haloperidol has been researched along with Emesis, Postoperative in 29 studies
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine whether prophylactic use of haloperidol in addition to dexamethasone decreased the incidence of postoperative nausea and vomiting in high-risk patients undergoing ambulatory surgery." | 9.14 | Effectiveness of combined haloperidol and dexamethasone versus dexamethasone only for postoperative nausea and vomiting in high-risk day surgery patients: a randomized blinded trial. ( Chaparro, LE; Gallo, T; Gonzalez, NJ; Peng, PW; Rivera, MF, 2010) |
| "Haloperidol, a major tranquilizer, has been found to have a potent antiemetic effect on postoperative nausea and vomiting (PONV), but the prophylactic effect of haloperidol plus dexamethasone on PONV has not been evaluated." | 9.13 | The prophylactic effect of haloperidol plus dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopically assisted vaginal hysterectomy. ( Chen, JY; Chu, CC; Ho, ST; Lee, Y; Shieh, JP; Tzeng, JI; Wang, JJ, 2008) |
| "Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT(3) antagonists." | 9.13 | Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. ( Bittner, EA; Grecu, L; Haspel, KL; Rosow, CE; Smith, SE, 2008) |
| "Haloperidol 1 mg and ondansetron 4 mg are equally safe and effective for postoperative nausea and vomiting prophylaxis." | 9.13 | Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting. ( Bittner, EA; Grecu, L; Kher, J; Rosow, CE; Smith, SE, 2008) |
| "Ondansetron is widely used for the prophylaxis of postoperative nausea and vomiting, while haloperidol is an antiemetic that lacks recent data on efficacy and adverse effects." | 9.12 | Haloperidol vs. ondansetron for the prevention of postoperative nausea and vomiting following gynaecological surgery. ( Aouad, MT; Azar, MS; Baraka, AS; Hakki, MA; Nasr, VG; Siddik-Sayyid, SM; Taha, SK; Zoorob, DG, 2007) |
| " The aim of this study was to compare the prophylactic antiemetic efficacy of haloperidol vs ondansetron for the prevention of postoperative nausea and vomiting (PONV) after general anesthesia." | 9.12 | Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. ( Chu, CC; Lai, HY; Lee, Y; Wang, JJ; Wang, PK; Yang, YL, 2007) |
| "In this randomized, double-blinded, placebo-controlled trial, a single, small IM dose of haloperidol 1 mg or 2 mg reduced the incidence of postoperative nausea and vomiting after spinal anesthesia with local anesthetic and intrathecal morphine." | 9.11 | Single-dose haloperidol for the prophylaxis of postoperative nausea and vomiting after intrathecal morphine. ( Avery, N; Costache, I; Parlow, JL; Turner, K, 2004) |
| "Many patients may experience postoperative nausea and vomiting (PONV) following laparoscopic sleeve gastrectomy (LSG)." | 6.78 | The combination of haloperidol, dexamethasone, and ondansetron for prevention of postoperative nausea and vomiting in laparoscopic sleeve gastrectomy: a randomized double-blind trial. ( Benevides, ML; de Aguilar-Nascimento, JE; Oliveira, SS, 2013) |
| "Low-dose haloperidol is known to be effective for the prevention of postoperative nausea and vomiting (PONV)." | 5.20 | Haloperidol dose combined with dexamethasone for PONV prophylaxis in high-risk patients undergoing gynecological laparoscopic surgery: a prospective, randomized, double-blind, dose-response and placebo-controlled study. ( Baek, J; Joo, J; Moon, YE; Park, YG, 2015) |
| "To examine whether prophylactic use of haloperidol in addition to dexamethasone decreased the incidence of postoperative nausea and vomiting in high-risk patients undergoing ambulatory surgery." | 5.14 | Effectiveness of combined haloperidol and dexamethasone versus dexamethasone only for postoperative nausea and vomiting in high-risk day surgery patients: a randomized blinded trial. ( Chaparro, LE; Gallo, T; Gonzalez, NJ; Peng, PW; Rivera, MF, 2010) |
| "Haloperidol, a major tranquilizer, has been found to have a potent antiemetic effect on postoperative nausea and vomiting (PONV), but the prophylactic effect of haloperidol plus dexamethasone on PONV has not been evaluated." | 5.13 | The prophylactic effect of haloperidol plus dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopically assisted vaginal hysterectomy. ( Chen, JY; Chu, CC; Ho, ST; Lee, Y; Shieh, JP; Tzeng, JI; Wang, JJ, 2008) |
| "Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT(3) antagonists." | 5.13 | Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. ( Bittner, EA; Grecu, L; Haspel, KL; Rosow, CE; Smith, SE, 2008) |
| "Haloperidol 1 mg and ondansetron 4 mg are equally safe and effective for postoperative nausea and vomiting prophylaxis." | 5.13 | Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting. ( Bittner, EA; Grecu, L; Kher, J; Rosow, CE; Smith, SE, 2008) |
| "Ondansetron is widely used for the prophylaxis of postoperative nausea and vomiting, while haloperidol is an antiemetic that lacks recent data on efficacy and adverse effects." | 5.12 | Haloperidol vs. ondansetron for the prevention of postoperative nausea and vomiting following gynaecological surgery. ( Aouad, MT; Azar, MS; Baraka, AS; Hakki, MA; Nasr, VG; Siddik-Sayyid, SM; Taha, SK; Zoorob, DG, 2007) |
| " The aim of this study was to compare the prophylactic antiemetic efficacy of haloperidol vs ondansetron for the prevention of postoperative nausea and vomiting (PONV) after general anesthesia." | 5.12 | Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. ( Chu, CC; Lai, HY; Lee, Y; Wang, JJ; Wang, PK; Yang, YL, 2007) |
| "In this randomized, double-blinded, placebo-controlled trial, a single, small IM dose of haloperidol 1 mg or 2 mg reduced the incidence of postoperative nausea and vomiting after spinal anesthesia with local anesthetic and intrathecal morphine." | 5.11 | Single-dose haloperidol for the prophylaxis of postoperative nausea and vomiting after intrathecal morphine. ( Avery, N; Costache, I; Parlow, JL; Turner, K, 2004) |
| " In postoperative nausea and vomiting (PONV), two randomized controlled trials found treatment with haloperidol comparable to ondansetron." | 4.89 | Using haloperidol as an antiemetic in palliative care: informing practice through evidence from cancer treatment and postoperative contexts. ( Bennett, MI; Blenkinsopp, A; McLean, SL, 2013) |
| "Droperidol has been an efficacious, inexpensive butyrophenone used since the early 1970s to prevent or treat postoperative nausea and vomiting." | 4.82 | Haloperidol: an alternative butyrophenone for nausea and vomiting prophylaxis in anesthesia. ( Smith, JC; Wright, EL, 2005) |
| "Settings were postoperative nausea or vomiting (1,994 patients), gastroenterology (261), chemotherapy (189), and radiation therapy (24)." | 3.81 | Is low-dose haloperidol a useful antiemetic?: A meta-analysis of published and unpublished randomized trials. ( Büttner, M; Tramèr, MR; von Elm, E; Walder, B, 2004) |
| "Haloperidol is an antipsychotic." | 2.84 | Haloperidol Versus Ondansetron for Treatment of Established Nausea and Vomiting Following General Anesthesia: A Randomized Clinical Trial. ( Aouad, MT; Barakat, HB; Korjian, S; Siddik-Sayyid, SM; Yazbeck-Karam, VG, 2017) |
| "Many patients may experience postoperative nausea and vomiting (PONV) following laparoscopic sleeve gastrectomy (LSG)." | 2.78 | The combination of haloperidol, dexamethasone, and ondansetron for prevention of postoperative nausea and vomiting in laparoscopic sleeve gastrectomy: a randomized double-blind trial. ( Benevides, ML; de Aguilar-Nascimento, JE; Oliveira, SS, 2013) |
| "To evaluate strategies to treat postoperative nausea and vomiting (PONV) in patients undergoing elective breast surgery." | 2.76 | Prophylaxis of postoperative nausea and vomiting in elective breast surgery. ( Fröhlich, CW; Göbel, U; Kerger, H; Lenz, C; Voigt, M; Waschke, KF, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.90) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (58.62) | 29.6817 |
| 2010's | 9 (31.03) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, CM | 1 |
| Wang, Y | 1 |
| Xue, Q | 1 |
| Yang, JJ | 1 |
| Zhu, Y | 1 |
| Benevides, ML | 1 |
| Oliveira, SS | 1 |
| de Aguilar-Nascimento, JE | 1 |
| McLean, SL | 1 |
| Blenkinsopp, A | 1 |
| Bennett, MI | 1 |
| Veiga-Gil, L | 1 |
| López-Olaondo, L | 1 |
| Pueyo, J | 1 |
| Callejas, R | 1 |
| Duque, P | 1 |
| Carrascosa, F | 1 |
| Joo, J | 1 |
| Park, YG | 1 |
| Baek, J | 1 |
| Moon, YE | 1 |
| Brettner, F | 1 |
| Janitza, S | 1 |
| Prüll, K | 1 |
| Weninger, E | 1 |
| Mansmann, U | 1 |
| Küchenhoff, H | 1 |
| Jovanovic, A | 1 |
| Pollwein, B | 1 |
| Chappell, D | 1 |
| Zwissler, B | 1 |
| von Dossow, V | 1 |
| Yazbeck-Karam, VG | 1 |
| Siddik-Sayyid, SM | 2 |
| Barakat, HB | 1 |
| Korjian, S | 1 |
| Aouad, MT | 2 |
| Dagtekin, O | 1 |
| Wiese, P | 1 |
| Wolter, K | 1 |
| Hermann, MM | 1 |
| Pietruck, C | 1 |
| Kampe, S | 1 |
| Tsai, YC | 1 |
| Feng, PH | 1 |
| Chu, KS | 1 |
| Lu, IC | 1 |
| Shieh, JP | 3 |
| Tzeng, JI | 3 |
| Ho, ST | 2 |
| Wang, JJ | 5 |
| Chu, CC | 5 |
| Kolodzie, K | 1 |
| Apfel, CC | 1 |
| Chaparro, LE | 1 |
| Gallo, T | 1 |
| Gonzalez, NJ | 1 |
| Rivera, MF | 1 |
| Peng, PW | 1 |
| Voigt, M | 1 |
| Fröhlich, CW | 1 |
| Waschke, KF | 1 |
| Lenz, C | 1 |
| Göbel, U | 1 |
| Kerger, H | 1 |
| Wang, PK | 3 |
| Tsay, PJ | 1 |
| Huang, CC | 1 |
| Lai, HY | 3 |
| Lin, PC | 1 |
| Huang, SJ | 1 |
| Lee, Y | 4 |
| Eberhart, LH | 1 |
| Mauch, M | 1 |
| Morin, AM | 1 |
| Wulf, H | 1 |
| Geldner, G | 1 |
| APPIANI, L | 1 |
| DYRBERG, V | 1 |
| Parlow, JL | 1 |
| Costache, I | 1 |
| Avery, N | 1 |
| Turner, K | 1 |
| Büttner, M | 1 |
| Walder, B | 1 |
| von Elm, E | 1 |
| Tramèr, MR | 1 |
| Smith, JC | 1 |
| Wright, EL | 1 |
| Taha, SK | 1 |
| Azar, MS | 1 |
| Nasr, VG | 1 |
| Hakki, MA | 1 |
| Zoorob, DG | 1 |
| Baraka, AS | 1 |
| Yang, YL | 2 |
| Rüsch, D | 1 |
| Arndt, C | 1 |
| Martin, H | 1 |
| Kranke, P | 1 |
| Wang, TF | 1 |
| Liu, YH | 1 |
| Habib, AS | 1 |
| Gan, TJ | 1 |
| Chen, JY | 1 |
| Rosow, CE | 2 |
| Haspel, KL | 1 |
| Smith, SE | 2 |
| Grecu, L | 2 |
| Bittner, EA | 2 |
| Kher, J | 1 |
| Chen, TY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 4 Study of Optimal Dose of Haloperidol[NCT01639599] | 150 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| A Randomized Controlled Trial: Role of EFTs (Emotional Freedom Techniques) in Reducing Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy.[NCT02169856] | 50 participants (Actual) | Interventional | 2013-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
cardiac arrhythmia on continuous standard lead EKG monitoring (NCT01639599)
Timeframe: postoperative 2 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Dexamethasone | 0 |
| Dexamethasone, Haloperiol 1mg | 0 |
| Dexamethasone + Haloperidol 2mg | 0 |
(NCT01639599)
Timeframe: postoperative 24 hours
| Intervention | participants (Number) |
|---|---|
| Dexamethasone | 0 |
| Dexamethasone, Haloperiol 1mg | 0 |
| Dexamethasone + Haloperidol 2mg | 0 |
incidence of nausea, vomiting and requirement for rescue antiemetics (NCT01639599)
Timeframe: postoperative 24 hours
| Intervention | participants (Number) |
|---|---|
| Dexamethasone | 21 |
| Dexamethasone, Haloperiol 1mg | 11 |
| Dexamethasone + Haloperidol 2mg | 10 |
measurement of sedation change using a visual analogue scale (visual analogue scale; the minimum: 0 = widely awake and the maximum: 10 = maximally asleep) (NCT01639599)
Timeframe: postoperative 30, 60, 90, and 120 min
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| postoperative 30 min | postoperative 60 min | postoperative 90 min | postoperative 120 min | |
| Dexamethasone | 4.6 | 4.4 | 3.5 | 3.0 |
| Dexamethasone + Haloperidol 2mg | 5.5 | 5.0 | 4.7 | 4.3 |
| Dexamethasone, Haloperiol 1mg | 4.7 | 4.4 | 4.0 | 3.2 |
4 reviews available for haloperidol and Emesis, Postoperative
| Article | Year |
|---|---|
Using haloperidol as an antiemetic in palliative care: informing practice through evidence from cancer treatment and postoperative contexts.
Topics: Antiemetics; Antineoplastic Agents; Haloperidol; Humans; Nausea; Ondansetron; Palliative Care; Posto | 2013 |
Nausea and vomiting after office-based anesthesia.
Topics: Anesthesia; Antiemetics; Droperidol; Haloperidol; Humans; Incidence; Metoclopramide; Neurokinin-1 Re | 2009 |
Is low-dose haloperidol a useful antiemetic?: A meta-analysis of published and unpublished randomized trials.
Topics: Antiemetics; Antineoplastic Agents; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Hal | 2004 |
Haloperidol: an alternative butyrophenone for nausea and vomiting prophylaxis in anesthesia.
Topics: Antiemetics; Butyrophenones; Death, Sudden, Cardiac; Droperidol; Haloperidol; Humans; Postoperative | 2005 |
19 trials available for haloperidol and Emesis, Postoperative
| Article | Year |
|---|---|
The combination of haloperidol, dexamethasone, and ondansetron for prevention of postoperative nausea and vomiting in laparoscopic sleeve gastrectomy: a randomized double-blind trial.
Topics: Adult; Analgesics, Opioid; Antiemetics; Brazil; Dexamethasone; Double-Blind Method; Drug Therapy, Co | 2013 |
Haloperidol dose combined with dexamethasone for PONV prophylaxis in high-risk patients undergoing gynecological laparoscopic surgery: a prospective, randomized, double-blind, dose-response and placebo-controlled study.
Topics: Adult; Antiemetics; Dexamethasone; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up | 2015 |
Haloperidol Versus Ondansetron for Treatment of Established Nausea and Vomiting Following General Anesthesia: A Randomized Clinical Trial.
Topics: Administration, Intravenous; Adult; Aged; Anesthesia, General; Antiemetics; Double-Blind Method; Ele | 2017 |
Haloperidol versus haloperidol plus ondansetron for the prophylaxis of postoperative nausea and vomiting after ophthalmologic surgery.
Topics: Double-Blind Method; Drug Therapy, Combination; Female; Haloperidol; Humans; Middle Aged; Ondansetro | 2009 |
Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.
Topics: Adult; Antiemetics; Cholecystectomy, Laparoscopic; Double-Blind Method; Drug Therapy, Combination; F | 2009 |
Effectiveness of combined haloperidol and dexamethasone versus dexamethasone only for postoperative nausea and vomiting in high-risk day surgery patients: a randomized blinded trial.
Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Anesthesia, General; Antiemetics; Dexamethasone; | 2010 |
Prophylaxis of postoperative nausea and vomiting in elective breast surgery.
Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrav | 2011 |
Comparison of dexamethasone with ondansetron or haloperidol for prevention of patient-controlled analgesia-related postoperative nausea and vomiting: a randomized clinical trial.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Antiemetics; Dexamethasone; Drug Therapy, | 2012 |
Impact of a multimodal anti-emetic prophylaxis on patient satisfaction in high-risk patients for postoperative nausea and vomiting.
Topics: Adult; Anesthetics, Intravenous; Antiemetics; Combined Modality Therapy; Dexamethasone; Drug Therapy | 2002 |
Single-dose haloperidol for the prophylaxis of postoperative nausea and vomiting after intrathecal morphine.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Antiemetics; Dose-Response Relationship, Drug; Double-B | 2004 |
Is low-dose haloperidol a useful antiemetic?: A meta-analysis of published and unpublished randomized trials.
Topics: Antiemetics; Antineoplastic Agents; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Hal | 2004 |
Haloperidol vs. ondansetron for the prevention of postoperative nausea and vomiting following gynaecological surgery.
Topics: Adult; Analysis of Variance; Anesthesia, General; Antiemetics; Double-Blind Method; Female; Gynecolo | 2007 |
Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Inhalation; Antiemetics; Double- | 2007 |
The addition of dexamethasone to dolasetron or haloperidol for treatment of established postoperative nausea and vomiting.
Topics: Adolescent; Adult; Aged; Antiemetics; Dexamethasone; Drug Therapy, Combination; Female; Haloperidol; | 2007 |
Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery.
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, In | 2008 |
The prophylactic effect of haloperidol plus dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopically assisted vaginal hysterectomy.
Topics: Adult; Antiemetics; Dexamethasone; Double-Blind Method; Droperidol; Drug Therapy, Combination; Femal | 2008 |
Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting.
Topics: Adult; Aged; Antiemetics; Elective Surgical Procedures; Female; Haloperidol; Heart Conduction System | 2008 |
Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting.
Topics: Adult; Aged; Antiemetics; Double-Blind Method; Drug Therapy, Combination; Elective Surgical Procedur | 2008 |
The timing of haloperidol administration does not affect its prophylactic antiemetic efficacy.
Topics: Adult; Aged; Anesthesia, General; Antiemetics; Double-Blind Method; Female; Haloperidol; Humans; Inj | 2008 |
7 other studies available for haloperidol and Emesis, Postoperative
| Article | Year |
|---|---|
Predicting early postoperative PONV using multiple machine-learning- and deep-learning-algorithms.
Topics: Algorithms; Artificial Intelligence; Deep Learning; Haloperidol; Humans; Machine Learning; Postopera | 2023 |
Low doses of haloperidol combined with ondansetron are not effective for prophylaxis of postoperative nausea and vomiting in susceptible patients.
Topics: Adolescent; Adult; Aged; Antiemetics; Cohort Studies; Drug Therapy, Combination; Female; Haloperidol | 2015 |
Gender-Specific Differences in Low-Dose Haloperidol Response for Prevention of Postoperative Nausea and Vomiting: A Register-Based Cohort Study.
Topics: Aged; Analgesics, Opioid; Anesthesia, General; Antiemetics; Cohort Studies; Female; Haloperidol; Hum | 2016 |
Haloperidol, droperidol, or neither for PONV prophylaxis.
Topics: Antiemetics; Droperidol; Haloperidol; Humans; Postoperative Nausea and Vomiting; Treatment Outcome | 2009 |
[R 1625 in the treatment of postoperative vomiting].
Topics: Anesthesia; Haloperidol; Humans; Hypnotics and Sedatives; Postoperative Nausea and Vomiting; Vomitin | 1961 |
Haloperidol (Serenase) in the prevention of postoperative nausea and vomiting.
Topics: Anesthesia; Haloperidol; Humans; Hypnotics and Sedatives; Nausea; Postoperative Nausea and Vomiting; | 1962 |
Haloperidol for postoperative nausea and vomiting: are we reinventing the wheel?
Topics: Antiemetics; Cost-Benefit Analysis; Droperidol; Drug Approval; Drug Costs; Drug Labeling; Drug Thera | 2008 |