halcinonide and Eczema

A 2-week, double-blind clinical trial was conducted to compare the efficacy and cosmetic acceptability of amcinonide cream 0.1 percent and halcinonide cream 0.1 percent in the treatment of 29 patients with eczematous dermatitis. The dermatologic status of each patient was rated by improvement in clinical signs and symptoms, by the investigator's overall evaluation, and by two patient evaluations. Both medications produced statistically significant and equivalent improvement by Week 2. However, amcinonide was significantly favored in the efficacy evaluation of relief from burning pain at Week 2 and in patient acceptability evaluations in regard to the absence of burning, stinging, and itching on application. The role of propylene glycol in the formulation of the halcinonide cream as a contributing cause of irritation is noted.

Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Clinical Trials as Topic; Double-Blind Method; Eczema; Halcinonide; Humans; Male; Middle Aged; Pharmaceutical Vehicles; Pregnenediones; Propylene Glycols; Triamcinolone

A comparative trial between betamethasone valerate and halcinonide has shown the former to be superior, thus contradicting the results from other trials. It is thought that the discrepancy is due to differences in the nature of the preparations used in the various studies. It is suggested that note is made of the base used in trials before final conclusions about the efficicacy of steroids are made.

Topics: Administration, Topical; Betamethasone; Betamethasone Valerate; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Eczema; Halcinonide; Humans; Ointments; Psoriasis; Skin Diseases

Halcinonide solution, 0.1 percent, was used to treat sixty-six patients with eczematous dermatoses. The majority of the responses were excellent, with the condition clearing completely in eight patients within the first week. The total mean amount of medication used by each patient for twice a day application for one or two weeks was less than 24 ml.

Topics: Adult; Dermatitis; Dermatitis, Seborrheic; Eczema; Eczema, Dyshidrotic; Female; Halcinonide; Humans; Male; Pregnenediones

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Eczema; Erythema; Female; Halcinonide; Humans; Lichen Planus; Male; Middle Aged; Ointments; Parapsoriasis; Pityriasis; Pregnenediones; Psoriasis; Skin Diseases