Page last updated: 2024-10-28

haloperidol and Aging

haloperidol has been researched along with Aging in 127 studies

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Practice guidelines recommend the use of low dose haloperidol when medication is needed to treat delirium with acute agitation in hospitalized older people."7.79Haloperidol overdosing in the treatment of agitated hospitalized older people with delirium: a retrospective chart review from a community teaching hospital. ( Dorokhine, I; Knapp, CM; Musuku, M; Patel, N; Zirker, W, 2013)
"The aim of the study was to examine the influence of hyperprolactinemia, induced by haloperidol (HAL) on age related morphology and function changes of epithelial cells in rat prostate lateral lobe."7.72Aging process of epithelial cells of the rat prostate lateral lobe in experimental hyperprolactinemia induced by haloperidol. ( Laszczyńska, M; Piasecka, M; Słuczanowska-Glabowska, S; Wylot, M, 2004)
"In haloperidol-induced catalepsy in rats (1."5.30Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders. ( Cohen, S; Levy, R; Speiser, Z, 1998)
"Haloperidol treatment (2 hours) accelerated striatal DA turnover similarly in all age groups, by about 100%."5.26Aging and haloperidol-induced dopamine turnover in the nigro-striatal pathway of C57BL/6J mice. ( Finch, CE; Osterburg, HH; Severson, JA, 1981)
" Recent studies suggest that aging may be associated with epigenetic changes and that valproic acid (VPA), a histone deacetylase inhibitor, may reverse such changes."3.80HDAC inhibitors restore the capacity of aged mice to respond to haloperidol through modulation of histone acetylation. ( Csernansky, JG; Dong, H; Fang, D; Gallardo, C; Gerst, N; Keegan, J; Matsumoto, M; Montalvo-Ortiz, JL; Tetsuka, K; Tucker, C, 2014)
"Practice guidelines recommend the use of low dose haloperidol when medication is needed to treat delirium with acute agitation in hospitalized older people."3.79Haloperidol overdosing in the treatment of agitated hospitalized older people with delirium: a retrospective chart review from a community teaching hospital. ( Dorokhine, I; Knapp, CM; Musuku, M; Patel, N; Zirker, W, 2013)
"The aim of the study was to examine the influence of hyperprolactinemia, induced by haloperidol (HAL) on age related morphology and function changes of epithelial cells in rat prostate lateral lobe."3.72Aging process of epithelial cells of the rat prostate lateral lobe in experimental hyperprolactinemia induced by haloperidol. ( Laszczyńska, M; Piasecka, M; Słuczanowska-Glabowska, S; Wylot, M, 2004)
"Olanzapine treated subjects showed reduced day 4 deficit (compared with day 1), with no significant difference from placebo beyond 6 h post dose."2.69A comparison of the effects of olanzapine, haloperidol and placebo on cognitive and psychomotor functions in healthy elderly volunteers. ( Beuzen, JN; Taylor, N; Wesnes, K; Wood, A, 1999)
"These results suggest that epigenetic changes at the striatal Drd2 promoter drive age-related increases in antipsychotic side effect susceptibility, and HDAC inhibitors may be an effective adjunct treatment strategy to reduce side effects in aged populations."1.46Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice. ( Csernansky, JG; Dong, H; Fang, D; Fisher, DW; Montalvo-Ortiz, JL; Rodríguez, G, 2017)
"Animal work on the behavioral effects of antipsychotic treatment suggests that different dosing regimens could affect drug sensitivity differently, with an intermittent treatment regimen tending to cause a sensitization effect, while a continuous treatment causing a tolerance."1.40Differential effects of intermittent versus continuous haloperidol treatment throughout adolescence on haloperidol sensitization and social behavior in adulthood. ( Gao, J; Li, M, 2014)
"Catalepsy was measured using the bar test."1.39Somatostatin antagonist induces catalepsy in the aged rat. ( Ionov, ID; Pushinskaya, II, 2013)
"In rodents and dog, histamine induces catalepsy, a dopamine-dependent phenomenon that resembles the extrapyramidal signs of Parkinson's disease (PD)."1.38Histamine- and haloperidol-induced catalepsy in aged mice: differential responsiveness to L-DOPA. ( Ionov, ID; Severtsev, NN, 2012)
"Catalepsy was measured using the bar test."1.38Somatostatin antagonist potentiates haloperidol-induced catalepsy in the aged rat. ( Ionov, ID; Severtsev, NN, 2012)
"Both haloperidol and clozapine produced catalepsy and haloperidol decreased locomotion in shipped and bred rats of both sexes, with sensitization to haloperidol-induced catalepsy developing with repeated dosing."1.35To breed or not to breed? Empirical evaluation of drug effects in adolescent rats. ( Evans, RL; Wiley, JL, 2009)
" Subsequently, in order to determine whether tolerance to the activity suppressive effects of these drugs would occur in adolescents, PN40 rats were dosed and assessed for an additional nine days."1.35Antipsychotic-induced suppression of locomotion in juvenile, adolescent and adult rats. ( Wiley, JL, 2008)
"Haloperidol did not increase NT/NN mRNA expression in the nucleus accumbens until postnatal day 15 and did not increase NT concentrations in this brain region until postnatal day 21."1.31The effects of acute antipsychotic drug administration on the neurotensin system of the developing rat brain. ( Kinkead, B; Nemeroff, CB; Owens, MJ, 2000)
"In haloperidol-induced catalepsy in rats (1."1.30Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders. ( Cohen, S; Levy, R; Speiser, Z, 1998)
" Eighteen-day-old rats were 35% and 63% more sensitive than adults to the effects of haloperidol on striatal and accumbens turnover and had steeper dose-response curves."1.29Developmental differences in acute nigrostriatal and mesocorticolimbic system response to haloperidol. ( Baldessarini, RJ; Barber, NI; Campbell, A; Gallitano, AL; Gelbard, HA; Marsh, E; Teicher, MH, 1993)
" Animals that were lesioned and treated with haloperidol chronically had longer durations of catalepsy at the first two dose-response determinations."1.29Partial 6-hydroxydopamine-induced lesions and haloperidol-induced catalepsy. ( Fisher, H; Johnson, SK; Wagner, GC, 1993)
"Catalepsy was measured by the bar test."1.28Effects of age and isolation on the evolution of catalepsy during chronic haloperidol treatment. ( Frussa-Filho, R; Otoboni, JR; Palermo-Neto, J; Uema, FT, 1992)
"In haloperidol-treated rats, unlike naive animals, activation of neostriatal D2 dopamine receptors induced a potent presynaptic inhibition of glutamate-mediated excitatory synaptic potentials."1.28Chronic neuroleptic treatment: D2 dopamine receptor supersensitivity and striatal glutamatergic transmission. ( Bernardi, G; Calabresi, P; De Murtas, M; Mercuri, NB, 1992)
"When naloxone was added to apomorphine there was a peculiar effect: the duration of the immobility reflex was increased significantly in rats of 20 days and adults, but not in 10-day-old rats."1.28Ontogeny of the endorphinergic and dopaminergic modulation on the immobility reflex elicited by clamping in rats. ( de la Cruz, F; Junquera, J; Russek, M, 1990)
"Haloperidol blood levels were not correlated with the age of the patient."1.27Blood levels of haloperidol in schizophrenic patients. ( Dekirmenjian, H; Shvartsburd, A; Smith, RC, 1983)
"Similarly, catalepsy induced by (-)-sulpiride (40 mg/kg, i."1.27Influence of (-)-sulpiride and YM-09151-2 on stereotyped behavior in chicks and catalepsy in rats. ( Wambebe, C, 1987)
" Dose-response studies of catalepsy and ptosis were conducted in male Sprague-Dawley rats aged 30, 56, or 100 days."1.27Decreasing sensitivity to neuroleptic agents in developing rats; evidence for a pharmacodynamic factor. ( Baldessarini, RJ; Campbell, A; Teicher, MH, 1988)
"carbachol) were applied, but did not appear until 18 months when partial agonists (e."1.27Age-related decrements in the muscarinic enhancement of K+-evoked release of endogenous striatal dopamine: an indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence. ( Dalton, TK; Hunt, WA; Joseph, JA, 1988)
"The behavioral effect (catalepsy) of HAL was less in old than in young rats."1.27Reduced metabolic response of the aged rat brain to haloperidol. ( Holloway, HW; Pizzolato, G; Rapoport, SI; Soncrant, TT, 1985)
"Haloperidol was administered i."1.26Age effects on haloperidol pharmacokinetics in male, Fischer-344 rats. ( Kapetanovic, IM; Rapoport, SI; Sweeney, DJ, 1982)
"Haloperidol treatment (2 hours) accelerated striatal DA turnover similarly in all age groups, by about 100%."1.26Aging and haloperidol-induced dopamine turnover in the nigro-striatal pathway of C57BL/6J mice. ( Finch, CE; Osterburg, HH; Severson, JA, 1981)
"It is proposed that the decrement in catalepsy occurring between 10 and 15 days of age is related to increased dopaminergic activity in the neostriatum."1.26Dopaminergic antagonism and catalepsy in the developing rat. ( Baez, LA; Burt, DK; Granneman, J; Shanklin, C, 1979)

Research

Studies (127)

TimeframeStudies, this research(%)All Research%
pre-199059 (46.46)18.7374
1990's38 (29.92)18.2507
2000's16 (12.60)29.6817
2010's11 (8.66)24.3611
2020's3 (2.36)2.80

Authors

AuthorsStudies
Szocsics, P1
Papp, P1
Havas, L1
Lőke, J1
Maglóczky, Z1
Huang, H1
Zhang, B1
Zheng, S1
Li, C1
Zhu, X1
Wang, J1
Montalvo-Ortiz, JL2
Fisher, DW1
Rodríguez, G1
Fang, D2
Csernansky, JG2
Dong, H2
McDougall, SA2
Mohd-Yusof, A1
Kaplan, GJ1
Abdulla, ZI1
Lee, RJ1
Crawford, CA2
Zirker, W1
Dorokhine, I1
Knapp, CM1
Patel, N1
Musuku, M1
Labouesse, MA1
Stadlbauer, U1
Langhans, W1
Meyer, U1
Keegan, J1
Gallardo, C1
Gerst, N1
Tetsuka, K1
Tucker, C1
Matsumoto, M1
Gao, J1
Li, M1
Wiley, JL3
Kendler, SH1
Burston, JJ1
Howard, DR1
Selley, DE1
Sim-Selley, LJ1
Black, MD1
Varty, GB1
Arad, M1
Barak, S1
De Levie, A1
Boulay, D1
Pichat, P1
Griebel, G1
Weiner, I3
Evans, RL1
Wegener, N1
Koch, M1
Toua, C1
Brand, L1
Möller, M1
Emsley, RA1
Harvey, BH2
Der-Ghazarian, T1
Charntikov, S1
Varela, FA1
Ionov, ID3
Severtsev, NN2
Pushinskaya, II1
Zuckerman, L1
Rehavi, M1
Nachman, R1
Nel, A1
Ohara, K1
Shibuya, H1
Andreassen, OA1
Ferrante, RJ1
Aamo, TO1
Beal, MF1
Jørgensen, HA1
Wylot, M1
Laszczyńska, M1
Słuczanowska-Glabowska, S1
Piasecka, M1
Burchinsky, SG1
Petkov, VV2
Petkov, VD2
Grahovska, T1
Konstantinova, E2
Rivera-Calimlim, L1
Hershey, L1
Marquis, JK1
Lippa, AS1
Pelham, RW1
Lorden, JF2
McKeon, TW2
Baker, HJ1
Cox, N1
Walkley, SU2
Oltmans, GA1
Beales, M1
Joseph, JA3
Bartus, RT1
Clody, D1
Morgan, D1
Finch, C1
Beer, B1
Sesack, S1
Hill, HF1
Engblom, J1
Meyer, ME1
Smith, RL1
Van Hartesveldt, C1
Shapiro, AK1
Shapiro, E1
Sowers, JR1
Resch, G1
Walker, S1
Sollars, E1
Campbell, A3
Baldessarini, RJ3
Shvartsburd, A1
Dekirmenjian, H1
Smith, RC1
Kapetanovic, IM1
Sweeney, DJ1
Rapoport, SI2
Kohno, Y1
Tanaka, M1
Nakagawa, R1
Ida, Y1
Iimori, K1
Nagasaki, N1
Dugas, M2
Zarifian, E2
Le Heuzey, MF2
Regnier, N1
Durand, G2
Bianchetti, G2
Morselli, PL2
Algeri, S1
Achilli, G1
Cimino, M1
Perego, C1
Ponzio, F1
Vantini, G1
Roffman, M1
Cordasco, F1
Kling, A1
Randall, PK1
Severson, JA2
Finch, CE2
Rowell, FJ1
Hui, SM1
Fairbairn, AF1
Eccleston, D1
Osterburg, HH1
Marwaha, J1
Hoffer, B1
Pittman, R1
Freedman, R1
Memo, M1
Lucchi, L1
Spano, PF2
Trabucchi, M2
Bowyer, JF1
Henderson, MG1
McMillen, BA1
Lin, MY1
Walters, DE2
De Vries, TJ1
Jonker, AJ1
Voorn, P1
Mulder, AH1
Schoffelmeer, AN1
Soghomonian, JJ1
Teicher, MH2
Barber, NI1
Gelbard, HA1
Gallitano, AL1
Marsh, E1
Steinpreis, RE2
Salamone, JD1
Dobie, DJ3
Merchant, KM3
Hamblin, MW1
Vatassery, GT1
Dysken, MW1
Dorsa, DM3
Johnson, SK1
Fisher, H1
Wagner, GC1
Levin, ED1
Torry, D1
Matsumoto, RR1
Bowen, WD1
Walker, JM1
Patrick, SL1
Zambon, AC1
Vo, VN1
Truong, DD1
De Costa, BR1
Rice, KC1
Lau, SM2
Tang, F2
Efange, SM1
Langason, RB1
Khare, AB1
Schneider, JS1
Wong, DF1
Young, D1
Wilson, PD1
Meltzer, CC1
Gjedde, A1
Parret, F1
Summ, RM1
Panos, JJ1
Lipska, BK1
Weinberger, DR1
Suzuki, A1
Otani, K1
Mihara, K1
Yasui, N1
Kondo, T1
Tokinaga, N1
Furukori, H1
Kaneko, S1
Inoue, Y1
Hayashi, K1
Speiser, Z1
Levy, R1
Cohen, S1
Poeggeler, B1
Rassoulpour, A1
Guidetti, P1
Wu, HQ1
Schwarcz, R1
Garver, DL1
Nair, TR1
Christensen, JD1
Holcomb, J1
Ramberg, J1
Kingsbury, S1
Hildebrandt, K1
Teuchert-Noodt, G1
Dawirs, RR1
Beuzen, JN1
Taylor, N1
Wesnes, K1
Wood, A1
Wallace, DR1
Mactutus, CF1
Booze, RM1
Lu, CC1
Tsai, SC1
Chien, EJ1
Tsai, CL1
Wang, PS1
Kinkead, B1
Owens, MJ1
Nemeroff, CB1
Yao, JK1
Reddy, R1
van Kammen, DP1
Andorn, AC1
Pappolla, MA1
Baier, PC1
Winkelmann, J1
Höhne, A1
Lancel, M1
Trenkwalder, C1
Hudick, JP1
Wajda, IJ1
Lajtha, A1
Govoni, S1
Cheronis, JC1
Erinoff, L1
Heller, A1
Hoffmann, PC1
Berger, RE1
Engel, BT1
Roth, GS1
McLennan, IS1
Lees, GJ1
Gluckman, PD1
Marti-Henneberg, C1
Thomsett, MJ1
Kaplan, SL1
Rudolph, AM1
Grumbach, MM1
Baez, LA1
Burt, DK1
Granneman, J1
Shanklin, C1
Beasley, BA1
Ford, DH1
Frussa-Filho, R1
Otoboni, JR1
Uema, FT1
Palermo-Neto, J1
Calabresi, P1
De Murtas, M1
Mercuri, NB1
Bernardi, G1
Saija, A1
Princi, P1
Imperatore, C1
De Pasquale, R1
Costa, G1
Creese, I2
Sibley, DR1
Xu, SX1
Raskind, MA1
Jahromi, SS1
Niesen, C1
Carlen, PL1
Hoskins, B1
Peeler, DF1
Lawson, K1
Barnes, AM1
Ho, IK1
Trent, F1
Nakamura, S1
Tepper, JM1
Drucker-Colín, R1
García-Hernández, F1
Neal, BS1
Joyce, JN1
Sylvester, PW1
Briski, KP1
de la Cruz, F1
Russek, M1
Junquera, J1
Chapman, CD1
Howard, SG1
Becú-Villalobos, D1
Lacau-Mengido, IM1
Libertun, C1
Atterwill, CK1
Brown, CG1
Conybeare, G1
Holland, CW1
Jones, CA1
Agnati, LF1
Fuxe, K1
Giardino, L1
Calza, L1
Zoli, M1
Battistini, N1
Benfenati, F1
Vanderhaeghen, JJ1
Guidolin, D1
Ruggeri, M1
Zisook, S1
Braff, DL1
Fine, MI1
Masserano, JM1
Weiner, N1
Wambebe, C1
Dalton, TK1
Hunt, WA1
Norman, AB1
Battaglia, G1
Popova, J1
Kennes, D1
Odberg, FO1
Bouquet, Y1
De Rycke, PH1
Burchill, SA1
Thody, AJ1
Feldon, J1
Erenberg, G1
Cruse, RP1
Rothner, AD1
Demarest, KT2
Moore, KE2
Riegle, GD2
Westerink, BH1
Koolstra, W1
Scalzo, FM1
Spear, LP1
Aoba, A1
Kakita, Y1
Yamaguchi, N1
Shido, M1
Tsuneizumi, T1
Shibata, M1
Kitani, K1
Hasegawa, K1
Pizzolato, G1
Soncrant, TT1
Holloway, HW1
Gemperle, M1
de Groot, MH1
Sirtori, C1
Smith, GR1
Taylor, CW1
Walker, JB1
Walker, JP1
Vertua, R1
Furlani, A1
Smran, A1
Abdullah, M1
Ahmad, NA1
Alrahlah, A1
Al-Maflehi, N1
Samran, A1
Suskov, II1
Sazonova, LA1

Reviews

5 reviews available for haloperidol and Aging

ArticleYear
[Effect of factors on plasma haloperidol concentration/dose ratio].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2003, Volume: 23, Issue:4

    Topics: Aging; Antipsychotic Agents; Body Weight; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug;

2003
Neurotransmitter receptors in the central nervous system and aging: pharmacological aspect (review).
    Experimental gerontology, 1984, Volume: 19, Issue:4

    Topics: Adenylyl Cyclases; Aging; Animals; Brain; Desipramine; Dopamine; Dopamine Antagonists; Female; Fluph

1984
Neuroleptic concentrations and clinical response.
    Annual review of pharmacology and toxicology, 1984, Volume: 24

    Topics: Aging; Antipsychotic Agents; Chlorpromazine; Chronic Disease; Drug Interactions; Fluphenazine; Halop

1984
Aging and the extrapyramidal system.
    The Medical clinics of North America, 1976, Volume: 60, Issue:6

    Topics: Aged; Aging; Basal Ganglia Diseases; Chlorpromazine; Chorea; Dopamine; Frontal Lobe; Gait; Haloperid

1976
Expression of the proneurotensin gene in the rat brain and its regulation by antipsychotic drugs.
    Annals of the New York Academy of Sciences, 1992, Volume: 668

    Topics: Aging; Animals; Antipsychotic Agents; Brain; Caudate Nucleus; Cyclic AMP Response Element-Binding Pr

1992

Trials

3 trials available for haloperidol and Aging

ArticleYear
Effects of various factors including the CYP2D6 genotype and coadministration of flunitrazepam on the steady-state plasma concentrations of bromperidol and its reduced metabolite.
    Psychopharmacology, 1998, Volume: 135, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Anti-Anxiety Agents; Antipsychotic Agents; Biotransformation; Cytoch

1998
Atrophic and static (neurodevelopmental) schizophrenic psychoses: premorbid functioning, symptoms and neuroleptic response.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 21, Issue:1

    Topics: Adult; Aging; Alcohol Drinking; Algorithms; Antipsychotic Agents; Atrophy; Brain; Cerebral Ventricle

1999
A comparison of the effects of olanzapine, haloperidol and placebo on cognitive and psychomotor functions in healthy elderly volunteers.
    Journal of psychopharmacology (Oxford, England), 1999, Volume: 13, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Antipsychotic Agents; Attention; Benzodiazepines; Cognition; Cross-O

1999

Other Studies

119 other studies available for haloperidol and Aging

ArticleYear
Interhemispheric differences of pyramidal cells in the primary motor cortices of schizophrenia patients investigated postmortem.
    Cerebral cortex (New York, N.Y. : 1991), 2023, 06-20, Volume: 33, Issue:13

    Topics: Aged; Aged, 80 and over; Aging; Animals; Antipsychotic Agents; Autopsy; Datasets as Topic; Disease M

2023
The effects of aging and dopaminergic inhibition on large scale maze learning in rhesus monkeys.
    Brain research bulletin, 2021, Volume: 175

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Administration, Intravenous; Aging; Anim

2021
Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice.
    Psychopharmacology, 2017, Volume: 234, Issue:16

    Topics: Acetylation; Aging; Animals; Benzamides; Corpus Striatum; Dopamine Antagonists; Haloperidol; Histone

2017
Postnatal manganese exposure does not alter dopamine autoreceptor sensitivity in adult and adolescent male rats.
    European journal of pharmacology, 2013, Apr-15, Volume: 706, Issue:1-3

    Topics: Aging; Animals; Animals, Newborn; Apomorphine; Autoreceptors; Behavior, Animal; Corpus Striatum; Dop

2013
Haloperidol overdosing in the treatment of agitated hospitalized older people with delirium: a retrospective chart review from a community teaching hospital.
    Drugs & aging, 2013, Volume: 30, Issue:8

    Topics: Aged; Aged, 80 and over; Aging; Anti-Anxiety Agents; Delirium; Dopamine Antagonists; Dose-Response R

2013
Chronic high fat diet consumption impairs sensorimotor gating in mice.
    Psychoneuroendocrinology, 2013, Volume: 38, Issue:11

    Topics: Acoustic Stimulation; Aging; Animals; Diet, High-Fat; Dietary Fats; Dopamine Antagonists; Dopaminerg

2013
HDAC inhibitors restore the capacity of aged mice to respond to haloperidol through modulation of histone acetylation.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:6

    Topics: Acetylation; Aging; Animals; Avoidance Learning; Benzamides; Conditioning, Psychological; Dopamine A

2014
Differential effects of intermittent versus continuous haloperidol treatment throughout adolescence on haloperidol sensitization and social behavior in adulthood.
    Progress in neuro-psychopharmacology & biological psychiatry, 2014, Oct-03, Volume: 54

    Topics: Aging; Animals; Antipsychotic Agents; Avoidance Learning; Drug Delivery Systems; Haloperidol; Male;

2014
Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats.
    Neuropharmacology, 2008, Volume: 55, Issue:7

    Topics: Aging; Animals; Antipsychotic Agents; Cells, Cultured; CHO Cells; Clozapine; Cricetinae; Cricetulus;

2008
Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat.
    Psychopharmacology, 2009, Volume: 202, Issue:1-3

    Topics: Aging; Amphetamine; Animals; Animals, Newborn; Antipsychotic Agents; Benzamides; Central Nervous Sys

2009
To breed or not to breed? Empirical evaluation of drug effects in adolescent rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2009, Volume: 27, Issue:1

    Topics: Aging; Animals; Antipsychotic Agents; Breeding; Catalepsy; Clozapine; Dose-Response Relationship, Dr

2009
Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatment.
    Brain research, 2009, Feb-09, Volume: 1253

    Topics: Aging; Animals; Anxiety; Apomorphine; Behavior, Animal; Benzoxazines; Brain; Cannabinoids; Dopamine

2009
The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical N-methyl-D-aspartate and D1 receptor binding in rats.
    Neuroscience, 2010, Jan-20, Volume: 165, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dopam

2010
Effects of repeated and acute aripiprazole or haloperidol treatment on dopamine synthesis in the dorsal striatum of young rats: comparison to adult rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Antipsychotic Agents; Aripiprazole; Autoreceptors; Brain Chemistry

2010
Histamine- and haloperidol-induced catalepsy in aged mice: differential responsiveness to L-DOPA.
    Psychopharmacology, 2012, Volume: 223, Issue:2

    Topics: Aging; Animals; Antiparkinson Agents; Catalepsy; Disease Models, Animal; Dopamine; Dose-Response Rel

2012
Somatostatin antagonist potentiates haloperidol-induced catalepsy in the aged rat.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 103, Issue:2

    Topics: Aging; Animals; Antipsychotic Agents; Catalepsy; Drug Synergism; Haloperidol; Male; Rats; Rats, Wist

2012
Somatostatin antagonist induces catalepsy in the aged rat.
    Psychopharmacology, 2013, Volume: 227, Issue:2

    Topics: Age Factors; Aging; Animals; Brain; Catalepsy; Dose-Response Relationship, Drug; Haloperidol; Inject

2013
Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:10

    Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Clozapine; Corpus Striatum; Disease

2003
Role of aging and striatal nitric oxide synthase activity in an animal model of tardive dyskinesia.
    Brain research bulletin, 2003, Aug-30, Volume: 61, Issue:4

    Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Comorbidity; Corpus Striatum; Disease Models

2003
Oral dyskinesias and histopathological alterations in substantia nigra after long-term haloperidol treatment of old rats.
    Neuroscience, 2003, Volume: 122, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Drug Adm

2003
Aging process of epithelial cells of the rat prostate lateral lobe in experimental hyperprolactinemia induced by haloperidol.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 2004, Volume: 49 Suppl 1

    Topics: Aging; Animals; Disease Models, Animal; Epithelial Cells; Haloperidol; Hyperprolactinemia; Male; Pro

2004
Antipsychotic-induced suppression of locomotion in juvenile, adolescent and adult rats.
    European journal of pharmacology, 2008, Jan-14, Volume: 578, Issue:2-3

    Topics: Age Factors; Aging; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relati

2008
Enkephalin receptor changes in rat brain during aging.
    General pharmacology, 1984, Volume: 15, Issue:6

    Topics: Aging; Animals; Cerebral Cortex; Corpus Striatum; Haloperidol; Hypothalamus; Levodopa; Male; Rats; R

1984
Dopamine receptor alterations with aging in mouse and rat corpus striatum.
    Biochemical pharmacology, 1981, Jul-01, Volume: 30, Issue:13

    Topics: Aging; Animals; Corpus Striatum; Dopamine; Haloperidol; In Vitro Techniques; Kinetics; Male; Mice; R

1981
Characterization of the rat mutant dystonic (dt): a new animal model of dystonia musculorum deformans.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1984, Volume: 4, Issue:8

    Topics: Aging; Animals; Apomorphine; Brain Chemistry; Disease Models, Animal; Dopamine; Dystonia Musculorum

1984
Decreased catalepsy response to haloperidol in the genetically dystonic (dt) rat.
    Brain research, 1984, Aug-06, Volume: 308, Issue:1

    Topics: 4-Butyrolactone; Aging; Animals; Brain; Catalepsy; Corpus Striatum; Dopamine; Dystonia; Golgi Appara

1984
Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation.
    Neurobiology of aging, 1983,Winter, Volume: 4, Issue:4

    Topics: Aging; Animals; Apomorphine; Corpus Striatum; Haloperidol; Humans; Motor Skills; Rats; Rats, Inbred

1983
Effects of pre- and postnatal haloperidol administrations to pregnant and nursing rats on brain catecholamine levels in their offspring.
    Developmental pharmacology and therapeutics, 1984, Volume: 7, Issue:3

    Topics: Aging; Animals; Animals, Suckling; Brain; Brain Chemistry; Catecholamines; Dopamine; Female; Haloper

1984
Haloperidol differentially potentiates tonic immobility, the dorsal immobility response, and catalepsy in the developing rat.
    Developmental psychobiology, 1984, Volume: 17, Issue:4

    Topics: Aging; Animals; Brain; Female; Haloperidol; Male; Motor Activity; Posture; Rats; Rats, Inbred Strain

1984
Tourette syndrome: history and present status.
    Advances in neurology, 1982, Volume: 35

    Topics: Aging; Clonidine; Demography; Ethnicity; Forecasting; Haloperidol; History, 15th Century; History, 1

1982
Developmental patterns of the hypothalamic-pituitary axis in the euthyroid and hypothyroid male rat.
    Neuroendocrinology, 1980, Volume: 30, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Gonadotropin-Releasing Hormone; Haloperidol; Hypothalamo-Hypophyse

1980
Effects of maturation and aging on behavioral responses to haloperidol in the rat.
    Psychopharmacology, 1981, Volume: 73, Issue:3

    Topics: Aging; Animals; Behavior, Animal; Blepharoptosis; Dose-Response Relationship, Drug; Haloperidol; Mal

1981
Blood levels of haloperidol in schizophrenic patients.
    Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Aging; Drug Interactions; Erythrocytes; Female; Half-Life; Haloperidol; Humans; M

1983
Age effects on haloperidol pharmacokinetics in male, Fischer-344 rats.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:2

    Topics: Aging; Animals; Brain; Haloperidol; Kinetics; Male; Rats; Rats, Inbred F344

1982
Postnatal development of noradrenaline and 3-methoxy-4-hydroxyphenylethyleneglycol sulphate levels in rat brain regions.
    Journal of neurochemistry, 1982, Volume: 39, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Brain; Glycols; Haloperidol; Male; Methoxyhydroxyphenylglycol; Nor

1982
[Plasma level monitoring of psychotropic drugs in children. I-Haloperidol (author's transl)].
    La Nouvelle presse medicale, 1982, Jun-19, Volume: 11, Issue:29

    Topics: Adolescent; Adult; Aging; Child; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Male

1982
Study on some compensatory responses of dopaminergic system in aging rats.
    Experimental brain research, 1982, Volume: Suppl 5

    Topics: Aging; Animals; Apomorphine; Butyrophenones; Corpus Striatum; Feedback; Haloperidol; Homovanillic Ac

1982
Apomorphine-induced stereotypy in mature and senescent rats following cessation of chronic haloperidol treatment.
    Communications in psychopharmacology, 1980, Volume: 4, Issue:4

    Topics: Aging; Animals; Apomorphine; Haloperidol; Humans; Male; Rats; Rats, Inbred Strains; Stereotyped Beha

1980
Aging and the regulation of striatal dopaminergic mechanisms in mice.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:3

    Topics: Aging; Animals; Apomorphine; Bromocriptine; Corpus Striatum; Haloperidol; Humans; Male; Mice; Mice,

1981
Total and free serum haloperidol levels in schizophrenic patients and the effect of age thioridazine and fatty acid on haloperidol-serum protein binding in vitro.
    British journal of clinical pharmacology, 1981, Volume: 11, Issue:4

    Topics: Adult; Aged; Aging; Drug Interactions; Female; Haloperidol; Humans; Male; Middle Aged; Oleic Acids;

1981
Aging and haloperidol-induced dopamine turnover in the nigro-striatal pathway of C57BL/6J mice.
    Neurobiology of aging, 1981,Fall, Volume: 2, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Corpus Striatum; Dopamine; Haloperidol; Male; Methyl

1981
Age-related electrophysiological changes in rat cerebellum.
    Brain research, 1980, Nov-10, Volume: 201, Issue:1

    Topics: Aging; Amphetamine; Animals; Cerebellum; Fluphenazine; gamma-Aminobutyric Acid; Haloperidol; Locus C

1980
Aging process affects a single class of dopamine receptors.
    Brain research, 1980, Dec-08, Volume: 202, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Aging; Animals; Corpus Striatum; Haloperidol; Hum

1980
The role of hyperthermia in amphetamine's interactions with NMDA receptors, nitric oxide, and age to produce neurotoxicity.
    Annals of the New York Academy of Sciences, 1995, Sep-15, Volume: 765

    Topics: Aging; Amphetamine; Animals; Arginine; Brain; Dizocilpine Maleate; Fever; Glutamic Acid; Haloperidol

1995
Changes in dopamine, serotonin and their metabolites in discrete brain areas of rat offspring after in utero exposure to cocaine or related drugs.
    Teratology, 1993, Volume: 48, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Amitriptyline; Amygdala; Analysis of Variance; Animals; Brain

1993
The D2 autoreceptor agonists SND 919 and PD 128483 decrease stereotypy in developing rats.
    Life sciences, 1994, Volume: 54, Issue:1

    Topics: Aging; Aminoquinolines; Animals; Benzothiazoles; Dopamine Agents; Dose-Response Relationship, Drug;

1994
Adaptive changes in rat striatal preproenkephalin expression and dopamine-opioid interactions upon chronic haloperidol treatment during different developmental stages.
    Brain research. Developmental brain research, 1994, Apr-15, Volume: 78, Issue:2

    Topics: Aging; Animals; Corpus Striatum; Dopamine; Embryonic and Fetal Development; Enkephalin, Ala(2)-MePhe

1994
Differential regulation of glutamate decarboxylase and preproenkephalin mRNA levels in the rat striatum.
    Brain research, 1994, Mar-21, Volume: 640, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Dopamine; Enkephalins; Female; Glutamate Decarbox

1994
Developmental differences in acute nigrostriatal and mesocorticolimbic system response to haloperidol.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1993, Volume: 9, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Corpus Striatum; Dopamine; Dose-Response Relationshi

1993
Effects of acute haloperidol and reserpine administration on vacuous jaw movements in three different age groups of rats.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:2

    Topics: Aging; Animals; Haloperidol; Jaw; Male; Mastication; Motor Activity; Rats; Rats, Sprague-Dawley; Res

1993
Blunting of the neurotensin mRNA response to haloperidol in the striatum of aging rats: possible relationship to decline in dopamine D2 receptor expression.
    Brain research, 1993, Jul-09, Volume: 616, Issue:1-2

    Topics: Aging; Analysis of Variance; Animals; Autoradiography; Corpus Striatum; Gene Expression; Haloperidol

1993
Partial 6-hydroxydopamine-induced lesions and haloperidol-induced catalepsy.
    Neuropharmacology, 1993, Volume: 32, Issue:3

    Topics: Aging; Animals; Apomorphine; Brain Chemistry; Catalepsy; Corpus Striatum; Dose-Response Relationship

1993
Acute and chronic nicotine effects on working memory in aged rats.
    Psychopharmacology, 1996, Volume: 123, Issue:1

    Topics: Age Factors; Aging; Animals; Dose-Response Relationship, Drug; Haloperidol; Male; Maze Learning; Mec

1996
Dissociation of the motor effects of (+)-pentazocine from binding to sigma 1 sites.
    European journal of pharmacology, 1996, Apr-22, Volume: 301, Issue:1-3

    Topics: Aging; Animals; Central Nervous System Depressants; Dystonia; Haloperidol; Head Movements; In Vitro

1996
The effect of haloperidol on met-enkephalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging.
    Progress in neuro-psychopharmacology & biological psychiatry, 1995, Volume: 19, Issue:7

    Topics: Aging; Animals; beta-Endorphin; Cholecystokinin; Corpus Striatum; Enkephalin, Methionine; Haloperido

1995
Age-related diminution of dopamine antagonist-stimulated vesamicol receptor binding.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1996, Volume: 37, Issue:7

    Topics: Aging; Animals; Brain; Dopamine Antagonists; Haloperidol; Iodine Radioisotopes; Iodobenzenes; Male;

1996
Preservation of autoreceptor-mediated increases in dopamine synthesis in aged mice with experimentally-induced parkinsonism.
    Neuroscience letters, 1997, Jan-31, Volume: 222, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Aromat

1997
Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:3

    Topics: Aging; Algorithms; Animals; Brain; Brain Chemistry; Computer Simulation; Corpus Striatum; Dopamine A

1997
Effects of clozapine and haloperidol on baseline levels of vacuous jaw movements in aged rats.
    Behavioural brain research, 1997, Volume: 86, Issue:2

    Topics: Aging; Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Mast

1997
Prefrontal cortical and hippocampal modulation of dopamine-mediated effects.
    Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42

    Topics: Aging; Amphetamine; Animals; Animals, Newborn; Apomorphine; Disease Models, Animal; Dopamine; Halope

1998
Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders.
    Journal of neural transmission. Supplementum, 1998, Volume: 52

    Topics: Aging; alpha-Methyltyrosine; Animals; Avoidance Learning; Catalepsy; Cognition; Cognition Disorders;

1998
The effect of aging on the response of striatal preproenkephalin and preprotachykinin mRNA contents to chronic haloperidol treatment in rats: measurement by solution-hybridization RNase protection assay.
    Neuroscience letters, 1998, Apr-17, Volume: 246, Issue:1

    Topics: Aging; Animals; Corpus Striatum; Enkephalins; Haloperidol; Male; Protein Precursors; Rats; Rats, Spr

1998
Dopaminergic control of kynurenate levels and N-methyl-D-aspartate toxicity in the developing rat striatum.
    Developmental neuroscience, 1998, Volume: 20, Issue:2-3

    Topics: Aging; Animals; Animals, Newborn; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine Agents; Dop

1998
A single neonatal dose of methamphetamine suppresses dentate granule cell proliferation in adult gerbils which is restored to control values by acute doses of haloperidol.
    Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:5-6

    Topics: Aging; Animals; Animals, Newborn; Bromodeoxyuridine; Cell Division; Dentate Gyrus; Gerbillinae; Halo

1999
Sigma binding sites identified by [(3)H] DTG are elevated in aged Fischer-344 x Brown Norway (F1) rats.
    Synapse (New York, N.Y.), 2000, Mar-15, Volume: 35, Issue:4

    Topics: Aging; Animals; Anticonvulsants; Binding Sites; Corpus Striatum; Guanidines; Haloperidol; Male; Racl

2000
Age-related differences in the secretion of calcitonin in male rats.
    Metabolism: clinical and experimental, 2000, Volume: 49, Issue:2

    Topics: Aging; Animals; Calcitonin; Calcium; Calcium Chloride; Dopamine Antagonists; Haloperidol; In Vitro T

2000
The effects of acute antipsychotic drug administration on the neurotensin system of the developing rat brain.
    Brain research. Developmental brain research, 2000, Nov-30, Volume: 124, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Antipsychotic Agents; Brain; Caudate Nucleus; Female; Haloperidol;

2000
Abnormal age-related changes of plasma antioxidant proteins in schizophrenia.
    Psychiatry research, 2000, Dec-27, Volume: 97, Issue:2-3

    Topics: Adolescent; Adult; Age Factors; Aging; Albumins; Antipsychotic Agents; Anxiety; Bilirubin; Depressio

2000
Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain.
    Free radical biology & medicine, 2001, Aug-01, Volume: 31, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aging; Alzheimer Disease; Autopsy; Brain; Catec

2001
Assessment of spontaneously occurring periodic limb movements in sleep in the rat.
    Journal of the neurological sciences, 2002, Jun-15, Volume: 198, Issue:1-2

    Topics: Aging; Animals; Anti-Dyskinesia Agents; Haloperidol; Hindlimb; Male; Movement; Periodicity; Rats; Ra

2002
The amphetamine-induced inhibition of dopamine biosynthesis in rat striatum.
    European journal of pharmacology, 1976, Volume: 35, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Corpus Striatum; Depression, Chemical; Dextroamphetamine; Dopamine

1976
[3H]Haloperidol and [3H]spiroperidol binding in rat striatum during ageing.
    The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:7

    Topics: Adenylyl Cyclases; Aging; Animals; Binding Sites; Butyrophenones; Corpus Striatum; Dopamine; Haloper

1978
Pharmacological analysis of the functional ontogeny of the nigrostriatal dopaminergic neurons.
    Brain research, 1979, Jun-29, Volume: 169, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Axons; Corpus Striatum; Dominance, Cerebral; Dopamine; Haloperidol

1979
Age-related changes in the nigrostriatum: a behavioral and biochemical analysis.
    Journal of gerontology, 1978, Volume: 33, Issue:5

    Topics: Aging; Amphetamine; Animals; Apomorphine; Female; Haloperidol; Male; Rats; Rats, Inbred Strains; Rec

1978
The development of tryptophan hydroxylase in the chicken brain: effects of p-chloroamphetamine and antagonists of serotonin, noradrenaline and dopamine.
    Neuropharmacology, 1979, Volume: 18, Issue:3

    Topics: Aging; Amphetamines; Animals; Brain; Chick Embryo; Chickens; Dopamine Antagonists; Haloperidol; Nore

1979
Hormone ontogeny in the ovine fetus. VI. Dopaminergic regulation of prolactin secretion.
    Endocrinology, 1979, Volume: 105, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Apomorphine; Bromocriptine; Dopamine; Female; Fetus; Gestational A

1979
Haloperidol plasma level monitoring in pediatric patients.
    Therapeutic drug monitoring, 1979, Volume: 1, Issue:1

    Topics: Adolescent; Adult; Aging; Child; Female; Haloperidol; Humans; Male; Movement Disorders; Psychotic Di

1979
Dopaminergic antagonism and catalepsy in the developing rat.
    European journal of pharmacology, 1979, Feb-15, Volume: 54, Issue:1-2

    Topics: Aging; Animals; Catalepsy; Dopamine; Dopamine Antagonists; Female; Haloperidol; Humans; Male; Rats;

1979
Effects of age and isolation on the evolution of catalepsy during chronic haloperidol treatment.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1992, Volume: 25, Issue:9

    Topics: Aging; Animals; Catalepsy; Drug Tolerance; Haloperidol; Housing, Animal; Male; Rats; Social Isolatio

1992
Chronic neuroleptic treatment: D2 dopamine receptor supersensitivity and striatal glutamatergic transmission.
    Annals of neurology, 1992, Volume: 31, Issue:4

    Topics: Aging; Animals; Antipsychotic Agents; Corpus Striatum; Ergolines; Glutamine; Haloperidol; Parasympat

1992
Ageing influences haloperidol-induced changes in the permeability of the blood-brain barrier in the rat.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:5

    Topics: Aging; Aminoisobutyric Acids; Animals; Blood-Brain Barrier; Cerebrovascular Circulation; Dopamine; H

1992
Expression of rat striatal D1 and D2 dopamine receptor mRNAs: ontogenetic and pharmacological studies.
    Neurochemistry international, 1992, Volume: 20 Suppl

    Topics: Aging; Animals; Animals, Newborn; Base Sequence; Benzazepines; Corpus Striatum; Haloperidol; Male; M

1992
Neurotensin mRNA expression in response to haloperidol is decreased in the dorsolateral striatum of aged rats.
    Annals of the New York Academy of Sciences, 1992, Volume: 668

    Topics: Aging; Animals; Corpus Striatum; Gene Expression; Haloperidol; Male; Neurotensin; Peptide Fragments;

1992
Amphetamine actions on pre- and postpubertal rat hippocampal dentate granule neurons.
    Brain research, 1991, Aug-09, Volume: 556, Issue:1

    Topics: Aging; Animals; Atenolol; Calcium Channels; Cocaine; Dextroamphetamine; Evoked Potentials; Haloperid

1991
Effects of haloperidol on motor and cognitive functioning in aged mice.
    Brain research bulletin, 1991, Volume: 27, Issue:2

    Topics: Aging; Animals; Cognition; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Mice, Inbred S

1991
Amphetamine exerts anomalous effects on dopaminergic neurons in neonatal rats in vivo.
    European journal of pharmacology, 1991, Nov-12, Volume: 204, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Apomorphine; Corpus Striatum; Dextroamphetamine; Dopamine; Electri

1991
A new motor test sensitive to aging and dopaminergic function.
    Journal of neuroscience methods, 1991, Volume: 39, Issue:2

    Topics: Aging; Animals; Body Weight; Dextroamphetamine; Dopamine; Haloperidol; Levodopa; Male; Motor Activit

1991
Dopamine D1 receptor behavioral responsitivity following selective lesions of the striatal patch compartment during development.
    Brain research. Developmental brain research, 1991, Jun-21, Volume: 60, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Analysis of Variance; Animals; An

1991
Diminished bioactivity of circulating prolactin despite increased immunoreactive hormone release in old versus young male rats.
    Endocrinology, 1990, Volume: 126, Issue:2

    Topics: Aging; Animals; Biological Assay; Bromocriptine; Cell Division; Haloperidol; Lymphoma; Male; Morphin

1990
Ontogeny of the endorphinergic and dopaminergic modulation on the immobility reflex elicited by clamping in rats.
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 1990, Volume: 9, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Dopamine; Dose-Response Relationshi

1990
Development of haloperidol-induced dopamine release in the rat striatum using intracerebral dialysis.
    Journal of neurochemistry, 1990, Volume: 54, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Corpus Striatum; Dialysis; Dopamine; Female; Haloper

1990
Developmental changes in FSH secretion induced by 5-hydroxytryptophan, naloxone and haloperidol in male and female rats.
    Brain research. Developmental brain research, 1989, Jun-01, Volume: 47, Issue:2

    Topics: 5-Hydroxytryptophan; Aging; Animals; Female; Follicle Stimulating Hormone; Haloperidol; Male; Naloxo

1989
Relation between dopaminergic control of pituitary lactotroph function and deceleration of age-related changes in serum prolactin of diet-restricted rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1989, Volume: 27, Issue:2

    Topics: Aging; Animals; Bromocriptine; Catalepsy; Diet; Dopamine; Female; Haloperidol; Male; Pituitary Gland

1989
Evidence for cholecystokinin-dopamine receptor interactions in the central nervous system of the adult and old rat. Studies on their functional meaning.
    Annals of the New York Academy of Sciences, 1985, Volume: 448

    Topics: Aging; Animals; Apomorphine; Brain; Cholecystokinin; Haloperidol; Male; Neurons; Nucleus Accumbens;

1985
Delirium: recognition and management in the older patient.
    Geriatrics, 1986, Volume: 41, Issue:6

    Topics: Aged; Aging; Anti-Anxiety Agents; Benzodiazepines; Delirium; Diagnosis, Differential; Drug-Related S

1986
The effects of reserpine and haloperidol on tyrosine hydroxylase activity in the brains of aged rats.
    Life sciences, 1986, Jul-21, Volume: 39, Issue:3

    Topics: Aging; Animals; Brain; Brain Mapping; Haloperidol; Male; Pterins; Rats; Reserpine; Tyrosine 3-Monoox

1986
Influence of (-)-sulpiride and YM-09151-2 on stereotyped behavior in chicks and catalepsy in rats.
    Japanese journal of pharmacology, 1987, Volume: 43, Issue:2

    Topics: Aging; Animals; Antipsychotic Agents; Benzamides; Catalepsy; Chickens; Dextroamphetamine; Fenclonine

1987
Decreasing sensitivity to neuroleptic agents in developing rats; evidence for a pharmacodynamic factor.
    Psychopharmacology, 1988, Volume: 94, Issue:1

    Topics: Administration, Oral; Aging; Animals; Antipsychotic Agents; Generalization, Psychological; Haloperid

1988
Age-related decrements in the muscarinic enhancement of K+-evoked release of endogenous striatal dopamine: an indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence.
    Brain research, 1988, Jun-28, Volume: 454, Issue:1-2

    Topics: Aging; Animals; Bethanechol; Bethanechol Compounds; Carbachol; Cholinergic Fibers; Corpus Striatum;

1988
Differential recovery rates of rat D2 dopamine receptors as a function of aging and chronic reserpine treatment following irreversible modification: a key to receptor regulatory mechanisms.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:5

    Topics: Aging; Animals; Apomorphine; Corpus Striatum; Guanylyl Imidodiphosphate; Haloperidol; In Vitro Techn

1987
Changes in the 5-HT-binding sites in the cerebral cortex, striatum and hypothalamus of rats during ageing and under the effect of dopaminergic agents.
    Acta physiologica et pharmacologica Bulgarica, 1987, Volume: 13, Issue:1

    Topics: Aging; Animals; Binding Sites; Cerebral Cortex; Corpus Striatum; Haloperidol; Hypothalamus; Levodopa

1987
Changes in naloxone and haloperidol effects during the development of captivity-induced jumping stereotypy in bank voles.
    European journal of pharmacology, 1988, Aug-09, Volume: 153, Issue:1

    Topics: Aging; Animals; Arvicolinae; Haloperidol; Naloxone; Stereotyped Behavior

1988
Dopaminergic inhibition of tyrosinase activity in hair follicular melanocytes of the mouse.
    The Journal of endocrinology, 1986, Volume: 111, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Bromocript

1986
Long-term attentional deficit in nonhandled males: possible involvement of the dopaminergic system.
    Psychopharmacology, 1988, Volume: 95, Issue:2

    Topics: Aging; Animals; Attention; Dextroamphetamine; Female; Haloperidol; Handling, Psychological; Male; Ra

1988
The natural history of Tourette syndrome: a follow-up study.
    Annals of neurology, 1987, Volume: 22, Issue:3

    Topics: Adaptation, Psychological; Adolescent; Adolescent Behavior; Adult; Aging; Clonidine; Fluphenazine; F

1987
Responsiveness of tuberoinfundibular dopamine neurons in the aged female rat to the stimulatory actions of prolactin.
    Neuroendocrinology, 1987, Volume: 45, Issue:3

    Topics: Aging; Animals; Dopamine; Feedback; Female; Haloperidol; Homeostasis; Hypothalamus; Median Eminence;

1987
Circadian variation of catecholamine excretion in rats: correlation with locomotor activity and effects of drugs.
    Neuropharmacology, 1986, Volume: 25, Issue:11

    Topics: Aging; Animals; Catecholamines; Circadian Rhythm; Dopamine; Epinephrine; Haloperidol; Male; Motor Ac

1986
Chronic haloperidol during development attenuates dopamine autoreceptor function in striatal and mesolimbic brain regions of young and older adult rats.
    Psychopharmacology, 1985, Volume: 85, Issue:3

    Topics: 4-Butyrolactone; Aging; Animals; Body Weight; Corpus Striatum; Dopamine; Female; Haloperidol; Limbic

1985
Adenohypophysial dopamine content and prolactin secretion in the aged male and female rat.
    Endocrinology, 1985, Volume: 116, Issue:4

    Topics: Aging; Animals; Biomechanical Phenomena; Brain; Bromocriptine; Catechol O-Methyltransferase; Dopamin

1985
Absence of age effect on plasma haloperidol neuroleptic levels in psychiatric patients.
    Journal of gerontology, 1985, Volume: 40, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aging; Female; Haloperidol; Humans; Male; Middle Aged

1985
Reduced metabolic response of the aged rat brain to haloperidol.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1985, Volume: 5, Issue:11

    Topics: Aging; Animals; Autoradiography; Brain; Catalepsy; Deoxyglucose; Glucose; Haloperidol; Male; Rats; R

1985
[Neuroleptoanalgesia].
    Aktuelle Probleme in der Chirurgie, 1970, Volume: 12

    Topics: Aged; Aging; Animals; Cardiac Surgical Procedures; Cardiovascular System; Catecholamines; Central Ne

1970
The clinical use of psychotherapeutic drugs in the elderly.
    Drugs, 1974, Volume: 8, Issue:2

    Topics: Aged; Aging; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Anxiety; Benzodiazepi

1974
[Collecting of the news].
    Minerva medica, 1974, Volume: 65, Issue:85 Suppl

    Topics: Aging; Air Pollution; Haloperidol; Health Education; Humans; Italy; Myocardial Infarction; Neoplasms

1974
Management of the psychogeriatric patient.
    Virginia medical monthly, 1973, Volume: 100, Issue:4

    Topics: Aged; Aging; Female; Haloperidol; Humans; Male; Mental Disorders

1973
Properties of adenylate cyclase from senescent rat brain.
    Brain research, 1973, May-17, Volume: 54

    Topics: Adenylyl Cyclases; Aging; Animals; Brain; Caudate Nucleus; Cell-Free System; Cerebellum; Cerebral Co

1973
Distribution of radioactivity in the tissues of young and adult rats after administration of tritiated haloperidol.
    European journal of pharmacology, 1968, Volume: 3, Issue:4

    Topics: Aging; Animals; Brain; Haloperidol; Injections, Intraperitoneal; Intestinal Mucosa; Kidney; Liver; L

1968
Influence of long -term thermal cycling and masticatory loading simulation on bond strength of roots filled with epoxy resin and calcium silicate based sealers.
    BMC oral health, 2023, 09-18, Volume: 23, Issue:1

    Topics: Aging; Analysis of Variance; Calcium Compounds; Epoxy Resins; Humans

2023
[Human cytogenetic affects in relation to sex, age and the duration of contract with a chemical mutagen].
    Doklady Akademii nauk SSSR, 1983, Volume: 273, Issue:6

    Topics: Adult; Aging; Chromosome Aberrations; Environmental Exposure; Epoxy Resins; Female; Humans; Lymphocy

1983