Page last updated: 2024-10-28

haloperidol and Brain Disorders

haloperidol has been researched along with Brain Disorders in 39 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Research Excerpts

ExcerptRelevanceReference
"The encephalopathy was worsened by hyperthermia, dehydration, and reintroduction of haloperidol, 5 days after the first discontinuation of the neuroleptic."5.30[Acute encephalomyopathy and persistent cerebellar syndrome after lithium salt and haloperidol poisoning]. ( de Barsy, T; Delbecq, J; Depré, A; Ghariani, S; Gille, M; Piéret, F; Saussu, F, 1997)
"We summarise preliminary findings from our ongoing magnetic resonance imaging and spectroscopy studies of first-episode schizophrenia patients being conducted prospectively from index evaluations through a period of two years; during this period, patients were treated with either a conventional antipsychotic such as haloperidol, or the atypical risperidone."3.70Research and treatment strategies in first-episode psychoses. The Pittsburgh experience. ( Haas, GL; Keshavan, MS; Pettegrew, JW; Schooler, NR; Sweeney, JA, 1998)
"Choreoathetotic syndromes are frequently observed in children after congenital cardiopathy surgery."1.36Late-onset choreoathetotic syndrome following heart surgery. ( Alessandrini, F; Avesani, M; Bertolasi, L; Bovi, P; Buffone, CE; Moretto, G; Musso, A; Ottaviani, S; Passarin, MG; Petrilli, G; Romito, S; Santini, F, 2010)
" Chronic administration of haloperidol (1 mg/kg, i."1.35Progesterone attenuates neuroleptic-induced orofacial dyskinesia via the activity of its metabolite, allopregnanolone, a positive GABA(A) modulating neurosteroid. ( Bishnoi, M; Chopra, K; Kulkarni, SK, 2008)
"To describe a case of possible toxic encephalopathy in a surgical patient receiving high-dose intravenous haloperidol."1.30Possible toxic encephalopathy following high-dose intravenous haloperidol. ( Maxa, JL; Ogu, CC; Taleghani, AM; Tanzi, M, 1997)
"The encephalopathy was worsened by hyperthermia, dehydration, and reintroduction of haloperidol, 5 days after the first discontinuation of the neuroleptic."1.30[Acute encephalomyopathy and persistent cerebellar syndrome after lithium salt and haloperidol poisoning]. ( de Barsy, T; Delbecq, J; Depré, A; Ghariani, S; Gille, M; Piéret, F; Saussu, F, 1997)
"Cysticercosis is a parasitic disease endemic in several developing countries where people consume raw or insufficiently cooked pork."1.28You drive me crazy: a case report of acute psychosis and neurocysticercosis. ( Milette, PC; Shriqui, CL, 1992)
" Evidence for this is based on the fact that in our patients and others mentioned in the literature the dosage and blood levels of lithium were not high."1.27Toxic irreversible encephalopathy induced by lithium carbonate and haloperidol. A report of 2 cases. ( Hurwitz, MD; Sandyk, R, 1983)
" A long-term use of haloperidol did not exert any significant influence on the cortical function of the formation of conditioned reflexes, but there was a retardation in the fixation of new conditioned reflexes after 6 months of drug administration."1.26[Pathophysiologic and morphologic changes in the central nervous system following long-term haloperidol administration]. ( Bobritskaia, ZM; Gorbatko, LG; Gordienko, ZhP; Litvinova, NM, 1981)
"Agitated patients with organic brain disorders represent relatively common diagnostic and management problems."1.26Treatment of the agitated patient with an organic brain disorder. ( Fauman, MA, 1978)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199021 (53.85)18.7374
1990's13 (33.33)18.2507
2000's4 (10.26)29.6817
2010's1 (2.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Passarin, MG1
Romito, S1
Avesani, M1
Alessandrini, F1
Petrilli, G1
Santini, F1
Bertolasi, L1
Musso, A1
Buffone, CE1
Ottaviani, S1
Bovi, P1
Moretto, G1
Laplante, F1
Stevenson, CW1
Gratton, A1
Srivastava, LK1
Quirion, R1
Wehrschuetz, M1
Simbrunner, J1
Enzinger, C1
Ebner, F1
Bishnoi, M1
Chopra, K1
Kulkarni, SK1
Barbosa, ER1
Marchiori, PE1
Scaff, M1
de Assis, JL1
Sandyk, R1
Hurwitz, MD1
Fage, D1
Guerin, B1
Feuerstein, C1
Demenge, P1
Scatton, B1
Appelbaum, PS1
Roth, LH1
Sumners, C1
Woodruff, GN1
Poat, JA1
Litvinova, NM1
Bobritskaia, ZM1
Gordienko, ZhP1
Gorbatko, LG1
Ouagazzal, A1
Nieoullon, A1
Amalric, M1
Bureau, YR1
Persinger, MA1
Goldman, SA2
Maxa, JL1
Taleghani, AM1
Ogu, CC1
Tanzi, M1
Gille, M1
Ghariani, S1
Piéret, F1
Delbecq, J1
Depré, A1
Saussu, F1
de Barsy, T1
Roe, DL1
Bardgett, ME1
Csernansky, CA1
Csernansky, JG1
Breggin, PR1
Keshavan, MS1
Schooler, NR1
Sweeney, JA1
Haas, GL1
Pettegrew, JW1
Joseph, MH1
Peters, SL1
Moran, PM1
Grigoryan, GA1
Young, AM1
Gray, JA1
Fauman, MA1
Veits, HR1
Destee, A1
Lehembre, P1
Petit, H1
Warot, P1
Shriqui, CL1
Milette, PC1
Pontecorvo, MJ1
Karbon, EW1
Goode, S1
Clissold, DB1
Borosky, SA1
Patch, RJ1
Ferkany, JW1
Johansson, P1
Jurand, A1
Martin, LV1
Weihmuller, FB1
Hadjiconstantinou, M1
Bruno, JP1
Neff, NH1
Niss, AI1
Trubkovich, MIa1
Nisenbaum, ES1
Stricker, EM1
Zigmond, MJ1
Berger, TW1
Nikulina, IuA1
Skrinskaia, IuA1
Popova, NK1
Browne, JL1
Hart, RR1
Pellis, SM1
Chen, YC1
Chesire, RM1
Teitelbaum, P1
Wahnschaffe, U1
Esslen, J1
Walsh, AC1
Walsh, BH1
O'Neill, DP1
Klawans, HL1
Holmes, AW1
Cohen, WJ1
Cohen, NH1
Matveev, VF1
Lapides, MI1
Mamtseva, VN1

Reviews

2 reviews available for haloperidol and Brain Disorders

ArticleYear
Lithium and neuroleptics in combination: is there enhancement of neurotoxicity leading to permanent sequelae?
    Journal of clinical pharmacology, 1996, Volume: 36, Issue:10

    Topics: Adult; Analysis of Variance; Antimanic Agents; Antipsychotic Agents; Brain; Brain Diseases; Drug Int

1996
Organic delusional disorder on a consultation-liaison psychiatry service. Report and review.
    Psychosomatics, 1992,Summer, Volume: 33, Issue:3

    Topics: Adult; Age Factors; Aged; Brain Diseases; Delusions; Diagnosis, Differential; Electroencephalography

1992

Other Studies

37 other studies available for haloperidol and Brain Disorders

ArticleYear
Late-onset choreoathetotic syndrome following heart surgery.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2010, Volume: 31, Issue:1

    Topics: Age of Onset; Anti-Dyskinesia Agents; Basal Ganglia; Brain Diseases; Cardiac Surgical Procedures; Ch

2010
Effects of neonatal ventral hippocampal lesion in rats on stress-induced acetylcholine release in the prefrontal cortex.
    Journal of neurochemistry, 2004, Volume: 91, Issue:6

    Topics: Acetylcholine; Animals; Animals, Newborn; Benzazepines; Brain Diseases; Dopamine; Dopamine Antagonis

2004
[Hemiballism-hemichorea syndrome].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2007, Volume: 179, Issue:1

    Topics: Anti-Dyskinesia Agents; Brain Diseases; Cerebrovascular Circulation; Chorea; Drug Therapy, Combinati

2007
Progesterone attenuates neuroleptic-induced orofacial dyskinesia via the activity of its metabolite, allopregnanolone, a positive GABA(A) modulating neurosteroid.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Feb-15, Volume: 32, Issue:2

    Topics: Animals; Antipsychotic Agents; Brain Diseases; Control Groups; Disease Models, Animal; Dopamine; Dys

2008
[Huntington chorea: report of 16 cases].
    Arquivos de neuro-psiquiatria, 1983, Volume: 41, Issue:2

    Topics: Adult; Aged; Brain Diseases; Chlorpromazine; Dementia; Diagnosis, Differential; Female; gamma-Aminob

1983
Toxic irreversible encephalopathy induced by lithium carbonate and haloperidol. A report of 2 cases.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1983, Nov-19, Volume: 64, Issue:22

    Topics: Adult; Bipolar Disorder; Brain Diseases; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female

1983
Time course of the changes in striatal acetylcholine levels induced by pergolide and haloperidol after lesion of the nigrostriatal dopaminergic pathways in the rat.
    Brain research, 1984, Sep-24, Volume: 310, Issue:2

    Topics: Acetylcholine; Animals; Brain Diseases; Corpus Striatum; Dopamine; Ergolines; Haloperidol; Male; Per

1984
Involuntary treatment in medicine and psychiatry.
    The American journal of psychiatry, 1984, Volume: 141, Issue:2

    Topics: Aged; Brain Diseases; Female; Haloperidol; Hospitals, General; Hospitals, Psychiatric; Humans; Infus

1984
Effects of specific dopamine lesions and dopamine receptor sensitivity on angiotensin II- and carbachol-induced thirst in rats.
    Psychopharmacology, 1981, Volume: 73, Issue:2

    Topics: Angiotensin II; Animals; Brain Diseases; Carbachol; Corpus Striatum; Dopamine; Haloperidol; Hydroxyd

1981
[Pathophysiologic and morphologic changes in the central nervous system following long-term haloperidol administration].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1981, Volume: 81, Issue:2

    Topics: Animals; Basal Ganglia Diseases; Brain Diseases; Caudate Nucleus; Cerebral Cortex; Conditioning, Cla

1981
Locomotor activation induced by MK-801 in the rat: postsynaptic interactions with dopamine receptors in the ventral striatum.
    European journal of pharmacology, 1994, Jan-14, Volume: 251, Issue:2-3

    Topics: Amphetamine; Animals; Brain; Brain Diseases; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamin

1994
Transient blocking of persistent gnawing by haloperidol in rats with seizure-induced multifocal brain damage.
    Life sciences, 1993, Volume: 52, Issue:10

    Topics: Animals; Behavior, Animal; Brain Diseases; Female; Haloperidol; Limbic System; Mastication; Rats; Ra

1993
Possible toxic encephalopathy following high-dose intravenous haloperidol.
    The Annals of pharmacotherapy, 1997, Volume: 31, Issue:6

    Topics: Antipsychotic Agents; Anxiety; Brain Diseases; Haloperidol; Humans; Male; Middle Aged

1997
[Acute encephalomyopathy and persistent cerebellar syndrome after lithium salt and haloperidol poisoning].
    Revue neurologique, 1997, Volume: 153, Issue:4

    Topics: Acute Disease; Adult; Antidepressive Agents; Antipsychotic Agents; Brain Diseases; Cerebellar Diseas

1997
Induction of Fos protein by antipsychotic drugs in rat brain following kainic acid-induced limbic-cortical neuronal loss.
    Psychopharmacology, 1998, Volume: 138, Issue:2

    Topics: Animals; Antipsychotic Agents; Brain; Brain Diseases; Cell Count; Clozapine; Dose-Response Relations

1998
Does clozapine treatment cause brain disease?
    Archives of general psychiatry, 1998, Volume: 55, Issue:9

    Topics: Adult; Age Factors; Brain Diseases; Child; Clozapine; Drug Therapy, Combination; Haloperidol; Humans

1998
Research and treatment strategies in first-episode psychoses. The Pittsburgh experience.
    The British journal of psychiatry. Supplement, 1998, Volume: 172, Issue:33

    Topics: Adolescent; Adult; Antipsychotic Agents; Brain Diseases; Developmental Disabilities; Episode of Care

1998
Modulation of latent inhibition in the rat by altered dopamine transmission in the nucleus accumbens at the time of conditioning.
    Neuroscience, 2000, Volume: 101, Issue:4

    Topics: Amphetamine; Animals; Association Learning; Behavior, Animal; Brain Diseases; Conditioning, Psycholo

2000
Treatment of the agitated patient with an organic brain disorder.
    JAMA, 1978, Jul-28, Volume: 240, Issue:4

    Topics: Adult; Aged; Antipsychotic Agents; Brain Damage, Chronic; Brain Diseases; Brain Injuries; Haloperido

1978
Haloperidol encephalopathy: case report.
    Military medicine, 1978, Volume: 143, Issue:3

    Topics: Adult; Brain Diseases; Haloperidol; Humans; Male; Military Medicine

1978
[Toxic encephalopathy caused by the combination of lithium and haloperidol].
    Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1978, Volume: 23, Issue:2

    Topics: Adjustment Disorders; Brain Diseases; Drug Therapy, Combination; Haloperidol; Humans; Lithium; Male;

1978
You drive me crazy: a case report of acute psychosis and neurocysticercosis.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1992, Volume: 37, Issue:2

    Topics: Acute Disease; Adult; Brain Diseases; Cysticercosis; Dexamethasone; Electroencephalography; Female;

1992
Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents.
    Brain research bulletin, 1991, Volume: 26, Issue:3

    Topics: Animals; Anticonvulsants; Brain Diseases; Electroshock; Haloperidol; Hypoxia; Male; Mice; Mice, Inbr

1991
Methylazoxymethanol (MAM)-induced brain lesion and oral dyskinesia in rats.
    Psychopharmacology, 1990, Volume: 100, Issue:1

    Topics: Animals; Azo Compounds; Behavior, Animal; Brain Diseases; Corpus Striatum; Dyskinesia, Drug-Induced;

1990
Teratogenic potential of two neurotropic drugs, haloperidol and dextromoramide, tested on mouse embryos.
    Teratology, 1990, Volume: 42, Issue:1

    Topics: Animals; Brain Diseases; Dextromoramide; Dose-Response Relationship, Drug; Female; Haloperidol; Leth

1990
Continued administration of GM1 ganglioside is required to maintain recovery from neuroleptic-induced sensorimotor deficits in MPTP-treated mice.
    Life sciences, 1989, Volume: 45, Issue:25

    Topics: Animals; Brain Diseases; Catalepsy; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; G(M1) Gangl

1989
[Various rarely encountered adverse effects and complications of psychopharmacotherapy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1985, Volume: 85, Issue:5

    Topics: Adult; Agnosia; Amitriptyline; Apraxias; Brain Diseases; Cerebral Cortex; Haloperidol; Humans; Male;

1985
Long-term effects of dopamine-depleting brain lesions on spontaneous activity of type II striatal neurons: relation to behavioral recovery.
    Brain research, 1986, Nov-29, Volume: 398, Issue:2

    Topics: Action Potentials; Animals; Brain Diseases; Corpus Striatum; Dopamine; Haloperidol; Hydroxydopamines

1986
[Characteristics of the brain dopamine system in mice carrying the quaking neurological mutation].
    Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 106, Issue:8

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Brai

1988
Exacerbation of tardive dyskinesia by Joseph disease.
    The Journal of clinical psychiatry, 1986, Volume: 47, Issue:6

    Topics: Aged; Brain Diseases; Cerebellar Ataxia; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Ment

1986
Head displacement and bracing in haloperidol-treated rats compared to rats with lateral hypothalamic damage.
    Physiology & behavior, 1985, Volume: 35, Issue:5

    Topics: Animals; Brain Diseases; Catalepsy; Disease Models, Animal; Haloperidol; Hydroxydopamines; Hypothala

1985
Structural evidence for the neurotoxicity of methylamphetamine in the frontal cortex of gerbils (Meriones unguiculatus): a light and electron microscopical study.
    Brain research, 1985, Jul-01, Volume: 337, Issue:2

    Topics: Animals; Brain Diseases; Dopamine; Drug Interactions; Female; Frontal Lobe; Gerbillinae; Haloperidol

1985
Presenile dementia: further experience with an anticoagulant-psychotherapy regimen.
    Journal of the American Geriatrics Society, 1974, Volume: 22, Issue:10

    Topics: Adult; Aged; Anticoagulants; Anxiety; Atrophy; Brain Diseases; Dementia; Dicumarol; Fear; Female; Ha

1974
Treatment of choreoathetotic movements in chronic liver disease with a dopamine-blocking agent. Pathophysiologic implications.
    Confinia neurologica, 1971, Volume: 33, Issue:5

    Topics: Aged; Basal Ganglia; Brain Diseases; Chorea; Dopamine; Electrocardiography; Electroencephalography;

1971
Lithium carbonate, haloperidol, and irreversible brain damage.
    JAMA, 1974, Dec-02, Volume: 230, Issue:9

    Topics: Acute Disease; Adult; Bipolar Disorder; Brain; Brain Diseases; Carbonates; Chronic Disease; Consciou

1974
[Pathomorphologic changes in the brain during long-term combined administration of lysergamide (LSD-25) and haloperidol (experimental morphologic study) s].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1971, Volume: 71, Issue:2

    Topics: Animals; Brain Diseases; Cerebral Cortex; DNA; Haloperidol; Histocytochemistry; Hypothalamus; Lyserg

1971
[On the treatment of psycopath-like states in children with psychotropic drugs after infectious and traumatic disorders of the central nervous system].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1967, Volume: 67, Issue:10

    Topics: Adolescent; Antidepressive Agents; Antisocial Personality Disorder; Brain Diseases; Brain Injuries;

1967