haloperidol has been researched along with Chemical and Drug Induced Liver Injury in 24 studies
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (41.67) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Kehinde, AJ | 1 |
| Halici, Z | 1 |
| Dursun, H | 1 |
| Keles, ON | 1 |
| Odaci, E | 1 |
| Suleyman, H | 1 |
| Aydin, N | 1 |
| Cadirci, E | 1 |
| Kalkan, Y | 1 |
| Unal, B | 1 |
| Manceaux, P | 1 |
| Constant, E | 1 |
| Zdanowicz, N | 1 |
| Jacques, D | 1 |
| Reynaert, C | 1 |
| HAEFNER, H | 1 |
| KUTSCHER, I | 1 |
| Schiele, B | 1 |
| Ablordeppey, SY | 1 |
| Borne, RF | 1 |
| Hummer, M | 1 |
| Kurz, M | 1 |
| Kurzthaler, I | 1 |
| Oberbauer, H | 1 |
| Miller, C | 1 |
| Fleischhacker, WW | 1 |
| Stockmeyer, M | 1 |
| Yagdiran, O | 1 |
| Haasen, C | 1 |
| Nika, E | 1 |
| Krausz, M | 1 |
| Naber, D | 1 |
| Coleman, JH | 1 |
| Evans, WE | 1 |
| Sow, A | 1 |
| Ba, A | 1 |
| Diop Mar, I | 1 |
| Fuller, CM | 1 |
| Yassinger, S | 1 |
| Donlon, P | 1 |
| Imperato, TJ | 1 |
| Ruebner, B | 1 |
| Van Bellinghen, M | 1 |
| Peuskens, J | 1 |
| Applemans, A | 1 |
| Serafetinides, EA | 1 |
| Collins, S | 1 |
| Clark, ML | 1 |
| McGill, DB | 1 |
| Motto, JD | 1 |
3 reviews available for haloperidol and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Management of marked liver enzyme increase during olanzapine treatment: a case report and review of the literature.
Topics: Age Factors; Antipsychotic Agents; Benzodiazepines; Chemical and Drug Induced Liver Injury; Clozapin | 2011 |
[COMPLICATIONS DURING CLINICAL THERAPY WITH PSYCHOPHARMACA].
Topics: Agranulocytosis; Autonomic Nervous System Diseases; Chemical and Drug Induced Liver Injury; Chlorpro | 1964 |
2 trials available for haloperidol and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Hepatotoxicity of clozapine.
Topics: Adult; Alanine Transaminase; Antipsychotic Agents; Aspartate Aminotransferases; Chemical and Drug In | 1997 |
Haloperidol, clopenthixol, and chlorpromazine in chronic schizophrenia. Chemically unrelated antipsychotics as therapeutic alternatives.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Analysis of Variance; Bilirubin; Blood Cell Count | 1972 |
19 other studies available for haloperidol and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Functional Oil from Black Seed Differentially Inhibits Aldose-reductase and Ectonucleotidase Activities by Up-regulating Cellular Energy in Haloperidol-induced Hepatic Toxicity in Rat Liver.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Aldehyde Reductase; Animals; Chemical and Drug I | 2017 |
Effect of chronic treatment of haloperidol on the rat liver: a stereological and histopathological study.
Topics: Animals; Antipsychotic Agents; Cell Count; Chemical and Drug Induced Liver Injury; Dose-Response Rel | 2009 |
[Therapeutic profile of haloperidol].
Topics: Agranulocytosis; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug | 1980 |
Detection of a neurotoxic quaternary pyridinium metabolite in the liver of haloperidol-treated rats.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High P | 1993 |
[Pancytopenia].
Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Diagnosis, Differential; Female; Haloperido | 2000 |
Switching to amisulpride due to hepatic complications.
Topics: Adult; Amisulpride; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Flupenthixol; Halo | 2002 |
Pharmacotherapy of the acute alcohol withdrawal syndrome.
Topics: Alcoholism; Anti-Anxiety Agents; Barbiturates; Chemical and Drug Induced Liver Injury; Chloral Hydra | 1975 |
[Rare and unusual drug intolerances, apropos of 6 cases].
Topics: Adolescent; Adult; Basal Ganglia Diseases; Chemical and Drug Induced Liver Injury; Child; Drug Hyper | 1977 |
Haloperidol-induced liver disease.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Haloperidol; Humans | 1977 |
Hepatotoxicity following treatment with bromperidol.
Topics: Adult; Bipolar Disorder; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; | 1989 |
Acute hepatic failure after occupational exposure to 2-nitropropane.
Topics: Alanine Transaminase; Alkanes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1985 |
Leads from the MMWR. Acute hepatic failure after occupational exposure to 2-nitropropane.
Topics: Alanine Transaminase; Alkanes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1985 |
An industrial outbreak of toxic hepatitis due to methylenedianiline.
Topics: Aniline Compounds; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; D | 1974 |