haloperidol has been researched along with Astrocytoma, Grade IV in 5 studies
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Temozolomide resistance remains a major obstacle in the treatment of glioblastoma (GBM)." | 8.31 | The DRD2 Antagonist Haloperidol Mediates Autophagy-Induced Ferroptosis to Increase Temozolomide Sensitivity by Promoting Endoplasmic Reticulum Stress in Glioblastoma. ( Chen, H; Chen, K; Chen, L; Huang, A; Huang, Y; Li, C; Li, H; Lu, Y; Qi, S; Shi, L; Song, C; Wang, T; Zhong, C, 2023) |
| "Temozolomide (TMZ) has been the first-line chemotherapeutic agent used, although to achieve a satisfactory clinical effect." | 5.51 | Synergistic Suppression of Glioblastoma Cell Growth by Combined Application of Temozolomide and Dopamine D2 Receptor Antagonists. ( Gao, L; Huang, X; Jiang, X; Li, J; Liu, X; Liu, Z; Zeng, T, 2019) |
| "Temozolomide resistance remains a major obstacle in the treatment of glioblastoma (GBM)." | 4.31 | The DRD2 Antagonist Haloperidol Mediates Autophagy-Induced Ferroptosis to Increase Temozolomide Sensitivity by Promoting Endoplasmic Reticulum Stress in Glioblastoma. ( Chen, H; Chen, K; Chen, L; Huang, A; Huang, Y; Li, C; Li, H; Lu, Y; Qi, S; Shi, L; Song, C; Wang, T; Zhong, C, 2023) |
| "Glioblastoma multiforme is the most common malignant primary brain tumor in adults." | 1.72 | Antitumor Effect of Traditional Drugs for Neurological Disorders: Preliminary Studies in Neural Tumor Cell Lines. ( Doello, K; Mesas, C; Ortiz, R; Perazzoli, G; Quiñonero, F; Rama, AR; Vélez, C, 2022) |
| "Temozolomide (TMZ) has been the first-line chemotherapeutic agent used, although to achieve a satisfactory clinical effect." | 1.51 | Synergistic Suppression of Glioblastoma Cell Growth by Combined Application of Temozolomide and Dopamine D2 Receptor Antagonists. ( Gao, L; Huang, X; Jiang, X; Li, J; Liu, X; Liu, Z; Zeng, T, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doello, K | 3 |
| Mesas, C | 3 |
| Quiñonero, F | 3 |
| Rama, AR | 3 |
| Vélez, C | 3 |
| Perazzoli, G | 3 |
| Ortiz, R | 3 |
| Shi, L | 1 |
| Chen, H | 1 |
| Chen, K | 1 |
| Zhong, C | 1 |
| Song, C | 1 |
| Huang, Y | 1 |
| Wang, T | 1 |
| Chen, L | 1 |
| Li, C | 1 |
| Huang, A | 1 |
| Qi, S | 1 |
| Li, H | 1 |
| Lu, Y | 1 |
| Liu, Z | 1 |
| Jiang, X | 1 |
| Gao, L | 1 |
| Liu, X | 1 |
| Li, J | 1 |
| Huang, X | 1 |
| Zeng, T | 1 |
| Golan, M | 1 |
| Schreiber, G | 1 |
| Avissar, S | 1 |
| Vilner, BJ | 1 |
| John, CS | 1 |
| Bowen, WD | 1 |
5 other studies available for haloperidol and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Antitumor Effect of Traditional Drugs for Neurological Disorders: Preliminary Studies in Neural Tumor Cell Lines.
Topics: Adult; Apoptosis; Biperiden; Brain Neoplasms; Cell Line, Tumor; Dextromethorphan; Fingolimod Hydroch | 2022 |
Antitumor Effect of Traditional Drugs for Neurological Disorders: Preliminary Studies in Neural Tumor Cell Lines.
Topics: Adult; Apoptosis; Biperiden; Brain Neoplasms; Cell Line, Tumor; Dextromethorphan; Fingolimod Hydroch | 2022 |
Antitumor Effect of Traditional Drugs for Neurological Disorders: Preliminary Studies in Neural Tumor Cell Lines.
Topics: Adult; Apoptosis; Biperiden; Brain Neoplasms; Cell Line, Tumor; Dextromethorphan; Fingolimod Hydroch | 2022 |
Antitumor Effect of Traditional Drugs for Neurological Disorders: Preliminary Studies in Neural Tumor Cell Lines.
Topics: Adult; Apoptosis; Biperiden; Brain Neoplasms; Cell Line, Tumor; Dextromethorphan; Fingolimod Hydroch | 2022 |
The DRD2 Antagonist Haloperidol Mediates Autophagy-Induced Ferroptosis to Increase Temozolomide Sensitivity by Promoting Endoplasmic Reticulum Stress in Glioblastoma.
Topics: Autophagy; Brain Neoplasms; Cell Line, Tumor; Dopamine D2 Receptor Antagonists; Drug Resistance, Neo | 2023 |
Synergistic Suppression of Glioblastoma Cell Growth by Combined Application of Temozolomide and Dopamine D2 Receptor Antagonists.
Topics: Animals; Antineoplastic Agents, Alkylating; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proli | 2019 |
Antidepressants elevate GDNF expression and release from C₆ glioma cells in a β-arrestin1-dependent, CREB interactive pathway.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents | 2011 |
Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.
Topics: Adenocarcinoma; Animals; Binding, Competitive; Breast Neoplasms; Carcinoma, Ductal, Breast; Glioblas | 1995 |