halofuginone has been researched along with Disease Models, Animal in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.27) | 18.2507 |
| 2000's | 11 (25.00) | 29.6817 |
| 2010's | 28 (63.64) | 24.3611 |
| 2020's | 4 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Bilal, N; Ceylan, SM; Kanmaz, MA; Sezgin, E; Sokucu, M; Uysal, E; Yurtseven, DG | 1 |
| Du, HL; Yu, H; Zhai, AD | 1 |
| Barzilai-Tutsch, H; Genin, O; Halevy, O; Pines, M | 1 |
| Evans, P; Genin, O; Halevy, O; Mordechay, S; Pines, M; Smullen, S | 1 |
| Bi, M; Fan, C; Guan, H; Hou, X; Li, Y; Liu, S; Liu, T; Shan, Z; Teng, W; Yang, R; Zhou, J | 1 |
| Arabacilar, P; Bantscheff, M; Bao, W; Bergamini, G; Bernard, RE; Del Rosario, J; Eisennagel, SH; Faelth Savitski, M; Force, TL; Gatto, GJ; Guo, Y; Halsey, WS; Hu, E; Hughes, AM; Joberty, G; Kirkpatrick, RB; Lal, H; Livi, GP; Lu, Q; Nayal, M; Olzinski, AR; Platchek, MC; Qin, P; Qu, XA; Quaile, MP; Rajpal, DK; Roethke, T; Sathe, GM; Schnackenberg, CG; Willette, RN; Wright, F; Xie, W | 1 |
| Amat, A; Cao, L; Ji, B; Li, J; Ma, H; Mu, W; Xu, B; Zhang, Z | 1 |
| Chen, N; Kang, Y; Mao, C; Shang, J; Zhan, W | 1 |
| Barzilai-Tutsch, H; Butler Browne, G; Dewulf, M; Halevy, O; Lamaze, C; Pines, M | 1 |
| Evans, P; Genin, O; Halevy, O; Mordechay, S; Pines, M; Wellner, G | 1 |
| Chak, A; Cipriano, C; Lash, RH; Marks, JM; Ponsky, JL; Schomisch, SJ; Wu, Y | 1 |
| Gao, MH; Geng, X; Li, Y; Li, YY; Liang, J; Liu, JB; Shen, RW; Zhang, B; Zhang, W | 1 |
| Barzilai-Tutsch, H; Bodanovsky, A; Genin, O; Guttman, N; Halevy, O; Levy, O; Pines, M | 1 |
| Baek, SY; Cho, ML; Kim, HY; Kim, SM; Kwok, SK; Lee, DG; Lee, J; Lim, MA; Park, EM; Park, JS; Park, MK; Park, SH; Woo, JW; Yang, EJ | 1 |
| Bopp, SE; Clardy, J; Clish, CB; Cortese, JF; Derbyshire, ER; Estiu, G; Galinsky, K; Herman, JD; Keller, TL; Lindquist, S; Lukens, AK; Mazitschek, R; Mota, MM; Patel, V; Pepper, LR; Ribacke, U; Santos, SA; Schimmel, P; Sullivan, WJ; Whitman, M; Wiest, O; Wirth, DF; Zhou, H; Zuzarte-Luis, V | 1 |
| Assis, PA; Cândido, LA; Chahud, F; De Figueiredo-Pontes, LL; Falcão, RP; Garcia, AB; Leão, V; Lima, AS; Nagler, A; Panepucci, RA; Pintão, CT; Rego, EM; Saggioro, FP | 1 |
| Bradley, J; Chaudhary, K; Koritzinsky, M; Liu, H; Madaio, MP; McGaha, TL; Ravishankar, B; Shinde, R; Xiao, W | 1 |
| Bian, Q; Cao, X; Crane, J; Cui, Z; Ding, S; Jin, X; Li, C; Qiu, T; Wan, M; Wang, L; Xie, H; Xie, L; Xie, M; Yu, B; Zhen, G | 1 |
| Bian, YP; Cheng, H; Pan, B; Song, GL; Xia, DD; Xu, KL; Yao, Y; Zeng, LY | 1 |
| Cypel, M; Guan, Z; Hirayama, S; Hwang, DM; Juvet, SC; Keller, TL; Keshavjee, S; Liu, M; Martinu, T; Matsuda, Y; Oishi, H; Saito, T; Sato, M; Whitman, MR | 1 |
| Bian, ZX; Du, J; Lin, SH; Liu, J; Mu, HX; Wang, D; Wang, HS; Xiao, HT; Yang, D; Zhao, L | 1 |
| Baker, DP; Fuchs, SY; Gober, M; Gui, J; Katlinski, KV; Marshall, CM; Rui, H; Seykora, JT; Sharma, M; Werth, VP; Yang, X | 1 |
| Allen, J | 1 |
| Ayan, F; Aydogan, F; Carkman, S; Durak, H; Erzin, Y; Gonenc, M; Karatas, A; Paksoy, M; Uzun, H | 1 |
| Kim, YM; Koo, BS; Park, JY; Park, YH; Rha, KS; Yoon, YH | 1 |
| Cekin, IE; Cincik, H; Dogru, S; Gungor, A; Ozdemir, T; Ulubil, SA | 1 |
| Larena-Avellaneda, A; Schmidt, K; Zeplin, PH | 1 |
| Atala, A; Gorbachinsky, I; Hodges, SJ; Krane, LS; Sirintrapun, J; Yoo, JJ | 1 |
| Bistoni, F; d'Enfert, C; Mosci, P; Pandey, N; Pietrella, D; Pines, M; Rachini, A; Vecchiarelli, A | 1 |
| Araújo, AG; Assis, PA; de Figueiredo-Pontes, LL; Falcão, RP; Garcia, AB; Jácomo, RH; Lima, AS; Nagler, A; Panepucci, RA; Rego, EM; Santana-Lemos, BA; Thomé, CH; Zago, MA | 1 |
| Cetinel, Ş; Karadeniz Cerit, K; Karakoyun, B; Özkan, N; Tolga Dağli, E; Tuğtepe, H; Yeğen, BÇ; Yüksel, M | 1 |
| Chen, W; Cheng, H; Li, Z; Pan, B; Song, G; Tian, J; Xu, K; Zeng, L | 1 |
| Bahr, JM; Braundmeier, AG; Hales, DB; Machado, SA; Nowak, RA; Quade, BJ | 1 |
| Barzilai-Tutsch, H; Genin, O; Halevy, O; Levi, O; Moshe, I; Pima, Y; Pines, M | 1 |
| Bona, C; Kodera, T; McGaha, T; Phelps, R; Pines, M; Spiera, H | 1 |
| Fevery, J; Nevens, F; Roskams, T; Van de Casteele, M; Van der Elst, I; van Pelt, JF | 1 |
| Eliashar, R; Maly, B; Nagler, A; Ochana, M; Pines, M; Sichel, JY | 1 |
| Benchetrit, S; Bernheim, J; Pines, M; Rashid, G; Rathaus, M; Yarkoni, S | 1 |
| Anderson, JE; Halevy, O; Huebner, KD; Jassal, DS; Pines, M | 1 |
| McLoon, LK | 1 |
| Knopov, V; Levi-Schaffer, F; Nagler, A; Pines, M; Slavin, S | 1 |
| Genina, O; Gofrit, O; Nagler, A; Ohana, M; Pines, M; Pode, D | 1 |
| Alexiev, R; Domb, A; Genina, O; Inbar, J; Nagler, A; Ohana, M; Pines, M | 1 |
| Nishioka, K; Yamamoto, T | 1 |
44 other study(ies) available for halofuginone and Disease Models, Animal
| Article | Year |
|---|---|
The Effects of Halofuginone on Wound Healing in the Rat Nasal Mucosa.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Epithelium; Female; Nasal Mucosa; Piperidines; Quinazolinones; Rats; Treatment Outcome; Wound Healing; Wounds and Injuries | 2020 |
Synergistic effect of halofuginone and dexamethasone on LPS‑induced acute lung injury in type II alveolar epithelial cells and a rat model.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Cell Survival; Dexamethasone; Disease Models, Animal; Drug Synergism; Humans; Inflammation; Lipopolysaccharides; NF-kappa B; Phosphorylation; Piperidines; Quinazolinones; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Early pathological signs in young dysf
Topics: Animals; Disease Models, Animal; Dysferlin; Fibrosis; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Piperidines; Protein Synthesis Inhibitors; Quinazolinones | 2020 |
Differential Effects of Halofuginone Enantiomers on Muscle Fibrosis and Histopathology in Duchenne Muscular Dystrophy.
Topics: Animals; Disease Models, Animal; Fibrosis; Male; Mice; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Piperidines; Quinazolinones | 2021 |
Effect of Halofuginone on the Pathogenesis of Autoimmune Thyroid Disease in Different Mice Models.
Topics: Animals; Disease Models, Animal; Female; Graves Disease; Mice; Mice, Inbred BALB C; Mice, Transgenic; Piperidines; Quinazolinones; Random Allocation; Th17 Cells; Thyroiditis, Autoimmune; Treatment Outcome | 2017 |
Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress.
Topics: Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Autophagy; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Fibrosis; Heart Failure; Humans; Hypertrophy, Left Ventricular; Induced Pluripotent Stem Cells; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Piperidines; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Quinazolinones; Stress, Physiological; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2017 |
Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model.
Topics: Animals; Anterior Cruciate Ligament; Anti-Inflammatory Agents; Cartilage, Articular; Collagen Type X; Disease Models, Animal; Gene Expression Regulation; Male; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Osteoarthritis; Piperidines; Quinazolinones; Signal Transduction; Transforming Growth Factor beta1 | 2017 |
Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation.
Topics: Acute Disease; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; DNA, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Inflammation; Piperidines; Quinazolinones; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Transcription Factor RelA | 2017 |
A promotive effect for halofuginone on membrane repair and synaptotagmin-7 levels in muscle cells of dysferlin-null mice.
Topics: Animals; Disease Models, Animal; Dysferlin; Humans; Mice; Mice, Knockout; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Myoblasts; Phosphatidylinositol 3-Kinases; Piperidines; Quinazolinones; Synaptotagmins | 2018 |
Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy.
Topics: Animals; Disease Models, Animal; Fibrillar Collagens; Fibrosis; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Phosphorylation; Piperidines; Quinazolinones; Signal Transduction; Smad3 Protein; Utrophin | 2019 |
Preliminary results of antiscarring therapy in the prevention of postendoscopic esophageal mucosectomy strictures.
Topics: Angiogenesis Inhibitors; Animals; Cicatrix; Disease Models, Animal; Dissection; Drug Therapy, Combination; Esophageal Diseases; Esophageal Stenosis; Esophagoscopy; Follow-Up Studies; Injections; Intestinal Mucosa; Mitomycin; Nucleic Acid Synthesis Inhibitors; Piperidines; Quinazolinones; Swine; Transforming Growth Factor beta3; Wound Healing | 2014 |
The effect of antifibrotic drug halofugine on Th17 cells in concanavalin A-induced liver fibrosis.
Topics: Actins; Alanine Transaminase; Albumins; Animals; Aspartate Aminotransferases; Cell Differentiation; Concanavalin A; Disease Models, Animal; Interferon-gamma; Interleukin-10; Interleukin-17; Interleukin-1beta; Interleukin-33; Interleukin-6; Interleukins; Liver; Liver Cirrhosis; Male; Nuclear Receptor Subfamily 1, Group F, Member 3; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Rats; Rats, Wistar; Th17 Cells; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2014 |
Halofuginone improves muscle-cell survival in muscular dystrophies.
Topics: Actins; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Survival; Diaphragm; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Macrophages; Mice; Mice, Inbred mdx; Mixed Function Oxygenases; Muscular Dystrophy, Duchenne; Myoblasts; Myofibrils; PAX7 Transcription Factor; Phosphatidylinositol 3-Kinases; Piperidines; Primary Cell Culture; Quinazolinones; Signal Transduction | 2014 |
Halofuginone ameliorates autoimmune arthritis in mice by regulating the balance between Th17 and Treg cells and inhibiting osteoclastogenesis.
Topics: Animals; Arthritis; Autoimmune Diseases; Cell Differentiation; Disease Models, Animal; Disease Progression; Forkhead Transcription Factors; Male; Mice; Mice, Inbred DBA; Mice, Knockout; NFATC Transcription Factors; Osteoclasts; Osteoprotegerin; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Signal Transduction; STAT3 Transcription Factor; T-Lymphocytes, Regulatory; Th17 Cells | 2014 |
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Topics: Amino Acyl-tRNA Synthetases; Animals; Antimalarials; Computer-Aided Design; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Resistance; Enzyme Inhibitors; Erythrocytes; Liver; Malaria, Falciparum; Mice; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Piperidines; Plasmodium falciparum; Protozoan Proteins; Quinazolines; Quinazolinones; Structure-Activity Relationship; Time Factors | 2015 |
Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model.
Topics: Animals; Disease Models, Animal; Humans; Immunophenotyping; Leukemia, Promyelocytic, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Neovascularization, Pathologic; Phosphorylation; Piperidines; Quinazolinones; Smad2 Protein; Tumor Cells, Cultured | 2015 |
The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity.
Topics: Amino Acids; Animals; Apoptosis; Autoimmunity; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression Regulation; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Lupus Erythematosus, Systemic; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells; Piperidines; Protein Serine-Threonine Kinases; Quinazolinones; Signal Transduction | 2015 |
Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone.
Topics: Animals; Anterior Cruciate Ligament; Bone and Bones; Bone Remodeling; Bone Resorption; Cartilage, Articular; Disease Models, Animal; Disease Progression; Male; Mice; Mice, Inbred C57BL; Osteoarthritis; Osteoclasts; Piperidines; Quinazolinones; Random Allocation; Rats; Rats, Inbred Lew; Transforming Growth Factor beta | 2016 |
[Significance of Th1/Th17 Imbalance in Mice with Acute Graft-versus-Host Disease].
Topics: Animals; Disease Models, Animal; Graft vs Host Disease; Interferon-gamma; Interleukin-17; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Piperidines; Quinazolinones; Th1 Cells; Th17 Cells | 2015 |
Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
Topics: Animals; Chronic Disease; Disease Models, Animal; Graft Rejection; Interleukin-17; Lung Transplantation; Male; Mice; Mice, Inbred C57BL; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Th17 Cells; Transplantation, Homologous | 2016 |
Halofuginone reduces the inflammatory responses of DSS-induced colitis through metabolic reprogramming.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Body Weight; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Fatty Acids; Gene Expression; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Liver; Male; Metabolic Networks and Pathways; Mice; Models, Biological; Oxidation-Reduction; Peroxidase; Phenotype; Piperidines; Quinazolinones; RNA, Messenger; Spleen | 2016 |
Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation.
Topics: Animals; Cell Line; Chemokines; Cytokines; Disease Models, Animal; Down-Regulation; Humans; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Psoriasis; Quinazolinones; Receptor, Interferon alpha-beta; Signal Transduction; Skin; Ubiquitination; Ultraviolet Therapy | 2016 |
Response of an ovine laryngeal injury model to a novel fibrosis inhibitor.
Topics: Administration, Oral; Administration, Topical; Animals; Collagen; Disease Models, Animal; Elastin; Fibrosis; Injections, Intralesional; Piperidines; Quinazolinones; Sheep; Treatment Outcome; Vocal Cords; Wound Healing | 2017 |
The effect of halofuginone, a specific inhibitor of collagen type 1 synthesis, in the prevention of pancreatic fibrosis in an experimental model of severe hyperstimulation and obstruction pancreatitis.
Topics: Amylases; Animals; Collagen Type I; Disease Models, Animal; Female; Fibrosis; Hyaluronic Acid; Lipase; Nitric Oxide; Pancreas; Pancreatic Diseases; Pancreatitis; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Rats; Rats, Wistar | 2008 |
The preventive effect of halofuginone on posterior glottic stenosis in a rabbit model.
Topics: Animals; Disease Models, Animal; Fibrosis; Glottis; Injections, Intraperitoneal; Laryngostenosis; Male; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Rabbits; Random Allocation | 2008 |
Efficacy of topical halofuginone in myringotomy patency.
Topics: Administration, Topical; Animals; Disease Models, Animal; Gelatin Sponge, Absorbable; Middle Ear Ventilation; Otitis Media with Effusion; Piperidines; Quinazolinones; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Time Factors; Tympanic Membrane; Wound Healing | 2010 |
Surface modification of silicone breast implants by binding the antifibrotic drug halofuginone reduces capsular fibrosis.
Topics: Animals; Breast Implants; Coated Materials, Biocompatible; Collagen Type I; Disease Models, Animal; Female; Fibrosis; Foreign-Body Reaction; Mammary Glands, Animal; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Rats; Rats, Sprague-Dawley; Silicon; Treatment Outcome | 2010 |
Halofuginone-coated urethral catheters prevent periurethral spongiofibrosis in a rat model of urethral injury.
Topics: Animals; Catheters; Cicatrix; Collagen Type I; Disease Models, Animal; Male; Piperidines; Quinazolinones; Rats; Rats, Sprague-Dawley; Staining and Labeling; Stents; Urethra; Urethral Diseases | 2011 |
Th17 cells and IL-17 in protective immunity to vaginal candidiasis.
Topics: Animals; beta-Defensins; Candida albicans; Candidiasis, Vulvovaginal; Disease Models, Animal; Female; Immunity; Interleukin-17; Interleukin-23; Lymph Nodes; Mice; Neutrophil Infiltration; Piperidines; Quinazolinones; Th17 Cells; Vagina | 2011 |
Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway.
Topics: Animals; Blood Cell Count; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Leukemic; Humans; Leukemia, Promyelocytic, Acute; Mice; Mice, SCID; Oncogene Proteins, Fusion; Piperidines; Protein Serine-Threonine Kinases; Quinazolinones; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Up-Regulation | 2011 |
The antifibrotic drug halofuginone reduces ischemia/reperfusion-induced oxidative renal damage in rats.
Topics: Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Fibrosis; Glutathione; Kidney Diseases; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Nephrectomy; Oxidative Stress; Peroxidase; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Rats; Rats, Wistar; Reperfusion Injury | 2013 |
TH17 cells are critical for skin-specific pathological injury in acute graft-versus-host disease.
Topics: Acute Disease; Animals; Bone Marrow Transplantation; Cell Differentiation; Cell Separation; Cells, Cultured; Disease Models, Animal; Female; Flow Cytometry; Graft vs Host Disease; Inflammation Mediators; Interleukin-17; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Piperidines; Quinazolinones; Skin; Th1 Cells; Th17 Cells; Time Factors | 2012 |
Validation of the aging hen (Gallus gallus domesticus) as an animal model for uterine leiomyomas.
Topics: Aging; Animals; Antineoplastic Agents; Chickens; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Leiomyoma; Oviducts; Piperidines; Poultry Diseases; Prevalence; Primary Cell Culture; Quinazolinones; Tumor Cells, Cultured; Uterine Neoplasms | 2012 |
Inhibition of muscle fibrosis and improvement of muscle histopathology in dysferlin knock-out mice treated with halofuginone.
Topics: Animals; Collagen; Disease Models, Animal; Dysferlin; Fibrosis; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Phosphorylation; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Smad3 Protein; Treatment Outcome | 2013 |
Effect of halofuginone on the development of tight skin (TSK) syndrome.
Topics: Animals; Animals, Newborn; Collagen; Disease Models, Animal; Fibrosis; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Scleroderma, Systemic; Skin Diseases | 2002 |
Halofuginone can worsen liver fibrosis in bile duct obstructed rats.
Topics: Aminopyrine; Animals; Bile Ducts; Breath Tests; Cholestasis, Extrahepatic; Collagen Type I; Collagen Type III; Disease Models, Animal; Ligation; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Male; Piperidines; Portal Pressure; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2004 |
Halofuginone prevents subglottic stenosis in a canine model.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Dogs; Fibroblasts; Follow-Up Studies; Humans; In Vitro Techniques; Laryngostenosis; Mitomycin; Nucleic Acid Synthesis Inhibitors; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Treatment Outcome | 2006 |
Halofuginone reduces the occurrence of renal fibrosis in 5/6 nephrectomized rats.
Topics: Animals; Blood Pressure; Case-Control Studies; Disease Models, Animal; Fibrosis; Kidney; Male; Nephrectomy; Piperidines; Protein Synthesis Inhibitors; Proteinuria; Quinazolinones; Rats; Rats, Wistar | 2007 |
Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone.
Topics: Actins; Age Factors; Animals; Cell Proliferation; Collagen Type I; Collagen Type III; Diaphragm; Disease Models, Animal; Fibrosis; Heart; Hepatocyte Growth Factor; Mice; Mice, Inbred mdx; Muscle Strength; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Myocardium; Physical Endurance; Piperidines; Protein Synthesis Inhibitors; Quadriceps Muscle; Quinazolinones; Respiratory Mechanics; Running; Time Factors; Ventricular Function, Left | 2008 |
Focusing on fibrosis: halofuginone-induced functional improvement in the mdx mouse model of Duchenne muscular dystrophy.
Topics: Age Factors; Animals; Collagen Type I; Collagen Type III; Disease Models, Animal; Fibrosis; Heart; Mice; Mice, Inbred mdx; Muscle Strength; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Myocardium; Physical Endurance; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Respiratory Mechanics; Time Factors; Ventricular Function, Left | 2008 |
Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: effect of halofuginone.
Topics: Animals; Collagen; Disease Models, Animal; Fibrosis; Graft vs Host Disease; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Osmolar Concentration; Piperidines; Quinazolines; Quinazolinones; Scleroderma, Localized; Skin | 1996 |
The effect of halofuginone, an inhibitor of collagen type i synthesis, on urethral stricture formation: in vivo and in vitro study in a rat model.
Topics: Animals; Collagen; Disease Models, Animal; Immunohistochemistry; In Situ Hybridization; Male; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Urethral Stricture | 2000 |
Reduction in dermal fibrosis in the tight-skin (Tsk) mouse after local application of halofuginone.
Topics: Administration, Topical; Animals; Cell Division; Collagen; Disease Models, Animal; Fibrosis; Male; Mast Cells; Mice; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Skin | 2001 |
Analysis of the effect of halofuginone on bleomycin-induced scleroderma.
Topics: Animals; Bleomycin; Collagen; Disease Models, Animal; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Scleroderma, Systemic; Specific Pathogen-Free Organisms; Treatment Outcome | 2002 |