halcinonide and Candidiasis--Cutaneous

The anti-inflammatory and antimicrobial activities of two topical creams, one containing halcinonide, neomycin and nystatin (HNN), and the other betamethasone valerate, gentamicin, iodochlorhydroxyquin and tolnaftate (BGI), were compared in a randomized, parallel study of 154 patients (eighty-seven secondarily infected eczematous dermatoses; sixty-seven cutaneous candidiasis). Repeated clinical assessments showed that the two creams produced equivalent therapeutic responses both in patients with infected eczematous lesions and candidiasis. HNN and BGI creams eradicated the bacterial pathogens isolated prior to treatment in 80% and 76%, respectively, of the patients with eczematous dermatoses. The organism most frequently isolated in these patients was S. aureus. Local irritation prompting discontinuance of therapy occurred in just one patient receiving HNN, and two patients receiving BGI.

Topics: Administration, Topical; Anti-Inflammatory Agents; Betamethasone Valerate; Candidiasis, Cutaneous; Clinical Trials as Topic; Clioquinol; Female; Gentamicins; Halcinonide; Humans; Male; Neomycin; Nystatin; Random Allocation; Skin Diseases, Infectious; Tolnaftate

Halcinonide-neomycin-amphotericin (HNA) cream was evaluated in the treatment of cutaneous candidiasis and inflammatory dermatoses. The anti-candidal properties of HNA were assessed in a parallel comparison with iodochlorhydroxyquin-hydrocortisone (I-HC) as the control drug. The overall therapeutic response with HNA was excellent in 38 (95%) of 40 patients as compared to 17 (43%) of 40 treated with I-HC. In 50 patients treated for psoriasis, eczematous dermatitis, or neurodermatitis, HNA was evaluated in a paired comparison with hydrocortisone (HC). The overall therapeutic response with HNA was excellent in 36 (72%) patients as compared to 18 (36%) with HC. There were no adverse reactions with HNA or the control drugs.

Topics: Administration, Topical; Adolescent; Adult; Aged; Amphotericin B; Anti-Inflammatory Agents; Candidiasis, Cutaneous; Child; Clinical Trials as Topic; Clioquinol; Dermatitis; Drug Combinations; Female; Halcinonide; Humans; Hydrocortisone; Male; Middle Aged; Neomycin; Pregnenediones; Time Factors

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amphotericin B; Candidiasis, Cutaneous; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Female; Halcinonide; Humans; Infant; Male; Middle Aged; Pregnenediones; Time Factors