halenaquinone and Malaria--Falciparum

halenaquinone has been researched along with Malaria--Falciparum* in 1 studies

Other Studies

1 other study(ies) available for halenaquinone and Malaria--Falciparum

Article	Year
New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16 Bioassay-directed fractionation of South Pacific marine sponges of the genus Xestospongia has led to the isolation of a number of halenaquinone-type polyketides, including two new derivatives named xestosaprol C methylacetal 7 and orhalquinone 8. Chemical characterization of these two new compounds was achieved by extensive 1D and 2D NMR spectroscopic studies. Evaluation of anti-phospholipase A(2), anti-farnesyltransferase and antiplasmodial activities of this series is presented and structure/activity relationships are discussed. Orhalquinone 8 displayed a significant inhibition of both human and yeast farnesyltransferase enzymes, with IC(50) value of 0.40 microM and was a moderate growth inhibitor of Plasmodium falciparum. Topics: Animals; Antimalarials; Cell Survival; Chlorocebus aethiops; Farnesyltranstransferase; Humans; Malaria, Falciparum; Phospholipase A2 Inhibitors; Phospholipases A2; Plasmodium falciparum; Quinones; Structure-Activity Relationship; Vero Cells; Xestospongia; Yeasts	2010

Article

Year

New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.

Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16

Bioassay-directed fractionation of South Pacific marine sponges of the genus Xestospongia has led to the isolation of a number of halenaquinone-type polyketides, including two new derivatives named xestosaprol C methylacetal 7 and orhalquinone 8. Chemical characterization of these two new compounds was achieved by extensive 1D and 2D NMR spectroscopic studies. Evaluation of anti-phospholipase A(2), anti-farnesyltransferase and antiplasmodial activities of this series is presented and structure/activity relationships are discussed. Orhalquinone 8 displayed a significant inhibition of both human and yeast farnesyltransferase enzymes, with IC(50) value of 0.40 microM and was a moderate growth inhibitor of Plasmodium falciparum.

Topics: Animals; Antimalarials; Cell Survival; Chlorocebus aethiops; Farnesyltranstransferase; Humans; Malaria, Falciparum; Phospholipase A2 Inhibitors; Phospholipases A2; Plasmodium falciparum; Quinones; Structure-Activity Relationship; Vero Cells; Xestospongia; Yeasts

2010