Page last updated: 2024-08-23

halofantrine and Long QT Syndrome

halofantrine has been researched along with Long QT Syndrome in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (38.10)	18.2507
2000's	11 (52.38)	29.6817
2010's	2 (9.52)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M	1
Brocks, DR; Patel, JP	1
Bouchy-Bagros, ML; Denjoy, I; Lupoglazoff, JM; Pull, L; Siriez, JY	1
Bindschedler, M; Degen, P; Lefèvre, G; Sioufi, A	1
Batey, AJ; Charman, WN; Coker, SJ; McIntosh, MP; Porter, CJ	1
Combes, JC; Garnier, JM; Minodier, P; Noël, G; Retornaz, K; Salles, M; Walters, H	1
Dumotier, B; Traebert, M	1
Barratt, G; Grabe-Guimarães, A; Guimarães, HN; Leite, EA; Machado-Coelho, GL; Mosqueira, VC	1
Pohjola-Sintonen, S; Raatikka, M; Siikamäki, H; Toivonen, L; Viitasalo, M	1
Castot, A; Le Coz, P; Rapoport, P	1
Cochard, JF; Favarel Garrigues, JC; le Bras, M; Monlun, E; Pillet, O	1
Nicolas, F; Nicolas, X	1
Edwards, G; Gundersen, SG; Myrvang, B; Platou, ES; Rostrup, M; von der Lippe, E	1
Batey, AJ; Coker, SJ; Edwards, G; Lambert, JP; Lightbown, ID	1
Jacqz-Aigrain, E; Olivier, C; Rizk, C; Zhang, D	1
Coker, SJ; Edwards, G; Lambert, JP; Lightbown, ID	1
Holmström, S; Kontula, K; Piippo, K; Raatikka, M; Swan, H; Toivonen, L; Viitasalo, M	1
Abernethy, DR; Barbey, JT; Mohanty, S; Ohrt, C; Pezzullo, JC; Schuster, BG; Wesche, DL	1
Gendrel, D; Imbert, P; Lavallée, I; Marc, E; Moulin, F; Treluyer, JM	1

Reviews

1 review(s) available for halofantrine and Long QT Syndrome

Article	Year
Antimalarial drugs: QT prolongation and cardiac arrhythmias. Expert opinion on drug safety, 2005, Volume: 4, Issue:3 Topics: Amodiaquine; Drug Approval; Electrophysiology; Humans; Long QT Syndrome; Malaria; Phenanthrenes; Risk Assessment; Risk Factors; Torsades de Pointes	2005

Trials

4 trial(s) available for halofantrine and Long QT Syndrome

Article	Year
Comparison of the cardiac effects of the antimalarials co-artemether and halofantrine in healthy participants. The American journal of tropical medicine and hygiene, 2002, Volume: 66, Issue:3 Topics: Administration, Oral; Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Cross-Over Studies; Double-Blind Method; Drug Combinations; Electrocardiography; Ethanolamines; Fluorenes; Heart; Heart Rate; Humans; Long QT Syndrome; Male; Phenanthrenes; Sesquiterpenes	2002
[Mefloquine versus halofantrine in children suffering from acute uncomplicated falciparum malaria]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2005, Volume: 12 Suppl 1 Topics: Adolescent; Antimalarials; Child; Child, Preschool; Female; Humans; Infant; Long QT Syndrome; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Treatment Outcome	2005
[Monitoring of long QT interval during treatment of malaria with halofantrine]. Medecine tropicale : revue du Corps de sante colonial, 1995, Volume: 55, Issue:4 Topics: Adolescent; Adult; Antimalarials; Drug Monitoring; Electrocardiography; Humans; Long QT Syndrome; Malaria; Male; Phenanthrenes; Prospective Studies	1995
Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation. British journal of clinical pharmacology, 2001, Volume: 51, Issue:3 Topics: Adult; Antimalarials; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Metabolic Clearance Rate; Molecular Conformation; Phenanthrenes	2001

Other Studies

16 other study(ies) available for halofantrine and Long QT Syndrome

Article	Year
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18 Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2002
Effect of experimental hyperlipidaemia on the electrocardiographic effects of repeated doses of halofantrine in rats. British journal of pharmacology, 2010, Volume: 161, Issue:6 Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Hyperlipidemias; Long QT Syndrome; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley	2010
Effect of halofantrine on QT interval in children. Pathogens and global health, 2012, Volume: 106, Issue:2 Topics: Adolescent; Antimalarials; Cardiac Electrophysiology; Child; Child, Preschool; Electrophysiological Phenomena; Female; Humans; Infant; Long QT Syndrome; Malaria, Falciparum; Male; Phenanthrenes	2012
Evaluation of the impact of altered lipoprotein binding conditions on halofantrine induced QTc interval prolongation in an anaesthetized rabbit model. The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:1 Topics: Animals; Antimalarials; Blood Proteins; Electrocardiography; Fasting; Food-Drug Interactions; Lipoproteins; Long QT Syndrome; Phenanthrenes; Postprandial Period; Protein Binding; Rabbits	2004
Cardiotoxicity reduction induced by halofantrine entrapped in nanocapsule devices. Life sciences, 2007, Mar-13, Volume: 80, Issue:14 Topics: Animals; Antimalarials; Bradycardia; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart; Hypotension; Lethal Dose 50; Long QT Syndrome; Malaria; Male; Mice; Nanocapsules; Phenanthrenes; Plasmodium berghei; Rats; Rats, Wistar	2007
Provocation of ventricular tachycardia by antimalarial drug halofantrine in congenital long QT syndrome. Clinical cardiology, 1994, Volume: 17, Issue:7 Topics: Adolescent; Adult; Antimalarials; Electrocardiography; Female; Follow-Up Studies; Humans; Long QT Syndrome; Male; Phenanthrenes; Syncope; Tachycardia, Ventricular; Torsades de Pointes	1994
Prolonged QT interval with halofantrine. Lancet (London, England), 1993, Jun-12, Volume: 341, Issue:8859 Topics: Adult; Antimalarials; Electrocardiography; Female; Humans; Long QT Syndrome; Phenanthrenes	1993
Prolonged QT interval with halofantrine. Lancet (London, England), 1993, Jun-12, Volume: 341, Issue:8859 Topics: Adult; Antimalarials; Female; Humans; Long QT Syndrome; Phenanthrenes; Torsades de Pointes	1993
Drug alert: halofantrine. Releve epidemiologique hebdomadaire, 1993, Sep-10, Volume: 68, Issue:37 Topics: Antimalarials; Electrocardiography; Humans; Long QT Syndrome; Malaria, Falciparum; Malaria, Vivax; Phenanthrenes	1993
Halofantrine-associated ventricular fibrillation in a young woman with no predisposing QTc prolongation. Scandinavian journal of infectious diseases, 1997, Volume: 29, Issue:2 Topics: Adult; Antimalarials; Female; Humans; Long QT Syndrome; Phenanthrenes; Ventricular Fibrillation	1997
Comparison of the acute cardiotoxicity of the antimalarial drug halofantrine in vitro and in vivo in anaesthetized guinea-pigs. British journal of pharmacology, 1997, Volume: 122, Issue:3 Topics: Animals; Antimalarials; Blood Pressure; Electrocardiography; Guinea Pigs; Heart Rate; In Vitro Techniques; Long QT Syndrome; Male; Myocardial Contraction; Papillary Muscles; Phenanthrenes; Refractory Period, Electrophysiological	1997
[Long QTc interval complicating halofantrine therapy in 2 children with Plasmodium falciparum malaria]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1999, Volume: 6, Issue:9 Topics: Adult; Antimalarials; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Humans; Infant; Long QT Syndrome; Malaria, Falciparum; Male; Phenanthrenes	1999
Potentiation of halofantrine-induced QTc prolongation by mefloquine: correlation with blood concentrations of halofantrine. British journal of pharmacology, 2001, Volume: 132, Issue:1 Topics: Action Potentials; Animals; Antimalarials; Blood Gas Analysis; Drug Synergism; Electrocardiography; Female; Hemodynamics; Hydrogen-Ion Concentration; Long QT Syndrome; Mefloquine; Phenanthrenes; Potassium; Rabbits	2001
Effect of the antimalarial drug halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A. The American journal of cardiology, 2001, Apr-01, Volume: 87, Issue:7 Topics: Adolescent; Adult; Amino Acid Sequence; Antimalarials; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Molecular Sequence Data; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Pedigree; Phenanthrenes; Sodium Channels; Tachycardia, Ventricular	2001
Sudden death in a traveller following halofantrine administration--Togo, 2000. Canada communicable disease report = Releve des maladies transmissibles au Canada, 2001, Jul-15, Volume: 27, Issue:14 Topics: Adult; Antimalarials; Cardiomyopathy, Hypertrophic; Contraindications; Death, Sudden, Cardiac; Humans; Long QT Syndrome; Malaria; Male; Mefloquine; Phenanthrenes; Togo; Travel	2001
[Cardiac rhythm disturbances and prolonged QT interval with halofantrine]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2001, Volume: 8, Issue:8 Topics: Adolescent; Antimalarials; Bradycardia; Child; Child, Preschool; Electrocardiography; Female; Humans; Infant; Long QT Syndrome; Malaria; Male; Phenanthrenes	2001