on Space Research (COSPAR), 1998, Volume: 22, Issue:2

    Topics: Amphetamine; Animals; Avoidance Learning; Behavior, Animal; Cobalt Radioisotopes; Dopamine Agents; D

1998
Behavioural and vegetative effects of dibutyryl cyclic AMP on conscious dogs.
    Neuropharmacology, 1976, Volume: 15, Issue:9

    Topics: Animals; Atropine; Behavior, Animal; Bucladesine; Butyrates; Cyclic AMP; Diarrhea; Dogs; Dose-Respon

1976
A comparison of narcotic analgesics with neuroleptics on behavioral measures of dopaminergic activity.
    Life sciences, 1975, Jul-01, Volume: 17, Issue:1

    Topics: Aggression; Amphetamine; Analgesics, Opioid; Animals; Apomorphine; Behavior, Animal; Brain; Cataleps

1975
Antagonism of cisplatin induced emesis in the dog.
    Research communications in chemical pathology and pharmacology, 1979, Volume: 23, Issue:1

    Topics: Animals; Antiemetics; Chlorpromazine; Cisplatin; Dogs; Dronabinol; Female; Haloperidol; Indoles; Mal

1979
Comparison of droperidol, haloperidol and prochlorperazine as postoperative anti-emetics.
    Canadian Anaesthetists' Society journal, 1979, Volume: 26, Issue:2

    Topics: Droperidol; Haloperidol; Humans; Postoperative Complications; Prochlorperazine; Sodium Chloride; Vom

1979
Gastric relaxation by morphine, apomorphine and fentanyl in the conscious dog.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 242, Issue:2

    Topics: Animals; Apomorphine; Benzimidazoles; Dogs; Domperidone; Fentanyl; Haloperidol; Morphine; Muscle Con

1979
Protracted vomiting following abrupt cessation of psychotropics: a case report.
    Canadian Psychiatric Association journal, 1978, Volume: 23, Issue:3

    Topics: Adult; Benztropine; Depression; Drug Therapy, Combination; Haloperidol; Humans; Imipramine; Male; Sc

1978
Therapeutical efficacy of a combination of apomorphine with sulpiride or metoclopramide in Parkinsonism.
    Psychopharmacologia, 1976, May-28, Volume: 47, Issue:2

    Topics: Adult; Apomorphine; Drug Therapy, Combination; Haloperidol; Humans; Male; Metoclopramide; Parkinson

1976
Sigma ligand-induced emesis in the pigeon.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:1

    Topics: Animals; Apomorphine; Columbidae; Dextromethorphan; Dizocilpine Maleate; Dopamine Agents; Guanidines

1992
Naloxone or haloperidol but not yohimbine reverse apomorphine-induced respiratory depression.
    Clinical neuropharmacology, 1992, Volume: 15, Issue:5

    Topics: Animals; Apomorphine; Dogs; Drug Interactions; Female; Haloperidol; Injections, Intravenous; Male; N

1992
The management of inoperable gastrointestinal obstruction in terminal cancer patients.
    Tumori, 1990, Aug-31, Volume: 76, Issue:4

    Topics: Abdominal Neoplasms; Adult; Aged; Aged, 80 and over; Butylscopolammonium Bromide; Drug Administratio

1990
[Comparison of central stimulating effects between ephedrine and apomorphine].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991, Volume: 12, Issue:5

    Topics: Animals; Apomorphine; Blepharoptosis; Catalepsy; Ephedrine; Haloperidol; Male; Mice; Motor Activity;

1991
Compounding nausea aid.
    American pharmacy, 1991, Volume: NS31, Issue:7

    Topics: Benztropine; Chemistry, Pharmaceutical; Dexamethasone; Diphenhydramine; Drug Combinations; Drug Comp

1991
The neuroleptic malignant syndrome.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 1990, Volume: 2, Issue:4

    Topics: Adult; Female; Haloperidol; Humans; Metoclopramide; Neuroleptic Malignant Syndrome; Postoperative Co

1990
Functional localization of specific receptors mediating gastrointestinal motor correlates of vomiting.
    The American journal of physiology, 1989, Volume: 256, Issue:1 Pt 1

    Topics: Animals; Apomorphine; Atropine; Copper; Copper Sulfate; Digestive System; Dogs; Domperidone; Female;

1989
Haloperidol and lorazepam for the treatment of nausea and vomiting associated with the treatment of intractable migraine headaches.
    Archives of neurology, 1989, Volume: 46, Issue:7

    Topics: Adult; Dihydroergotamine; Female; Haloperidol; Humans; Lorazepam; Migraine Disorders; Nausea; Vomiti

1989
[Management of vomiting induced by polychemotherapy in Hodgkin's disease].
    Orvosi hetilap, 1989, Jun-25, Volume: 130, Issue:26

    Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Halop

1989
Persistent supersensitivity vomiting following neuroleptic withdrawal in an adolescent.
    Biological psychiatry, 1986, Volume: 21, Issue:4

    Topics: Adolescent; Haloperidol; Humans; Male; Substance Withdrawal Syndrome; Vomiting

1986
Haloperidol in the treatment of nausea and vomiting due to cytotoxic drug administration.
    Current therapeutic research, clinical and experimental, 1973, Volume: 15, Issue:9

    Topics: Administration, Oral; Aged; Antineoplastic Agents; Female; Haloperidol; Humans; Male; Middle Aged; N

1973
Antagonism of apomorphine-induced sterotypy and emesis in dogs by thioridazine, haloperidol, and pimozide.
    Psychopharmacologia, 1972, Volume: 26, Issue:2

    Topics: Animals; Apomorphine; Behavior, Animal; Blood-Brain Barrier; Chemoreceptor Cells; Corpus Striatum; D

1972
The effect of haloperidol with promethazine on postoperative vomiting.
    Archivum chirurgicum Neerlandicum, 1970, Volume: 22, Issue:4

    Topics: Anesthesia, General; Atropine; Haloperidol; Humans; Nausea; Promethazine; Vomiting

1970
A comparative study of the inhibitory effects of haloperidol and trifluperidol on learned shock-avoidance behavioural habits and on apomorphine-induced emesis in mongrel dogs and in beagles.
    Psychopharmacologia, 1965, Nov-16, Volume: 8, Issue:4

    Topics: Animals; Antidepressive Agents; Apomorphine; Avoidance Learning; Behavior, Animal; Dogs; Haloperidol

1965
Dental erosion patterns from intrinsic acid regurgitation and vomiting.
    Australian dental journal, 2002, Volume: 47, Issue:2

    Topics: Adult; Aged; Bicuspid; Bulimia; Case-Control Studies; Chi-Square Distribution; Chronic Disease; Cusp

2002