Page last updated: 2024-10-28

haloperidol and Autism

haloperidol has been researched along with Autism in 52 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Research Excerpts

ExcerptRelevanceReference
"The aim of the study was to investigate safety, efficacy and tolerability of risperidone in comparison with haloperidol in the long-term treatment of autistic disorder."9.13Comparison of long-term efficacy and safety of risperidone and haloperidol in children and adolescents with autistic disorder. An open label maintenance study. ( Baykara, A; Baykara, B; Dirik, E; Emiroglu, FN; Gencer, O; Miral, S, 2008)
"The ABC-C and the Childhood Autism Rating Scale scores improved with cyproheptadine."9.11Cyproheptadine in the treatment of autistic disorder: a double-blind placebo-controlled trial. ( Akhondzadeh, S; Amini, H; Erfani, S; Gudarzi, SS; Mohammadi, MR; Tehrani-Doost, M; Yasamy, MT, 2004)
"Clomipramine, haloperidol, and placebo were compared with baseline in the treatment of autism, and overall outcome, specific symptoms, and side effects were examined."9.09Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study. ( Gow, R; Konstantareas, M; Parker, K; Remington, G; Sloman, L, 2001)
"The findings suggest that olanzapine is a promising treatment for children with autistic disorder."9.09Olanzapine versus haloperidol in children with autistic disorder: an open pilot study. ( Cater, J; Choudhury, MS; Delaney, MA; Malone, RP; Sheikh, RM, 2001)
"The aim of the study was to investigate safety, efficacy and tolerability of risperidone in comparison with haloperidol in the long-term treatment of autistic disorder."5.13Comparison of long-term efficacy and safety of risperidone and haloperidol in children and adolescents with autistic disorder. An open label maintenance study. ( Baykara, A; Baykara, B; Dirik, E; Emiroglu, FN; Gencer, O; Miral, S, 2008)
"The ABC-C and the Childhood Autism Rating Scale scores improved with cyproheptadine."5.11Cyproheptadine in the treatment of autistic disorder: a double-blind placebo-controlled trial. ( Akhondzadeh, S; Amini, H; Erfani, S; Gudarzi, SS; Mohammadi, MR; Tehrani-Doost, M; Yasamy, MT, 2004)
"Clomipramine, haloperidol, and placebo were compared with baseline in the treatment of autism, and overall outcome, specific symptoms, and side effects were examined."5.09Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study. ( Gow, R; Konstantareas, M; Parker, K; Remington, G; Sloman, L, 2001)
"The findings suggest that olanzapine is a promising treatment for children with autistic disorder."5.09Olanzapine versus haloperidol in children with autistic disorder: an open pilot study. ( Cater, J; Choudhury, MS; Delaney, MA; Malone, RP; Sheikh, RM, 2001)
" We assessed the relationship between pre- and perinatal complications and TD/WD in a sample of 118 children with autism who participated in an ongoing long-term prospective study of the efficacy and safety of haloperidol."3.69Haloperidol-related dyskinesias and pre- and perinatal complications in autistic children. ( Adams, PB; Armenteros, JL; Campbell, M; Eisenberg, ZW, 1995)
"The long-term effects of haloperidol on weight were assessed in 30 children, 25 males and 5 females, diagnosed with autistic disorder whose ages ranged from 3."3.68Haloperidol withdrawal and weight changes in autistic children. ( Anderson, LT; Campbell, M; Malone, RP; Shay, J; Silva, RR, 1993)
"Haloperidol was shown to be a powerful therapeutic agent when administered for 4 weeks and free of side effects; at doses ranging from 0."2.66The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children. ( Adams, P; Anderson, LT; Campbell, M; Perry, R; Shell, J; Small, AM, 1989)
"Bilateral intraocular pressures were monitored before and after the first 7 ECTs and intermittently after ECT for 10 months of maintenance ECT."1.40Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy. ( Reti, IM; Wachtel, LE; Ying, H, 2014)
"Subjects were children with autism requiring pharmacotherapy for target symptoms."1.30Neuroleptic-related dyskinesias in autistic children: a prospective, longitudinal study. ( Adams, PB; Armenteros, JL; Campbell, M; Eisenberg, ZW; Malone, RP; Overall, JE, 1997)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-199026 (50.00)18.7374
1990's15 (28.85)18.2507
2000's8 (15.38)29.6817
2010's2 (3.85)24.3611
2020's1 (1.92)2.80

Authors

AuthorsStudies
Syamkumar, S1
Dossetor, D1
Wachtel, LE1
Reti, IM1
Ying, H1
Nakamae, T1
Ribeiro, KM1
Assumpção, FB1
Valente, KD1
Akhondzadeh, S1
Erfani, S1
Mohammadi, MR1
Tehrani-Doost, M1
Amini, H1
Gudarzi, SS1
Yasamy, MT1
Nilsson, M1
Carlsson, A1
Markinhuhta, KR1
Sonesson, C1
Pettersson, F1
Gullme, M1
Carlsson, ML1
Strawn, JR1
Keck, PE1
Gencer, O1
Emiroglu, FN1
Miral, S1
Baykara, B1
Baykara, A1
Dirik, E1
Realmuto, GM1
Main, B1
Campbell, M20
Anderson, LT8
Deutsch, SI4
Green, WH6
Grega, DM1
Perry, R8
Small, AM9
Caplan, R1
Cohen, IL3
Posner, D2
Triebel, D1
Armenteros, JL2
Adams, PB3
Eisenberg, ZW2
Sanchez, LE1
Uysal, S1
Hallin, A1
Minderaa, RB3
Anderson, GM3
Volkmar, FR3
Akkerhuis, GW2
Cohen, DJ4
Ernst, M2
Devi, L1
Silva, RR2
Gonzalez, NM1
Malone, RP6
Shay, J1
Brasić, JR1
Barnett, JY1
Overall, JE4
Kobayashi, R1
Kurita, H1
Remington, G1
Sloman, L1
Konstantareas, M1
Parker, K1
Gow, R1
Cater, J1
Sheikh, RM1
Choudhury, MS1
Delaney, MA1
Heath, A1
Meier, M2
Samit, C1
Sachar, EJ1
Hoshino, Y1
Yashima, Y1
Ishige, K1
Kaneko, M1
Kumashiro, H1
Johnson, WT1
Caparulo, BK1
Stárková, L1
Wiedermann, J1
Wong, SE1
Floyd, J1
Innocent, AJ1
Woolsey, JE1
Locascio, JJ2
Kafantaris, V2
Lynch, NS1
Ghaziuddin, M1
Tsai, LY1
Ghaziuddin, N1
Choroco, MC1
Spencer, EK3
Littlejohns, CS1
Clarke, DJ1
Corbett, JA1
Meiselas, KD1
Oberfield, R1
Peselow, ED1
Angrist, B1
Fisher, W1
Piazza, CC1
Page, TJ1
Adams, P2
Shell, J1
Harcherick, D1
McDaniel, KD1
Poland, RE1
Rubin, RT1
Lynch, N1
Curren, EL1
Nobler, MS1
van Engeland, H1
Freedman, DX1
Hoder, EL1
McPhedran, P1
Hansen, CR1
Young, JG1
Milstoc, M1
Platovsky, G1
Wolsky, BB1
Die Trill, ML1
Meiselas, K1
Golden, RR1
Ornitz, EM1
Sandyk, R1
Faretra, G1
Dooher, L1
Dowling, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Galantamine Versus Placebo in Childhood Autism[NCT00252603]Phase 320 participants Interventional2004-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for haloperidol and Autism

ArticleYear
[Diversity of obsessive-compulsive disorder and pharmacotherapy associated with obsessive-compulsive spectrum disorders].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2011, Volume: 113, Issue:10

    Topics: Antipsychotic Agents; Autistic Disorder; Body Dysmorphic Disorders; Clomipramine; Comorbidity; Disru

2011
Psychiatric drug treatment in children.
    The Journal of the Maine Medical Association, 1979, Volume: 70, Issue:5

    Topics: Adolescent; Amphetamines; Antipsychotic Agents; Anxiety; Autistic Disorder; Behavior Therapy; Child;

1979

Trials

13 trials available for haloperidol and Autism

ArticleYear
Cyproheptadine in the treatment of autistic disorder: a double-blind placebo-controlled trial.
    Journal of clinical pharmacy and therapeutics, 2004, Volume: 29, Issue:2

    Topics: Autistic Disorder; Basal Ganglia Diseases; Child; Child, Preschool; Cyproheptadine; Double-Blind Met

2004
Comparison of long-term efficacy and safety of risperidone and haloperidol in children and adolescents with autistic disorder. An open label maintenance study.
    European child & adolescent psychiatry, 2008, Volume: 17, Issue:4

    Topics: Adolescent; Adolescent Behavior; Antipsychotic Agents; Autistic Disorder; Child; Child Behavior; Dos

2008
Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms.
    The American journal of psychiatry, 1984, Volume: 141, Issue:10

    Topics: Autistic Disorder; Child; Child, Preschool; Clinical Trials as Topic; Discrimination Learning; Doubl

1984
The effects of haloperidol on learning and behavior in autistic children.
    Journal of autism and developmental disorders, 1982, Volume: 12, Issue:2

    Topics: Autistic Disorder; Child; Child Behavior; Child, Preschool; Discrimination Learning; Double-Blind Me

1982
A comparison of live and videotape ratings: clomipramine and haloperidol in autism.
    Psychopharmacology bulletin, 1995, Volume: 31, Issue:2

    Topics: Autistic Disorder; Child; Child, Preschool; Clomipramine; Double-Blind Method; Female; Haloperidol;

1995
Plasma beta-endorphin levels, naltrexone, and haloperidol in autistic children.
    Psychopharmacology bulletin, 1993, Volume: 29, Issue:2

    Topics: Autistic Disorder; beta-Endorphin; Child; Child, Preschool; Double-Blind Method; Female; Haloperidol

1993
Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study.
    Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Autistic Disorder; Basal

2001
Olanzapine versus haloperidol in children with autistic disorder: an open pilot study.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2001, Volume: 40, Issue:8

    Topics: Antipsychotic Agents; Autistic Disorder; Benzodiazepines; Child; Child Development Disorders, Pervas

2001
A comparison of haloperidol and behavior therapy and their interaction in autistic children.
    Journal of the American Academy of Child Psychiatry, 1978,Autumn, Volume: 17, Issue:4

    Topics: Autistic Disorder; Behavior Therapy; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind

1978
A comparison of haloperidol, behavior therapy, and their interaction in autistic children [proceedings].
    Psychopharmacology bulletin, 1979, Volume: 15, Issue:2

    Topics: Autistic Disorder; Behavior Therapy; Child; Child, Preschool; Clinical Trials as Topic; Female; Halo

1979
The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children.
    Journal of autism and developmental disorders, 1989, Volume: 19, Issue:2

    Topics: Autistic Disorder; Child, Preschool; Clinical Trials as Topic; Discrimination Learning; Double-Blind

1989
Neuroleptic-related dyskinesias in autistic children: a prospective study.
    Psychopharmacology bulletin, 1985, Volume: 21, Issue:1

    Topics: Autistic Disorder; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Dyskinesi

1985
Should autistic children be treated with haloperidol?
    The American journal of psychiatry, 1985, Volume: 142, Issue:7

    Topics: Autistic Disorder; Child; Clinical Trials as Topic; Dyskinesia, Drug-Induced; Haloperidol; Hospitali

1985

Other Studies

37 other studies available for haloperidol and Autism

ArticleYear
Severe movement disorder and psychosis from haloperidol withdrawal in a 7-year-old girl with autism.
    Journal of paediatrics and child health, 2021, Volume: 57, Issue:2

    Topics: Antipsychotic Agents; Autistic Disorder; Child; Female; Haloperidol; Humans; Movement Disorders; Psy

2021
Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy.
    The journal of ECT, 2014, Volume: 30, Issue:1

    Topics: Aggression; Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Child; Electroconvulsive Thera

2014
[Landau-Kleffner and autistic regression: the importance of differential diagnosis].
    Arquivos de neuro-psiquiatria, 2002, Volume: 60, Issue:3-B

    Topics: Anticonvulsants; Autistic Disorder; Child, Preschool; Diagnosis, Differential; Electroencephalograph

2002
The dopaminergic stabiliser ACR16 counteracts the behavioural primitivization induced by the NMDA receptor antagonist MK-801 in mice: implications for cognition.
    Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:4

    Topics: Animals; Autistic Disorder; Behavior, Animal; Cognition; Dizocilpine Maleate; Dopamine Antagonists;

2004
Risperidone: new indication. Behavioural disorders in children with autism or mental disabilities: no progress.
    Prescrire international, 2006, Volume: 15, Issue:82

    Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Child; Child Behavior Disorders; Child, Prescho

2006
Early bicarbonate loading and dantroline for ziprasidone/haloperidol-induced neuroleptic malignant syndrome.
    The Journal of clinical psychiatry, 2006, Volume: 67, Issue:4

    Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Combined Modality Therapy; Dantrolene; Disrupti

2006
Coincidence of Tourette's disorder and infantile autism.
    Journal of autism and developmental disorders, 1982, Volume: 12, Issue:4

    Topics: Adolescent; Autistic Disorder; Dopamine; Haloperidol; Humans; Male; Neurotransmitter Agents; Tourett

1982
Psychopharmacological treatment of children with the syndrome of autism.
    Pediatric annals, 1984, Volume: 13, Issue:4

    Topics: Amphetamines; Antipsychotic Agents; Autistic Disorder; Child; Child, Preschool; Haloperidol; Humans;

1984
Behavioral effects of haloperidol in young autistic children. An objective analysis using a within-subjects reversal design.
    Journal of the American Academy of Child Psychiatry, 1980,Autumn, Volume: 19, Issue:4

    Topics: Autistic Disorder; Child; Child, Preschool; Female; Haloperidol; Humans; Male

1980
A study of haloperidol in young autistic children: a within-subjects design using objective rating scales.
    Psychopharmacology bulletin, 1980, Volume: 16, Issue:3

    Topics: Autistic Disorder; Child; Child, Preschool; Double-Blind Method; Female; Haloperidol; Humans; Male;

1980
Haloperidol-related dyskinesias and pre- and perinatal complications in autistic children.
    Psychopharmacology bulletin, 1995, Volume: 31, Issue:2

    Topics: Autistic Disorder; Child; Child, Preschool; Diagnosis, Differential; Dyskinesia, Drug-Induced; Femal

1995
Noradrenergic and adrenergic functioning in autism.
    Biological psychiatry, 1994, Aug-15, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Autistic Disorder; Brain; Child; Epinephrine; Female; Haloperido

1994
Haloperidol withdrawal and weight changes in autistic children.
    Psychopharmacology bulletin, 1993, Volume: 29, Issue:2

    Topics: Autistic Disorder; Body Weight; Child; Child, Preschool; Female; Haloperidol; Humans; Male; Prospect

1993
Hyperkinesias in a prepubertal boy with autistic disorder treated with haloperidol and valproic acid.
    Psychological reports, 1997, Volume: 80, Issue:1

    Topics: Anti-Dyskinesia Agents; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autistic Dis

1997
Neuroleptic-related dyskinesias in autistic children: a prospective, longitudinal study.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1997, Volume: 36, Issue:6

    Topics: Antipsychotic Agents; Autistic Disorder; Child; Child, Preschool; Dyskinesia, Drug-Induced; Female;

1997
Perception metamorphosis phenomenon in autism.
    Psychiatry and clinical neurosciences, 1998, Volume: 52, Issue:6

    Topics: Adolescent; Auditory Perception; Autistic Disorder; Female; Haloperidol; Humans; Intellectual Disabi

1998
Brief report: delusional disorder in a male adolescent with high-functioning PDDNOS.
    Journal of autism and developmental disorders, 1999, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Antipsychotic Agents; Autistic Disorder; Child Development Disorders, Pervasive;

1999
Effects of small doses of haloperidol on autistic children.
    Fukushima journal of medical science, 1979, Volume: 26, Issue:1-2

    Topics: Autistic Disorder; Child, Preschool; Female; Haloperidol; Humans; Intellectual Disability; Male

1979
Pica and elevated blood lead level in autistic and atypical children.
    American journal of diseases of children (1960), 1976, Volume: 130, Issue:1

    Topics: Adolescent; Autistic Disorder; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Dimercaprol; E

1976
Our experience with incisive neuroleptic drugs in child psychiatry.
    Acta Universitatis Palackianae Olomucensis Facultatis Medicae, 1991, Volume: 131

    Topics: Antipsychotic Agents; Autistic Disorder; Child; Haloperidol; Humans; Mental Disorders; Obsessive-Com

1991
Applying a DRO schedule and compliance training to reduce aggressive and self-injurious behavior in an autistic man: a case report.
    Journal of behavior therapy and experimental psychiatry, 1991, Volume: 22, Issue:4

    Topics: Adult; Aggression; Autistic Disorder; Behavior Therapy; Carbamazepine; Combined Modality Therapy; Ha

1991
Factors related to haloperidol response and dyskinesias in autistic children.
    Psychopharmacology bulletin, 1991, Volume: 27, Issue:2

    Topics: Autistic Disorder; Child, Preschool; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Infant;

1991
Brief report: haloperidol treatment of trichotillomania in a boy with autism and mental retardation.
    Journal of autism and developmental disorders, 1991, Volume: 21, Issue:3

    Topics: Autistic Disorder; Child; Dose-Response Relationship, Drug; Education of Intellectually Disabled; Ha

1991
Stereotypies and tardive dyskinesia: abnormal movements in autistic children.
    Psychopharmacology bulletin, 1990, Volume: 26, Issue:2

    Topics: Adolescent; Autistic Disorder; Child, Preschool; Dyskinesia, Drug-Induced; Haloperidol; Humans; Infa

1990
Tourette-like disorder in Asperger's syndrome.
    The British journal of psychiatry : the journal of mental science, 1990, Volume: 156

    Topics: Adolescent; Autistic Disorder; Female; Haloperidol; Humans; Male; Pregnancy; Prenatal Exposure Delay

1990
Differentiation of stereotypies from neuroleptic-related dyskinesias in autistic children.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:3

    Topics: Autistic Disorder; Blinking; Child; Child, Preschool; Diagnosis, Differential; Dyskinesia, Drug-Indu

1989
Assessing independent and interactive effects of behavioral and pharmacologic interventions for a client with dual diagnoses.
    Journal of behavior therapy and experimental psychiatry, 1989, Volume: 20, Issue:3

    Topics: Autistic Disorder; Behavior Therapy; Child; Combined Modality Therapy; Follow-Up Studies; Hallucinat

1989
Whole blood serotonin and tryptophan in autism: temporal stability and the effects of medication.
    Journal of autism and developmental disorders, 1989, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Autistic Disorder; Female; Haloperidol; Humans; Male; Phenothiaz

1989
Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 2).
    Clinical pediatrics, 1986, Volume: 25, Issue:3

    Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Benzodiazepines; Child; Chlorpromazine; Haloper

1986
Plasma growth hormone response to insulin-induced hypoglycemia in infantile autism: a pilot study.
    Journal of autism and developmental disorders, 1986, Volume: 16, Issue:1

    Topics: Autistic Disorder; Child, Preschool; Female; Growth Hormone; Haloperidol; Humans; Hypoglycemia; Hypo

1986
Long-term efficacy of haloperidol in autistic children: continuous versus discontinuous drug administration.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1989, Volume: 28, Issue:1

    Topics: Autistic Disorder; Child; Child, Preschool; Drug Administration Schedule; Dyskinesia, Drug-Induced;

1989
Tourette-like symptoms associated with neuroleptic therapy in an autistic child.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1989, Volume: 28, Issue:1

    Topics: Autistic Disorder; Child, Preschool; Diagnosis, Differential; Dyskinesia, Drug-Induced; Haloperidol;

1989
[Current developments in the treatment of autistic children].
    Nederlands tijdschrift voor geneeskunde, 1989, Feb-04, Volume: 133, Issue:5

    Topics: Autistic Disorder; Behavior Therapy; Child; Child Development; Haloperidol; Humans; Psychotherapy

1989
Whole blood serotonin in autistic and normal subjects.
    Journal of child psychology and psychiatry, and allied disciplines, 1987, Volume: 28, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Autistic Disorder; Blood Platelets; Child; Child, Preschool; Chr

1987
Cholinesterase activities in blood in infantile autism.
    Biological psychiatry, 1987, Volume: 22, Issue:2

    Topics: Acetylcholinesterase; Autistic Disorder; Butyrylcholinesterase; Cholinesterases; Erythrocytes; Femal

1987
Further speculations on possible dopamine-opioid link in autism.
    Journal of autism and developmental disorders, 1986, Volume: 16, Issue:1

    Topics: Autistic Disorder; Dopamine; Endorphins; Haloperidol; Humans

1986
Comparison of haloperidol and fluphenazine in disturbed children.
    The American journal of psychiatry, 1970, Volume: 126, Issue:11

    Topics: Aggression; Anxiety; Autistic Disorder; Child; Child, Preschool; Female; Fluphenazine; Haloperidol;

1970