Page last updated: 2024-10-28

haloperidol and Chemical Dependence

haloperidol has been researched along with Chemical Dependence in 78 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Research Excerpts

ExcerptRelevanceReference
"Co-occurring substance use disorders, mostly involving alcohol, cannabis or cocaine, occur commonly in patients with schizophrenia and are associated with increased morbidity and mortality."6.71First episode schizophrenia-related psychosis and substance use disorders: acute response to olanzapine and haloperidol. ( Clark, WS; Glick, I; Green, AI; Hamer, RM; Lieberman, JA; Strakowski, SM; Tohen, MF, 2004)
"Co-occurring substance use disorders (SUD), including alcohol, are common in schizophrenia (SZ) and are associated with poor outcome."5.40Schizophrenia and co-occurring substance use disorder: reward, olfaction and clozapine. ( Gibson, LE; Green, AI; Mesholam-Gately, RI; Seidman, LJ, 2014)
"Cocaine cues significantly increased anxiety, ACTH, cortisol, and HVA."5.08Haloperidol antagonism of cue-elicited cocaine craving. ( Berger, SP; Carr, K; Crawford, CA; Delucchi, K; Hall, S; Mickalian, JD; Reid, MS, 1996)
"Eighteen patients (7 men, 11 women) from one of the centres taking part in a multicentre comparative study of remoxipride and haloperidol in the treatment of acute schizophrenia were investigated separately to study the effect of the two neuroleptic drugs on cognitive abilities."5.06Cognitive disturbances in neuroleptic therapy. ( Klieser, E; Strauss, WH, 1990)
" When the diagnosis of haloperidol-induced acute dystonia was made, 3 mg of intravenous biperiden was promptly administered with complete clinical resolution in 15 min."3.91Involuntary movements in an adolescent: what are the causes? ( Brito, N; Fernandes, A; Moura, L; Vaz, AS, 2019)
"Co-occurring substance use disorders, mostly involving alcohol, cannabis or cocaine, occur commonly in patients with schizophrenia and are associated with increased morbidity and mortality."2.71First episode schizophrenia-related psychosis and substance use disorders: acute response to olanzapine and haloperidol. ( Clark, WS; Glick, I; Green, AI; Hamer, RM; Lieberman, JA; Strakowski, SM; Tohen, MF, 2004)
"The technical term 'drug dependence' was officially adopted by WHO's Expert Committee on Addiction in 1964."2.38[Overview of the progress in drug dependence studies--mainly focussing on psychic dependence]. ( Yanagita, T, 1992)
"Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal."1.46Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. ( Benowitz, NL; Horng, H; Smollin, CG; Vo, KT, 2017)
"Co-occurring substance use disorders (SUD), including alcohol, are common in schizophrenia (SZ) and are associated with poor outcome."1.40Schizophrenia and co-occurring substance use disorder: reward, olfaction and clozapine. ( Gibson, LE; Green, AI; Mesholam-Gately, RI; Seidman, LJ, 2014)
"Co-morbid substance abuse was uncommon."1.39Prevalence and clinical presentation of HIV positive female psychiatric inpatients. ( Uys, H, 2013)
"Cariprazine (RGH-188) is a D₃-preferring dopamine D₃/D₂ receptor partial agonist antipsychotic candidate for the treatment of schizophrenia and bipolar mania."1.39Cariprazine (RGH-188), a D₃-preferring dopamine D₃/D₂ receptor partial agonist antipsychotic candidate demonstrates anti-abuse potential in rats. ( Gyertyán, I; Kiss, B; Román, V; Sághy, K; Szombathelyi, Z, 2013)
"Schizophrenia Care and Assessment Program, a large, prospective study of treatment for schizophrenia conducted July 1997 through September 2003."1.34Characteristics and use patterns of patients taking first-generation depot antipsychotics or oral antipsychotics for schizophrenia. ( Ascher-Svanum, H; Faries, D; Marder, SR; Montgomery, W; Shi, L; Zhu, B, 2007)
" Chronic administration of many DA antagonists alters dopaminergic function, causing a supersensitivity to DA agonists."1.30Enhanced neurobehavioral effects of cocaine with chronic neuroleptic exposure in rats. ( Kosten, TA, 1997)
"We report a patient with drug abuse who developed multiple psychotic symptoms including euphoria, excitement, hallucination and delirium during sedation with propofol under spinal anesthesia."1.30[A patient with drug abuse who developed multiple psychotic symptoms during sedation with propofol]. ( Kitajima, T; Mishio, M; Okuda, Y; Yamaguchi, S, 1998)
"In many organic psychoses, including psychosis due to ingestion of an atropine-like drug, use of anti-psychotic drug should be avoided."1.25Psychotropic drugs in the management of psychiatric emergencies. ( Ketai, R, 1975)

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-199037 (47.44)18.7374
1990's18 (23.08)18.2507
2000's12 (15.38)29.6817
2010's10 (12.82)24.3611
2020's1 (1.28)2.80

Authors

AuthorsStudies
Lindsley, CW1
Hopkins, CR1
Vaz, AS1
Brito, N1
Moura, L1
Fernandes, A1
Arranz, B1
Garriga, M1
Bernardo, M1
González-Pinto, A1
Arrojo, M1
Torrens, M1
Tirado-Muñoz, J1
Fonseca, F1
Sáiz, PA1
Flórez, G1
Goikolea, JM1
Zorrilla, I1
Cunill, R1
Castells, X1
Becoña, E1
López, A1
San, L1
Hardman, MI1
Sprung, J1
Weingarten, TN1
Uys, H1
Oluwole, LO1
Dada, MU1
Obadeji, A1
Mesholam-Gately, RI1
Gibson, LE1
Seidman, LJ1
Green, AI2
Vo, KT1
Horng, H1
Smollin, CG1
Benowitz, NL1
MacDonald, K1
Wilson, M1
Minassian, A1
Vilke, GM1
Becker, O1
Tallian, K1
Cobb, P1
Perez, R1
Galangue, B1
Feifel, D1
Bédard, AM1
Maheux, J1
Lévesque, D1
Samaha, AN1
Román, V1
Gyertyán, I2
Sághy, K1
Kiss, B1
Szombathelyi, Z1
Gál, K1
Wynchank, D1
Berk, M1
Suetsugu, S1
Morita, N1
Alevizos, B1
Tohen, MF1
Hamer, RM1
Strakowski, SM1
Lieberman, JA1
Glick, I1
Clark, WS1
Jung, IK1
Lee, HJ1
Cho, BH1
Papazisis, G1
Kouvelas, D1
Mastrogianni, A1
Karastergiou, A1
Potvin, S1
Mancini-Marïe, A1
Fahim, C1
Mensour, B1
Lévesque, J1
Karama, S1
Beauregard, M1
Rompré, PP1
Stip, E1
Shi, L1
Ascher-Svanum, H1
Zhu, B1
Faries, D1
Montgomery, W1
Marder, SR1
Kantrowitz, JT1
Srihari, VH1
Tek, C1
Fuchs, V1
Burbes, E1
Coper, H1
Buhrich, N1
Morris, G1
Cook, G1
Penn, JR1
Mackenzie, TB1
Jack, RA1
Kaufmann, M1
Kahaner, K1
Peselow, ED1
Gershon, S2
Weddington, WW1
Leventhal, BL1
Kulik, AV1
Wilbur, R1
Busch, KT1
Schulz, H1
Risberg, J1
Doenecke, AL1
Heuermann, RC1
LeDuc, PA1
Mittleman, G1
Richardson, NR1
Smith, AM1
Roberts, DC1
Patel, A1
Getsos, JP1
Moussa, G1
Damato, AN1
Shenoy, RS1
Tesar, GE1
Stone, AM1
Greenstein, RA1
Gamble, G1
McLellan, AT1
Berger, SP1
Hall, S2
Mickalian, JD1
Reid, MS1
Crawford, CA1
Delucchi, K1
Carr, K1
Ettenberg, A1
MacConell, LA1
Geist, TD1
Kuribara, H1
Sekine, H1
Nakahara, Y1
Kosten, TA1
Yamaguchi, S1
Mishio, M1
Okuda, Y1
Kitajima, T1
Hernandez-Avila, CA1
Ortega-Soto, HA1
Jasso, A1
Hasfura-Buenaga, CA1
Kranzler, HR1
Thomas, MJ1
Malenka, RC1
Bonci, A1
Göpel, C1
Laufer, C1
Marcus, A1
Lal, H1
Snyder, R1
Eldore, A1
Zylber-Katz, E1
de-Nour, AK1
Lee, AS1
Greenblatt, DJ1
Gross, PL1
Harris, J1
Shader, RI1
Ciraulo, DA1
Gruner, E1
Hefez, A1
Allen, RM1
Young, SJ1
Kocur, J1
Ketai, R1
Akpaffiong, MJ1
Yanagita, T1
Nambudiri, DE1
Young, RC1
Bowers, MB1
Mazure, CM1
Nelson, JC1
Jatlow, PI1
Strauss, WH1
Klieser, E1
Sabet-Sharghi, F1
Hutzler, JC1
Shalev, A1
Hermesh, H1
Munitz, H1
Goldney, R1
Bowes, J1
Spence, N1
Czechowicz, A1
Hurley, R1
Kumor, K1
Sherer, M1
Jaffe, J1
van der Laan, JW1
Hillen, FC1
Aravena, R1
Torres, R1
Sherer, MA1
Hoffman, AS1
Schwartz, HI1
Novick, RM1
Pozuelo, J1
Kerr, FW1
Carranza-Acevedo, J1
Estrada-Robles, U1
Duncan, JW1
Angrist, B1
Lee, HK1
LeCompte, G1
Friedman, JJ1
Sinacore, R1
Modestin, J1
Moskowitz, D1
Melikian, V1
Eddy, JD1
Paton, A1
Voelkel, A1
Sigell, LT1
Flessa, HC1
Hezar-Khani, F1
Vogelberg, K1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Clonidine on Responses to Imagery Scripts[NCT00318760]Phase 192 participants (Actual)Interventional2005-06-14Completed
Effects of Propranolol on Responses to Drug-Related Imagery Scripts[NCT00688805]Phase 140 participants (Actual)Interventional2007-12-12Terminated
PET Assays of Striatal Dopamine Markers in Cocaine Craving[NCT01036516]14 participants (Anticipated)Observational1998-06-23Completed
Efficacy of Quetiapine in Treating Patients With Active Substance Use Disorder and Schizophrenia[NCT00156715]Phase 423 participants (Actual)Interventional2004-03-31Completed
Risperidone Long-Acting for Alcohol and Schizophrenia Treatment (R-LAST)[NCT00130923]Phase 495 participants (Actual)Interventional2005-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinical Symptoms

The main outcome measure of clinical symptoms was the Positive and Negative Symptoms Scale. This is a 30 item scale for assessing patients diagnosed with schizophrenia. Each item is rated on a 1 (absent) to 7 (extreme) scale. The minimum total score is 30 and the maximum is 210. (NCT00156715)
Timeframe: 12 Weeks

InterventionUnits on a scale (Mean)
QUET65.5

Mean Number of Drinking Days Per Week

Timeline Follow-back (TLFB) procedure was used at screening and baseline to establish current substance use, and it was also used weekly during the course of the study to assess continued alcohol and other substance use. TLFB cosisted of using a calendar and sasking participants to report alcohol and other drug use since last visit. At the screening visit, the TLFB was done for the four weeks prior to the visit. (NCT00156715)
Timeframe: 12 Weeks

InterventionDrinking Days per Week (Mean)
QUET2.7

Average Over Time of Frequency of Drinking Days (Used to Evaluate Treatment Efficacy)

Frequency of drinking days is obtained each week retrospectively as the number of drinking days during the prior week (assessed using the Timeline Followback). Mixed models are used to obtain estimates of efficacy from the partial data provided by each subject while adherent to assigned treatment (under the 'missing at random' assumption). The 'explanatory' estimands (target of the mixed model estimation) are defined in terms of population quantities that would have occurred had all subjects remained on assigned treatment throughout the study. The point estimate for each arm is reported under Number. (NCT00130923)
Timeframe: 6 months

Interventiondrinking days per week (Number)
Risperidone Long Acting Injectable (LAI)2.84
Oral Risperidone Aka Risperdal3.46

Average Over Time of Global Functioning (Used to Evaluate Treatment Efficacy)

A rater assesses social, occupational and psychological functioning on a hypothetical continuum of mental health - illness (using Global Assessment of Functioning); scores range from 100 to 1, where higher values represent a better outcome. Mixed models are used to obtain estimates of efficacy from the partial data provided by each subject while adherent to assigned treatment (under the 'missing at random' assumption). The 'explanatory' estimands (target of the mixed model estimation) are defined in terms of population quantities that would have occurred had all subjects remained on assigned treatment throughout the study. The point estimate for each arm is reported under Number. (NCT00130923)
Timeframe: 6 months

Interventionordinal severity of impairment (Number)
Risperidone Long Acting Injectable (LAI)50.8
Oral Risperidone Aka Risperdal49.9

Average Over Time of Positive and Negative Symptoms (Used to Evaluate Treatment Efficacy)

A rater assesses positive and negative symptoms of schizophrenia using a 30-item scale (Positive and Negative Symptom Score) Scores range from 30 to 210, where higher values represent a worse outcome. Mixed models are used to obtain estimates of efficacy from the partial data provided by each subject while adherent to assigned treatment (under the 'missing at random' assumption). The 'explanatory' estimands (target of the mixed model estimation) are defined in terms of population quantities that would have occurred had all subjects remained on assigned treatment throughout the study. The point estimate for each arm is reported under Number. (NCT00130923)
Timeframe: 6 months

Interventionordinal severity of symptoms (Number)
Risperidone Long Acting Injectable (LAI)78.2
Oral Risperidone Aka Risperdal75.5

Average Over Time of Severity of Illness and Global Improvement (Used to Evaluate Treatment Efficacy)

A rater assesses the severity of illness and global impression using a scale from 1 to 7 (Clinical Global Impression), where higher values represent a worse outcome. Mixed models are used to obtain estimates of efficacy from the partial data provided by each subject while adherent to assigned treatment (under the 'missing at random' assumption). The 'explanatory' estimands (target of the mixed model estimation) are defined in terms of population quantities that would have occurred had all subjects remained on assigned treatment throughout the study. The point estimate for each arm is reported under Number. (NCT00130923)
Timeframe: 6 months

Interventionordinal unit of severity (Number)
Risperidone Long Acting Injectable (LAI)4.02
Oral Risperidone Aka Risperal3.96

Change Over Time in Frequency of Heavy Drinking Days (Used to Evaluate Treatment Efficacy)

Frequency of heavy drinking days is obtained each week retrospectively as the number of heavy drinking days during the prior week (assessed by the Timeline Followback Scale). A heavy drinking day is defined as 4 or more drinks per day for a female and 5 or more drinks per day for a male. Mixed models are used to obtain estimates of efficacy from the partial data provided by each subject while adherent to assigned treatment (under the 'missing at random' assumption). The 'explanatory' estimands (target of the mixed model estimation) are defined in terms of population quantities that would have occurred had all subjects remained on assigned treatment throughout the study. The point estimate for each arm is reported under Number. (NCT00130923)
Timeframe: 6 months

Interventionheavy drinking days per week (Number)
Risperidone Long Acting Injectable (LAI)-.11
Oral Risperidone Aka Risperal.68

Number of Participants With Medication Adherence

Number of participants with medication adherence (defined as taking medication at least 75% of the days in the treatment period). (NCT00130923)
Timeframe: 6 months

InterventionParticipants (Count of Participants)
Risperidone Long Acting Injectable (LAI)43
Oral Risperidone Aka Risperdal28

Reviews

8 reviews available for haloperidol and Chemical Dependence

ArticleYear
Return of D
    Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17

    Topics: Animals; Drug Discovery; Humans; Ligands; Molecular Targeted Therapy; Neoplasms; Parkinson Disease;

2017
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
    Bosnian journal of basic medical sciences, 2019, May-20, Volume: 19, Issue:2

    Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor

2019
[Organic solvent-related mental disorders].
    Ryoikibetsu shokogun shirizu, 2003, Issue:40

    Topics: Administration, Inhalation; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Haloperidol; Human

2003
The agitated patient, Part II: Pharmacologic treatment.
    Hospital & community psychiatry, 1993, Volume: 44, Issue:7

    Topics: Akathisia, Drug-Induced; Drug Therapy, Combination; Emergencies; Haloperidol; Humans; Lorazepam; Neu

1993
Narcotic dependence, narcotic action and dopamine receptors.
    Life sciences, 1975, Aug-15, Volume: 17, Issue:4

    Topics: Adenylyl Cyclases; Animals; Apomorphine; Behavior, Animal; Brain; Corpus Striatum; Cyclic AMP; Dopam

1975
[Overview of the progress in drug dependence studies--mainly focussing on psychic dependence].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1992, Volume: 100, Issue:2

    Topics: Animals; Benzodiazepines; Haloperidol; Humans; Limbic System; Methadone; Naloxone; Receptors, Dopami

1992
Mortality from neuroleptic malignant syndrome.
    The Journal of clinical psychiatry, 1989, Volume: 50, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dantrolene; Dopamine Agents; Female; Haloperidol;

1989
[Alcoholic psychoses: therapeutic schemes].
    Revista medica de Chile, 1988, Volume: 116, Issue:4

    Topics: Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Chlormethia

1988

Trials

7 trials available for haloperidol and Chemical Dependence

ArticleYear
Efficacy of nefazodone in the treatment of neuroleptic induced extrapyramidal side effects: a double-blind randomised parallel group placebo-controlled trial.
    Human psychopharmacology, 2003, Volume: 18, Issue:4

    Topics: Acute Disease; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Basal Ganglia Disease

2003
First episode schizophrenia-related psychosis and substance use disorders: acute response to olanzapine and haloperidol.
    Schizophrenia research, 2004, Feb-01, Volume: 66, Issue:2-3

    Topics: Adolescent; Adult; Benzodiazepines; Comorbidity; Diagnostic and Statistical Manual of Mental Disorde

2004
Haloperidol antagonism of cue-elicited cocaine craving.
    Lancet (London, England), 1996, Feb-24, Volume: 347, Issue:9000

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anxiety; Cocaine; Conditioning, Psychological; Cross

1996
Haloperidol antagonism of cue-elicited cocaine craving.
    Lancet (London, England), 1996, Feb-24, Volume: 347, Issue:9000

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anxiety; Cocaine; Conditioning, Psychological; Cross

1996
Haloperidol antagonism of cue-elicited cocaine craving.
    Lancet (London, England), 1996, Feb-24, Volume: 347, Issue:9000

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anxiety; Cocaine; Conditioning, Psychological; Cross

1996
Haloperidol antagonism of cue-elicited cocaine craving.
    Lancet (London, England), 1996, Feb-24, Volume: 347, Issue:9000

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anxiety; Cocaine; Conditioning, Psychological; Cross

1996
Haloperidol antagonism of cue-elicited cocaine craving.
    Lancet (London, England), 1996, Feb-24, Volume: 347, Issue:9000

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anxiety; Cocaine; Conditioning, Psychological; Cross

1996
Haloperidol antagonism of cue-elicited cocaine craving.
    Lancet (London, England), 1996, Feb-24, Volume: 347, Issue:9000

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anxiety; Cocaine; Conditioning, Psychological; Cross

1996
Haloperidol antagonism of cue-elicited cocaine craving.
    Lancet (London, England), 1996, Feb-24, Volume: 347, Issue:9000

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anxiety; Cocaine; Conditioning, Psychological; Cross

1996
Haloperidol antagonism of cue-elicited cocaine craving.
    Lancet (London, England), 1996, Feb-24, Volume: 347, Issue:9000

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anxiety; Cocaine; Conditioning, Psychological; Cross

1996
Haloperidol antagonism of cue-elicited cocaine craving.
    Lancet (London, England), 1996, Feb-24, Volume: 347, Issue:9000

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anxiety; Cocaine; Conditioning, Psychological; Cross

1996
Treatment of inhalant-induced psychotic disorder with carbamazepine versus haloperidol.
    Psychiatric services (Washington, D.C.), 1998, Volume: 49, Issue:6

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Dyskinesia, Drug-Induced; Haloperidol;

1998
Haloperidol in barbiturate detoxification.
    Military medicine, 1977, Volume: 142, Issue:11

    Topics: Adolescent; Adult; Barbiturates; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Fem

1977
Cognitive disturbances in neuroleptic therapy.
    Acta psychiatrica Scandinavica. Supplementum, 1990, Volume: 358

    Topics: Adult; Antipsychotic Agents; Benzamides; Cognition Disorders; Double-Blind Method; Haloperidol; Huma

1990
The antagonism of amphetamine-induced symptomatology by a neuroleptic.
    The American journal of psychiatry, 1974, Volume: 131, Issue:7

    Topics: Amphetamine; Brain Chemistry; Clinical Trials as Topic; Dopamine; Dopamine Antagonists; Dose-Respons

1974

Other Studies

63 other studies available for haloperidol and Chemical Dependence

ArticleYear
Involuntary movements in an adolescent: what are the causes?
    BMJ case reports, 2019, Dec-10, Volume: 12, Issue:12

    Topics: Adolescent; Alcoholic Intoxication; Antipsychotic Agents; Biperiden; Dystonia; Emergency Service, Ho

2019
Clinical practice guideline on pharmacological and psychological management of adult patients with schizophrenia spectrum disorders and a comorbid substance use.
    Adicciones, 2022, Apr-01, Volume: 34, Issue:2

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Haloperidol; Humans; Nicotine; Olanzapine; Practice Gu

2022
Prevalence and clinical presentation of HIV positive female psychiatric inpatients.
    African journal of psychiatry, 2013, Volume: 16, Issue:1

    Topics: Adult; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Comorbidity; Cross-Sectional Studie

2013
Self-inflicted bilateral orchidectomy precipitated by erotic bizarre delusions: a case report.
    African journal of psychiatry, 2013, Volume: 16, Issue:2

    Topics: Adult; Antipsychotic Agents; Haloperidol; Humans; Male; Prognosis; Recurrence; Schizophrenia, Parano

2013
Schizophrenia and co-occurring substance use disorder: reward, olfaction and clozapine.
    Schizophrenia research, 2014, Volume: 155, Issue:1-3

    Topics: Adult; Antipsychotic Agents; Clozapine; Female; Fluphenazine; Haloperidol; Humans; Male; Middle Aged

2014
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
    The Journal of emergency medicine, 2017, Volume: 52, Issue:5

    Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Se

2017
A naturalistic study of intramuscular haloperidol versus intramuscular olanzapine for the management of acute agitation.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:3

    Topics: Acute Disease; Adult; Antipsychotic Agents; Benzodiazepines; Dose-Response Relationship, Drug; Drug

2012
Prior haloperidol, but not olanzapine, exposure augments the pursuit of reward cues: implications for substance abuse in schizophrenia.
    Schizophrenia bulletin, 2013, Volume: 39, Issue:3

    Topics: Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Conditioning, Classic

2013
Cariprazine (RGH-188), a D₃-preferring dopamine D₃/D₂ receptor partial agonist antipsychotic candidate demonstrates anti-abuse potential in rats.
    Psychopharmacology, 2013, Volume: 226, Issue:2

    Topics: Animals; Antipsychotic Agents; Aripiprazole; Benzoxazoles; Cocaine-Related Disorders; Dopamine Agoni

2013
Dopamine D3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference.
    Neuroreport, 2003, Jan-20, Volume: 14, Issue:1

    Topics: Animals; Avoidance Learning; Benzazepines; Benzopyrans; Cocaine; Conditioning, Classical; Dopamine A

2003
Dependence and chronic psychosis with D-nor-pseudoephedrine.
    European psychiatry : the journal of the Association of European Psychiatrists, 2003, Volume: 18, Issue:8

    Topics: Antipsychotic Agents; Appetite; Appetite Depressants; Benzodiazepines; Central Nervous System Stimul

2003
Persistent psychotic disorder in an adolescent with a past history of butane gas dependence.
    European psychiatry : the journal of the Association of European Psychiatrists, 2004, Volume: 19, Issue:8

    Topics: Adolescent; Antipsychotic Agents; Butanes; Diagnostic and Statistical Manual of Mental Disorders; Ha

2004
Anabolic androgenic steroid abuse and mood disorder: a case report.
    The international journal of neuropsychopharmacology, 2007, Volume: 10, Issue:2

    Topics: Adult; Anabolic Agents; Antipsychotic Agents; Bipolar Disorder; Haloperidol; Humans; Impulsive Behav

2007
Increased striatal gray matter densities in patients with schizophrenia and substance use disorder: a voxel-based morphometry study.
    Psychiatry research, 2007, Apr-15, Volume: 154, Issue:3

    Topics: Adult; Antipsychotic Agents; Cell Count; Corpus Striatum; Diagnostic and Statistical Manual of Menta

2007
Characteristics and use patterns of patients taking first-generation depot antipsychotics or oral antipsychotics for schizophrenia.
    Psychiatric services (Washington, D.C.), 2007, Volume: 58, Issue:4

    Topics: Administration, Oral; Adult; Alcoholism; Antipsychotic Agents; Black People; Cohort Studies; Comorbi

2007
Resolution of tardive dyskinesia after addition of aripiprazole to haloperidol depot.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:5

    Topics: Antipsychotic Agents; Aripiprazole; Delayed-Action Preparations; Dose-Response Relationship, Drug; D

2007
The influence of haloperidol and aminooxyacetic acid on etonitazene, alcohol, diazepam and barbital consumption.
    Drug and alcohol dependence, 1984, Volume: 14, Issue:2

    Topics: Acetates; Alcohol Drinking; Aminooxyacetic Acid; Animals; Barbital; Barbiturates; Benzimidazoles; Br

1984
Bromo-DMA: the Australasian hallucinogen?
    The Australian and New Zealand journal of psychiatry, 1983, Volume: 17, Issue:3

    Topics: Adult; Amphetamines; Australia; DOM 2,5-Dimethoxy-4-Methylamphetamine; Female; Hallucinogens; Halope

1983
Organic mental disorder associated with metrizamide.
    Psychosomatics, 1983, Volume: 24, Issue:9

    Topics: Female; Haloperidol; Humans; Metrizamide; Middle Aged; Substance-Related Disorders

1983
Unintentional haloperidol abuse.
    The American journal of psychiatry, 1982, Volume: 139, Issue:2

    Topics: Adult; Diazepam; Female; Haloperidol; Humans; Substance-Related Disorders

1982
Steroid psychoses: case report and brief overview.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:2

    Topics: Adult; Dose-Response Relationship, Drug; Female; Giant Cell Arteritis; Haloperidol; Humans; Predniso

1982
Malicious abuse of haloperidol.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:10

    Topics: Haloperidol; Humans; Prisoners; Substance-Related Disorders

1982
Delirium and stereotypy from anticholinergic antiparkinson drugs.
    Progress in neuro-psychopharmacology & biological psychiatry, 1982, Volume: 6, Issue:1

    Topics: Adult; Aged; Benztropine; Delirium; Diazepam; Drug Therapy, Combination; Dyskinesia, Drug-Induced; E

1982
[The acute psychiatric emergency].
    Zeitschrift fur Alternsforschung, 1981, Volume: 36, Issue:4

    Topics: Acute Disease; Aged; Alcoholism; Amitriptyline; Brain Ischemia; Cognition Disorders; Consciousness D

1981
Regional cerebral blood flow measurements by 133Xe-inhalation: methodology and applications in neuropsychology and psychiatry.
    Brain and language, 1980, Volume: 9, Issue:1

    Topics: Adult; Affective Symptoms; Aged; Alcoholism; Cerebrovascular Circulation; Computers; Dementia; Femal

1980
Treatment of haloperidol abuse with diphenhydramine.
    The American journal of psychiatry, 1980, Volume: 137, Issue:4

    Topics: Adolescent; Adult; Alcohol Drinking; Diazepam; Diphenhydramine; Female; Haloperidol; Humans; Male; S

1980
Interactions between chronic haloperidol treatment and cocaine in rats: an animal model of intermittent cocaine use in neuroleptic treated populations.
    Psychopharmacology, 1993, Volume: 110, Issue:4

    Topics: Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I

1993
A single injection of either flupenthixol decanoate or haloperidol decanoate produces long-term changes in cocaine self-administration in rats.
    Drug and alcohol dependence, 1994, Volume: 36, Issue:1

    Topics: Animals; Cocaine; Flupenthixol; Haloperidol; Injections, Intramuscular; Male; Rats; Rats, Wistar; Re

1994
The Osborn wave of hypothermia in normothermic patients.
    Clinical cardiology, 1994, Volume: 17, Issue:5

    Topics: Adult; Aged; Angina Pectoris; Body Temperature; Chest Pain; Cocaine; Electrocardiography; Female; Ha

1994
Pitfalls in the treatment of jimsonweed intoxication.
    The American journal of psychiatry, 1994, Volume: 151, Issue:9

    Topics: Adolescent; Contraindications; Datura stramonium; Drug Therapy, Combination; Haloperidol; Humans; Lo

1994
Cocaine use by schizophrenic outpatients who receive depot neuroleptic medication.
    Hospital & community psychiatry, 1993, Volume: 44, Issue:2

    Topics: Adult; Ambulatory Care; Chronic Disease; Cocaine; Combined Modality Therapy; Comorbidity; Delayed-Ac

1993
Effects of haloperidol in a response-reinstatement model of heroin relapse.
    Psychopharmacology, 1996, Volume: 124, Issue:3

    Topics: Animals; Dopamine Antagonists; Extinction, Psychological; Haloperidol; Heroin; Male; Narcotics; Rats

1996
Characteristics of behavioural stimulant effect of N-cyanomethylmethamphetamine, a main product of smoking methamphetamine mixed with tobacco: evaluation by ambulatory activity in mice.
    Pharmacology & toxicology, 1996, Volume: 78, Issue:6

    Topics: Amphetamines; Animals; Behavior, Animal; Central Nervous System Stimulants; Dopamine Antagonists; Do

1996
Enhanced neurobehavioral effects of cocaine with chronic neuroleptic exposure in rats.
    Schizophrenia bulletin, 1997, Volume: 23, Issue:2

    Topics: Animals; Antipsychotic Agents; Cocaine; Discrimination, Psychological; Dopamine; Dopamine Antagonist

1997
[A patient with drug abuse who developed multiple psychotic symptoms during sedation with propofol].
    Masui. The Japanese journal of anesthesiology, 1998, Volume: 47, Issue:5

    Topics: Adult; Anesthesia, Spinal; Antipsychotic Agents; Haloperidol; Humans; Hypnotics and Sedatives; Intra

1998
Modulation of long-term depression by dopamine in the mesolimbic system.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Aug-01, Volume: 20, Issue:15

    Topics: Animals; Benzazepines; Conditioning, Psychological; Dopamine; Dopamine Agonists; Dopamine Antagonist

2000
Three cases of angel's trumpet tea-induced psychosis in adolescent substance abusers.
    Nordic journal of psychiatry, 2002, Volume: 56, Issue:1

    Topics: Adolescent; Alkaloids; Antipsychotic Agents; Charcoal; Cholinergic Antagonists; Hallucinogens; Halop

2002
Anticoagulant abuse: a psychotic syndrome?
    The Journal of nervous and mental disease, 1979, Volume: 167, Issue:7

    Topics: Adult; Denial, Psychological; Diagnosis, Differential; Female; Haloperidol; Hemorrhage; Humans; Psyc

1979
Treatment of drug-induced dystonic reactions.
    JACEP, 1979, Volume: 8, Issue:11

    Topics: Adolescent; Adult; Benztropine; Diphenhydramine; Dystonia; Female; Haloperidol; Humans; Injections,

1979
Fatal hyperthermia following haloperidol therapy of sedative-hypnotic withdrawal.
    The Journal of clinical psychiatry, 1978, Volume: 39, Issue:8

    Topics: Adult; Barbiturates; Dose-Response Relationship, Drug; Fever; Haloperidol; Humans; Male; Methaqualon

1978
[Combined haloperidol and scopolamine for tranquilization of extremely restless patients].
    Harefuah, 1978, Jun-15, Volume: 94, Issue:12

    Topics: Barbiturates; Drug Combinations; Haloperidol; Humans; Psychomotor Agitation; Scopolamine; Substance-

1978
Phencyclidine-induced psychosis.
    The American journal of psychiatry, 1978, Volume: 135, Issue:9

    Topics: Adolescent; Adult; Female; Haloperidol; Humans; Male; Military Medicine; Phencyclidine; Psychoses, S

1978
[Some psychotoxicological problems exemplified by lysergic acid diethylamide].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1975, Mar-01, Volume: 28, Issue:5

    Topics: Adolescent; Age Factors; Animals; Haloperidol; Humans; Lysergic Acid Diethylamide; Phenoxybenzamine;

1975
Psychotropic drugs in the management of psychiatric emergencies.
    Postgraduate medicine, 1975, Volume: 58, Issue:4

    Topics: Administration, Oral; Amphetamine; Chlorpromazine; Hallucinogens; Haloperidol; Humans; Hypotension;

1975
Risk factors for neuroleptic malignant syndrome.
    Journal of the National Medical Association, 1992, Volume: 84, Issue:9

    Topics: Adult; Drug Therapy, Combination; Female; Haloperidol; Humans; Lithium; Neuroleptic Malignant Syndro

1992
A case of late-onset crack dependence and subsequent psychosis in the elderly.
    Journal of substance abuse treatment, 1991, Volume: 8, Issue:4

    Topics: Crack Cocaine; Delusions; Hallucinations; Haloperidol; Humans; Male; Middle Aged; Psychoses, Substan

1991
Psychotogenic drug use and neuroleptic response.
    Schizophrenia bulletin, 1990, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Antipsychotic Agents; Bipolar Disorder; Depressive Disorder; Haloperidol; Homovan

1990
Psychotogenic drug use and neuroleptic response.
    Schizophrenia bulletin, 1990, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Antipsychotic Agents; Bipolar Disorder; Depressive Disorder; Haloperidol; Homovan

1990
Psychotogenic drug use and neuroleptic response.
    Schizophrenia bulletin, 1990, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Antipsychotic Agents; Bipolar Disorder; Depressive Disorder; Haloperidol; Homovan

1990
Psychotogenic drug use and neuroleptic response.
    Schizophrenia bulletin, 1990, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Antipsychotic Agents; Bipolar Disorder; Depressive Disorder; Haloperidol; Homovan

1990
Prophylaxis of steroid-induced psychiatric syndromes.
    Psychosomatics, 1990,Winter, Volume: 31, Issue:1

    Topics: Adult; Dibenzocycloheptenes; Female; Haloperidol; Humans; Lithium; Prednisone; Protriptyline; Substa

1990
The psychiatric intensive care unit.
    The British journal of psychiatry : the journal of mental science, 1985, Volume: 146

    Topics: Adult; Affective Disorders, Psychotic; Antipsychotic Agents; Australia; Critical Care; Female; Halop

1985
Haloperidol-induced dystonia in cocaine addicts.
    Lancet (London, England), 1986, Dec-06, Volume: 2, Issue:8519

    Topics: Adult; Cocaine; Dystonia; Haloperidol; Humans; Male; Substance-Related Disorders

1986
The potentiation of morphine-withdrawal jumping by clonidine is antagonized by m-chlorophenylpiperazine and not by haloperidol.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 283, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Behavior, Animal; Clonidine; Dopamine Antagonists;

1986
Intravenous cocaine: psychiatric effects, biological mechanisms.
    Biological psychiatry, 1988, Volume: 24, Issue:8

    Topics: Adult; Arousal; Brain; Chromatography, High Pressure Liquid; Cocaine; Dose-Response Relationship, Dr

1988
Catatonic reaction to accidental haloperidol overdose: an unrecognized drug abuse risk.
    The Journal of nervous and mental disease, 1986, Volume: 174, Issue:7

    Topics: Adult; Catatonia; Haloperidol; Humans; Male; Parkinson Disease, Secondary; Substance-Related Disorde

1986
Suppression of craving and other signs of dependence in morphine-addicted monkeys by administration of alpha-methyl-para-tyrosine.
    Mayo Clinic proceedings, 1972, Volume: 47, Issue:9

    Topics: Animals; Female; Fenclonine; Haloperidol; Haplorhini; Humans; Hypothalamus; Injections, Intravenous;

1972
[Intense pentazocine abstinence syndrome. Treatment of a clinical case].
    Archivos de investigacion medica, 1974, Volume: 5 SUPPL 1

    Topics: Administration, Oral; Adult; Butyrophenones; Diazepam; Drug Evaluation; Female; Haloperidol; Humans;

1974
Persisting psychotic states in adolescent drug users.
    Child psychiatry and human development, 1974,Fall, Volume: 5, Issue:1

    Topics: Adolescent; Cataplexy; Child, Institutionalized; Chlorpromazine; Delusions; Hallucinations; Hallucin

1974
Non-addictive drug antagonist program in a community setting.
    American journal of public health, 1973, Volume: 63, Issue:9

    Topics: Adolescent; Adult; Age Factors; Allied Health Personnel; Ambulatory Care; Community Health Services;

1973
[Noxa-disposition relationship in physically explainable psychoses].
    Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie, 1973, Volume: 113, Issue:2

    Topics: Adult; Age Factors; Body Constitution; Dibenzylchlorethamine; Female; Haloperidol; Humans; Middle Ag

1973
Use of haloperidol to reduce LSD flashbacks.
    Military medicine, 1971, Volume: 136, Issue:9

    Topics: Hallucinations; Haloperidol; Humans; Lysergic Acid Diethylamide; Male; Naval Medicine; Psychoses, Su

1971
The stimulant effect of drugs on indocyanine green clearance by the liver.
    Gut, 1972, Volume: 13, Issue:10

    Topics: Adult; Aged; Anticonvulsants; Densitometry; Drug Therapy; Ear, External; Female; Half-Life; Haloperi

1972
[Complications caused by anonymous preclinical medication].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:7

    Topics: Amitriptyline; Antidepressive Agents; Barbiturates; Bromides; Cannabis; Chlordiazepoxide; Delirium;

1970
Drug interactions with anticoagulants.
    JAMA, 1970, Dec-14, Volume: 214, Issue:11

    Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Anticoagulants; Ascorbic Acid; Barbiturates; Blood Co

1970
[A case of chronic piperazine abuse].
    Der Nervenarzt, 1965, Volume: 36, Issue:8

    Topics: Adult; Bipolar Disorder; Haloperidol; Humans; Male; Movement Disorders; Piperazines; Substance-Relat

1965